HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Future Table of Contents: Volume 181 / No. 3 / Aug 1, 2008

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

IMMUNOGENETICS

HOST DEFENSE

INFLAMMATION

CLINICAL IMMUNOLOGY

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

PU.1, a Shared Transcriptional Regulator of Innate and Adaptive Immune Cell Fates

Harinder Singh

Pillars Article: The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell, 1990. 61: 113-124.

Michael J. Klemsz, Scott R. McKercher, Antonio Celada, Charles Van Beveren, and Richard A. Maki

BRIEF REVIEWS

Auditing Protein Therapeutics "Management" by Professional APCs: Toward Prevention of Immune Responses against Therapeutic Proteins

Suryasarathi Dasgupta, Jagadeesh Bayry, Sebastien Andre, Jordan D. Dimitrov, Srinivas V. Kaveri, and Sebastien Lacroix-Desmazes

CUTTING EDGE

Multiple Sclerosis-Like Lesions Induced by Effector CD8 T Cells Recognizing a Sequestered Antigen on Oligodendrocytes

Amit Saxena, Jan Bauer, Tanja Scheikl, Jacques Zappulla, Marc Audebert, Sabine Desbois, Ari Waisman, Hans Lassmann, Roland S. Liblau, and Lennart T. Mars

The Transmembrane E3 Ligase GRAIL (Gene Related to Anergy in Lymphocytes) Ubiquitinates the Costimulatory Molecule CD40L (CD40 Ligand) during the Induction of T Cell Anergy

Neil B. Lineberry, Leon L. Su, Jack T. Lin, Greg P. Coffey, Christine M. Seroogy, and C. Garrison Fathman

Priming of Natural Killer Cells by IL-18

Julie Chaix, Marlowe S. Tessmer, Kasper Hoebe, Nicolas Fuseri, Bernhard Ryffel, Marc Dalod, Lena Alexopoulou, Bruce Beutler, Laurent Brossay, Eric Vivier, and Thierry Walzer

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

Allele-Selective Effect of PA28 in MHC Class I Antigen Processing

Taketoshi Yamano, Hidetoshi Sugahara, Shusaku Mizukami, Shigeo Murata, Tomoki Chiba, Keiji Tanaka, and Heiichiro Udono

Type I Interferon-Induced, NKT Cell-Mediated Negative Control of CD8 T Cell Priming by Dendritic Cells

Petra Bochtler, Andrea Kroger, Reinhold Schirmbeck, and Jorg Reimann

The Transcription Factor Fli-1 Modulates Marginal Zone and Follicular B Cell Development in Mice

Xian K. Zhang, Omar Moussa, Amanda LaRue, Sarah Bradshaw, Ivan Molano, Demetri D. Spyropoulos, Gary S. Gilkeson, and Dennis K. Watson

HIF-1 Is Up-regulated in Activated Mast Cells by a Process That Involves Calcineurin and NFAT

Aurelia Walczak-Drzewiecka, Marcin Ratajewski, Waldemar Wagner, and Jaroslaw Dastych

IFN Regulatory Factor-1 Negatively Regulates CD4+CD25+ Regulatory T Cell Differentiation by Repressing Foxp3 Expression

Alessandra Fragale, Lucia Gabriele, Emilia Stellacci, Paola Borghi, Edvige Perrotti, Ramona Ilari, Angela Lanciotti, Anna Lisa Remoli, Massimo Venditti, Filippo Belardelli, and Angela Battistini

Acquisition of Suppressive Function by Activated Human CD4+CD25- T Cells Is Associated with the Expression of CTLA-4 Not FoxP3

Yong Zheng, Claire N. Manzotti, Fiona Burke, Laure Dussably, Omar Qureshi, Lucy S.K. Walker, and David M. Sansom

Mechanisms Underlying Blockade of Allograft Acceptance by TLR Ligands

Paige M. Porrett, Xueli Yuan, David F. LaRosa, Patrick T. Walsh, Jaeseok Yang, Wenda Gao, Peiying Li, Jidong Zhang, Javeed M. Ansari, Wayne W. Hancock, Mohamed H. Sayegh, Maria Koulmanda, Terry B. Strom, and Laurence A. Turka

IFN- Induces the Erosion of Preexisting CD8 T Cell Memory during Infection with a Heterologous Intracellular Bacterium

Renu Dudani, Kaja Murali-Krishna, Lakshmi Krishnan, and Subash Sad

SCART Scavenger Receptors Identify a Novel Subset of Adult T Cells

Jan Kisielow, Manfred Kopf, and Klaus Karjalainen

Identification of Initiator B Cells, a Novel Subset of Activation-Induced Deaminase-Dependent B-1-Like Cells That Mediate Initiation of Contact Sensitivity

Steven M. Kerfoot, Marian Szczepanik, James W. Tung, and Philip W. Askenase

An Endogenous Prostaglandin Enhances Environmental Phthalate-Induced Apoptosis in Bone Marrow B Cells: Activation of Distinct but Overlapping Pathways

Stephanie L. Bissonnette, Jessica E. Teague, David H. Sherr, and Jennifer J. Schlezinger

Low- versus High-Baseline Epinephrine Output Shapes Opposite Innate Cytokine Profiles: Presence of Lewis- and Fischer-Like Neurohormonal Immune Phenotypes in Humans?

Ilia J. Elenkov, Richard Kvetnansky, Akira Hashiramoto, Vladimir K. Bakalov, Amrey A. Link, Keith Zachman, Marianna Crane, Daniela Jezova, Jozef Rovensky, Mariana A. Dimitrov, Philip W. Gold, Sergio Bonini, Thomas Fleisher, George P. Chrousos, and Ronald L. Wilder

The Agonists of TLR4 and 9 Are Sufficient to Activate Memory B Cells to Differentiate into Plasma Cells In Vitro but Not In Vivo

Katharina Richard, Susan K. Pierce, and Wenxia Song

TCR Antagonism by Peptide Requires High TCR Expression

Daniel S. Jones, Peter Reichardt, Mandy L. Ford, Lindsay J. Edwards, and Brian D. Evavold

Influence of a Non-NK Cell Region of Chromosome 6 on CD4+ Invariant NK T Cell Homeostasis

David Vallois, Marie-Claude Gagnerault, Philip Avner, Ute C. Rogner, Christian Boitard, Kamel Benlagha, Andre Herbelin, and Francoise Lepault

IL-21-Induced Isotype Switching to IgG and IgA by Human Naive B Cells Is Differentially Regulated by IL-4

Danielle T. Avery, Vanessa L. Bryant, Cindy S. Ma, Rene deWaalMalefyt, and Stuart G. Tangye

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN- Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

Rowan Higgs, Joan Ni Gabhann, Nadia Ben Larbi, Eamon P. Breen, Katherine A. Fitzgerald, and Caroline A. Jefferies

Macrophages Pulsed with Streptococcus pneumoniae Elicit a T Cell-Dependent Antibody Response upon Transfer into Naive Mice

Sam Vasilevsky, Jesus Colino, Roman Puliaev, David H. Canaday, and Clifford M. Snapper

Polyclonal Adaptive Regulatory CD4 Cells That Can Reverse Type I Diabetes Become Oligoclonal Long-Term Protective Memory Cells

Elana Godebu, Daphne Summers-Torres, Melissa E. Lin, Bas J. G. Baaten, and Linda M. Bradley

CTLA4 Expression Is an Indicator and Regulator of Steady-State CD4+FoxP3+ T Cell Homeostasis

Anita L. Tang, John R. Teijaro, Modesta N. Njau, Smita S. Chandran, Agnes Azimzadeh, Steven G. Nadler, David M. Rothstein, and Donna L. Farber

Activated CD8 T Cells Redistribute to Antigen-Free Lymph Nodes and Exhibit Effector and Memory Characteristics

C. Colin Brinkman, Stacey L. Sheasley-O'Neill, Andrew R. Ferguson, and Victor H. Engelhard

Pemphigus Vulgaris IgG Directly Inhibit Desmoglein 3-Mediated Transinteraction

Wolfgang-Moritz Heupel, Detlef Zillikens, Detlev Drenckhahn, and Jens Waschke

CD28 Controls Differentiation of Regulatory T Cells from Naive CD4 T Cells

Fei Guo, Cristina Iclozan, Woong-Kyung Suh, Claudio Anasetti, and Xue-Zhong Yu

Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation

Celine S. Lages, Isabelle Suffia, Paula A. Velilla, Bin Huang, Gregg Warshaw, David A. Hildeman, Yasmine Belkaid, and Claire Chougnet

Dual Signaling of MyD88 and TIR Domain-Containing Adaptor-Inducing IFN- Is Critical for Maximal TLR4-Induced Dendritic Cell Maturation

Hua Shen, Bethany M. Tesar, Wendy E. Walker, and Daniel R. Goldstein

Pancreatitis-Associated Protein 2 Modulates Inflammatory Responses in Macrophages

Domenico Viterbo, Martin H. Bluth, Yin-yao Lin, Cathy M. Mueller, Raj Wadgaonkar, and Michael E. Zenilman

Identification of an Evolutionarily Conserved Transcriptional Signature of CD8 Memory Differentiation That Is Shared by T and B Cells

W. Nicholas Haining, Benjamin L. Ebert, Aravind Subrmanian, E. John Wherry, Quentin Eichbaum, John W. Evans, Raymond Mak, Stephen Rivoli, Jennifer Pretz, Jill Angelosanto, John S. Smutko, Bruce D. Walker, Susan M. Kaech, Rafi Ahmed, Lee M. Nadler, and Todd R. Golub

Endometrial NK Cells Are Special Immature Cells that Await Pregnancy

Irit Manaster, Saar Mizrahi, Debra Goldman-Wohl, Hen Y. Sela, Noam Stern-Ginossar, Dilkla Lankry, Raizy Gruda, Arye Hurwitz, Yuval Bdolach, Ronit Haimov-Kochman, Simcha Yagel, and Ofer Mandelboim

Expression of Macrophage Migration Inhibitory Factor by Neuroblastoma Leads to the Inhibition of Antitumor T Cell Reactivity In Vivo

Qiang Zhou, Xiaocai Yan, Jill Gershan, Rimas J. Orentas, and Bryon D. Johnson

Bilirubin Possesses Powerful Immunomodulatory Activity and Suppresses Experimental Autoimmune Encephalomyelitis

Yingru Liu, Ping Li, Jie Lu, Wei Xiong, Joel Oger, Wolfram Tetzlaff, and Max Cynader

Stromal Cells Confer Lymph Node-Specific Properties by Shaping a Unique Microenvironment Influencing Local Immune Responses

Manuela Ahrendt, Swantje Iris Hammerschmidt, Oliver Pabst, Reinhard Pabst, and Ulrike Bode

Th1, Th2, and Th17 Effector T Cell-induced Autoimmune Gastritis Differs in Pathological Pattern and in Susceptibility to Suppression by Regulatory T Cells

Georg H. Stummvoll, Richard J. DiPaolo, Eva N. Huter, Todd S. Davidson, Deborah Glass, Jerrold M. Ward, and Ethan M. Shevach

IL-2 Receptor -Chain Signaling Controls Immunosuppressive CD4+ T Cells in the Draining Lymph Nodes and Lung during Allergic Airway Inflammation In Vivo

Aysefa Doganci, Roman Karwot, Joachim H. Maxeiner, Petra Scholtes, Edgar Schmitt, Markus F. Neurath, Hans Anton Lehr, I.-Cheng Ho, and Susetta Finotto

Lack of Plasma Protein Hemopexin Dampens Mercury-Induced Autoimmune Response in Mice

Sharmila Fagoonee, Cristiana Caorsi, Mirella Giovarelli, Meredin Stoltenberg, Lorenzo Silengo, Fiorella Altruda, Giovanni Camussi, Emanuela Tolosano, and Benedetta Bussolati

Modulation of T Cell Activation by Stomatin-like Protein 2

Mark G. Kirchhof, Luan A. Chau, Caitlin D. Lemke, Santosh Vardhana, Peter J. Darlington, Maria E. Marquez, Roy Taylor, Kamilia Rizkalla, Isaac Blanca, Michael L. Dustin, and Joaquin Madrenas

MOLECULAR AND STRUCTURAL IMMUNOLOGY

Mutational Characterization of Pancreatitis-Associated Protein 2 Domains Involved in Mediating Cytokine Secretion in Macrophages and the NF-B Pathway

Domenico Viterbo, Martin H. Bluth, Cathy M. Mueller, and Michael E. Zenilman

ICOS Ligation Recruits the p50 PI3K Regulatory Subunit to the Immunological Synapse

Camille Fos, Audrey Salles, Valerie Lang, Florent Carrette, Stephane Audebert, Sonia Pastor, Marguerite Ghiotto, Daniel Olive, Georges Bismuth, and Jacques A. Nunes

Amyloid Precursor-Like Protein 2 Increases the Endocytosis, Instability, and Turnover of the H2-Kd MHC Class I Molecule

Amit Tuli, Mahak Sharma, Mary M. McIlhaney, James E. Talmadge, Naava Naslavsky, Steve Caplan, and Joyce C. Solheim

Identification of Residues in the C4 Domain of Polymeric IgM Essential for Interaction with Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1)

Ashfaq Ghumra, Jean-Philippe Semblat, Richard S. McIntosh, Ahmed Raza, Ingunn B. Rasmussen, Ranveig Braathen, Finn-Eirik Johansen, Inger Sandlie, Patricia K. Mongini, J. Alexandra Rowe, and Richard J. Pleass

IMMUNOGENETICS

Tetrameric and Homodimeric Camelid IgGs Originate from the Same IgH Locus

Ikbel Achour, Patricia Cavelier, Magali Tichit, Christiane Bouchier, Pierre Lafaye, and Francois Rougeon

Selection of the Alternative Exon 1 from the cd5 Gene Down-Regulates Membrane Level of the Protein in B Lymphocytes

Soizic Garaud, Christelle Le Dantec, Christian Berthou, Peter M. Lydyard, Pierre Youinou, and Yves Renaudineau

Genetic Analysis of SH2D4A, a Novel Adapter Protein Related to TSAd and ALX, Reveals a Redundant Function in T Cells

Philip E. Lapinski, Jennifer A. Oliver, Lynn A. Kamen, Elizabeth D. Hughes, Thomas L. Saunders, and Philip D. King

HOST DEFENSE

Lipoproteins of Listeria monocytogenes Are Critical for Virulence and TLR2-mediated Immune Activation

Silke Machata, Svetlin Tchatalbachev, Walid Mohamed, Lothar Jansch, Torsten Hain, and Trinad Chakraborty

Deletion of Flagellin's Hypervariable Region Abrogates Antibody-Mediated Neutralization and Systemic Activation of TLR5-Dependent Immunity

Clement Nempont, Delphine Cayet, Martin Rumbo, Coralie Bompard, Vincent Villeret, and Jean-Claude Sirard

Protein Kinase D1: A New Component in TLR9 Signaling

Jeoung-Eun Park, Young-In Kim, and Ae-Kyung Yi

CREB, ATF, and AP-1 Transcription Factors Regulate IFN- Secretion by Human T Cells in Response to Mycobacterial Antigen

Buka Samten, James C. Townsend, Steven E. Weis, Anindita Bhoumik, Peter Klucar, Homayoun Shams, and Peter F. Barnes

HIV Envelope Binding by Macrophage-Expressed gp340 Promotes HIV-1 Infection

Georgetta Cannon, Yanjie Yi, Houping Ni, Earl Stoddard, David A. Scales, Donald I. VanRyk, Irwin Chaiken, Daniel Malamud, and Drew Weissman

Tyk2-Signaling Plays an Important Role in Host Defense against Escherichia coli through IL-23-Induced IL-17 Production by T Cells

Risa Nakamura, Kensuke Shibata, Hisakata Yamada, Kazuya Shimoda, Keiichi Nakayama, and Yasunobu Yoshikai

IL-10 Helps Control Pathogen Load during High-Level Bacteremia

Diana Londono, Adriana Marques, Ronald L. Hornung, and Diego Cadavid

DAP Kinase-Related Apoptosis-Inducing Kinase-2 Contributes to West Nile Virus Entry into the Brain and Lethal Encephalitis

Shuhui Wang, Thomas Welte, Maureen McGargill, Terrence Town, Jesse Thompson, John F. Anderson, Richard A. Flavell, Erol Fikrig, Stephen M. Hedrick, and Tian Wang

Type I IFNs Enhance Susceptibility to Chlamydia muridarum Lung Infection by Enhancing Apoptosis of Local Macrophages

Hongyu Qiu, Yijun Fan, Antony George Joyee, Shuhe Wang, Xiaobing Han, Hong Bai, Lei Jiao, Van Rooijen Nico, and Xi Yang

Low Molecular Weight Hyaluronic Acid Increases the Self-Defense of Skin Epithelium by Induction of -Defensin 2 via TLR2 and TLR4

Silvia Gariboldi, Marco Palazzo, Laura Zanobbio, Silvia Selleri, Michele Sommariva, Lucia Sfondrini, Stefano Cavicchini, Andrea Balsari, and Cristiano Rumio

CD8+ T Lymphocytes Control Murine Cytomegalovirus Replication in the Central Nervous System of Newborn Animals

Glenn R.B. Bantug, Djurdijca Cekinovic, Russell Bradford, Thad Koontz, Stipan Jonjic, and William J. Britt

Naive Precursor Frequencies and MHC Binding Rather Than the Degree of Epitope Diversity Shape CD8+ T Cell Immunodominance

Maya F. Kotturi, Iain Scott, Tom Wolfe, Bjoern Peters, John Sidney, Hilde Cheroutre, Matthias G. vonHerrath, Michael J. Buchmeier, Howard Grey, and Alessandro Sette

Adenovirus Vector-Induced Innate Inflammatory Mediators, MAPK Signaling, As Well As Adaptive Immune Responses Are Dependent upon Both TLR2 and TLR9 In Vivo

Daniel M. Appledorn, S. Patial, A. McBride, S. Godbehere, N. VanRooijen, N. Parameswaran, and Andrea Amalfitano

INFLAMMATION

Points Of Control Exerted along the Macrophage-Endothelial Cell-Polymorphonuclear Neutrophil Axis by Platelet Endothelial Cell Adhesion Moleculre-1 (PECAM-1) in the Innate Immune Response of Acute Colonic Inflammation

Naohito Sugimoto, Tao Rui, Min Yang, Sulaiman Bharwani, Osamu Handa, Norimasa Yoshida, Toshikazu Yoshikawa, and Peter Kvietys

In Vivo Interstitial Migration of Primitive Macrophages Mediated by JNK-Matrix Metalloproteinase 13 Signaling in Response to Acute Injury

Yong Zhang, Xue-Tao Bai, Kang-Yong Zhu, Yi Jin, Min Deng, Huang-Ying Le, Yan-Fang Fu, Yi Chen, Jiang Zhu, A. Thomas Look, John Kanki, Zhu Chen, Sai-Juan Chen, and Ting Xi Liu

Activated Protein C Up-Regulates IL-10 and Inhibits Tissue Factor in Blood Monocytes

Lisa J. Toltl, Suzanne Beaudin, and Patricia C. Liaw, for the Canadian Critical Care Translational Biology Group

Oncostatin M Receptor- Signaling Limits Monocytic Cell Recruitment in Acute Inflammation

Emily Hams, Chantal S. Colmont, Vincent Dioszeghy, Victoria J. Hammond, Ceri A. Fielding, Anwen S. Williams, Minoru Tanaka, Atsushi Miyajima, Philip R. Taylor, Nicholas Topley, and Simon A. Jones

Activation of Human Alveolar Macrophages via P2 Receptors: Coupling to Intracellular Ca2+ Increases and Cytokine Secretion

Daniel Myrtek, Tobias Muller, Verena Geyer, Natalie Derr, Davide Ferrari, Gernot Zissel, Thorsten Durk, Stephan Sorichter, Werner Luttmann, Michael Kuepper, Johannes Norgauer, Francesco Di Virgilio, J. Christian Virchow,Jr., and Marco Idzko

IL-6 Regulates Neutrophil Trafficking during Acute Inflammation via STAT3

Ceri A. Fielding, Rachel M. McLoughlin, Louise McLeod, Chantal S. Colmont, Meri Najdovska, Dianne Grail, Matthias Ernst, Simon A. Jones, Nicholas Topley, and Brendan J. Jenkins

The PDE4 Inhibitor Rolipram Prevents NF-B Binding Activity and Proinflammatory Cytokine Release in Human Chorionic Cells

Roxane Herve, Thomas Schmitz, Daniele Evain-Brion, Dominique Cabrol, Marie-Josephe Leroy, and Celine Mehats

The Epithelial Anion Transporter Pendrin Is Induced by Allergy and Rhinovirus Infection, Regulates Airway Surface Liquid, and Increases Airway Reactivity and Inflammation in an Asthma Model

Yasuhiro Nakagami, Silvio Favoreto,Jr., Guohua Zhen, Sung-Woo Park, Louis T. Nguyenvu, Douglas A. Kuperman, Gregory M. Dolganov, Xiaozhu Huang, Homer A. Boushey, Pedro C. Avila, and David J. Erle

CLINICAL IMMUNOLOGY

Excessive Production of IFN- in Patients with Systemic Lupus Erythematosus and Its Contribution to Induction of B Lymphocyte Stimulator/B Cell-Activating Factor/TNF Ligand Superfamily-13B

Masayoshi Harigai, Manabu Kawamoto, Masako Hara, Tetsuo Kubota, Naoyuki Kamatani, and Nobuyuki Miyasaka

Human Antiinflammatory Macrophages Induce Foxp3+GITR+CD25+ Regulatory T Cells That Suppress via Membrane-Bound TGF-1

Nigel D.L. Savage, Tjitske deBoer, Kimberley V. Walburg, Simone A. Joosten, Krista vanMeijgaarden, Annemiek Geluk, and Tom H.M. Ottenhoff

An Unusual CD56brightCD16low NK Cell Subset Dominates the Early Posttransplant Period Following HLA-Matched Hematopoietic Stem Cell Transplantation

Nicolas Dulphy, Philippe Haas, Marc Busson, Stephanie Belhadj, Regis PeffaultdeLatour, Marie Robin, Maryvonnick Carmagnat, Pascale Loiseau, Ryad Tamouza, Catherine Scieux, Claire Rabian, James P. DiSanto, Dominique Charron, Anne Janin, Gerard Socie, and Antoine Toubert

TGF- Promotes Thyroid Epithelial Cell Hyperplasia and Fibrosis in IFN--Deficient NOD.H-2h4 Mice

Shiguang Yu, Gordon C. Sharp, and Helen Braley-Mullen

Cells That Produce Deleterious Autoreactive Antibodies Are Vulnerable to Suicide

Haitao Niu, Danny T.M. Leung, Chun Hung Ma, Eric C.Y. Law, Frankie C.H. Tam, and Pak-Leong Lim