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On the cover: Frozen section of jejunum from a 6-wk-old female NOD mouse that had undergone thymectomy 3 days after birth. CD4⁺ T cells (stained brown) in the lamina propria are normal in number, but CD8⁺ cells in the epithelial layer (intraepithelial lymphocytes) are markedly depleted after neonatal thymectomy. Locke, N. R., S. Stankovic, D. P. Funda, and L. C. Harrison. 2006. TCRγδ intraepithelial lymphocytes are required for self-tolerance. J. Immunol. 176: 6553–6559.

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