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On the cover: Immunohistochemistry image of a paraffin-embedded metastasis section from a vaccinated melanoma patient stained for Melan-A (in brown). This example of a region with undetectable Melan-A antigen expression in some melanoma cells illustrates the loss of Melan-A antigen expression by tumor cells and therefore escape from CTL recognition. Appay, V., C. Jandus, V. Voelter, S. Reynard, S. E. Coupland, D. Rimoldi, D. Lienard, P. Guillaume, A. M. Krieg, J.-C. Cerottini, P. Romero, S. Leyvraz, N. Rufer, and D. E. Speiser. 2006. New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site. J. Immunol. 177:1670–1678.
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