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On the cover: Linear epitope mapping of positive sera of mice immunized with different recombinant prion protein preparations (left and middle). Right panel shows reactivity of a polyclonal antiserum obtained by rabbit immunization. Peptides covering prion protein and selected controls were covalently linked to CovaLink NH Modules and sera were analyzed by ELISA technique. Kaiser-Schulz, G., A. Heit, L. Quintanilla-Martinez, F. Hammerschmidt, S. Hess, L. Jennen, H. Rezaei, H. Wagner, and H. M. Schäzl. 2007. Polylactide-coglycolide microspheres coencapsulating recombinant tandem prion protein with CpG-oligonucleotide break self-tolerance to prion protein in wild-type mice and induce CD4 and CD8 T cell responses. J. Immunol. 179: 2797–2807.
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