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On the cover: Knee joint section of a TNF-deficient mouse with IL-17-accelerated arthritis, stained with safranin O. IL-17 overexpression enhances K/B×N serum transfer arthritis independent of TNF-α. Note the influx of inflammatory cells, destaining of the cartilage as a marker for proteoglycan depletion, and areas with erosion of articular cartilage. Koenders, M. I., E. Lubberts, F. A. J. van de Loo, B. Oppers-Walgreen, L. van den Bersselaar, M. M. Helsen, J. K. Kolls, F. E. Di Padova, L. A. B. Joosten, and W. B. van den Berg. 2006. Interleukin-17 acts independently of TNF-α under arthritic conditions. J. Immunol. 176: 6262–6269.

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