IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2008 180: 2721-2722. [Full Text] [PDF]  

PILLARS OF IMMUNOLOGY:

Antigen Presentation: Discovery of the Peptide TAP

Luc Van Kaer
J Immunol 2008 180: 2723-2724. [Full Text] [PDF]  

Pillars Article: Transport Protein Genes in the Murine MHC: Possible Implications for Antigen Processing. Science 1990. 250: 1723–1726.

John J. Monaco, Sungae Cho, and Michelle Attaya
J Immunol 2008 180: 2725-2728. [PDF] [Original Pillars Article]  

Pillars Article: MHC Class II Region Encoding Proteins Related to the Multidrug Resistance Family of Transmembrane Transporters. Nature 1990. 348: 738–741.

Edward V. Deverson, Irene R. Gow, W. John Coadwell, John J. Monaco, Geoffrey W. Butcher, and Jonathan C. Howard
J Immunol 2008 180: 2729-2732. [PDF] [Original Pillars Article]  

Pillars Article: Sequences Encoded in the Class II Region of the MHC Related to the ’ABC’ Superfamily of Transporters. Nature 1990. 348: 741–744.

John Trowsdale, Isabel Hanson, Ian Mockridge, Stephan Beck, Alain Townsend, and Adrian Kelly
J Immunol 2008 180: 2733-2736. [PDF] [Original Pillars Article]  

Pillars Article: A Gene in the Human Major Histocompatibility Complex Class II Region Controlling the Class I Antigen Presentation Pathway. Nature 1990. 348: 744–747.

Thomas Spies, Maureen Bresnahan, Seiamak Bahram, Daniele Arnold, George Blanck, Elizabeth Mellins, Donald Pious, and Robert DeMars
J Immunol 2008 180: 2737-2740. [PDF] [Original Pillars Article]  

BRIEF REVIEWS:

Mechanisms for Decreased Function of B Cells in Aged Mice and Humans

Daniela Frasca, Ana Marie Landin, Richard L. Riley, and Bonnie B. Blomberg
J Immunol 2008 180: 2741-2746. [Abstract] [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: TNFR-Shedding by CD4⁺CD25⁺ Regulatory T Cells Inhibits the Induction of Inflammatory Mediators

Geertje J. D. van Mierlo, Hans U. Scherer, Marjolijn Hameetman, Mary E. Morgan, Roelof Flierman, Tom W. J. Huizinga, and René E. M. Toes
J Immunol 2008 180: 2747-2751. [Abstract] [Full Text] [PDF]  

Cutting Edge: IL-27 Is a Potent Inducer of IL-10 but Not FoxP3 in Murine T Cells

Marcel Batten, Noelyn M. Kljavin, Ji Li, Michael J. Walter, Frederic J. de Sauvage, and Nico Ghilardi
J Immunol 2008 180: 2752-2756. [Abstract] [Full Text] [PDF]  

Cutting Edge: TGF-β-Induced Expression of Foxp3 in T cells Is Mediated through Inactivation of ERK

Xunrong Luo, Qiang Zhang, Victoria Liu, Zhenbiao Xia, Kathryn L. Pothoven, and Chung Lee
J Immunol 2008 180: 2757-2761. [Abstract] [Full Text] [PDF]  

Cutting Edge: Contributions of Apoptosis and Anergy to Systemic T Cell Tolerance

Luke Barron, Birgit Knoechel, Jens Lohr, and Abul K. Abbas
J Immunol 2008 180: 2762-2766. [Abstract] [Full Text] [PDF]  

Cutting Edge: Selective Expression of Inhibitory or Activating Killer Cell Ig-Like Receptors in Circulating CD4⁺ T Lymphocytes

Natacha Remtoula, Armand Bensussan, and Anne Marie-Cardine
J Immunol 2008 180: 2767-2771. [Abstract] [Full Text] [PDF]  

Cutting Edge: Vasoactive Intestinal Peptide (VIP) Induces Differentiation of Th17 Cells with a Distinctive Cytokine Profile

Mahesh Yadav, Jennifer Rosenbaum, and Edward J. Goetzl
J Immunol 2008 180: 2772-2776. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

β-Glucan Activates Microglia without Inducing Cytokine Production in Dectin-1-Dependent Manner

Vaibhav B. Shah, Yongcheng Huang, Rohan Keshwara, Tammy Ozment-Skelton, David L. Williams, and Lakhu Keshvara
J Immunol 2008 180: 2777-2785. [Abstract] [Full Text] [PDF]  

1,25-Dihydroxyvitamin D₃ Induces CCR10 Expression in Terminally Differentiating Human B Cells

Aiko-Konno Shirakawa, Daisuke Nagakubo, Kunio Hieshima, Takashi Nakayama, Zhe Jin, and Osamu Yoshie
J Immunol 2008 180: 2786-2795. [Abstract] [Full Text] [PDF]  

Notch1 Signaling and Regulatory T Cell Function

Naoki Asano, Tomohiro Watanabe, Atsushi Kitani, Ivan J. Fuss, and Warren Strober
J Immunol 2008 180: 2796-2804. [Abstract] [Full Text] [PDF]  

Polyclonal MHC Ib-Restricted CD8⁺ T Cells Undergo Homeostatic Expansion in the Absence of Conventional MHC-Restricted T Cells

David C. Jay, Lisa M. Reed-Loisel, and Peter E. Jensen
J Immunol 2008 180: 2805-2814. [Abstract] [Full Text] [PDF]  

RhoA Is Involved in LFA-1 Extension Triggered by CXCL12 but Not in a Novel Outside-In LFA-1 Activation Facilitated by CXCL9

Ronit Pasvolsky, Valentin Grabovsky, Cinzia Giagulli, Ziv Shulman, Revital Shamri, Sara W. Feigelson, Carlo Laudanna, and Ronen Alon
J Immunol 2008 180: 2815-2823. [Abstract] [Full Text] [PDF]  

Critical Synergy of CD30 and OX40 Signals in CD4 T Cell Homeostasis and Th1 Immunity to Salmonella

Fabrina Gaspal, Vasileios Bekiaris, Mi-Yeon Kim, David R. Withers, Saeeda Bobat, Ian C. M. MacLennan, Graham Anderson, Peter J. Lane, and Adam F. Cunningham
J Immunol 2008 180: 2824-2829. [Abstract] [Full Text] [PDF]  

Mitigation of Experimental Allergic Encephalomyelitis by TGF-β Induced Foxp3⁺ Regulatory T Lymphocytes through the Induction of Anergy and Infectious Tolerance

Ramesh K. Selvaraj and Terrence L. Geiger
J Immunol 2008 180: 2830-2838. [Abstract] [Full Text] [PDF]  

Heparan Sulfate and Heparin Enhance ERK Phosphorylation and Mediate preBCR-Dependent Events during B Lymphopoiesis

Craig D. Milne, Steven A. Corfe, and Christopher J. Paige
J Immunol 2008 180: 2839-2847. [Abstract] [Full Text] [PDF]  

IL-10 Suppresses Mast Cell IgE Receptor Expression and Signaling In Vitro and In Vivo

Sarah Kennedy Norton, Brian Barnstein, Jennifer Brenzovich, Daniel P. Bailey, Mohit Kashyap, Kelly Speiran, Jill Ford, Daniel Conrad, Stephanie Watowich, Matthew R. Moralle, Christopher L. Kepley, Peter J. Murray, and John J. Ryan
J Immunol 2008 180: 2848-2854. [Abstract] [Full Text] [PDF]  

Constitutive Expression of IL-7 Receptor Does Not Support Increased Expansion or Prevent Contraction of Antigen-Specific CD4 or CD8 T Cells following Listeria monocytogenes Infection

Jodie S. Haring, Xuefang Jing, Julie Bollenbacher-Reilley, Hai-Hui Xue, Warren J. Leonard, and John T. Harty
J Immunol 2008 180: 2855-2862. [Abstract] [Full Text] [PDF]  

B Lymphocyte Depletion by CD20 Monoclonal Antibody Prevents Diabetes in Nonobese Diabetic Mice despite Isotype-Specific Differences in FcR Effector Functions

Yan Xiu, Carmen P. Wong, Jean-David Bouaziz, Yasuhito Hamaguchi, Yaming Wang, Shannon M. Pop, Roland M. Tisch, and Thomas F. Tedder
J Immunol 2008 180: 2863-2875. [Abstract] [Full Text] [PDF]  

Lysosomal Cysteine and Aspartic Proteases Are Heterogeneously Expressed and Act Redundantly to Initiate Human Invariant Chain Degradation

Cristina M. Costantino, Howard C. Hang, Sally C. Kent, David A. Hafler, and Hidde L. Ploegh
J Immunol 2008 180: 2876-2885. [Abstract] [Full Text] [PDF]  

The Role for Monocyte Chemoattractant Protein-1 in the Generation and Function of Memory CD8⁺ T Cells

Tao Wang, Hehua Dai, Ni Wan, Yolonda Moore, and Zhenhua Dai
J Immunol 2008 180: 2886-2893. [Abstract] [Full Text] [PDF]  

AIMP1/p43 Protein Induces the Maturation of Bone Marrow-Derived Dendritic Cells with T Helper Type 1-Polarizing Ability

Eugene Kim, Seung Hyun Kim, Sunghoon Kim, Daeho Cho, and Tae Sung Kim
J Immunol 2008 180: 2894-2902. [Abstract] [Full Text] [PDF]  

STAT3 Is Indispensable to IL-27-Mediated Cell Proliferation but Not to IL-27-Induced Th1 Differentiation and Suppression of Proinflammatory Cytokine Production

Toshiyuki Owaki, Masayuki Asakawa, Noriko Morishima, Izuru Mizoguchi, Fumio Fukai, Kiyoshi Takeda, Junichiro Mizuguchi, and Takayuki Yoshimoto
J Immunol 2008 180: 2903-2911. [Abstract] [Full Text] [PDF]  

Late Signals from CD27 Prevent Fas-Dependent Apoptosis of Primary CD8⁺ T Cells

Douglas V. Dolfi, Alina C. Boesteanu, Constantinos Petrovas, Dong Xia, Eric A. Butz, and Peter D. Katsikis
J Immunol 2008 180: 2912-2921. [Abstract] [Full Text] [PDF]  

KIR2DL4 Differentially Signals Downstream Functions in Human NK Cells through Distinct Structural Modules

S. M. Shahjahan Miah, Tracey L. Hughes, and Kerry S. Campbell
J Immunol 2008 180: 2922-2932. [Abstract] [Full Text] [PDF]  

Mutation in the Fas Pathway Impairs CD8⁺ T Cell Memory

Renu Dudani, Marsha Russell, Henk van Faassen, Lakshmi Krishnan, and Subash Sad
J Immunol 2008 180: 2933-2941. [Abstract] [Full Text] [PDF]  

Involvement of Secretory and Endosomal Compartments in Presentation of an Exogenous Self-Glycolipid to Type II NKT Cells

Keshab Chandra Roy, Igor Maricic, Archana Khurana, Trevor R. F. Smith, Ramesh C. Halder, and Vipin Kumar
J Immunol 2008 180: 2942-2950. [Abstract] [Full Text] [PDF]  

Splenic Stromal Microenvironment Negatively Regulates Virus-Activated Plasmacytoid Dendritic Cells through TGF-β

Li Li, Shuxun Liu, Ting Zhang, Wei Pan, Xiao Yang, and Xuetao Cao
J Immunol 2008 180: 2951-2956. [Abstract] [Full Text] [PDF]  

Proliferative Expansion and Acquisition of Effector Activity by Memory CD4⁺ T Cells in the Lungs following Pulmonary Virus Infection

Erika L. Wissinger, Whitney W. Stevens, Steven M. Varga, and Thomas J. Braciale
J Immunol 2008 180: 2957-2966. [Abstract] [Full Text] [PDF]  

Expression of ICOS on Human Melanoma-Infiltrating CD4⁺CD25^highFoxp3⁺ T Regulatory Cells: Implications and Impact on Tumor-Mediated Immune Suppression

Laura Strauss, Christoph Bergmann, Miroslaw J. Szczepanski, Stephan Lang, John M. Kirkwood, and Theresa L. Whiteside
J Immunol 2008 180: 2967-2980. [Abstract] [Full Text] [PDF]  

Regulatory and Conventional CD4⁺ T Cells Show Differential Effects Correlating with PD-1 and B7-H1 Expression after Immunotherapy

Kory L. Alderson, Qing Zhou, Vanessa Berner, Danice E. C. Wilkins, Jonathan M. Weiss, Bruce R. Blazar, Lisbeth A. Welniak, Robert H. Wiltrout, Doug Redelman, and William J. Murphy
J Immunol 2008 180: 2981-2988. [Abstract] [Full Text] [PDF]  

Interactions of T Cells with Fibroblast-Like Synoviocytes: Role of the B7 Family Costimulatory Ligand B7-H3

Chinh N. Tran, Seth G. Thacker, Deanna M. Louie, Jennifer Oliver, Peter T. White, Judith L. Endres, Andrew G. Urquhart, Kevin C. Chung, and David A. Fox
J Immunol 2008 180: 2989-2998. [Abstract] [Full Text] [PDF]  

Rat CD4⁺CD8⁺ Macrophages Kill Tumor Cells through an NKG2D- and Granzyme/Perforin-Dependent Mechanism

Tomohisa Baba, Sari Iwasaki, Takako Maruoka, Akira Suzuki, Utano Tomaru, Hitoshi Ikeda, Takashi Yoshiki, Masanori Kasahara, and Akihiro Ishizu
J Immunol 2008 180: 2999-3006. [Abstract] [Full Text] [PDF]  

The Tec Kinases Itk and Rlk Regulate NKT Cell Maturation, Cytokine Production, and Survival

Martin Felices and Leslie J. Berg
J Immunol 2008 180: 3007-3018. [Abstract] [Full Text] [PDF]  

Blood Monocyte Subsets Differentially Give Rise to CD103⁺ and CD103^– Pulmonary Dendritic Cell Populations

Claudia Jakubzick, Frank Tacke, Florent Ginhoux, Amy J. Wagers, Nico van Rooijen, Matthias Mack, Miriam Merad, and Gwendalyn J. Randolph
J Immunol 2008 180: 3019-3027. [Abstract] [Full Text] [PDF]  

Alternatively Activated Macrophages Regulate Extracellular Levels of the Hormone Placental Lactogen via Receptor-Mediated Uptake and Transcytosis

Julia Kzhyshkowska, Alexei Gratchev, Christina Schmuttermaier, Heike Brundiers, Liis Krusell, Srinivas Mamidi, Jingjing Zhang, Gail Workman, E. Helene Sage, Christine Anderle, Peter Sedlmayr, and Sergij Goerdt
J Immunol 2008 180: 3028-3037. [Abstract] [Full Text] [PDF]  

Prophylactic Treatment with Fms-Like Tyrosine Kinase-3 Ligand after Burn Injury Enhances Global Immune Responses to Infection

Julia Bohannon, Weihua Cui, Robert Cox, Rene Przkora, Edward Sherwood, and Tracy Toliver-Kinsky
J Immunol 2008 180: 3038-3048. [Abstract] [Full Text] [PDF]  

CCR5-Dependent Regulatory T Cell Migration Mediates Fungal Survival and Severe Immunosuppression

Ana Paula Moreira, Karen Angelica Cavassani, Fabrine Sales Massafera Tristão, Ana Paula Campanelli, Roberto Martinez, Marcos Antonio Rossi, and João S. Silva
J Immunol 2008 180: 3049-3056. [Abstract] [Full Text] [PDF]  

Dermal Dendritic Cells, and Not Langerhans Cells, Play an Essential Role in Inducing an Immune Response

Atsushi Fukunaga, Noor M. Khaskhely, Coimbatore S. Sreevidya, Scott N. Byrne, and Stephen E. Ullrich
J Immunol 2008 180: 3057-3064. [Abstract] [Full Text] [PDF]  

Phenotypic and Functional Characterization of Ultraviolet Radiation-Induced Regulatory T Cells

Akira Maeda, Stefan Beissert, Thomas Schwarz, and Agatha Schwarz
J Immunol 2008 180: 3065-3071. [Abstract] [Full Text] [PDF]  

The Fas Death Signaling Pathway Connecting Reactive Oxygen Species Generation and FLICE Inhibitory Protein Down-Regulation

Liying Wang, Neelam Azad, Lalana Kongkaneramit, Fei Chen, Yongju Lu, Bing-Hua Jiang, and Yon Rojanasakul
J Immunol 2008 180: 3072-3080. [Abstract] [Full Text] [PDF]  

Exosomes As a Short-Range Mechanism to Spread Alloantigen between Dendritic Cells during T Cell Allorecognition

Angela Montecalvo, William J. Shufesky, Donna Beer Stolz, Mara G. Sullivan, Zhiliang Wang, Sherrie J. Divito, Glenn D. Papworth, Simon C. Watkins, Paul D. Robbins, Adriana T. Larregina, and Adrian E. Morelli
J Immunol 2008 180: 3081-3090. [Abstract] [Full Text] [PDF]  

Differential Roles of Galectin-1 and Galectin-3 in Regulating Leukocyte Viability and Cytokine Secretion

Sean R. Stowell, Yuning Qian, Sougata Karmakar, Natalia S. Koyama, Marcelo Dias-Baruffi, Hakon Leffler, Rodger P. McEver, and Richard D. Cummings
J Immunol 2008 180: 3091-3102. [Abstract] [Full Text] [PDF]  

Spontaneous Renal Allograft Acceptance Associated with "Regulatory" Dendritic Cells and IDO

Charles H. Cook, Alice A. Bickerstaff, Jiao-Jing Wang, Tibor Nadasdy, Patricia Della Pelle, Robert B. Colvin, and Charles G. Orosz
J Immunol 2008 180: 3103-3112. [Abstract] [Full Text] [PDF]  

Absence of CTL Responses to Early Viral Antigens Facilitates Viral Persistence

Anita Schildknecht, Sarah Welti, Markus B. Geuking, Lars Hangartner, and Maries van den Broek
J Immunol 2008 180: 3113-3121. [Abstract] [Full Text] [PDF]  

Tumor-Specific CD4⁺ T Cells Render the Tumor Environment Permissive for Infiltration by Low-Avidity CD8⁺ T Cells

S. B. Justin Wong, Rinke Bos, and Linda A. Sherman
J Immunol 2008 180: 3122-3131. [Abstract] [Full Text] [PDF]  

Radiation-Induced IFN- Production within the Tumor Microenvironment Influences Antitumor Immunity

Amit A. Lugade, Elizabeth W. Sorensen, Scott A. Gerber, James P. Moran, John G. Frelinger, and Edith M. Lord
J Immunol 2008 180: 3132-3139. [Abstract] [Full Text] [PDF]  

ICOS Mediates the Development of Insulin-Dependent Diabetes Mellitus in Nonobese Diabetic Mice

Daniel Hawiger, Elise Tran, Wei Du, Carmen J. Booth, Li Wen, Chen Dong, and Richard A. Flavell
J Immunol 2008 180: 3140-3147. [Abstract] [Full Text] [PDF]  

Vesicle-Associated Membrane Protein-8/Endobrevin Negatively Regulates Phagocytosis of Bacteria in Dendritic Cells

Yong Hou Sunny Ho, Deyu Tarika Cai, Cheng-Chun Wang, Dachuan Huang, and Siew Heng Wong
J Immunol 2008 180: 3148-3157. [Abstract] [Full Text] [PDF]  

Knockdown of Mgat5 Inhibits Breast Cancer Cell Growth with Activation of CD4⁺ T Cells and Macrophages

Dongqing Li, Yanmei Li, Xianglei Wu, Qiao Li, Jing Yu, Jie Gen, and Xiao-Lian Zhang
J Immunol 2008 180: 3158-3165. [Abstract] [Full Text] [PDF]  

Abnormal NF-B Function Characterizes Human Type 1 Diabetes Dendritic Cells and Monocytes

Zia U. A. Mollah, Saparna Pai, Craig Moore, Brendan J. O’Sullivan, Matthew J. Harrison, Judy Peng, Karen Phillips, Johannes B. Prins, John Cardinal, and Ranjeny Thomas
J Immunol 2008 180: 3166-3175. [Abstract] [Full Text] [PDF]  

Phylogenetic Conservation of Glycoprotein 96 Ability to Interact with CD91 and Facilitate Antigen Cross-Presentation

Jacques Robert, Thaminda Ramanayake, Gregory D. Maniero, Heidi Morales, and Asiya S. Chida
J Immunol 2008 180: 3176-3182. [Abstract] [Full Text] [PDF]  

Contribution of Neural Crest-Derived Cells in the Embryonic and Adult Thymus

Katie Foster, Julie Sheridan, Henrique Veiga-Fernandes, Kathleen Roderick, Vassilis Pachnis, Ralf Adams, Clare Blackburn, Dimitris Kioussis, and Mark Coles
J Immunol 2008 180: 3183-3189. [Abstract] [Full Text] [PDF] Data Supplement  

Expansion of Effector Memory TCR Vβ4⁺CD8⁺ T Cells Is Associated with Latent Infection-Mediated Resistance to Transplantation Tolerance

Dale Stapler, Eun D. Lee, Saranya A. Selvaraj, Andrew G. Evans, Leslie S. Kean, Samuel H. Speck, Christian P. Larsen, and Shivaprakash Gangappa
J Immunol 2008 180: 3190-3200. [Abstract] [Full Text] [PDF]  

Selection of an Antibody Library Identifies a Pathway to Induce Immunity by Targeting CD36 on Steady-State CD8⁺ Dendritic Cells

Elisa Tagliani, Pierre Guermonprez, Jorge Sepúlveda, María López-Bravo, Carlos Ardavín, Sebastian Amigorena, Federica Benvenuti, and Oscar R. Burrone
J Immunol 2008 180: 3201-3209. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Characterizing the N-Terminal Processing Motif of MHC Class I Ligands

Mark M. Schatz, Björn Peters, Nadja Akkad, Nina Ullrich, Alejandra Nacarino Martinez, Oliver Carroll, Sascha Bulik, Hans-Georg Rammensee, Peter van Endert, Hermann-Georg Holzhütter, Stefan Tenzer, and Hansjörg Schild
J Immunol 2008 180: 3210-3217. [Abstract] [Full Text] [PDF]  

Differential Activation of Dual Promoters Alters Dβ2 Germline Transcription during Thymocyte Development

Ruth E. McMillan and Michael L. Sikes
J Immunol 2008 180: 3218-3228. [Abstract] [Full Text] [PDF]  

Modifications in Small Interfering RNA That Separate Immunostimulation from RNA Interference

Florian Eberle, Kerstin Gießler, Christopher Deck, Klaus Heeg, Mirjam Peter, Clemens Richert, and Alexander H. Dalpke
J Immunol 2008 180: 3229-3237. [Abstract] [Full Text] [PDF]  

The Tumor Suppressor Death-Associated Protein Kinase Targets to TCR-Stimulated NF-B Activation

Ya-Ting Chuang, Li-Wen Fang, Ming-Hsien Lin-Feng, Ruey-Hwa Chen, and Ming-Zong Lai
J Immunol 2008 180: 3238-3249. [Abstract] [Full Text] [PDF]  

IMMUNOGENETICS:

Through Regulation of TCR Expression Levels, an Idd7 Region Gene(s) Interactively Contributes to the Impaired Thymic Deletion of Autoreactive Diabetogenic CD8⁺ T Cells in Nonobese Diabetic Mice

David V. Serreze, Caroline Morgane Choisy-Rossi, Alexandra E. Grier, T. Mathew Holl, Harold D. Chapman, J. Reed Gahagan, Melissa A. Osborne, Weidong Zhang, Benjamin L. King, Aaron Brown, Derry Roopenian, and Michele P. Marron
J Immunol 2008 180: 3250-3259. [Abstract] [Full Text] [PDF]  

Regulation of the NK Cell Alloreactivity to Bone Marrow Cells by the Combination of the Host NK Gene Complex and MHC Haplotypes

Koho Iizuka, Anthony A. Scalzo, Hong Xian, and Wayne M. Yokoyama
J Immunol 2008 180: 3260-3267. [Abstract] [Full Text] [PDF]  

Large-Scale Characterization of Natural Ligands Explains the Unique Gluten-Binding Properties of HLA-DQ2

Dariusz Stepniak, Martina Wiesner, Arnoud H. de Ru, Antonis K. Moustakas, Jan Wouter Drijfhout, George K. Papadopoulos, Peter A. van Veelen, and Frits Koning
J Immunol 2008 180: 3268-3278. [Abstract] [Full Text] [PDF]  

Immunodominance of the V_H1–46 Antibody Gene Segment in the Primary Repertoire of Human Rotavirus-Specific B Cells Is Reduced in the Memory Compartment through Somatic Mutation of Nondominant Clones

Cuixia Tian, Grace K. Luskin, Kevin M. Dischert, James N. Higginbotham, Bryan E. Shepherd, and James E. Crowe, Jr
J Immunol 2008 180: 3279-3288. [Abstract] [Full Text] [PDF] Data Supplement  

Vra4 Congenic Rats with Allelic Differences in the Class II Transactivator Gene Display Altered Susceptibility to Experimental Autoimmune Encephalomyelitis

Karin Harnesk, Maria Swanberg, Johan Öckinger, Margarita Diez, Olle Lidman, Erik Wallström, Anna Lobell, Tomas Olsson, and Fredrik Piehl
J Immunol 2008 180: 3289-3296. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Significant Virus Replication in Langerhans Cells following Application of HIV to Abraded Skin: Relevance to Occupational Transmission of HIV

Tatsuyoshi Kawamura, Yoshio Koyanagi, Yuumi Nakamura, Youichi Ogawa, Atsuya Yamashita, Taku Iwamoto, Masahiko Ito, Andrew Blauvelt, and Shinji Shimada
J Immunol 2008 180: 3297-3304. [Abstract] [Full Text] [PDF]  

Effects of Liver X Receptor Agonist Treatment on Pulmonary Inflammation and Host Defense

Kathleen Smoak, Jennifer Madenspacher, Samithamby Jeyaseelan, Belinda Williams, Darlene Dixon, Katie R. Poch, Jerry A. Nick, G. Scott Worthen, and Michael B. Fessler
J Immunol 2008 180: 3305-3312. [Abstract] [Full Text] [PDF]  

Properdin Plays a Protective Role in Polymicrobial Septic Peritonitis

Cordula M. Stover, Jeni C. Luckett, Bernd Echtenacher, Aline Dupont, Sue E. Figgitt, Jane Brown, Daniela N. Männel, and Wilhelm J. Schwaeble
J Immunol 2008 180: 3313-3318. [Abstract] [Full Text] [PDF]  

Airway Epithelial versus Immune Cell Stat1 Function for Innate Defense against Respiratory Viral Infection

Laurie P. Shornick, Audrey G. Wells, Yong Zhang, Anand C. Patel, Guangming Huang, Kazutaka Takami, Moises Sosa, Nikhil A. Shukla, Eugene Agapov, and Michael J. Holtzman
J Immunol 2008 180: 3319-3328. [Abstract] [Full Text] [PDF] Data Supplement  

Fc Receptors Regulate Immune Activation and Susceptibility during Mycobacterium tuberculosis Infection

Paul J. Maglione, Jiayong Xu, Arturo Casadevall, and John Chan
J Immunol 2008 180: 3329-3338. [Abstract] [Full Text] [PDF]  

MHC Class II-Associated Invariant Chain Linkage of Antigen Dramatically Improves Cell-Mediated Immunity Induced by Adenovirus Vaccines

Peter Johannes Holst, Maria Rathmann Sorensen, Camilla Maria Mandrup Jensen, Cathrine Orskov, Allan Randrup Thomsen, and Jan Pravsgaard Christensen
J Immunol 2008 180: 3339-3346. [Abstract] [Full Text] [PDF]  

Glycosylation-Dependent Interactions of C-Type Lectin DC-SIGN with Colorectal Tumor-Associated Lewis Glycans Impair the Function and Differentiation of Monocyte-Derived Dendritic Cells

Motohiro Nonaka, Bruce Yong Ma, Ryuuya Murai, Natsuko Nakamura, Makoto Baba, Nobuko Kawasaki, Keiko Hodohara, Shinji Asano, and Toshisuke Kawasaki
J Immunol 2008 180: 3347-3356. [Abstract] [Full Text] [PDF]  

Platelet-Activating Factor Receptor Contributes to Host Defense against Pseudomonas aeruginosa Pneumonia but Is Not Essential for the Accompanying Inflammatory and Procoagulant Response

Marieke A. D. van Zoelen, Sandrine Florquin, Joost C. M. Meijers, Regina de Beer, Alex F. de Vos, Onno J. de Boer, and Tom van der Poll
J Immunol 2008 180: 3357-3365. [Abstract] [Full Text] [PDF]  

Blockade of Antimicrobial Proteins S100A8 and S100A9 Inhibits Phagocyte Migration to the Alveoli in Streptococcal Pneumonia

Marie-Astrid Raquil, Nadia Anceriz, Pascal Rouleau, and Philippe A. Tessier
J Immunol 2008 180: 3366-3374. [Abstract] [Full Text] [PDF]  

Antigen-Specific CD4⁺ T Cells Produce Sufficient IFN- to Mediate Robust Protective Immunity against Genital Chlamydia muridarum Infection

Weidang Li, Ashlesh K. Murthy, M. Neal Guentzel, J. Seshu, Thomas G. Forsthuber, Guangming Zhong, and Bernard P. Arulanandam
J Immunol 2008 180: 3375-3382. [Abstract] [Full Text] [PDF]  

Fine Specificity of Neonatal Lymphocytes to an Abundant Malaria Blood-Stage Antigen: Epitope Mapping of Plasmodium falciparum MSP1₃₃

Indu Malhotra, Alex N. Wamachi, Peter L. Mungai, Elton Mzungu, Davy Koech, Eric Muchiri, Ann M. Moormann, and Christopher L. King
J Immunol 2008 180: 3383-3390. [Abstract] [Full Text] [PDF]  

Antiviral Activity of the Long Chain Pentraxin PTX3 against Influenza Viruses

Patrick C. Reading, Silvia Bozza, Brad Gilbertson, Michelle Tate, Silvia Moretti, Emma R. Job, Erika C. Crouch, Andrew G. Brooks, Lorena E. Brown, Barbara Bottazzi, Luigina Romani, and Alberto Mantovani
J Immunol 2008 180: 3391-3398. [Abstract] [Full Text] [PDF]  

Human Lymphatic Endothelial Cells Express Multiple Functional TLRs

Amarendra Pegu, Shulin Qin, Beth A. Fallert Junecko, Riccardo E. Nisato, Michael S. Pepper, and Todd A. Reinhart
J Immunol 2008 180: 3399-3405. [Abstract] [Full Text] [PDF]  

Stimulation of Enhanced CD8 T Cell Responses Following Immunization with a Hyper-Antigen Secreting Intracytosolic Bacterial Pathogen

Megan J. Smithey, Suzanne Brandt, Nancy E. Freitag, Darren E. Higgins, and H. G. Archie Bouwer
J Immunol 2008 180: 3406-3416. [Abstract] [Full Text] [PDF]  

⁺ T Cells Involvement in Viral Immune Control of Chronic Human Herpesvirus 8 Infection

Serge Barcy, Stephen C. De Rosa, Jeffrey Vieira, Kurt Diem, Minako Ikoma, Corey Casper, and Lawrence Corey
J Immunol 2008 180: 3417-3425. [Abstract] [Full Text] [PDF]  

Human Factor H Interacts Selectively with Neisseria gonorrhoeae and Results in Species-Specific Complement Evasion

Jutamas Ngampasutadol, Sanjay Ram, Sunita Gulati, Sarika Agarwal, Chongqing Li, Alberto Visintin, Brian Monks, Guillermo Madico, and Peter A. Rice
J Immunol 2008 180: 3426-3435. [Abstract] [Full Text] [PDF]  

Mycobacterial Lipopeptides Elicit CD4⁺ CTLs in Mycobacterium tuberculosis-Infected Humans

Max Bastian, Tobias Braun, Heiko Bruns, Martin Röllinghoff, and Steffen Stenger
J Immunol 2008 180: 3436-3446. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Inhibition of Monocyte Chemoattractant Protein-1 Ameliorates Rat Adjuvant-Induced Arthritis

Shiva Shahrara, Amanda E. I. Proudfoot, Christy C. Park, Michael V. Volin, G. Kenneth Haines, James M. Woods, Christopher H. Aikens, Tracy M. Handel, and Richard M. Pope
J Immunol 2008 180: 3447-3456. [Abstract] [Full Text] [PDF]  

Neutropenia with Impaired Immune Response to Streptococcus pneumoniae in Ceramide Kinase-Deficient Mice

Christine Graf, Barbara Zemann, Philipp Rovina, Nicole Urtz, Andrea Schanzer, Roland Reuschel, Diana Mechtcheriakova, Matthias Müller, Evelin Fischer, Claudia Reichel, Susanna Huber, Janet Dawson, Josef G. Meingassner, Andreas Billich, Satoru Niwa, Rudolf Badegruber, Paul P. Van Veldhoven, Bernd Kinzel, Thomas Baumruker, and Frédéric Bornancin
J Immunol 2008 180: 3457-3466. [Abstract] [Full Text] [PDF]  

Lymphotoxin-1β2 and LIGHT Induce Classical and Noncanonical NF-B-Dependent Proinflammatory Gene Expression in Vascular Endothelial Cells

Lisa A. Madge, Martin S. Kluger, Jordan S. Orange, and Michael J. May
J Immunol 2008 180: 3467-3477. [Abstract] [Full Text] [PDF]  

Lipoteichoic Acid-Induced Lung Inflammation Depends on TLR2 and the Concerted Action of TLR4 and the Platelet-Activating Factor Receptor

Sylvia Knapp, Sonja von Aulock, Masja Leendertse, Isabella Haslinger, Christian Draing, Douglas T. Golenbock, and Tom van der Poll
J Immunol 2008 180: 3478-3484. [Abstract] [Full Text] [PDF]  

Etk/BMX, a Btk Family Tyrosine Kinase, and Mal Contribute to the Cross-Talk between MyD88 and FAK Pathways

Noha Semaan, Ghada Alsaleh, Jacques-Eric Gottenberg, Dominique Wachsmann, and Jean Sibilia
J Immunol 2008 180: 3485-3491. [Abstract] [Full Text] [PDF]  

Transcriptional Complex Formation of c-Fos, STAT3, and Hepatocyte NF-1 Is Essential for Cytokine-Driven C-Reactive Protein Gene Expression

Teppei Nishikawa, Keisuke Hagihara, Satoshi Serada, Tomoyasu Isobe, Atsumi Matsumura, Jian Song, Toshio Tanaka, Ichiro Kawase, Tetsuji Naka, and Kazuyuki Yoshizaki
J Immunol 2008 180: 3492-3501. [Abstract] [Full Text] [PDF]  

Subversion of a Lysosomal Pathway Regulating Neutrophil Apoptosis by a Major Bacterial Toxin, Pyocyanin

Lynne R. Prince, Stephen M. Bianchi, Kathryn M. Vaughan, Martin A. Bewley, Helen M. Marriott, Sarah R. Walmsley, Graham W. Taylor, David J. Buttle, Ian Sabroe, David H. Dockrell, and Moira K. B. Whyte
J Immunol 2008 180: 3502-3511. [Abstract] [Full Text] [PDF]  

Resolvin E1 Metabolome in Local Inactivation during Inflammation-Resolution

Song Hong, Timothy F. Porter, Yan Lu, Sungwhan F. Oh, Padmini S. Pillai, and Charles N. Serhan
J Immunol 2008 180: 3512-3519. [Abstract] [Full Text] [PDF]  

Innate Immune Responses to TREM-1 Activation: Overlap, Divergence, and Positive and Negative Cross-Talk with Bacterial Lipopolysaccharide

Ken Dower, Debra K. Ellis, Kathryn Saraf, Scott A. Jelinsky, and Lih-Ling Lin
J Immunol 2008 180: 3520-3534. [Abstract] [Full Text] [PDF]  

Dipeptidyl Peptidase I-Dependent Neutrophil Recruitment Modulates the Inflammatory Response to Sendai Virus Infection

Antonina M. Akk, Pamela M. Simmons, Happy W. Chan, Eugene Agapov, Michael J. Holtzman, Mitchell H. Grayson, and Christine T. N. Pham
J Immunol 2008 180: 3535-3542. [Abstract] [Full Text] [PDF]  

Mast Cell-Fibroblast Interactions Induce Matrix Metalloproteinase-9 Release from Fibroblasts: Role for IgE-Mediated Mast Cell Activation

Melanie Abel and Harissios Vliagoftis
J Immunol 2008 180: 3543-3550. [Abstract] [Full Text] [PDF]  

IL-4 Is a Critical Determinant in the Generation of Allergic Inflammation Initiated by a Constitutively Active Stat6

Sarita Sehra, Heather A. Bruns, Ayele-Nati N. Ahyi, Evelyn T. Nguyen, Nathan W. Schmidt, E. Grace Michels, Götz-Ulrich von Bülow, and Mark H. Kaplan
J Immunol 2008 180: 3551-3559. [Abstract] [Full Text] [PDF]  

Loss of ABCG1 Results in Chronic Pulmonary Inflammation

Ángel Baldán, Aldrin V. Gomes, Peipei Ping, and Peter A. Edwards
J Immunol 2008 180: 3560-3568. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Bacillus Calmette-Guérin Vaccination of Human Newborns Induces T Cells with Complex Cytokine and Phenotypic Profiles

Andreia P. Soares, Thomas J. Scriba, Sarah Joseph, Ryhor Harbacheuski, Rose Ann Murray, Sebastian J. Gelderbloem, Anthony Hawkridge, Gregory D. Hussey, Holden Maecker, Gilla Kaplan, and Willem A. Hanekom
J Immunol 2008 180: 3569-3577. [Abstract] [Full Text] [PDF]  

Questionable Relevance of T Lymphocytes in Renal Cell Carcinoma

Brant A. Inman, Xavier Frigola, Kimberley J. Harris, Susan M. Kuntz, Christine M. Lohse, Bradley C. Leibovich, and Eugene D. Kwon
J Immunol 2008 180: 3578-3584. [Abstract] [Full Text] [PDF]  

Vaccination of a Melanoma Patient with Mature Dendritic Cells Pulsed with MAGE-3 Peptides Triggers the Activity of Nonvaccine Anti-Tumor Cells

Javier Carrasco, Aline Van Pel, Bart Neyns, Bernard Lethé, Francis Brasseur, Nicolina Renkvist, Pierre van der Bruggen, Nicolas van Baren, Robert Paulus, Kris Thielemans, Thierry Boon, and Danièle Godelaine
J Immunol 2008 180: 3585-3593. [Abstract] [Full Text] [PDF]  

Morphine Induces Defects in Early Response of Alveolar Macrophages to Streptococcus pneumoniae by Modulating TLR9-NF-B Signaling

Jinghua Wang, Roderick A. Barke, Richard Charboneau, Reto Schwendener, and Sabita Roy
J Immunol 2008 180: 3594-3600. [Abstract] [Full Text] [PDF]  

Redirecting Therapeutic T Cells against Myelin-Specific T Lymphocytes Using a Humanized Myelin Basic Protein-HLA-DR2- Chimeric Receptor

Ioana Moisini, Phuong Nguyen, Lars Fugger, and Terrence L. Geiger
J Immunol 2008 180: 3601-3611. [Abstract] [Full Text] [PDF]  

CORRECTIONS:

Brain microenvironment promotes the final functional maturation of tumor-specific effector CD8⁺ T cells

F. Masson, T. Calzascia, W. Di Berardino-Besson, N. de Tribolet, P.-Y. Dietrich, and P. R. Walker
J Immunol 2008 180: 3612. [Full Text] [PDF]  

Cutting edge: a transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway

K. C. El Kasmi, A. M. Smith, L. Williams, G. Neale, A. Panopolous, S. S. Watowich, H. Häcker, B. M. J. Foxwell, and P. J. Murray
J Immunol 2008 180: 3612. [Full Text] [PDF]  

Membrane vesicles are immunogenic facsimiles of Salmonella typhimurium that potently activate dendritic cells, prime B and T cell responses, and stimulate protective immunity in vivo

R. C. Alaniz, B. L. Deatherage, J. C. Lara, and B. T. Cookson
J Immunol 2008 180: 3612. [Full Text] [PDF]  

TLR ligands differentially modulate T cell responses to acute and chronic antigen presentation

N. J. Singh, M. Cox, and R. H. Schwartz
J Immunol 2008 180: 3612. [Full Text] [PDF]  

Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins

Y. Li, J. Yan, P. De, H.-C. Chang, A. Yamauchi, K. W. Christopherson, II, N. C. Paranavitana, X. Peng, C. Kim, V. Munugulavadla, R. Kapur, H. Chen, W. Shou, J. C. Stone, M. H. Kaplan, M. C. Dinauer, D. L. Durden, and L. A. Quilliam
J Immunol 2008 180: 3612. [Full Text] [PDF]  

ICOS controls the pool size of effector-memory and regulatory T cells

Y. Burmeister, T. Lischke, A. C. Dahler, H. W. Mages, K.-P. Lam, A. J. Coyle, R. A. Kroczek, and A. Hutloff
J Immunol 2008 180: 3613. [Full Text] [PDF]  

Pregnancy allows the transfer and differentiation of fetal lymphoid progenitors into functional T and B cells in mothers

K. Khosrotehrani, M. Leduc, V. Bachy, S. N. Huu, M. Oster, A. Abbas, S. Uzan, and S. Aractingi
J Immunol 2008 180: 3613. [Full Text] [PDF]  

Protein interactions between CD2 and Lck are required for the lipid raft distribution of CD2

R. J. Nunes, M. A. A. Castro, C. M. Gonçalves, M. Bamberger, C. F. Pereira, G. Bismuth, and A. M. Carmo
J Immunol 2008 180: 3613. [Full Text] [PDF]  

Role of the β-subunit arginine/lysine finger in integrin heterodimer formation and function

V. Gupta, J. L. Alonso, T. Sugimori, M. Issafi, J.-P. Xiong, and M. A. Arnaout
J Immunol 2008 180: 3613. [Full Text] [PDF]  

Activated renal macrophages are markers of disease onset and disease remission in lupus nephritis

L. Schiffer, R. Bethunaickan, M. Ramanujam, W. Huang, M. Schiffer, H. Tao, M. M. Madaio, E. P. Bottinger, and A. Davidson
J Immunol 2008 180: 3613. [Full Text] [PDF]  

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