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On the cover: Upon tight T cell/APC couple formation, a deep T cell invagination forms at the center of the cellular interface with APC cell membrane still attached. It is enriched in receptor/ligand couples, most prominently CD2/CD48. CD48GFP fluorescence from the APC reaching into the T cell invagination is shown (1 min steps). Singleton, K., N. Parvaze, K. R. Dama, K. S. Chen, P. Jennings, B. Purtic, M. D. Sjaastad, C. Gilpin, M. M. Davis, and C. Wülfing. 2006. A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapse. J. Immunol. 177: 4402–4413.
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