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Future Table of Contents: Volume 183 / No. 12 / Dec 15, 2009

IN THIS ISSUE

BRIEF REVIEWS

CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

IMMUNOGENETICS

HOST DEFENSE

INFLAMMATION

CLINICAL IMMUNOLOGY

IN THIS ISSUE

BRIEF REVIEWS

Inflammasome-Associated Nucleotide-Binding Domain, Leucine-Rich Repeat Proteins and Inflammatory Diseases

Sushmita Jha and Jenny P.-Y. Ting

CUTTING EDGE

Depletion of Foxp3+ Cells Leads to Induction of Autoimmunity by Specific Ablation of Regulatory T Cells in Genetically Targeted Mice

Jeong Kim, Katharina Lahl, Shohei Hori, Christoph Loddenkemper, Ashutosh Chaudhry, Paul deRoos, Alexander Rudensky, and Tim Sparwasser

Normal Regional Lymph Node Enrichment of Antigen-Specific Regulatory T Cells with Autoimmune, Disease-Suppressive Capacity

Karen M. Wheeler, Eileen T. Samy, and Kenneth S. K. Tung

Inhibitory Effects of CD4 and CD8 on T Cell Activation Induced by High-Affinity, Noncognate Ligands

Adam S. Chervin, Jennifer D. Stone, Natalie A. Bowerman, and David M. Kranz

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

IL-7 Enhances Thymic Human T Cell Development in "Human Immune System" Rag2-/-IL-2Rc-/- Mice without Affecting Peripheral T Cell Homeostasis

Anja U. van Lent, Wendy Dontje, Maho Nagasawa, Rachida Siamari, Arjen Q. Bakker, Stephan M. Pouw, Kelly A. Maijoor, Kees Weijer, Jan J. Cornelissen, Bianca Blom, James P. Di Santo, Hergen Spits, and Nicolas Legrand

Activated CD8+ T-Effector/Memory Cells Eliminate CD4+ CD25+ Foxp3+ T-Suppressor Cells from Tumors via FasL Mediated Apoptosis

Mehmet O. Kilinc, Rachael B. Rowswell-Turner, Tao Gu, Lauren P. Virtuoso, and Nejat K. Egilmez

B7-1/2 (CD80/CD86) Direct Signaling to B Cells Enhances IgG Secretion

Friederike C. Rau, Jacquelyn Dieter, Zhang Luo, Stephen O. Priest, and Nicole Baumgarth

Tracking the Total CD8 T Cell Response to Infection Reveals Substantial Discordance in Magnitude and Kinetics between Inbred and Outbred Hosts

Deepa Rai, Nhat-Long L. Pham, John T. Harty, and Vladimir P. Badovinac

Autoimmune Regulator Deficiency Results in Decreased Expression of CCR4 and CCR7 Ligands and in Delayed Migration of CD4+ Thymocytes

Martti Laan, Kai Kisand, Vivian Kont, Kaidi Moll, Liina Tserel, Hamish S. Scott, and Part Peterson

The IL-27 p28 Subunit Binds Cytokine-Like Factor 1 to Form a Cytokine Regulating NK and T Cell Activities Requiring IL-6R for Signaling

Sandrine Crabe, Angelique Guay-Giroux, Aurelie Jeanne Tormo, Dorothee Duluc, Rami Lissilaa, Florence Guilhot, Ulrick Mavoungou-Bigouagou, Fouad Lefouili, Isabelle Cognet, Walter Ferlin, Greg Elson, Pascale Jeannin, and Jean-Francois Gauchat

IFN- Expressed by T Cells Regulates the Persistence of Antigen Presentation by Limiting the Survival of Dendritic Cells

Marsha S. Russell, Renu Dudani, Lakshmi Krishnan, and Subash Sad

Siglec-E Is Up-Regulated and Phosphorylated Following Lipopolysaccharide Stimulation in Order to Limit TLR-Driven Cytokine Production

Caroline R. Boyd, Selinda J. Orr, Shaun Spence, James F. Burrows, Joanne Elliott, Helen P. Carroll, Kiva Brennan, Joan Ni Gabhann, Wilson A. Coulter, James A. Johnston, and Caroline A. Jefferies

Ubiquitin-Conjugation of ORFF DNA Vaccine Leads to Enhanced Cell-Mediated Immune Response and Induces Protection against Both Antimony-Susceptible and -Resistant Strains of Leishmania donovani

Ankur Sharma and Rentala Madhubala

Langerin+CD8+ Dendritic Cells Are Critical for Cross-Priming and IL-12 Production in Response to Systemic Antigens

Kathryn J. Farrand, Nina Dickgreber, Patrizia Stoitzner, Franca Ronchese, Troels R. Petersen, and Ian F. Hermans

Integration of Distinct Intracellular Signaling Pathways at Distal Regulatory Elements Directs T-bet Expression in Human CD4+ T Cells

Katarzyna Placek, Sona Gasparian, Maryaline Coffre, Sylvie Maiella, Emmanuel Sechet, Elisabetta Bianchi, and Lars Rogge

Human Activated T Lymphocytes Modulate IDO Expression in Tumors through Th1/Th2 Balance

Jessica Godin-Ethier, Sandy Pelletier, Laila-Aicha Hanafi, Philippe O. Gannon, Marie-Andree Forget, Jean-Pierre Routy, Mohamed-Rachid Boulassel, Urszula Krzemien, Simon Tanguay, Jean-Baptiste Lattouf, Nathalie Arbour, and Rejean Lapointe

Bim-Mediated Apoptosis Is Not Necessary for Thymic Negative Selection to Ubiquitous Self-Antigens

Qian Hu, Alyssa Sader, Julia C. Parkman, and Troy A. Baldwin

Asynchronous RAG-1 Expression during B Lymphopoiesis

Robert S. Welner, Brandt L. Esplin, Karla P. Garrett, Rosana Pelayo, Herve Luche, Hans Jorg Fehling, and Paul W. Kincade

Brain-Derived Neurotrophic Factor (BDNF) Induces Sustained Elevation of Intracellular Ca2+ in Rodent Microglia

Yoshito Mizoguchi, Akira Monji, Takahiro Kato, Yoshihiro Seki, Leo Gotoh, Hideki Horikawa, Satoshi O. Suzuki, Toru Iwaki, Miyuki Yonaha, Sadayuki Hashioka, and Shigenobu Kanba

Mesenchymal Stem Cells Derived from Human Gingiva Are Capable of Immunomodulatory Functions and Ameliorate Inflammation-Related Tissue Destruction in Experimental Colitis

Qunzhou Zhang, Shihong Shi, Yi Liu, Jettie Uyanne, Yufang Shi, Songtao Shi, and Anh D. Le

Activation, Immune Polarization, and Graft-versus-Leukemia Activity of Donor T Cells Are Regulated by Specific Subsets of Donor Bone Marrow Antigen-Presenting Cells in Allogeneic Hemopoietic Stem Cell Transplantation

Jian-Ming Li, Lauren T. Southerland, Ying Lu, Kataryna A. Darlak, Cynthia R. Giver, Douglas W. McMillin, Wayne A. C. Harris, David L. Jaye, and Edmund K. Waller

An Innate Response to Allogeneic Nonself Mediated by Monocytes

Daniel Zecher, Nico van Rooijen, David M. Rothstein, Warren D. Shlomchik, and Fadi G. Lakkis

The Runx3 Transcription Factor Augments Th1 and Down-Modulates Th2 Phenotypes by Interacting with and Attenuating GATA3

Kazuyoshi Kohu, Hidetaka Ohmori, Won Fen Wong, Daisuke Onda, Takeshi Wakoh, Shunsuke Kon, Masakatsu Yamashita, Toshinori Nakayama, Masato Kubo, and Masanobu Satake

Role of CX3CL1/Fractalkine in Osteoclast Differentiation and Bone Resorption

Keiichi Koizumi, Yurika Saitoh, Takayuki Minami, Nobuhiro Takeno, Koichi Tsuneyama, Tatsuro Miyahara, Takashi Nakayama, Hiroaki Sakurai, Yasuo Takano, Miyuki Nishimura, Toshio Imai, Osamu Yoshie, and Ikuo Saiki

TLR2 Engagement on Dendritic Cells Promotes High Frequency Effector and Memory CD4 T Cell Responses

Smita S. Chandran, David Verhoeven, John R. Teijaro, Matthew J. Fenton, and Donna L. Farber

Soluble B and T Lymphocyte Attenuator Possesses Antitumor Effects and Facilitates Heat Shock Protein 70 Vaccine-Triggered Antitumor Immunity against a Murine TC-1 Cervical Cancer Model In Vivo

Lingfei Han, Wei Wang, Yong Fang, Zuohua Feng, Shujie Liao, Wei Li, Yan Li, Chunxiao Li, Mayinuer Maitituoheti, Hong Dong, Zhiwen Lai, Qinglei Gao, Ling Xi, Mingfu Wu, Daowen Wang, Jianfeng Zhou, Li Meng, Shixuan Wang, and Ding Ma

Sublingual Immunization with Nonreplicating Antigens Induces Antibody-Forming Cells and Cytotoxic T Cells in the Female Genital Tract Mucosa and Protects against Genital Papillomavirus Infection

Nicolas Cuburu, Mi-Na Kweon, Catherine Hervouet, Hye-Ran Cha, Yuk-Ying S. Pang, Jan Holmgren, Konrad Stadler, John T. Schiller, Fabienne Anjuere, and Cecil Czerkinsky

Viruses within the Flaviviridae Decrease CD4 Expression, and Inhibit HIV Replication in Human CD4+ Cells

Jinhua Xiang, James H. McLinden, Robert A. Rydze, Qing Chang, Thomas M. Kaufman, Donna Klinzman, and Jack T. Stapleton

IL-13R2 Membrane and Soluble Isoforms Differ in Humans and Mice

Weiguo Chen, Umasundari Sivaprasad, Yasuhiro Tabata, Aaron M. Gibson, Matthew T. Stier, Fred D. Finkelman, and Gurjit K. Khurana Hershey

Neuronal IB Kinase Protects Mice from Autoimmune Encephalomyelitis by Mediating Neuroprotective and Immunosuppressive Effects in the CNS

Mary Emmanouil, Era Taoufik, Vivian Tseveleki, Sotiris-Spyros Vamvakas, Theodore Tselios, Michael Karin, Hans Lassmann, and Lesley Probert

Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages

Tatsukuni Ohno, Keisuke Oboki, Naoki Kajiwara, Eiichi Morii, Katsuyuki Aozasa, Richard A. Flavell, Ko Okumura, Hirohisa Saito, and Susumu Nakae

Dual Control of Antitumor CD8 T Cells through the Programmed Death-1/Programmed Death-Ligand 1 Pathway and Immunosuppressive CD4 T Cells: Regulation and Counterregulation

Andrew J. Currie, Amy Prosser, Alison McDonnell, Amanda L. Cleaver, Bruce W. S. Robinson, Gordon J. Freeman, and Robbert G. van der Most

Thymus-Blood Protein Interactions are Highly Effective in Negative Selection and Regulatory T Cell Induction

Danielle F. Atibalentja, Craig A. Byersdorfer, and Emil R. Unanue

The Yellow Fever Virus Vaccine Induces a Broad and Polyfunctional Human Memory CD8+ T Cell Response

Rama S. Akondy, Nathan D. Monson, Joseph D. Miller, Srilatha Edupuganti, Dirk Teuwen, Hong Wu, Farah Quyyumi, Seema Garg, John D. Altman, Carlos Del Rio, Harry L. Keyserling, Alexander Ploss, Charles M. Rice, Walter A. Orenstein, Mark J. Mulligan, and Rafi Ahmed

RasGRP1 Is Required for Human NK Cell Function

Suk Hyung Lee, Sohyun Yun, Jiwon Lee, Mi Jeong Kim, Zheng-Hao Piao, Mira Jeong, Jin Woong Chung, Tae-Don Kim, Suk Ran Yoon, Philip D. Greenberg, and Inpyo Choi

MOLECULAR AND STRUCTURAL IMMUNOLOGY

Duality of Enhancer Functioning Mode Revealed in a Reduced TCR-Gene Enhancer Knockin Mouse Model

Marie Bonnet, Fang Huang, Touati Benoukraf, Olivier Cabaud, Christophe Verthuy, Anaelle Boucher, Sebastien Jaeger, Pierre Ferrier, and Salvatore Spicuglia

New Design of MHC Class II Tetramers to Accommodate Fundamental Principles of Antigen Presentation

Elise Landais, Pablo A. Romagnoli, Adam L. Corper, John Shires, John Altman, Ian A. Wilson, K. Christopher Garcia, and Luc Teyton

Modulation of Allergenicity of Major House Dust Mite Allergens Der f 1 and Der p 1 by Interaction with an Endogenous Ligand

Toshiro Takai, Takeshi Kato, Hideki Hatanaka, Kyoko Inui, Takuya Nakazawa, Saori Ichikawa, Kouichi Mitsuishi, Hideoki Ogawa, and Ko Okumura

Signal-Transducing Adaptor Protein-2 Regulates Stromal Cell-Derived Factor-1-Induced Chemotaxis in T Cells

Yuichi Sekine, Osamu Ikeda, Satoshi Tsuji, Chikako Yamamoto, Ryuta Muromoto, Asuka Nanbo, Kenji Oritani, Akihiko Yoshimura, and Tadashi Matsuda

IMMUNOGENETICS

The Tpl2 Mutation Sluggish Impairs Type I IFN Production and Increases Susceptibility to Group B Streptococcal Disease

Nengming Xiao, Celine Eidenschenk, Philippe Krebs, Katharina Brandl, Amanda L. Blasius, Yu Xia, Kevin Khovananth, Nora G. Smart, and Bruce Beutler

HOST DEFENSE

Enhanced susceptibility to Leishmania infection in resistant mice in the absence of immediate early response gene X-1

Oleg E. Akilov, Irina V. Ustyugova, Liang Zhi, Tayyaba Hasan, and Mei X. Wu

Tumor Progression Locus 2 (Map3k8) Is Critical for Host Defense Against Listeria monocytogenes and IL-1 Production

Lisa A. Mielke, Karen L. Elkins, Lai Wei, Robyn Starr, Philip N. Tsichlis, John J. O'Shea, and Wendy T. Watford

In a Murine Tuberculosis Model, the Absence of Homeostatic Chemokines Delays Granuloma Formation and Protective Immunity

Shabaana A. Khader, Javier Rangel-Moreno, Jeffrey J. Fountain, Cynthia A. Martino, William W. Reiley, John E. Pearl, Gary M. Winslow, David L. Woodland, Troy D. Randall, and Andrea M. Cooper

The Heavy Chain Variable Segment Gene Repertoire in Chronic Chagas Heart Disease

Vanina Grippo, Evelyn Mahler, Fernando E. Elias, Ana Cauerhff, Karina A. Gomez, Maria C. Tentori, Aurora Ruiz, Carlos A. Vigliano, Ruben P. Laguens, Claudia Berek, Mariano J. Levin

IL-23 Is Required for Protection against Systemic Infection with Listeria monocytogenes

Karen D. Meeks, Amy N. Sieve, Jay K. Kolls, Nico Ghilardi, and Rance E. Berg

Distinct Antiviral Roles for Human 2,5-Oligoadenylate Synthetase Family Members against Dengue Virus Infection

Ren-Jye Lin, Han-Pang Yu, Bi-Lan Chang, Wei-Chun Tang, Ching-Len Liao, and Yi-Ling Lin

Accumulation of CD11b+ Lung Dendritic Cells in Response to Fungal Infection Results from the CCR2-Mediated Recruitment and Differentiation of Ly-6Chigh Monocytes

John J. Osterholzer, Gwo-Hsiao Chen, Michal A. Olszewski, Jeffrey L. Curtis, Gary B. Huffnagle, and Galen B. Toews

-Defensins 2 and 3 Together Promote Resistance to P. aeruginosa Keratitis

Minhao Wu, Sharon A. McClellan, Ronald P. Barrett, Yunfan Zhang, and Linda D. Hazlett

Involvement of the NLRP3 Inflammasome in Innate and Humoral Adaptive Immune Responses to Fungal -Glucan

Himanshu Kumar, Yutaro Kumagai, Tetsuo Tsuchida, Paul A. Koenig, Takashi Satoh, Zijin Guo, Myoung Ho Jang, Tatsuya Saitoh, Shizuo Akira, and Taro Kawai

Infection with Arginase-Deficient Leishmania major Reveals a Parasite Number-Dependent and Cytokine-Independent Regulation of Host Cellular Arginase Activity and Disease Pathogenesis

Helen M. Muleme, Rosa M. Reguera, Alicia Berard, Richard Azinwi, Ping Jia, Ifeoma B. Okwor, Stephen Beverley, and Jude E. Uzonna

Inflation and Long-Term Maintenance of CD8 T Cells Responding to a Latent Herpesvirus Depend upon Establishment of Latency and Presence of Viral Antigens

Anna Lang, James D. Brien, and Janko Nikolich-Zugich

Neutrophils and Macrophages Cooperate in Host Resistance against Leishmania braziliensis Infection

Fernanda O. Novais, Romulo C. Santiago, Andre Bafica, Ricardo Khouri, Lilian Afonso, Valeria M. Borges, Claudia Brodskyn, Manoel Barral-Netto, Aldina Barral, and Camila I. de Oliveira

Helicobacter pylori Induces MAPK Phosphorylation and AP-1 Activation Via a NOD1-Dependent Mechanism

Cody C. Allison, Thomas A. Kufer, Elisabeth Kremmer, Maria Kaparakis, and Richard L. Ferrero

INFLAMMATION

Signaling Crosstalk during Sequential TLR4 and TLR9 Activation Amplifies the Inflammatory Response of Mouse Macrophages

Dominic De Nardo, Christine M. De Nardo, Thao Nguyen, John A. Hamilton, and Glen M. Scholz

Matrix Metalloproteinase (MMP)-1 and MMP-3 induce macrophage MMP-9: Evidence for the Role of TNF- and Cyclooxygenase-2

Michel Steenport, K. M. Faisal Khan, Baoheng Du, Sarah E. Barnhard, Andrew J. Dannenberg, and Domenick J. Falcone

Novel Role for Aldose Reductase in Mediating Acute Inflammatory Responses in the Lung

Thyyar M. Ravindranath, Phyllus Y. Mong, Radha Ananthakrishnan, Qing Li, Nosirudeen Quadri, Ann Marie Schmidt, Ravichandran Ramasamy, and Qin Wang

Cell Surface Externalization of Annexin A1 as a Failsafe Mechanism Preventing Inflammatory Responses During Secondary Necrosis

Karin Blume, Szabolcs Soeroes, Michaela Waibel, Hildegard Keppeler, Sebastian Wesselborg, Martin Herrmann, Klaus Schulze-Osthoff, and Kirsten Lauber

Decreased Levels of Secretory Leucoprotease Inhibitor in the Pseudomonas-Infected Cystic Fibrosis Lung Are Due to Neutrophil Elastase Degradation

Sinead Weldon, Paul McNally, Noel G. McElvaney, J. Stuart Elborn, Danny F. McAuley, Julien Wartelle, Abderrazzaq Belaaouaj, Rodney L. Levine, and Clifford C. Taggart

DcR3 Protects Islet Cells from Apoptosis through Modulating Adcyap1 and Bank1 Expression

Bing Han and Jiangping Wu

Inhibition of IL-17A Attenuates Atherosclerotic Lesion Development in ApoE-Deficient Mice

Christian Erbel, Lili Chen, Florian Bea, Susanne Wangler, Sultan Celik, Felix Lasitschka, Ying Wang, Dittmar Bockler, Hugo A. Katus, and Thomas J. Dengler

Expression of Soluble Vascular Endothelial Growth Factor Receptor-1 in Human Monocyte-Derived Mature Dendritic Cells Contributes to Their Antiangiogenic Property

Masatoshi Kishuku, Yasuhiko Nishioka, Shinji Abe, Jun Kishi, Hirokazu Ogino, Yoshinori Aono, Momoyo Azuma, Katsunori Kinoshita, Batmungh Rentsenhand, Hideki Makino, Priya Ranjan, Kazuo Minakuchi, and Saburo Sone

CCR7 Modulates Pulmonary and Lymph Node Inflammatory Responses in Cigarette Smoke-Exposed Mice

Tine Demoor, Ken R. Bracke, Karim Y. Vermaelen, Lisa Dupont, Guy F. Joos, and Guy G. Brusselle

IL-1R1/MyD88 Signaling Is Critical for Elastase-Induced Lung Inflammation and Emphysema

Isabelle Couillin, Virginie Vasseur, Sabine Charron, Pamela Gasse, Marie Tavernier, Julien Guillet, Vincent Lagente, Lizette Fick, Muazzam Jacobs, Fernando Rodrigues Coelho, Rene Moser, and Bernhard Ryffel

CD69 Controls the Pathogenesis of Allergic Airway Inflammation

Takako Miki-Hosokawa, Akihiro Hasegawa, Chiaki Iwamura, Kenta Shinoda, Soichi Tofukuji, Yukiko Watanabe, Hiroyuki Hosokawa, Shinichiro Motohashi, Kahoko Hashimoto, Mutsunori Shirai, Masakatsu Yamashita, and Toshinori Nakayama

Dynamics of the Interaction of Human IgG Subtype Immune Complexes with Cells Expressing R and H Allelic Forms of a Low-Affinity Fc Receptor CD32A

Rangaiah Shashidharamurthy, Fang Zhang, Aaron Amano, Aparna Kamat, Ravichandran Panchanathan, Daniel Ezekwudo, Cheng Zhu, and Periasamy Selvaraj

CLINICAL IMMUNOLOGY

Autoantibodies against C1q in Systemic Lupus Erythematosus are Antigen-Driven

Monica Schaller, Cornelia Bigler, Doris Danner, Henrik J. Ditzel, and Marten Trendelenburg

In Vivo Induction of Type 1-Like Regulatory T Cells Using Genetically Modified B Cells Confers Long-Term IL-10-Dependent Antigen-Specific Unresponsiveness

Roxana Roohi Ahangarani, Wim Janssens, Luc VanderElst, Vincent Carlier, Thierry VandenDriessche, Marinee Chuah, Birgit Weynand, Jeroen A. J. Vanoirbeek, Marc Jacquemin, and Jean-Marie Saint-Remy

Differential Role of the Fas/Fas Ligand Apoptotic Pathway in Inflammation and Lung Fibrosis Associated with Reovirus 1/L-Induced Bronchiolitis Obliterans Organizing Pneumonia and Acute Respiratory Distress Syndrome

Andrea D. Lopez, Sreedevi Avasarala, Suman Grewal, Anuradha K. Murali, and Lucille London

ERK-Dependent T Cell Receptor Threshold Calibration in Rheumatoid Arthritis

Karnail Singh, Pratima Deshpande, Sergey Pryshchep, Ines Colmegna, Vladimir Liarski, Cornelia M. Weyand, and Jorg J. Goronzy

A Dual Action of Rheumatoid Arthritis Synovial Fibroblast IL-15 Expression on the Equilibrium between CD4+CD25+ Regulatory T Cells and CD4+CD25- Responder T Cells

Marta Benito-Miguel, Yolanda Garcia-Carmona, Alejandro Balsa, Carlos Perez de Ayala, Tatiana Cobo-Ibanez, Emilio Martin-Mola, and Maria-Eugenia Miranda-Carus

Allele *1 of HS1.2 Enhancer Associates with Selective IgA Deficiency and IgM Concentration

Vincenzo Giambra, Rossella Cianci, Serena Lolli, Claudia Mattioli, Giacomo Tampella, Marco Cattalini, Sebnem S. Kilic, Franco Pandolfi, Alessandro Plebani, and Domenico Frezza

The Kinase Inhibitors Sunitinib and Sorafenib Differentially Affect Natural Killer Cell Antitumor Reactivity In Vitro

Matthias Krusch, Julia Salih, Manuela Schlicke, Tina Baessler, Kerstin Maria Kampa, Frank Mayer, and Helmut Rainer Salih