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On the cover: Overlay of a pseudocolored Fura-2 (a calcium indicator) fluorescence emission ratio image and a bright field image of splenic lymphocytes. Fluid shear force applied with an angled micropipette (visible at top) triggers an increase in cytosolic Ca2+ (red cells) in B but not T lymphocytes within the fluid stream. Liu et al. Distinct calcium channels regulate responses of primary B lymphocytes to B cell receptor engagement and mechanical stimuli. J. Immunol. 174:68
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