HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Future Table of Contents: Volume 183 / No. 11 / Dec 1, 2009

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

IMMUNOGENETICS

HOST DEFENSE

INFLAMMATION

CLINICAL IMMUNOLOGY

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

A Crucial Door to the Mast Cell Mystery Knocked In

Toshiaki Kawakami

Fate of Bone Marrow-Derived Cultured Mast Cells after Intracutaneous, Intraperitoneal, and Intravenous Transfer into Genetically Mast Cell-Deficient W/Wv Mice. Evidence That Cultured Mast Cells Can Give Rise to Both Connective Tissue Type and Mucosal Mast Cells

Toru Nakano, Takashi Sonoda, C. Hayashi, Atsushi Yamatodani, Yoshio Kanayama, Tei-Ichi Yamamura, Hidekazu Asai, Takeshi Yonezawa, Yukihiko Kitamura, and Stephen J. Galli

BRIEF REVIEWS

Inflammasome-Associated Nucleotide-Binding Domain, Leucine-Rich Repeat Proteins and Inflammatory Diseases

Sushmita Jha and Jenny P.-Y. Ting

CUTTING EDGE

Requirement of MARCH-I-Mediated MHC II Ubiquitination for the Maintenance of Conventional Dendritic Cells

Mari Ohmura-Hoshino, Yohei Matsuki, Mari Mito-Yoshida, Eiji Goto, Masami Aoki-Kawasumi, Manabu Nakayama, Osamu Ohara, and Satoshi Ishido

Memory CD8 T Cell Compartment Grows in Size with Immunological Experience but Nevertheless Can Lose Function

Katharina M. Huster, Christian Stemberger, Georg Gasteiger, Wolfgang Kastenmuller, Ingo Drexler, and Dirk H. Busch

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

Peroxisome Proliferator-Activated Receptor (PPAR) Ligands Enhance Human B Cell Antibody Production and Differentiation

Tatiana M. Garcia-Bates, Carolyn J. Baglole, Matthew P. Bernard, Thomas I. Murant, Patricia J. Simpson-Haidaris, and Richard P. Phipps

Impaired NK Cytolytic Activity and Enhanced Tumor Growth in NK Lytic-Associated Molecule-Deficient Mice

Richard G. Hoover, Gail Gullickson, and Jacki Kornbluth

NOD2 Ligation Subverts IFN- Production by Liver Plasmacytoid Dendritic Cells and Inhibits Their T Cell Allostimulatory Activity via B7-H1 Up-Regulation

Antonino Castellaneta, Tina L. Sumpter, Lieping Chen, Daisuke Tokita, and Angus W. Thomson

Intranasal Immunization Promotes Th17 Immune Responses

Beata M. Zygmunt, Faiza Rharbaoui, Lothar Groebe, and Carlos A. Guzman

Chimeric NKG2D Expressing T Cells Eliminate Immunosuppression and Activate Immunity within the Ovarian Tumor Microenvironment

Amorette Barber, Agnieszka Rynda, and Charles L. Sentman

RREB-1 Is a Transcriptional Repressor of HLA-G

Sebastien Flajollet, Isabelle Poras, Edgardo D. Carosella, and Philippe Moreau

TLR2 Promotes Th2/Th17 Responses via TLR4 and TLR7/8 by Human Dendritic Cells by Abrogating the Type I IFN Amplification Loop

Mark H. Wenink, Kim C. M. Santegoets, Jacobus C. A. Broen, Lenny van Bon, Shahla Abdollahi-Roodsaz, Calin Popa, Richard Huijbens, Thijs Remijn, Erik Lubberts, Piet L. C. M. van Riel, Wim B. van den Berg, and Timothy R. D. J. Radstake

Innate Immune CD11b+Gr-1+ Cells, Suppressor Cells, Affect the Immune Response during Theiler's Virus-Induced Demyelinating Disease

Jenna L. Bowen and Julie K. Olson

IL-9 Regulates Pathology during Primary and Memory Responses to Respiratory Syncytial Virus Infection

Jonathan S. Dodd, Eda Lum, John Goulding, Roshell Muir, Jacques Van Snick, and Peter J. M. Openshaw

Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses

Qiong Wang, Deepti R. Nagarkar, Emily R. Bowman, Dina Schneider, Babina Gosangi, Jing Lei, Ying Zhao, Christina L. McHenry, Richai V. Burgens, David J. Miller, Umadevi Sajjan, and Marc B. Hershenson

Estrogen Regulates Transcription Factors STAT-1 and NF-B to Promote Inducible Nitric Oxide Synthase and Inflammatory Responses

Rujuan Dai, Rebecca A. Phillips, Ebru Karpuzoglu, Deena Khan, and S. Ansar Ahmed

Limited Role of CD4+Foxp3+ Regulatory T Cells in the Control of Experimental Cerebral Malaria

Christiane Steeg, Guido Adler, Tim Sparwasser, Bernhard Fleischer, and Thomas Jacobs

Prostacyclin Inhibits IFN--Stimulated Cytokine Expression by Reduced Recruitment of CBP/p300 to STAT1 in a SOCS-1-Independent Manner

Derek Strassheim, Suzzette R. Riddle, Danielle L. Burke, Mark W. Geraci, and Kurt R. Stenmark

Systemic Increase in the Ratio between Foxp3+ and IL-17-Producing CD4+ T Cells in Healthy Pregnancy but not in Preeclampsia

Brigitte Santner-Nanan, Michael John Peek, Roma Khanam, Luise Richarts, Erhua Zhu, Barbara Fazekas de St Groth, and Ralph Nanan

Female and Male Sex Hormones Differentially Regulate Expression of Ifi202, an Interferon-Inducible Lupus Susceptibility Gene within the Nba2 Interval

Ravichandran Panchanathan, Hui Shen, Melanie Gubbels Bupp, Karen A. Gould, and Divaker Choubey

Absence of the Transcriptional Repressor Blimp-1 in Hematopoietic Lineages Reveals Its Role in Dendritic Cell Homeostatic Development and Function

Yueh-Hsuan Chan, Ming-Feng Chiang, Yueh-Chiao Tsai, Shin-Tang Su, Ming-Hsu Chen, Mau-Sheng Hou, and Kuo-I. Lin

SOCS3 in T and NKT Cells Negatively Regulates Cytokine Production and Ameliorates ConA-Induced Hepatitis

Mako Nakaya, Masayuki Hashimoto, Ryusuke Nakagawa, Yu Wakabayashi, Takuma Ishizaki, Ichiro Takada, Kyoko Komai, Hiroki Yoshida, and Akihiko Yoshimura

Dendritic Cells Secrete the Immunosuppressive HLA-G Molecule upon CTLA4-Ig Treatment: Implication in Human Renal Transplant Acceptance

Rajia Bahri, Abderrahim Naji, Catherine Menier, Bernard Charpentier, Edgardo D. Carosella, Nathalie Rouas-Freiss, and Antoine Durrbach

Interplay between Chromatin Remodeling and Epigenetic Changes during Lineage-Specific Commitment to Granzyme B Expression

Torsten Juelich, Elissa Sutcliffe, Alice Denton, Yiqing He, Peter C. Doherty, Christopher Parish, Steven J. Turner, David Tremethick, and Sudha Rao

Mast Cell Differentiation and Activation Is Closely Linked to Expression of Genes Coding for the Serglycin Proteoglycan Core Protein and a Distinct Set of Chondroitin Sulfate and Heparin Sulfotransferases

Anette Duelli, Elin Ronnberg, Ida Waern, Maria Ringvall, Svein O. Kolset, and Gunnar Pejler

Sex Steroid Ablation Enhances Hematopoietic Recovery following Cytotoxic Antineoplastic Therapy in Aged Mice

Jarrod A. Dudakov, Gabrielle L. Goldberg, Jessica J. Reiseger, Katerina Vlahos, Ann P. Chidgey, and Richard L. Boyd

Dendritic Cells Matured by Inflammation Induce CD86-Dependent Priming of Naive CD8+ T Cells in the Absence of Their Cognate Peptide Antigen

Asher Maroof, Lynette Beattie, Alun Kirby, Mark Coles, and Paul M. Kaye

Apoptotic Dendritic Cells Induce Tolerance in Mice through Suppression of Dendritic Cell Maturation and Induction of Antigen-Specific Regulatory T Cells

Rahul Kushwah, Jordan R. Oliver, Jinyi Zhang, Katherine A. Siminovitch, and Jim Hu

Deciphering the Immune Function and Regulation by a Toll-Like Receptor of the Cytokine EMAPII in the Lesioned CNS Using a Leech Model

David Schikorski, Virginie Cuvillier-Hot, Celine Boidin-Wichlacz, Christian Slomianny, Michel Salzet, and Aurelie Tasiemski

Dominant Expression of the Inhibitory FcRIIB Prevents Antigen Presentation by Murine Plasmacytoid Dendritic Cells

Marcella Flores, Dharmesh D. Desai, Matthew Downie, Bitao Liang, Michael P. Reilly, Steven E. McKenzie, and Raphael Clynes

Plasmacytoid Dendritic Cells Regulate Autoreactive B Cell Activation via Soluble Factors and in a Cell-to-Cell Contact Manner

Chuanlin Ding, Yihua Cai, Jose Marroquin, Suzanne T. Ildstad, and Jun Yan

Neonatal Innate TLR-Mediated Responses Are Distinct from Those of Adults

Tobias R. Kollmann, Juliet Crabtree, Annie Rein-Weston, Darren Blimkie, Francis Thommai, Xiu Yu Wang, Pascal M. Lavoie, Jeff Furlong, Edgardo S. Fortuno, III, Adeline M. Hajjar, Natalie R. Hawkins, Steven G. Self, and Christopher B. Wilson

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

Anneli Jager, Valerie Dardalhon, Raymond A. Sobel, Estelle Bettelli, and Vijay K. Kuchroo

Tc17 CD8 T Cells: Functional Plasticity and Subset Diversity

Hung-Rong Yen, Timothy J. Harris, Satoshi Wada, Joseph F. Grosso, Derese Getnet, Monica V. Goldberg, Kai-Li Liang, Tullia C. Bruno, Kristin J. Pyle, Siaw-Li Chan, Robert A. Anders, Cornelia L. Trimble, Adam J. Adler, Tzou-Yien Lin, Drew M. Pardoll, Ching-Tai Huang, and Charles G. Drake

Recruitment of Sprouty1 to Immune Synapse Regulates T Cell Receptor Signaling

Jun Sung Lee, Ji Eun Lee, Yu Mi Oh, Jong Bae Park, Heonsik Choi, Chung Yeon Choi, In-Hoo Kim, Seung Hoon Lee, and Kyungho Choi

Processing in the Endoplasmic Reticulum Generates an Epitope on the Insulin A Chain that Stimulates Diabetogenic CD8 T Cell Responses

Helen Brosi, Michael Reiser, Tarvo Rajasalu, Andreas Spyrantis, Franz Oswald, Bernhard Otto Boehm, and Reinhold Schirmbeck

Ineffective Vaccination against Solid Tumors Can Be Enhanced by Hematopoietic Cell Transplantation

Alexander Filatenkov, Antonia M. S. Muller, William Wei-Lin Tseng, Sussan Dejbakhsh-Jones, Daniel Winer, Richard Luong, Judith A. Shizuru, Edgar G. Engleman, and Samuel Strober

P-Selectin Glycoprotein Ligand-1 Negatively Regulates T-Cell Immune Responses

Masanori Matsumoto, Masayuki Miyasaka, and Takako Hirata

Inhibition of RANK Expression and Osteoclastogenesis by TLRs and IFN- in Human Osteoclast Precursors

Jong-Dae Ji, Kyung-Hyun Park-Min, Zenxin Shen, Roberto J. Fajardo, Steven R. Goldring, Kevin P. McHugh, and Lionel B. Ivashkiv

Dynamic Regulation of Notch 1 and Notch 2 Surface Expression during T Cell Development and Activation Revealed by Novel Monoclonal Antibodies

Emma Fiorini, Estelle Merck, Anne Wilson, Isabel Ferrero, Wei Jiang, Ute Koch, Floriane Auderset, Elisa Laurenti, Fabienne Tacchini-Cottier, Michel Pierres, Freddy Radtke, Sanjiv A. Luther, and H. Robson MacDonald

SHP-2 Expression Negatively Regulates NK Cell Function

Amanda K. Purdy and Kerry S. Campbell

MHC Drives TCR Repertoire Shaping, but not Maturation, in Recent Thymic Emigrants

Evan G. Houston, Jr. and Pamela J. Fink

SLAT/Def6 Plays a Critical Role in the Development of Th17 Cell-Mediated Experimental Autoimmune Encephalomyelitis

Ann J. Canonigo-Balancio, Camille Fos, Thomas Prod'homme, Stephane Becart, and Amnon Altman

A Nonadjuvanted Polypeptide Nanoparticle Vaccine Confers Long-Lasting Protection against Rodent Malaria

Stephen A. Kaba, Clara Brando, Qin Guo, Christian Mittelholzer, Senthilkumar Raman, David Tropel, Ueli Aebi, Peter Burkhard, and David E. Lanar

Ectopic T-bet Expression Licenses Dendritic Cells for IL-12-Independent Priming of Type 1 T Cells In Vitro

Michael W. Lipscomb, Lu Chen, Jennifer L. Taylor, Christina Goldbach, Simon C. Watkins, Pawel Kalinski, Lisa H. Butterfield, Amy K. Wesa, and Walter J. Storkus

Autophagic Compartments Gain Access to the MHC Class II Compartments in Thymic Epithelium

Michiyuki Kasai, Isei Tanida, Takashi Ueno, Eiki Kominami, Sachiko Seki, Tohru Ikeda, and Toshiaki Mizuochi

T Cell Intrinsic Heterodimeric Complexes between HVEM and BTLA Determine Receptivity to the Surrounding Microenvironment

Timothy C. Cheung, Lisa M. Oborne, Marcos W. Steinberg, Matthew G. Macauley, Satoshi Fukuyama, Hideki Sanjo, Claire D'Souza, Paula S. Norris, Klaus Pfeffer, Kenneth M. Murphy, Mitchell Kronenberg, Patricia G. Spear, and Carl F. Ware

Role of T Cell TGF- Signaling and IL-17 in Allograft Acceptance and Fibrosis Associated with Chronic Rejection

Susan M. Faust, Guanyi Lu, Bernard L. Marini, Weiping Zou, David Gordon, Yoichiro Iwakura, Yasmina Laouar, and D. Keith Bishop

Taking Advantage: High-Affinity B Cells in the Germinal Center Have Lower Death Rates, but Similar Rates of Division, Compared to Low-Affinity Cells

Shannon M. Anderson, Ashraf Khalil, Mohamed Uduman, Uri Hershberg, Yoram Louzoun, Ann M. Haberman, Steven H. Kleinstein, and Mark J. Shlomchik

Transforming Growth Factor Neutralization within Cardiac Allografts by Decorin Gene Transfer Attenuates Chronic Rejection

Susan M. Faust, Guanyi Lu, Sherri C. Wood, and D. Keith Bishop

Endogenous Interleukin-21 Restricts CD8+ T Cell Expansion and Is Not Required for Tumor Immunity

Henrik Sondergaard, Jonathan M. Coquet, Adam P. Uldrich, Nicole McLaughlin, Dale I. Godfrey, Pallavur V. Sivakumar, Kresten Skak, and Mark J. Smyth

MOLECULAR AND STRUCTURAL IMMUNOLOGY

Dynamic Regulation of CXCR1 and CXCR2 Homo- and Heterodimers

Laura Martinez Munoz, Pilar Lucas, Gemma Navarro, Ana I. Checa, Rafael Franco, Carlos Martinez-A., Jose Miguel Rodriguez-Frade, and Mario Mellado

Coexistence of Closed and Open Conformations of Complement Factor B in the Alternative Pathway C3bB(Mg2+) Proconvertase

Eva Torreira, Agustin Tortajada, Tamara Montes, Santiago Rodriguez de Cordoba, and Oscar Llorca

Hematopoietic Lineage Cell-Specific Protein 1 Is Recruited to the Immunological Synapse by IL-2-Inducible T Cell Kinase and Regulates Phospholipase C1 Microcluster Dynamics during T Cell Spreading

Esteban Carrizosa, Timothy S. Gomez, Christine M. Labno, Deborah A. Klos Dehring, Xiaohong Liu, Bruce D. Freedman, Daniel D. Billadeau, and Janis K. Burkhardt

Serine 649 Phosphorylation within the Protein Kinase C-Regulated Domain Down-Regulates CARMA1 Activity in Lymphocytes

Miguel E. Moreno-Garcia, Karen Sommer, Claudia Haftmann, Clayton Sontheimer, Sarah F. Andrews, and David J. Rawlings

MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation

Soren E. Degn, Annette G. Hansen, Rudi Steffensen, Christian Jacobsen, Jens C. Jensenius, and Steffen Thiel

Cytosolic Aminopeptidases Influence MHC Class I-Mediated Antigen Presentation in an Allele-Dependent Manner

Eunkyung Kim, Heechun Kwak, and Kwangseog Ahn

MAPK, Phosphatidylinositol 3-Kinase, and Mammalian Target of Rapamycin Pathways Converge at the Level of Ribosomal Protein S6 Phosphorylation to Control Metabolic Signaling in CD8 T Cells

Robert J. Salmond, Juliet Emery, Klaus Okkenhaug, and Rose Zamoyska

IMMUNOGENETICS

The DC-SIGN of Zebrafish: Insights into the Existence of a CD209 Homologue in a Lower Vertebrate and Its Involvement in Adaptive Immunity

Ai-fu Lin, Li-xin Xiang, Qu-long Wang, Wei-ren Dong, Yong-feng Gong, and Jian-zhong Shao

HOST DEFENSE

Enhanced Susceptibility to Leishmania Infection in Resistant Mice in the Absence of Immediate Early Response Gene X-1

Oleg E. Akilov, Irina V. Ustyugova, Liang Zhi, Tayyaba Hasan, and Mei X. Wu

Increased Inflammation, Impaired Bacterial Clearance, and Metabolic Disruption after Gram-Negative Sepsis in Mkp-1-Deficient Mice

W. Joshua Frazier, Xianxi Wang, Lyn M. Wancket, Xiang-An Li, Xiaomei Meng, Leif D. Nelin, Andrew C. B. Cato, and Yusen Liu

Early Response of Mucosal Epithelial Cells during Toxoplasma gondii Infection

Chia-Hsin Ju, Annapoorani Chockalingam, and Cynthia A. Leifer

Immune Gene and Cell Enrichment Is Associated with a Good Prognosis in Ependymoma

Andrew M. Donson, Diane K. Birks, Valerie N. Barton, Qi Wei, Bette K. Kleinschmidt-DeMasters, Michael H. Handler, Allen Waziri, Michael Wang, and Nicholas K. Foreman

Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection

Michelle D. Tate, Yi-Mo Deng, Jessica E. Jones, Gary P. Anderson, Andrew G. Brooks, and Patrick C. Reading

Identification of Lipoteichoic Acid as a Ligand for Draper in the Phagocytosis of Staphylococcus aureus by Drosophila Hemocytes

Yumi Hashimoto, Yukichika Tabuchi, Kenji Sakurai, Mayumi Kutsuna, Kenji Kurokawa, Takeshi Awasaki, Kazuhisa Sekimizu, Yoshinobu Nakanishi, and Akiko Shiratsuchi

INFLAMMATION

TLR Cross-Talk Specifically Regulates Cytokine Production by B Cells from Chronic Inflammatory Disease Patients

Madhumita Jagannathan, Hatice Hasturk, YanMei Liang, Hyunjin Shin, Jeremy T. Hetzel, Alpdogan Kantarci, Daniel Rubin, Marie E. McDonnell, Thomas E. Van Dyke, Lisa M. Ganley-Leal, and Barbara S. Nikolajczyk

The Oxazolidinone Derivative Locostatin Induces Cytokine Appeasement

Antoine Menoret, Jeremy P. McAleer, Soo-Mun Ngoi, Swagatam Ray, Nicholas A. Eddy, Gabriel Fenteany, Seung-Joo Lee, Robert J. Rossi, Bijay Mukherji, David L. Allen, Nitya G. Chakraborty, and Anthony T. Vella

Lipopolysaccharide Sensitizes Neonatal Hypoxic-Ischemic Brain Injury in a MyD88-Dependent Manner

Xiaoyang Wang, Linnea Stridh, Wenli Li, Justin Dean, Anders Elmgren, Liming Gan, Kristina Eriksson, Henrik Hagberg, and Carina Mallard

CCR5 Ligands Modulate CXCL12-Induced Chemotaxis, Adhesion, and Akt Phosphorylation of Human Cord Blood CD34+ Cells

Sunanda Basu and Hal E. Broxmeyer

Inhibition of IL-17A Attenuates Atherosclerotic Lesion Development in ApoE-Deficient Mice

Christian Erbel, Lili Chen, Florian Bea, Susanne Wangler, Sultan Celik, Felix Lasitschka, Ying Wang, Dittmar Bockler, Hugo A. Katus, and Thomas J. Dengler

CD80 Blockade Enhance GILZ Expression and Suppress Experimental Autoimmune Encephalomyelitis

Shailesh P. Dudhgaonkar, Srihari B. Janardhanam, Krithika N. Kodumudi, and Mythily Srinivasan

Calcium-Independent Phospholipase A2-Akt Signaling Is Involved in Lipopolysaccharide-Induced Reduced NADP Oxidase 1 Expression and Foam Cell Formation

Sun-Hye Lee, Dae-Weon Park, Sung Chul Park, Yun-Ki Park, Seong Yeon Hong, Jae-Ryong Kim, Chu-Hee Lee, and Suk-Hwan Baek

G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation

Christian Sina, Olga Gavrilova, Matti Forster, Andreas Till, Stefanie Derer, Friederike Hildebrand, Bjorn Raabe, Athena Chalaris, Jurgen Scheller, Ateequr Rehmann, Andre Franke, Stephan Ott, Robert Hasler, Susanna Nikolaus, Ulrich R. Folsch, Stefan Rose-John, Hui-Ping Jiang, Jun Li, Stefan Schreiber, and Philip Rosenstiel

Natural Occurring IL-17 Producing T Cells Regulate the Initial Phase of Neutrophil Mediated Airway Responses

Shinya Tanaka, Takayuki Yoshimoto, Tetsuji Naka, Susumu Nakae, Yo-ichi Iwakura, Daniel Cua, and Masato Kubo

Fms-Like Tyrosine Kinase 3 Ligand Regulates Migratory Pattern and Antigen Uptake of Lung Dendritic Cell Subsets in a Murine Model of Allergic Airway Inflammation

Zhifei Shao, Toluwalope O. Makinde, Halvor S. McGee, Xiang Wang, and Devendra K. Agrawal

Tyrosine Kinase 2 Plays Critical Roles in the Pathogenic CD4 T Cell Responses for the Development of Experimental Autoimmune Encephalomyelitis

Akiko Oyamada, Hiori Ikebe, Momoe Itsumi, Hirokazu Saiwai, Seiji Okada, Kazuya Shimoda, Yoichiro Iwakura, Keiichi Nakayama, Yukihide Iwamoto, Yasunobu Yoshikai, and Hisakata Yamada

Unlike Th1, Th17 Cells Mediate Sustained Autoimmune Inflammation and Are Highly Resistant to Restimulation-Induced Cell Death

Guangpu Shi, Madhu Ramaswamy, Barbara P. Vistica, Catherine A. Cox, Cuiyan Tan, Eric F. Wawrousek, Richard M. Siegel, and Igal Gery

Selective Down-Regulation of Neutrophil Mac-1 in Endotoxemic Hepatic Microcirculation via IL-10

Gustavo B. Menezes, Woo-Yong Lee, Hong Zhou, Christopher C. M. Waterhouse, Denise Carmona Cara, and Paul Kubes

CLINICAL IMMUNOLOGY

Auto-Antibodies against C1q in Systemic Lupus Erythematosus Are Antigen-Driven

Monica Schaller, Cornelia Bigler, Doris Danner, Henrik J. Ditzel, and Marten Trendelenburg

Systematic Classification of Primary Immunodeficiencies Based on Clinical, Pathological, and Laboratory Parameters

Crina Samarghitean, Csaba Ortutay, and Mauno Vihinen

The Cutaneous Biochemical Redox Barrier: A Component of the Innate Immune Defenses against Sensitization by Highly Reactive Environmental Xenobiotics

Chris Pickard, Fethi Louafi, Carolann McGuire, Kelly Lowings, Pawan Kumar, Hywel Cooper, Rebecca J. Dearman, Marie Cumberbatch, Ian Kimber, Eugene Healy, and Peter S. Friedmann

Cell-Specific CD4+ T Cell Clonotypes in Peripheral Blood and the Pancreatic Islets Are Distinct

Li Li, Qiuming He, Alaina Garland, Zuoan Yi, Lydia T. Aybar, Thomas B. Kepler, Jeffrey A. Frelinger, Bo Wang, and Roland Tisch

Immunomodulation of Nasal Epithelial Cells by Staphylococcus aureus-Derived Serine Proteases

Claudia Rudack, Florian Sachse, Nils Albert, Karsten Becker, and Christof von Eiff

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

Jean M. Fletcher, Roisin Lonergan, Lisa Costelloe, Katie Kinsella, Barry Moran, Cliona O'Farrelly, Niall Tubridy, and Kingston H. G. Mills