IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2006 177: 1-2. [Full Text] [PDF]  

PILLARS OF IMMUNOLOGY:

Homing in on L-Selectin

Steven D. Rosen
J Immunol 2006 177: 3-4. [Full Text] [PDF] [Original Pillars Article]  

Pillars Article: A Cell-Surface Molecule Involved in Organ-Specific Homing of Lymphocytes. Nature 1983. 304: 30–34.

W. Michael Gallatin, Irving L. Weissman, and Eugene C. Butcher
J Immunol 2006 177: 5-9. [PDF]  

BRIEF REVIEWS:

Intracellular TLR Signaling: A Structural Perspective on Human Disease

Michael V. Lasker and Satish K. Nair
J Immunol 2006 177: 11-16. [Abstract] [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: The Silent Chemokine Receptor D6 Is Required for Generating T Cell Responses That Mediate Experimental Autoimmune Encephalomyelitis

LiPing Liu, Gerard J. Graham, Anita Damodaran, Taofang Hu, Sergio A. Lira, Margaret Sasse, Claudia Canasto-Chibuque, Donald N. Cook, and Richard M. Ransohoff
J Immunol 2006 177: 17-21. [Abstract] [Full Text] [PDF]  

Cutting Edge: STAT1 and T-bet Play Distinct Roles in Determining Outcome of Visceral Leishmaniasis Caused by Leishmania donovani

Lucia E. Rosas, Heidi M. Snider, Joseph Barbi, Anjali A. Satoskar, Geanncarlo Lugo-Villarino, Tracy Keiser, Tracy Papenfuss, Joan E. Durbin, Danuta Radzioch, Laurie H. Glimcher, and Abhay R. Satoskar
J Immunol 2006 177: 22-25. [Abstract] [Full Text] [PDF]  

Cutting Edge: Impaired Glycosphingolipid Trafficking and NKT Cell Development in Mice Lacking Niemann-Pick Type C1 Protein

Yuval Sagiv, Kelly Hudspeth, Jochen Mattner, Nicolas Schrantz, Randi K. Stern, Dapeng Zhou, Paul B. Savage, Luc Teyton, and Albert Bendelac
J Immunol 2006 177: 26-30. [Abstract] [Full Text] [PDF]  

Cutting Edge: Dendritic Cells Are Essential for In Vivo IL-12 Production and Development of Resistance against Toxoplasma gondii Infection in Mice

Cheng-Hu Liu, Yu-ting Fan, Alexandra Dias, Lisia Esper, Radiah A. Corn, Andre Bafica, Fabiana S. Machado, and Julio Aliberti
J Immunol 2006 177: 31-35. [Abstract] [Full Text] [PDF]  

Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex

Dean Toy, David Kugler, Martin Wolfson, Tim Vanden Bos, Jesse Gurgel, Jonathan Derry, Joel Tocker, and Jacques Peschon
J Immunol 2006 177: 36-39. [Abstract] [Full Text] [PDF]  

Cutting Edge: Induction of B7-H4 on APCs through IL-10: Novel Suppressive Mode for Regulatory T Cells

Ilona Kryczek, Shuang Wei, Linhua Zou, Gefeng Zhu, Peter Mottram, Huanbin Xu, Lieping Chen, and Weiping Zou
J Immunol 2006 177: 40-44. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

B Cells and Dendritic Cells from V8 Light Chain Transgenic Mice Activate MRL-lpr/gld CD4⁺ T Cells

Britte C. Beaudette-Zlatanova, Tina Ling, Mark J. Shlomchik, Ann Marshak-Rothstein, and Ian R. Rifkin
J Immunol 2006 177: 45-52. [Abstract] [Full Text] [PDF]  

Tolerance to Proinsulin-2 Is Due to Radioresistant Thymic Cells

Béatrice Faideau, Chantal Lotton, Bruno Lucas, Isabelle Tardivel, John F. Elliott, Christian Boitard, and Jean-Claude Carel
J Immunol 2006 177: 53-60. [Abstract] [Full Text] [PDF]  

Head Kidney-Derived Macrophages of Common Carp (Cyprinus carpio L.) Show Plasticity and Functional Polarization upon Differential Stimulation

Maaike Joerink, Carla M. S. Ribeiro, René J. M. Stet, Trudi Hermsen, Huub F. J. Savelkoul, and Geert F. Wiegertjes
J Immunol 2006 177: 61-69. [Abstract] [Full Text] [PDF]  

ERK and p38 MAPK Signaling Pathways Negatively Regulate CIITA Gene Expression in Dendritic Cells and Macrophages

Yongxue Yao, Qi Xu, Myung-Ja Kwon, Ranyia Matta, Yusen Liu, Soon-Cheol Hong, and Cheong-Hee Chang
J Immunol 2006 177: 70-76. [Abstract] [Full Text] [PDF]  

CD48 Is an Allergen and IL-3-Induced Activation Molecule on Eosinophils

Ariel Munitz, Ido Bachelet, Ron Eliashar, Marat Khodoun, Fred D. Finkelman, Marc E. Rothenberg, and Francesca Levi-Schaffer
J Immunol 2006 177: 77-83. [Abstract] [Full Text] [PDF]  

IL-2 Immunotoxin Therapy Modulates Tumor-Associated Regulatory T Cells and Leads to Lasting Immune-Mediated Rejection of Breast Cancers in neu-Transgenic Mice

Keith L. Knutson, Yushe Dang, Hailing Lu, Jason Lukas, Bond Almand, Ekram Gad, Ehizoje Azeke, and Mary L. Disis
J Immunol 2006 177: 84-91. [Abstract] [Full Text] [PDF]  

Injury-Induced Suppression of Effector T Cell Immunity Requires CD1d-Positive APCs and CD1d-Restricted NKT Cells

Jessica L. Palmer, Julia M. Tulley, Elizabeth J. Kovacs, Richard L. Gamelli, Masaru Taniguchi, and Douglas E. Faunce
J Immunol 2006 177: 92-99. [Abstract] [Full Text] [PDF]  

Differential Effects of IL-15 and IL-21 in Myeloid (CD11b⁺) and Lymphoid (CD11b^–) Bone Marrow Cells

Martin Pelletier and Denis Girard
J Immunol 2006 177: 100-108. [Abstract] [Full Text] [PDF]  

The Basic Helix-Loop-Helix Transcription Factor HEBAlt Is Expressed in Pro-T Cells and Enhances the Generation of T Cell Precursors

Duncheng Wang, Carol L. Claus, Giovanna Vaccarelli, Marsela Braunstein, Thomas M. Schmitt, Juan Carlos Zúñiga-Pflücker, Ellen V. Rothenberg, and Michele K. Anderson
J Immunol 2006 177: 109-119. [Abstract] [Full Text] [PDF]  

Interleukin-21 Enhances NK Cell Activation in Response to Antibody-Coated Targets

Julie M. Roda, Robin Parihar, Amy Lehman, Aruna Mani, Susheela Tridandapani, and William E. Carson, III
J Immunol 2006 177: 120-129. [Abstract] [Full Text] [PDF]  

Kynurenine Pathway Enzymes in Dendritic Cells Initiate Tolerogenesis in the Absence of Functional IDO

Maria L. Belladonna, Ursula Grohmann, Paolo Guidetti, Claudia Volpi, Roberta Bianchi, Maria C. Fioretti, Robert Schwarcz, Francesca Fallarino, and Paolo Puccetti
J Immunol 2006 177: 130-137. [Abstract] [Full Text] [PDF]  

Self-Antigen Maintains the Innate Antibacterial Function of Self-Specific CD8 T Cells In Vivo

Salim Dhanji, Michael T. Chow, and Hung-Sia Teh
J Immunol 2006 177: 138-146. [Abstract] [Full Text] [PDF]  

Flotillin-1 Regulates IgE Receptor-Mediated Signaling in Rat Basophilic Leukemia (RBL-2H3) Cells

Naoto Kato, Mamoru Nakanishi, and Naohide Hirashima
J Immunol 2006 177: 147-154. [Abstract] [Full Text] [PDF]  

A Modified Tyrosinase-Related Protein 2 Epitope Generates High-Affinity Tumor-Specific T Cells but Does Not Mediate Therapeutic Efficacy in an Intradermal Tumor Model

Jennifer A. McWilliams, Sean M. McGurran, Steven W. Dow, Jill E. Slansky, and Ross M. Kedl
J Immunol 2006 177: 155-161. [Abstract] [Full Text] [PDF]  

Tumor Escape Mutants Develop within an Immune-Privileged Environment in the Absence of T Cell Selection

Peter W. Chen, Toshihiko Uno, and Bruce R. Ksander
J Immunol 2006 177: 162-168. [Abstract] [Full Text] [PDF]  

Leptin Selectively Augments Thymopoiesis in Leptin Deficiency and Lipopolysaccharide-Induced Thymic Atrophy

Ryan W. Hick, Amanda L. Gruver, Melissa S. Ventevogel, Barton F. Haynes, and Gregory D. Sempowski
J Immunol 2006 177: 169-176. [Abstract] [Full Text] [PDF]  

Increased Level and Longevity of Protective Immune Responses Induced by DNA Vaccine Expressing the HIV-1 Env Glycoprotein when Combined with IL-21 and IL-15 Gene Delivery

Elizabeth Bolesta, Aleksandra Kowalczyk, Andrzej Wierzbicki, Cheryl Eppolito, Yutaro Kaneko, Masafumi Takiguchi, Leonidas Stamatatos, Protul A. Shrikant, and Danuta Kozbor
J Immunol 2006 177: 177-191. [Abstract] [Full Text] [PDF]  

Indexation as a Novel Mechanism of Lymphocyte Homeostasis: The Number of CD4⁺CD25⁺ Regulatory T Cells Is Indexed to the Number of IL-2-Producing Cells

Afonso R. M. Almeida, Bruno Zaragoza, and Antonio A. Freitas
J Immunol 2006 177: 192-200. [Abstract] [Full Text] [PDF]  

Prolonged Cell Cycle Transit Is a Defining and Developmentally Conserved Hemopoietic Stem Cell Property

Jens M. Nygren, David Bryder, and Sten Eirik W. Jacobsen
J Immunol 2006 177: 201-208. [Abstract] [Full Text] [PDF]  

G Protein-Coupled Receptor 83 Overexpression in Naive CD4⁺CD25^– T Cells Leads to the Induction of Foxp3⁺ Regulatory T Cells In Vivo

Wiebke Hansen, Karin Loser, Astrid M. Westendorf, Dunja Bruder, Susanne Pfoertner, Christiane Siewert, Jochen Huehn, Stefan Beissert, and Jan Buer
J Immunol 2006 177: 209-215. [Abstract] [Full Text] [PDF]  

Galectin-1-Matured Human Monocyte-Derived Dendritic Cells Have Enhanced Migration through Extracellular Matrix

Jennifer A. Fulcher, Sara T. Hashimi, Ernest L. Levroney, Mabel Pang, Kevin B. Gurney, Linda G. Baum, and Benhur Lee
J Immunol 2006 177: 216-226. [Abstract] [Full Text] [PDF] Data Supplement  

Tight Linkage between Translation and MHC Class I Peptide Ligand Generation Implies Specialized Antigen Processing for Defective Ribosomal Products

Shu-Bing Qian, Eric Reits, Jacques Neefjes, Jeanne M. Deslich, Jack R. Bennink, and Jonathan W. Yewdell
J Immunol 2006 177: 227-233. [Abstract] [Full Text] [PDF]  

IL-18 Bridges Innate and Adaptive Immunity through IFN- and the CD134 Pathway

Joseph R. Maxwell, Rajwardhan Yadav, Robert J. Rossi, Carl E. Ruby, Andrew D. Weinberg, Hector L. Aguila, and Anthony T. Vella
J Immunol 2006 177: 234-245. [Abstract] [Full Text] [PDF]  

FOXP3⁺CD4⁺CD25⁺ Adaptive Regulatory T Cells Express Cyclooxygenase-2 and Suppress Effector T Cells by a Prostaglandin E₂-Dependent Mechanism

Milada Mahic, Sheraz Yaqub, C. Christian Johansson, Kjetil Taskén, and Einar M. Aandahl
J Immunol 2006 177: 246-254. [Abstract] [Full Text] [PDF]  

Accumulation of CD8⁺ T Cells in Advanced-Stage Tumors and Delay of Disease Progression following Secondary Immunization against an Immunorecessive Epitope

Christina M. Ryan and Todd D. Schell
J Immunol 2006 177: 255-267. [Abstract] [Full Text] [PDF]  

CD44 Differentially Activates Mouse NK T Cells and Conventional T Cells

Jonathan Larkin, Gourapura J. Renukaradhya, Venkataraman Sriram, Wenjun Du, Jacquelyn Gervay-Hague, and Randy R. Brutkiewicz
J Immunol 2006 177: 268-279. [Abstract] [Full Text] [PDF]  

Follicular Dendritic Cells Are Related to Bone Marrow Stromal Cell Progenitors and to Myofibroblasts

Raquel Muñoz-Fernández, Francisco Javier Blanco, Cecilia Frecha, Francisco Martín, Maria Kimatrai, Ana Clara Abadía-Molina, José Marcos García-Pacheco, and Enrique G. Olivares
J Immunol 2006 177: 280-289. [Abstract] [Full Text] [PDF]  

Lymphotoxin Pathway-Directed, Autoimmune Regulator-Independent Central Tolerance to Arthritogenic Collagen

Robert K. Chin, Mingzhao Zhu, Peter A. Christiansen, Wenhua Liu, Carl Ware, Leena Peltonen, Xuejun Zhang, Linjie Guo, Shuhua Han, Biao Zheng, and Yang-Xin Fu
J Immunol 2006 177: 290-297. [Abstract] [Full Text] [PDF]  

TLR Activation of Langerhans Cell-Like Dendritic Cells Triggers an Antiviral Immune Response

Claudia N. Renn, David Jesse Sanchez, Maria Teresa Ochoa, Annaliza J. Legaspi, Chang-Keun Oh, Philip T. Liu, Stephan R. Krutzik, Peter A. Sieling, Genhong Cheng, and Robert L. Modlin
J Immunol 2006 177: 298-305. [Abstract] [Full Text] [PDF]  

IL-2 In Vivo Activities and Antitumor Efficacy Enhanced by an Anti-IL-2 mAb

Daisuke Kamimura, Yukihisa Sawa, Masae Sato, Eviryanti Agung, Toshio Hirano, and Masaaki Murakami
J Immunol 2006 177: 306-314. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

IFN- and Its Receptor Subunit IFNGR1 Are Recruited to the IFN--Activated Sequence Element at the Promoter Site of IFN--Activated Genes: Evidence of Transactivational Activity in IFNGR1

Chulbul M. I. Ahmed and Howard M. Johnson
J Immunol 2006 177: 315-321. [Abstract] [Full Text] [PDF]  

Analysis of TLR4 Polymorphic Variants: New Insights into TLR4/MD-2/CD14 Stoichiometry, Structure, and Signaling

Prasad Rallabhandi, Jessica Bell, Marina S. Boukhvalova, Andrei Medvedev, Eva Lorenz, Moshe Arditi, Val G. Hemming, Jorge C. G. Blanco, David M. Segal, and Stefanie N. Vogel
J Immunol 2006 177: 322-332. [Abstract] [Full Text] [PDF]  

Trends in Antibody Sequence Changes during the Somatic Hypermutation Process

Louis A. Clark, Skanth Ganesan, Sarah Papp, and Herman W. T. van Vlijmen
J Immunol 2006 177: 333-340. [Abstract] [Full Text] [PDF]  

Inhibition of MHC Class II Expression and Immune Responses by c-MIR

Mari Ohmura-Hoshino, Yohei Matsuki, Masami Aoki, Eiji Goto, Mari Mito, Mika Uematsu, Terutaka Kakiuchi, Hak Hotta, and Satoshi Ishido
J Immunol 2006 177: 341-354. [Abstract] [Full Text] [PDF]  

Structural Phylogenetic Analysis of Activation-Induced Deaminase Function

H. Travis Ichikawa, Mark P. Sowden, Andrew T. Torelli, Jürgen Bachl, Pinwei Huang, Geoffrey S. C. Dance, Shauna H. Marr, Jacques Robert, Joseph E. Wedekind, Harold C. Smith, and Andrea Bottaro
J Immunol 2006 177: 355-361. [Abstract] [Full Text] [PDF]  

The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20

Jessica L. Teeling, Wendy J. M. Mackus, Luus J. J. M. Wiegman, Jeroen H. N. van den Brakel, Stephen A. Beers, Ruth R. French, Tom van Meerten, Saskia Ebeling, Tom Vink, Jerry W. Slootstra, Paul W. H. I. Parren, Martin J. Glennie, and Jan G. J. van de Winkel
J Immunol 2006 177: 362-371. [Abstract] [Full Text] [PDF]  

Signal Regulatory Protein Molecules Are Differentially Expressed by CD8^– Dendritic Cells

Mireille H. Lahoud, Anna I. Proietto, Kate H. Gartlan, Susie Kitsoulis, Joan Curtis, James Wettenhall, Mariam Sofi, Carmel Daunt, Meredith O’Keeffe, Irina Caminschi, Keith Satterley, Alexandra Rizzitelli, Petra Schnorrer, Atsushi Hinohara, Yasunori Yamaguchi, Li Wu, Gordon Smyth, Emanuela Handman, Ken Shortman, and Mark D. Wright
J Immunol 2006 177: 372-382. [Abstract] [Full Text] [PDF]  

Characterization of Human Complement Receptor Type 2 (CR2/CD21) as a Receptor for IFN-: A Potential Role in Systemic Lupus Erythematosus

Rengasamy Asokan, Jing Hua, Kendra A. Young, Hannah J. Gould, Jonathan P. Hannan, Damian M. Kraus, Gerda Szakonyi, Gabrielle J. Grundy, Xiaojiang S. Chen, Mary K. Crow, and V. Michael Holers
J Immunol 2006 177: 383-394. [Abstract] [Full Text] [PDF]  

E2A Expression Stimulates Ig Hypermutation

Ulrike Schoetz, Manuela Cervelli, Yan-Dong Wang, Petra Fiedler, and Jean-Marie Buerstedde
J Immunol 2006 177: 395-400. [Abstract] [Full Text] [PDF]  

p300/Cyclic AMP-Responsive Element Binding-Binding Protein Mediates Transcriptional Coactivation by the CD28 T Cell Costimulatory Receptor

Sarada L. Nandiwada, Wei Li, Ruan Zhang, and Daniel L. Mueller
J Immunol 2006 177: 401-413. [Abstract] [Full Text] [PDF]  

IMMUNOGENETICS:

A Role for DNA Hypomethylation and Histone Acetylation in Maintaining Allele-Specific Expression of Mouse NKG2A in Developing and Mature NK Cells

Sally L. Rogers, Arefeh Rouhi, Fumio Takei, and Dixie L. Mager
J Immunol 2006 177: 414-421. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Mycobacterium tuberculosis LprA Is a Lipoprotein Agonist of TLR2 That Regulates Innate Immunity and APC Function

Nicole D. Pecora, Adam J. Gehring, David H. Canaday, W. Henry Boom, and Clifford V. Harding
J Immunol 2006 177: 422-429. [Abstract] [Full Text] [PDF]  

Haemophilus influenzae Surface Fibrils Contribute to Serum Resistance by Interacting with Vitronectin

Teresia Hallström, Elena Trajkovska, Arne Forsgren, and Kristian Riesbeck
J Immunol 2006 177: 430-436. [Abstract] [Full Text] [PDF]  

Secreted Proteins from Mycobacterium tuberculosis Gain Access to the Cytosolic MHC Class-I Antigen-Processing Pathway

David M. Lewinsohn, Jeff E. Grotzke, Amy S. Heinzel, LiQing Zhu, Pamela J. Ovendale, Mark Johnson, and Mark R. Alderson
J Immunol 2006 177: 437-442. [Abstract] [Full Text] [PDF]  

Novel Activities of Cyclophilin A and Cyclosporin A during HIV-1 Infection of Primary Lymphocytes and Macrophages

Manisha Saini and Mary Jane Potash
J Immunol 2006 177: 443-449. [Abstract] [Full Text] [PDF]  

Four Distinct Patterns of Memory CD8 T Cell Responses to Chronic Murine Cytomegalovirus Infection

Michael W. Munks, Kathy S. Cho, Amelia K. Pinto, Sophie Sierro, Paul Klenerman, and Ann B. Hill
J Immunol 2006 177: 450-458. [Abstract] [Full Text] [PDF]  

Pneumocystis Cell Wall -Glucans Induce Dendritic Cell Costimulatory Molecule Expression and Inflammatory Activation through a Fas-Fas Ligand Mechanism

Eva M. Carmona, Robert Vassallo, Zvezdana Vuk-Pavlovic, Joseph E. Standing, Theodore J. Kottom, and Andrew H. Limper
J Immunol 2006 177: 459-467. [Abstract] [Full Text] [PDF]  

Impaired Generation of Reactive Oxygen Species during Differentiation of Dendritic Cells (DCs) by Mycobacterium tuberculosis Secretory Antigen (MTSA) and Subsequent Activation of MTSA-DCs by Mycobacteria Results in Increased Intracellular Survival

Aprajita Sinha, Anjana Singh, Vijaya Satchidanandam, and Krishnamurthy Natarajan
J Immunol 2006 177: 468-478. [Abstract] [Full Text] [PDF]  

Altered CD4⁺ T Cell Phenotype and Function Determine the Susceptibility to Mucosal Candidiasis in Transgenic Mice Expressing HIV-1

Daniel Lewandowski, Miriam Marquis, Francine Aumont, Annie-Claude Lussier-Morin, Marianne Raymond, Serge Sénéchal, Zaher Hanna, Paul Jolicoeur, and Louis de Repentigny
J Immunol 2006 177: 479-491. [Abstract] [Full Text] [PDF]  

Evaluation of Immunological Paradigms in a Virus Model: Are Dendritic Cells Critical for Antiviral Immunity and Viral Clearance?

Richard P. Ciavarra, Amber Stephens, Sandra Nagy, Margaret Sekellick, and Christina Steel
J Immunol 2006 177: 492-500. [Abstract] [Full Text] [PDF]  

The Meningococcal Vaccine Candidate GNA1870 Binds the Complement Regulatory Protein Factor H and Enhances Serum Resistance

Guillermo Madico, Jo Anne Welsch, Lisa A. Lewis, Anne McNaughton, David H. Perlman, Catherine E. Costello, Jutamas Ngampasutadol, Ulrich Vogel, Dan M. Granoff, and Sanjay Ram
J Immunol 2006 177: 501-510. [Abstract] [Full Text] [PDF]  

Persistence and Function of Central and Effector Memory CD4⁺ T Cells following Infection with a Gastrointestinal Helminth

Colby Zaph, Kathryn A. Rook, Michael Goldschmidt, Markus Mohrs, Phillip Scott, and David Artis
J Immunol 2006 177: 511-518. [Abstract] [Full Text] [PDF]  

The Peptidoglycan-Degrading Property of Lysozyme Is Not Required for Bactericidal Activity In Vivo

James A. Nash, Tiffany Nicole S. Ballard, Timothy E. Weaver, and Henry T. Akinbi
J Immunol 2006 177: 519-526. [Abstract] [Full Text] [PDF]  

Stat3 Is Required for Cytoprotection of the Respiratory Epithelium during Adenoviral Infection

Yohei Matsuzaki, Yan Xu, Machiko Ikegami, Valérie Besnard, Kwon-Sik Park, William M. Hull, Susan E. Wert, and Jeffrey A. Whitsett
J Immunol 2006 177: 527-537. [Abstract] [Full Text] [PDF]  

Toll/IL-1R Domain-Containing Adaptor Protein (TIRAP) Is a Critical Mediator of Antibacterial Defense in the Lung against Klebsiella pneumoniae but Not Pseudomonas aeruginosa

Samithamby Jeyaseelan, Scott K. Young, Masahiro Yamamoto, Patrick G. Arndt, Shizuo Akira, Jay K. Kolls, and G. Scott Worthen
J Immunol 2006 177: 538-547. [Abstract] [Full Text] [PDF]  

SIGIRR Promotes Resistance against Pseudomonas aeruginosa Keratitis by Down-Regulating Type-1 Immunity and IL-1R1 and TLR4 Signaling

Xi Huang, Linda D. Hazlett, Wenjin Du, and Ronald P. Barrett
J Immunol 2006 177: 548-556. [Abstract] [Full Text] [PDF]  

Agonistic Monoclonal Antibody Against CD40 Receptor Decreases Lymphocyte Apoptosis and Improves Survival in Sepsis

Steven J. Schwulst, Mitchell H. Grayson, Peter J. DiPasco, Christopher G. Davis, Tejal S. Brahmbhatt, Thomas A. Ferguson, and Richard S. Hotchkiss
J Immunol 2006 177: 557-565. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis

Yutaka Komiyama, Susumu Nakae, Taizo Matsuki, Aya Nambu, Harumichi Ishigame, Shigeru Kakuta, Katsuko Sudo, and Yoichiro Iwakura
J Immunol 2006 177: 566-573. [Abstract] [Full Text] [PDF]  

Transcellular Secretion of Group V Phospholipase A₂ from Epithelium Induces ₂-Integrin-Mediated Adhesion and Synthesis of Leukotriene C₄ in Eosinophils

Nilda M. Muñoz, Angelo Y. Meliton, Anissa Lambertino, Evan Boetticher, Jonathan Learoyd, Faraz Sultan, Xiangdong Zhu, Wonhwa Cho, and Alan R. Leff
J Immunol 2006 177: 574-582. [Abstract] [Full Text] [PDF]  

A Mechanism for Neurodegeneration Induced by Group B Streptococci through Activation of the TLR2/MyD88 Pathway in Microglia

Seija Lehnardt, Philipp Henneke, Egil Lien, Dennis L. Kasper, Joseph J. Volpe, Ingo Bechmann, Robert Nitsch, Joerg R. Weber, Douglas T. Golenbock, and Timothy Vartanian
J Immunol 2006 177: 583-592. [Abstract] [Full Text] [PDF]  

Epithelial Inflammation Is Associated with CCL28 Production and the Recruitment of Regulatory T Cells Expressing CCR10

Bertus Eksteen, Alice Miles, Stuart M. Curbishley, Chris Tselepis, Allister J. Grant, Lucy S. K. Walker, and David H. Adams
J Immunol 2006 177: 593-603. [Abstract] [Full Text] [PDF]  

The Src Family Kinases Hck and Fgr Are Dispensable for Inside-Out, Chemoattractant-Induced Signaling Regulating 2 Integrin Affinity and Valency in Neutrophils, but Are Required for 2 Integrin-Mediated Outside-In Signaling Involved in Sustained Adhesion

Cinzia Giagulli, Linda Ottoboni, Elena Caveggion, Barbara Rossi, Clifford Lowell, Gabriela Constantin, Carlo Laudanna, and Giorgio Berton
J Immunol 2006 177: 604-611. [Abstract] [Full Text] [PDF]  

Adenoviral-Mediated Overexpression of SOCS3 Enhances IgG Immune Complex-Induced Acute Lung Injury

Hongwei Gao, L. Marco Hoesel, Ren-Feng Guo, Nicholas J. Rancilio, J. Vidya Sarma, and Peter A. Ward
J Immunol 2006 177: 612-620. [Abstract] [Full Text] [PDF]  

Gender Differences in Murine Airway Responsiveness and Lipopolysaccharide-Induced Inflammation

Jeffrey W. Card, Michelle A. Carey, J. Alyce Bradbury, Laura M. DeGraff, Daniel L. Morgan, Michael P. Moorman, Gordon P. Flake, and Darryl C. Zeldin
J Immunol 2006 177: 621-630. [Abstract] [Full Text] [PDF]  

Proinflammatory Role of Glucocorticoid-Induced TNF Receptor-Related Gene in Acute Lung Inflammation

Salvatore Cuzzocrea, Giuseppe Nocentini, Rosanna Di Paola, Massimiliano Agostini, Emanuela Mazzon, Simona Ronchetti, Concetta Crisafulli, Emanuela Esposito, Achille P. Caputi, and Carlo Riccardi
J Immunol 2006 177: 631-641. [Abstract] [Full Text] [PDF]  

A Regulatory Effect of the Balance between TNF- and IL-6 in the Granulomatous and Inflammatory Response to Rhodococcus aurantiacus Infection in Mice

Yimin and Masashi Kohanawa
J Immunol 2006 177: 642-650. [Abstract] [Full Text] [PDF]  

Lovastatin-Induced Apoptosis in Macrophages through the Rac1/Cdc42/JNK Pathway

Shu-Ling Liang, Hongli Liu, and Aimin Zhou
J Immunol 2006 177: 651-656. [Abstract] [Full Text] [PDF]  

Identification of a TLR-Independent Pathway for Borrelia burgdorferi-Induced Expression of Matrix Metalloproteinases and Inflammatory Mediators through Binding to Integrin ₃₁

Aruna K. Behera, Ethan Hildebrand, Satoshi Uematsu, Shizuo Akira, Jenifer Coburn, and Linden T. Hu
J Immunol 2006 177: 657-664. [Abstract] [Full Text] [PDF]  

C/EBP Blocks p65 Phosphorylation and Thereby NF-B-Mediated Transcription in TNF-Tolerant Cells

Andreas Zwergal, Martina Quirling, Bernd Saugel, Karin C. Huth, Carmen Sydlik, Valeria Poli, Dieter Neumeier, H. W. Löms Ziegler-Heitbrock, and Korbinian Brand
J Immunol 2006 177: 665-672. [Abstract] [Full Text] [PDF]  

Conserved Nontypeable Haemophilus influenzae-Derived TLR2-Binding Lipopeptides Synergize with IFN- to Increase Cytokine Production by Resident Murine and Human Alveolar Macrophages

Antonello Punturieri, Phil Copper, Timothy Polak, Paul J. Christensen, and Jeffrey L. Curtis
J Immunol 2006 177: 673-680. [Abstract] [Full Text] [PDF]  

Peptidoglycan-Induced IL-6 Production in RAW 264.7 Macrophages Is Mediated by Cyclooxygenase-2, PGE₂/PGE₄ Receptors, Protein Kinase A, IB Kinase, and NF-B

Bing-Chang Chen, Chiao-Chun Liao, Ming-Jen Hsu, Yi-Ting Liao, Chia-Chin Lin, Joen-Rong Sheu, and Chien-Huang Lin
J Immunol 2006 177: 681-693. [Abstract] [Full Text] [PDF]  

FcRIIa, Not FcRIIb, Is Constitutively and Functionally Expressed on Skin-Derived Human Mast Cells

Wei Zhao, Christopher L. Kepley, Penelope A. Morel, Lawrence M. Okumoto, Yoshihiro Fukuoka, and Lawrence B. Schwartz
J Immunol 2006 177: 694-701. [Abstract] [Full Text] [PDF]  

Inhibition of Mixed Lineage Kinase 3 Prevents HIV-1 Tat-Mediated Neurotoxicity and Monocyte Activation

Ziye Sui, Shongshan Fan, Lynn Sniderhan, Elizabeth Reisinger, Angela Litzburg, Giovanni Schifitto, Harris A. Gelbard, Stephen Dewhurst, and Sanjay B. Maggirwar
J Immunol 2006 177: 702-711. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Hierarchy of Fetoprotein (AFP)-Specific T Cell Responses in Subjects with AFP-Positive Hepatocellular Cancer

Yang Liu, Sean Daley, Viktoria N. Evdokimova, David D. Zdobinski, Douglas M. Potter, and Lisa H. Butterfield
J Immunol 2006 177: 712-721. [Abstract] [Full Text] [PDF]  

Homozygosity for the IgG2 Subclass Allotype G2M(n) Protects against Severe Infection in Hereditary C2 Deficiency

Göran Jönsson, Vivi-Anne Oxelius, Lennart Truedsson, Jean Henrik Braconier, Gunnar Sturfelt, and Anders G. Sjöholm
J Immunol 2006 177: 722-728. [Abstract] [Full Text] [PDF]  

Detailed Analysis of Intrahepatic CD8 T Cells in the Normal and Hepatitis C-Infected Liver Reveals Differences in Specific Populations of Memory Cells with Distinct Homing Phenotypes

Mathis Heydtmann, Debbie Hardie, Philip L. Shields, Jeff Faint, Christopher D. Buckley, James J. Campbell, Michael Salmon, and David H. Adams
J Immunol 2006 177: 729-738. [Abstract] [Full Text] [PDF]  

Circulating and Liver Resident CD4⁺CD25⁺ Regulatory T Cells Actively Influence the Antiviral Immune Response and Disease Progression in Patients with Hepatitis B

Dongping Xu, Junliang Fu, Lei Jin, Hui Zhang, Chunbao Zhou, Zhengsheng Zou, Jing-Min Zhao, Bin Zhang, Ming Shi, Xilai Ding, Zirong Tang, Yang-Xin Fu, and Fu-Sheng Wang
J Immunol 2006 177: 739-747. [Abstract] [Full Text] [PDF]  

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