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On the cover: Molecular modeling of the preferred interaction of I-A^s with the encephalitogenic region of myelin-associated oligodendrocytic basic protein, MOBP15-36, predicts the experimentally confirmed core epitope for the encephalitogenic T cells, MOBP20-28. The same region contains a preferred interaction with HLA-DRA^*0101, HLA-DRB1^*1501, one of the HLA molecules associated with multiple sclerosis, at MOBP18-26. Kerlero de Rosbo et al. The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1^*1501. J. Immunol. 173:1426.

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