IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2004 173: 4257-4258. [Full Text] [PDF]  

PILLARS OF IMMUNOLOGY:

The Birth of Molecular Immunology

Patricia J. Gearhart
J Immunol 2004 173: 4259. [Full Text] [PDF] [Original Pillars Article]  

Pillars Article: Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions

N. Hozumi and S. Tonegawa
J Immunol 2004 173: 4260-4264. [PDF]  

BRIEF REVIEWS:

Receptor Editing in Positive and Negative Selection of B Lymphopoiesis

Efrat Edry and Doron Melamed
J Immunol 2004 173: 4265-4271. [Abstract] [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: Heterozygote Advantage in Autoimmune Disease: Hierarchy of Protection/Susceptibility Conferred by HLA and Killer Ig-Like Receptor Combinations in Psoriatic Arthritis

George W. Nelson, Maureen P. Martin, Dafna Gladman, Judith Wade, John Trowsdale, and Mary Carrington
J Immunol 2004 173: 4273-4276. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Dissection of BXSB Lupus Phenotype Using Mice Congenic for Chromosome 1 Demonstrates That Separate Intervals Direct Different Aspects of Disease

Michelle E. K. Haywood, Nicola J. Rogers, S. Jane Rose, Joseph Boyle, Aileen McDermott, Joanna M. Rankin, Vasuky Thiruudaian, Margarita R. Lewis, Liliane Fossati-Jimack, Shozo Izui, Mark J. Walport, and Bernard J. Morley
J Immunol 2004 173: 4277-4285. [Abstract] [Full Text] [PDF]  

Divergent Trophoblast Responses to Bacterial Products Mediated by TLRs

Vikki M. Abrahams, Paulomi Bole-Aldo, Yeon Mee Kim, Shawn L. Straszewski-Chavez, Tinnakorn Chaiworapongsa, Roberto Romero, and Gil Mor
J Immunol 2004 173: 4286-4296. [Abstract] [Full Text] [PDF]  

Enhanced Tumor-Specific Long-Term Immunity of Hemaggluttinating Virus of Japan-Mediated Dendritic Cell-Tumor Fused Cell Vaccination by Coadministration with CpG Oligodeoxynucleotides

Kazuya Hiraoka, Seiji Yamamoto, Satoru Otsuru, Seiji Nakai, Katsuto Tamai, Ryuichi Morishita, Toshio Ogihara, and Yasufumi Kaneda
J Immunol 2004 173: 4297-4307. [Abstract] [Full Text] [PDF]  

Rapid Response of Marginal Zone B Cells to Viral Particles

Dominique Gatto, Christiane Ruedl, Bernhard Odermatt, and Martin F. Bachmann
J Immunol 2004 173: 4308-4316. [Abstract] [Full Text] [PDF]  

Early Divergence of Fc Receptor I Signals for Receptor Up-Regulation and Internalization from Degranulation, Cytokine Production, and Survival

Jiro Kitaura, Wenbin Xiao, Mari Maeda-Yamamoto, Yuko Kawakami, Clifford A. Lowell, and Toshiaki Kawakami
J Immunol 2004 173: 4317-4323. [Abstract] [Full Text] [PDF]  

Intestinal Epithelial Antigen Induces Mucosal CD8 T Cell Tolerance, Activation, and Inflammatory Response

Zhanju Liu and Leo Lefrançois
J Immunol 2004 173: 4324-4330. [Abstract] [Full Text] [PDF]  

Antisense Oligonucleotides Down-Regulating Costimulation Confer Diabetes-Preventive Properties to Nonobese Diabetic Mouse Dendritic Cells

Jennifer Machen, Jo Harnaha, Robert Lakomy, Alexis Styche, Massimo Trucco, and Nick Giannoukakis
J Immunol 2004 173: 4331-4341. [Abstract] [Full Text] [PDF]  

Bone Marrow Precursors of Nonobese Diabetic Mice Develop into Defective Macrophage-Like Dendritic Cells In Vitro

Tatjana Nikolic, Marjolijn Bunk, Hemmo A. Drexhage, and Pieter J. M. Leenen
J Immunol 2004 173: 4342-4351. [Abstract] [Full Text] [PDF]  

Induction of a CD4⁺ T Regulatory Type 1 Response by Cyclooxygenase-2-Overexpressing Glioma

Yasuharu Akasaki, Gentao Liu, Nancy H. C. Chung, Moneeb Ehtesham, Keith L. Black, and John S. Yu
J Immunol 2004 173: 4352-4359. [Abstract] [Full Text] [PDF]  

Development of CD4⁺ Macrophages from Intrathymic T Cell Progenitors Is Induced by Thymic Epithelial Cells

Eiji Esashi, Hiroaki Ito, Katsuhiko Ishihara, Toshio Hirano, Shigeo Koyasu, and Atsushi Miyajima
J Immunol 2004 173: 4360-4367. [Abstract] [Full Text] [PDF]  

Melanoma Differentiation-Associated Gene-7/IL-24 Gene Enhances NF-B Activation and Suppresses Apoptosis Induced by TNF

Sita Aggarwal, Yasunari Takada, Abner M. Mhashilkar, Kerry Sieger, Sunil Chada, and Bharat B. Aggarwal
J Immunol 2004 173: 4368-4376. [Abstract] [Full Text] [PDF]  

Direct Antigen Presentation by a Xenograft Induces Immunity Independently of Secondary Lymphoid Organs

Bethany M. Tesar, Geetha Chalasani, Lonnette Smith-Diggs, Fady K. Baddoura, Fadi G. Lakkis, and Daniel R. Goldstein
J Immunol 2004 173: 4377-4386. [Abstract] [Full Text] [PDF]  

Repertoire and Immunofocusing of CD8 T Cell Responses Generated by HIV-1 gag-pol and Expression Library Immunization Vaccines

Rana A. K. Singh and Michael A. Barry
J Immunol 2004 173: 4387-4393. [Abstract] [Full Text] [PDF]  

A Nonclassical MHC Class I Molecule Restricts CTL-Mediated Rejection of a Syngeneic Melanoma Tumor

Eugene Y. Chiang and Iwona Stroynowski
J Immunol 2004 173: 4394-4401. [Abstract] [Full Text] [PDF]  

DNA Methylation Is a Nonredundant Repressor of the Th2 Effector Program

Karen W. Makar and Christopher B. Wilson
J Immunol 2004 173: 4402-4406. [Abstract] [Full Text] [PDF]  

Perturbed Homeostasis of Peripheral T Cells Elicits Decreased Susceptibility to Anti-CD3-Induced Apoptosis in Prediabetic Nonobese Diabetic Mice

Wen Yang, Shabbir Hussain, Qing-Sheng Mi, Pere Santamaria, and Terry L. Delovitch
J Immunol 2004 173: 4407-4416. [Abstract] [Full Text] [PDF]  

IL-16 Activates Plasminogen-Plasmin System and Promotes Human Eosinophil Migration into Extracellular Matrix via CCR3-Chemokine-Mediated Signaling and by Modulating CD4 Eosinophil Expression

Claudine Ferland, Nicolas Flamand, Francis Davoine, Jamila Chakir, and Michel Laviolette
J Immunol 2004 173: 4417-4424. [Abstract] [Full Text] [PDF]  

bcl-x_L Is Critical for Dendritic Cell Survival In Vivo

Huiming Hon, Edmund B. Rucker, III, Lothar Hennighausen, and Joshy Jacob
J Immunol 2004 173: 4425-4432. [Abstract] [Full Text] [PDF]  

Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4⁺CD25⁺ Regulatory T Cells

E. Ashley Moseman, Xueqing Liang, Amanda J. Dawson, Angela Panoskaltsis-Mortari, Arthur M. Krieg, Yong-Jun Liu, Bruce R. Blazar, and Wei Chen
J Immunol 2004 173: 4433-4442. [Abstract] [Full Text] [PDF]  

LFA-1 on CD4⁺ T Cells Is Required for Optimal Antigen-Dependent Activation In Vivo

Sravanthi Kandula and Clara Abraham
J Immunol 2004 173: 4443-4451. [Abstract] [Full Text] [PDF]  

Activation of Acid Sphingomyelinase and Its Inhibition by the Nitric Oxide/Cyclic Guanosine 3',5'-Monophosphate Pathway: Key Events in Escherichia coli-Elicited Apoptosis of Dendritic Cells

Sestina Falcone, Cristiana Perrotta, Clara De Palma, Addolorata Pisconti, Clara Sciorati, Annalisa Capobianco, Patrizia Rovere-Querini, Angelo A. Manfredi, and Emilio Clementi
J Immunol 2004 173: 4452-4463. [Abstract] [Full Text] [PDF]  

Relevance of the Direct Pathway of Sensitization in Corneal Transplantation Is Dictated by the Graft Bed Microenvironment

Syed Huq, Ying Liu, Gilles Benichou, and M. Reza Dana
J Immunol 2004 173: 4464-4469. [Abstract] [Full Text] [PDF]  

Ikaros Null Mice Display Defects in T Cell Selection and CD4 versus CD8 Lineage Decisions

Julie A. Urban and Susan Winandy
J Immunol 2004 173: 4470-4478. [Abstract] [Full Text] [PDF]  

CpG DNA Induces IgG Class Switch DNA Recombination by Activating Human B Cells through an Innate Pathway That Requires TLR9 and Cooperates with IL-10

Bing He, Xugang Qiao, and Andrea Cerutti
J Immunol 2004 173: 4479-4491. [Abstract] [Full Text] [PDF]  

DNA Fusion Vaccines Induce Targeted Epitope-Specific CTLs against Minor Histocompatibility Antigens from a Normal or Tolerized Repertoire

Jason Rice, Sarah Buchan, Hamlata Dewchand, Elizabeth Simpson, and Freda K. Stevenson
J Immunol 2004 173: 4492-4499. [Abstract] [Full Text] [PDF]  

Critical Role of TNF Receptor Type-2 (p75) as a Costimulator for IL-2 Induction and T Cell Survival: A Functional Link to CD28

Edward Y. Kim and Hung-Sia Teh
J Immunol 2004 173: 4500-4509. [Abstract] [Full Text] [PDF]  

Aged Mice Develop Protective Antitumor Immune Responses with Appropriate Costimulation

Joseph Lustgarten, Ana Lucia Dominguez, and Marilyn Thoman
J Immunol 2004 173: 4510-4515. [Abstract] [Full Text] [PDF]  

Tracking of V8.2-Positive Encephalitogenic T Cells by Complementarity-Determining Region 3 Spectratyping and Subsequent Southern Blot Hybridization in Lewis Rats after Neuroantigen Sensitization

Hiroshi Sakuma, Kuniko Kohyama, Youngheun Jee, and Yoh Matsumoto
J Immunol 2004 173: 4516-4522. [Abstract] [Full Text] [PDF]  

An IL-4R Allelic Variant, I50, Acts as a Gain-of-Function Variant Relative to V50 for Stat6, But Not Th2 Differentiation

Linda Stephenson, Mary H. Johns, Emily Woodward, Ana L. Mora, and Mark Boothby
J Immunol 2004 173: 4523-4528. [Abstract] [Full Text] [PDF]  

Transcription of Ig Germline Genes in Single Human B Cells and the Role of Cytokines in Isotype Determination

David J. Fear, Natalie McCloskey, Brian O’Connor, Gary Felsenfeld, and Hannah J. Gould
J Immunol 2004 173: 4529-4538. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

MHC Class II Molecules Traffic into Lipid Rafts during Intracellular Transport

Neil J. Poloso, Aura Muntasell, and Paul A. Roche
J Immunol 2004 173: 4539-4546. [Abstract] [Full Text] [PDF]  

Complement Components C5 and C7: Recombinant Factor I Modules of C7 Bind to the C345C Domain of C5

Chuong-Thu Thai and Ronald T. Ogata
J Immunol 2004 173: 4547-4552. [Abstract] [Full Text] [PDF]  

Homologs of CD83 from Elasmobranch and Teleost Fish

Yuko Ohta, Eric Landis, Thomas Boulay, Ruth B. Phillips, Bertrand Collet, Chris J. Secombes, Martin F. Flajnik, and John D. Hansen
J Immunol 2004 173: 4553-4560. [Abstract] [Full Text] [PDF]  

IL-4-Induced Gene-1 Is a Leukocyte L-Amino Acid Oxidase with an Unusual Acidic pH Preference and Lysosomal Localization

James M. Mason, Mamta D. Naidu, Michele Barcia, Debra Porti, Sangeeta S. Chavan, and Charles C. Chu
J Immunol 2004 173: 4561-4567. [Abstract] [Full Text] [PDF]  

A Profound Alteration of Blood TCRB Repertoire Allows Prediction of Cerebral Malaria

Alexis Collette, Sébastien Bagot, Maria E. Ferrandiz, Pierre-André Cazenave, Adrien Six, and Sylviane Pied
J Immunol 2004 173: 4568-4575. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

An Important Role for Polymeric Ig Receptor-Mediated Transport of IgA in Protection against Streptococcus pneumoniae Nasopharyngeal Carriage

Keer Sun, Finn-Eirik Johansen, Lars Eckmann, and Dennis W. Metzger
J Immunol 2004 173: 4576-4581. [Abstract] [Full Text] [PDF]  

Superoxide Production at Phagosomal Cup/Phagosome through I Protein Kinase C during FcR-Mediated Phagocytosis in Microglia

Takehiko Ueyama, Michelle R. Lennartz, Yukiko Noda, Toshihiro Kobayashi, Yasuhito Shirai, Kyoko Rikitake, Tomoko Yamasaki, Shigeto Hayashi, Norio Sakai, Harumichi Seguchi, Makoto Sawada, Hideki Sumimoto, and Naoaki Saito
J Immunol 2004 173: 4582-4589. [Abstract] [Full Text] [PDF] Data Supplement  

Activation of CD8 T Cells by Mycobacterial Vaccination Protects against Pulmonary Tuberculosis in the Absence of CD4 T Cells

Jun Wang, Michael Santosuosso, Patricia Ngai, Anna Zganiacz, and Zhou Xing
J Immunol 2004 173: 4590-4597. [Abstract] [Full Text] [PDF]  

The Emerging Pathogen Moraxella catarrhalis Interacts with Complement Inhibitor C4b Binding Protein through Ubiquitous Surface Proteins A1 and A2

Therése Nordström, Anna M. Blom, Arne Forsgren, and Kristian Riesbeck
J Immunol 2004 173: 4598-4606. [Abstract] [Full Text] [PDF]  

Novel and Promiscuous CTL Epitopes in Conserved Regions of Gag Targeted by Individuals with Early Subtype C HIV Type 1 Infection from Southern Africa

Agatha M. Masemola, Tumelo N. Mashishi, Greg Khoury, Helba Bredell, Maria Paximadis, Tiyani Mathebula, Debra Barkhan, Adrian Puren, Efthyia Vardas, Mark Colvin, Lynn Zijenah, David Katzenstein, Rosemary Musonda, Susan Allen, Newton Kumwenda, Taha Taha, Glenda Gray, James McIntyre, Salim Abdool Karim, Haynes W. Sheppard, and Clive M. Gray
J Immunol 2004 173: 4607-4617. [Abstract] [Full Text] [PDF]  

A Nonneutralizing Anti-HIV-1 Antibody Turns into a Neutralizing Antibody When Expressed on the Surface of HIV-1-Susceptible Cells: A New Way to Fight HIV

Seung-Jae Lee, Laura Garza, Jun Yao, Abner L. Notkins, and Paul Zhou
J Immunol 2004 173: 4618-4626. [Abstract] [Full Text] [PDF]  

Selective Impairment of TLR-Mediated Innate Immunity in Human Newborns: Neonatal Blood Plasma Reduces Monocyte TNF- Induction by Bacterial Lipopeptides, Lipopolysaccharide, and Imiquimod, but Preserves the Response to R-848

Ofer Levy, Kol A. Zarember, Rene M. Roy, Colette Cywes, Paul J. Godowski, and Michael R. Wessels
J Immunol 2004 173: 4627-4634. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Lipoproteins, Not Lipopolysaccharide, Are the Key Mediators of the Proinflammatory Response Elicited by Heat-Killed Brucella abortus

Guillermo H. Giambartolomei, Astrid Zwerdling, Juliana Cassataro, Laura Bruno, Carlos A. Fossati, and Mario T. Philipp
J Immunol 2004 173: 4635-4642. [Abstract] [Full Text] [PDF]  

Stimulus-Dependent Requirement for Granulocyte-Macrophage Colony-Stimulating Factor in Inflammation

Andrew D. Cook, Emma L. Braine, and John A. Hamilton
J Immunol 2004 173: 4643-4651. [Abstract] [Full Text] [PDF]  

The Antibiotic Polymyxin B Modulates P2X₇ Receptor Function

Davide Ferrari, Cinzia Pizzirani, Elena Adinolfi, Sylvia Forchap, Barbara Sitta, Laura Turchet, Simonetta Falzoni, Mattia Minelli, Roberto Baricordi, and Francesco Di Virgilio
J Immunol 2004 173: 4652-4660. [Abstract] [Full Text] [PDF]  

CCAAT/Enhancer-Binding Protein Isoforms and the Regulation of -Smooth Muscle Actin Gene Expression by IL-1

Biao Hu, Zhe Wu, Hong Jin, Naozumi Hashimoto, Tianju Liu, and Sem H. Phan
J Immunol 2004 173: 4661-4668. [Abstract] [Full Text] [PDF]  

Absence of Procarboxypeptidase R Induces Complement-Mediated Lethal Inflammation in Lipopolysaccharide-Primed Mice

Suzuka Asai, Tomoo Sato, Toyohiro Tada, Tomomi Miyamoto, Noriaki Kimbara, Noboru Motoyama, Hidechika Okada, and Noriko Okada
J Immunol 2004 173: 4669-4674. [Abstract] [Full Text] [PDF]  

Human Parvovirus B19 Transgenic Mice Become Susceptible to Polyarthritis

Naruhiko Takasawa, Yasuhiko Munakata, Keiko Kumura Ishii, Yuichi Takahashi, Minako Takahashi, Yi Fu, Tomonori Ishii, Hiroshi Fujii, Takako Saito, Hiroshi Takano, Tetsuo Noda, Misao Suzuki, Masato Nose, Suzan Zolla-Patzner, and Takeshi Sasaki
J Immunol 2004 173: 4675-4683. [Abstract] [Full Text] [PDF]  

Serum Amyloid A-Activating Factor-1 (SAF-1) Transgenic Mice Are Prone to Develop a Severe Form of Inflammation-Induced Arthritis

Alpana Ray, Deepak Kumar, Arvind Shakya, Charles R. Brown, James L. Cook, and Bimal K. Ray
J Immunol 2004 173: 4684-4691. [Abstract] [Full Text] [PDF]  

The Role of the Th2 CC Chemokine Ligand CCL17 in Pulmonary Fibrosis

John A. Belperio, Maria Dy, Lynne Murray, Marie D. Burdick, Ying Y. Xue, Robert M. Strieter, and Michael P. Keane
J Immunol 2004 173: 4692-4698. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Dual Mode of Action of a Human Anti-Epidermal Growth Factor Receptor Monoclonal Antibody for Cancer Therapy

Wim K. Bleeker, Jeroen J. Lammerts van Bueren, Heidi H. van Ojik, Arnout F. Gerritsen, Marielle Pluyter, Mischa Houtkamp, Ed Halk, Joel Goldstein, Janine Schuurman, Marc A. van Dijk, Jan G. J. van de Winkel, and Paul W. H. I. Parren
J Immunol 2004 173: 4699-4707. [Abstract] [Full Text] [PDF]  

Deletion of the Complement Anaphylatoxin C3a Receptor Attenuates, Whereas Ectopic Expression of C3a in the Brain Exacerbates, Experimental Autoimmune Encephalomyelitis

Laura Boos, Iain L. Campbell, Robert Ames, Rick A. Wetsel, and Scott R. Barnum
J Immunol 2004 173: 4708-4714. [Abstract] [Full Text] [PDF]  

Induction of Immunological Tolerance/Hyporesponsiveness in Baboons with a Nondepleting CD4 Antibody

Dawn Winsor-Hines, Christopher Merrill, Mark O’Mahony, Patricia E. Rao, Stephen P. Cobbold, Herman Waldmann, Douglas J. Ringler, and Paul D. Ponath
J Immunol 2004 173: 4715-4723. [Abstract] [Full Text] [PDF] Data Supplement  

A Critical Role for FcRIIB in the Induction of Rheumatoid Factors

Thomas Moll, Lars Nitschke, Michael Carroll, Jeffrey V. Ravetch, and Shozo Izui
J Immunol 2004 173: 4724-4728. [Abstract] [Full Text] [PDF]  

A Transient Post-Translationally Modified Form of Cartilage Type II Collagen Is Ignored by Self-Reactive T Cells

Hisakata Yamada, Balik Dzhambazov, Robert Bockermann, Thomas Blom, and Rikard Holmdahl
J Immunol 2004 173: 4729-4735. [Abstract] [Full Text] [PDF]  

Anti-Idiotype x Anti-CD44 Bispecific Antibodies Inhibit Invasion of Lymphoid Organs by B Cell Lymphoma

Esther Avin, Joseph Haimovich, and Nurit Hollander
J Immunol 2004 173: 4736-4743. [Abstract] [Full Text] [PDF]  

Negative Role of Colony-Stimulating Factor-1 in Macrophage, T Cell, and B Cell Mediated Autoimmune Disease in MRL-Fas^lpr Mice

Deborah M. Lenda, E. Richard Stanley, and Vicki R. Kelley
J Immunol 2004 173: 4744-4754. [Abstract] [Full Text] [PDF]  

CORRECTIONS:

Characterization of the Heparin-Binding Properties of IL-6

Rosemary S. Mummery and Christopher C. Rider
J Immunol 2004 173: 4755. [Full Text] [PDF]  

Bone Marrow-Derived Progenitor Cells Are Important for Lung Repair after Lipopolysaccharide-Induced Lung Injury

Mitsuhiro Yamada, Hiroshi Kubo, Seiichi Kobayashi, Kota Ishizawa, Muneo Numasaki, Shinsaku Ueda, Takashi Suzuki, and Hidetada Sasaki
J Immunol 2004 173: 4755. [Full Text] [PDF]  

The Structure of H-2K^b and K^bm8 Complexed to a Herpes Simplex Virus Determinant: Evidence for a Conformational Switch That Governs T Cell Repertoire Selection and Viral Resistance

Andrew I. Webb, Natalie A. Borg, Michelle A. Dunstone, Lars Kjer-Nielsen, Travis Beddoe, James McCluskey, Francis R. Carbone, Stephen P. Bottomley, Marie-Isabel Aguilar, Anthony W. Purcell, and Jamie Rossjohn
J Immunol 2004 173: 4756. [Full Text] [PDF]  

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