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On the cover: Three-dimensional structure of single chain TNF (scTNF) as derived from molecular stimulation studies. scTNF is a stabilized derivative (due to two peptide linkers) of the human homotrimeric TNF. This form of TNF shows full bioactivity, increased stability, and interesting new properties in vivo. Krippner-Heidenreich, A., I. Grunwald, G. Zimmermann, M. Kühnle, J. Gerspach, T. Sterns, S. D. Shnyder, J. H. Gill, D. Männel, K. Pfizenmaier, and P. Scheurich. 2008. Single chain TNF, a TNF derivative with enhanced stability and antitumoral activity. J. Immunol. 180: 8176–8183.
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