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On the cover: CFSE-dilution profile of adoptively transferred OT-II T cells from the inguinal lymph node of C57BL/6 recipient mice after OVA immunization in the presence of a catalytic antioxidant. Profile confirms that redox modulation did not affect in vivo T cell expansion, but dramatically inhibited adaptive immune effector function. Tse, H. M., M. J. Milton, S. Schreiner, J. L. Profozich, M. Trucco, and J. D. Piganelli. 2007. Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness. J. Immunol. 178: 908–917.
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