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On the cover: Toluidine blue staining of joint tissue section from a collagen-induced arthritic mouse treated with an anti-TWEAK blocking monoclonal antibody. Significantly reduced inflammation and less bone/cartilage damage were seen with TWEAK blockade. Perper, S. J., B. Browning, L. C. Burkly, S. Weng, C. Gao, K. Giza, L. Su, L. Tarilonte, T. Crowell, L. Rajman, L. Runkel, M. Scott, G. J. Atkins, D. M. Findlay, T. S. Zheng, and H. Hess. 2006. TWEAK is a novel arthritogenic mediator. J. Immunol. 177: 2610–2620.

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