IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2003 171: 1121-1122. [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: In Vivo Induction of Integrated HIV-1 Expression by Mycobacteria Is Critically Dependent on Toll-Like Receptor 2

André Báfica, Charles A. Scanga, Marco L. Schito, Sara Hieny, and Alan Sher
J Immunol 2003 171: 1123-1127. [Abstract] [Full Text] [PDF]  

Cutting Edge: T Lymphocyte Activation by Repeated Immunological Synapse Formation and Intermittent Signaling

Mustapha Faroudi, Rossana Zaru, Pierre Paulet, Sabina Müller, and Salvatore Valitutti
J Immunol 2003 171: 1128-1132. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Baculovirus Induces an Innate Immune Response and Confers Protection from Lethal Influenza Virus Infection in Mice

Takayuki Abe, Hitoshi Takahashi, Hiroyuki Hamazaki, Naoko Miyano-Kurosaki, Yoshiharu Matsuura, and Hiroshi Takaku
J Immunol 2003 171: 1133-1139. [Abstract] [Full Text] [PDF]  

Differential Expression of Smad7 Transcripts Identifies the CD4⁺CD45RC^high Regulatory T Cells That Mediate Type V Collagen-Induced Tolerance to Lung Allografts

Teruaki Mizobuchi, Kazuhiro Yasufuku, Yan Zheng, M. Azizul Haque, Kathleen M. Heidler, Kena Woods, Gerald N. Smith, Jr., Oscar W. Cummings, Takehiko Fujisawa, Janice S. Blum, and David S. Wilkes
J Immunol 2003 171: 1140-1147. [Abstract] [Full Text] [PDF]  

Macrophages of the Splenic Marginal Zone Are Essential for Trapping of Blood-Borne Particulate Antigen but Dispensable for Induction of Specific T Cell Responses

Peter Aichele, Jana Zinke, Leander Grode, Reto A. Schwendener, Stefan H. E. Kaufmann, and Peter Seiler
J Immunol 2003 171: 1148-1155. [Abstract] [Full Text] [PDF]  

The Immune Response Modifier and Toll-Like Receptor 7 Agonist S-27609 Selectively Induces IL-12 and TNF- Production in CD11c⁺CD11b⁺CD8^- Dendritic Cells

Christie L. Doxsee, Tony R. Riter, Michael J. Reiter, Shelia J. Gibson, John P. Vasilakos, and Ross M. Kedl
J Immunol 2003 171: 1156-1163. [Abstract] [Full Text] [PDF]  

IL-18 Binding Protein Protects Against Contact Hypersensitivity

Thomas Plitz, Pierre Saint-Mézard, Masataka Satho, Susanne Herren, Caroline Waltzinger, Marcelo de Carvalho Bittencourt, Marie H. Kosco-Vilbois, and Yolande Chvatchko
J Immunol 2003 171: 1164-1171. [Abstract] [Full Text] [PDF]  

Constitutive Caspase Activation and Impaired Death-Inducing Signaling Complex Formation in CD95-Resistant, Long-Term Activated, Antigen-Specific T Cells

Gudrun Strauss, Ingrid Knape, Ingo Melzner, and Klaus-Michael Debatin
J Immunol 2003 171: 1172-1182. [Abstract] [Full Text] [PDF]  

Fas Ligand on Tumor Cells Mediates Inactivation of Neutrophils

Yi-Ling Chen, Shun-Hua Chen, Jiu-Yao Wang, and Bei-Chang Yang
J Immunol 2003 171: 1183-1191. [Abstract] [Full Text] [PDF]  

Antibody Repertoire and Gene Expression Profile: Implications for Different Developmental and Functional Traits of Splenic and Peritoneal B-1 Lymphocytes

Karsten Kretschmer, Anke Jungebloud, Jana Stopkowicz, Britta Stoermann, Reinhard Hoffmann, and Siegfried Weiss
J Immunol 2003 171: 1192-1201. [Abstract] [Full Text] [PDF] Data Supplement  

Hemopoietic Function After Use of IL-1 with Chemotherapy or Irradiation

Renee V. Gardner, Evangeline McKinnon, Connie Poretta, and Lily Leiva
J Immunol 2003 171: 1202-1206. [Abstract] [Full Text] [PDF]  

Early Defect Prethymic in Bone Marrow T Cell Progenitors in Athymic nu/nu Mice

Devavani Chatterjea-Matthes, Marcos E. García-Ojeda, Sussan Dejbakhsh-Jones, Libuse Jerabek, Markus G. Manz, Irving L. Weissman, and Samuel Strober
J Immunol 2003 171: 1207-1215. [Abstract] [Full Text] [PDF]  

Scurfin (FoxP3) Controls T-Dependent Immune Responses In Vivo Through Regulation of CD4⁺ T Cell Effector Function

Deborah J. Kasprowicz, P. Scott Smallwood, Aaron J. Tyznik, and Steven F. Ziegler
J Immunol 2003 171: 1216-1223. [Abstract] [Full Text] [PDF]  

Theileria parva-Transformed T Cells Show Enhanced Resistance to Fas/Fas Ligand-Induced Apoptosis

Peter Küenzi, Pascal Schneider, and Dirk A. E. Dobbelaere
J Immunol 2003 171: 1224-1231. [Abstract] [Full Text] [PDF]  

L-Arginine Consumption by Macrophages Modulates the Expression of CD3 Chain in T Lymphocytes

Paulo C. Rodriguez, Arnold H. Zea, Joanna DeSalvo, Kirk S. Culotta, Jovanny Zabaleta, David G. Quiceno, Juan B. Ochoa, and Augusto C. Ochoa
J Immunol 2003 171: 1232-1239. [Abstract] [Full Text] [PDF]  

Enhanced Priming of Multispecific, Murine CD8⁺ T Cell Responses by DNA Vaccines Expressing Stress Protein-Binding Polytope Peptides

Reinhold Schirmbeck, Nicolas Fissolo, Paul Chaplin, and Jörg Reimann
J Immunol 2003 171: 1240-1246. [Abstract] [Full Text] [PDF]  

Regulation of Polyclonal T Cell Responses by an MHC Anchor-Substituted Variant of Myelin Oligodendrocyte Glycoprotein 35-55

Mandy L. Ford and Brian D. Evavold
J Immunol 2003 171: 1247-1254. [Abstract] [Full Text] [PDF]  

A Giant GTPase, Very Large Inducible GTPase-1, Is Inducible by IFNs

Thorsten Klamp, Ulrich Boehm, Daniela Schenk, Klaus Pfeffer, and Jonathan C. Howard
J Immunol 2003 171: 1255-1265. [Abstract] [Full Text] [PDF] Data Supplement  

CD4⁺ NKT Cells, But Not Conventional CD4⁺ T Cells, Are Required to Generate Efferent CD8⁺ T Regulatory Cells Following Antigen Inoculation in an Immune-Privileged Site

Takahiko Nakamura, Koh-Hei Sonoda, Douglas E. Faunce, Jenny Gumperz, Takashi Yamamura, Sachiko Miyake, and Joan Stein-Streilein
J Immunol 2003 171: 1266-1271. [Abstract] [Full Text] [PDF]  

Blockade of Programmed Death-1 Engagement Accelerates Graft-Versus-Host Disease Lethality by an IFN--Dependent Mechanism

Bruce R. Blazar, Beatriz M. Carreno, Angela Panoskaltsis-Mortari, Laura Carter, Yoshiko Iwai, Hideo Yagita, Hiroyuki Nishimura, and Patricia A. Taylor
J Immunol 2003 171: 1272-1277. [Abstract] [Full Text] [PDF]  

Chronic Exposure to Low Levels of Antigen in the Periphery Causes Reversible Functional Impairment Correlating with Changes in CD5 Levels in Monoclonal CD8 T Cells

Panagiota Stamou, James de Jersey, Danielle Carmignac, Clio Mamalaki, Dimitris Kioussis, and Brigitta Stockinger
J Immunol 2003 171: 1278-1284. [Abstract] [Full Text] [PDF]  

Constitutively Active Protein Kinase B Enhances Lck and Erk Activities and Influences Thymocyte Selection and Activation

Shin-Young Na, Amiya Patra, Yvonne Scheuring, Alexander Marx, Mauro Tolaini, Dimitris Kioussis, Brian Hemmings, Thomas Hünig, and Ursula Bommhardt
J Immunol 2003 171: 1285-1296. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

The Onecut Transcription Factor Hepatocyte Nuclear Factor-6 Controls B Lymphopoiesis in Fetal Liver

Caroline Bouzin, Frédéric Clotman, Jean-Christophe Renauld, Frédéric P. Lemaigre, and Guy G. Rousseau
J Immunol 2003 171: 1297-1303. [Abstract] [Full Text] [PDF]  

Mutation of a Dibasic Amino Acid Motif Within the C Terminus of the P2X₇ Nucleotide Receptor Results in Trafficking Defects and Impaired Function

Loren C. Denlinger, Julie A. Sommer, Karen Parker, Lalitha Gudipaty, Philip L. Fisette, Jyoti W. Watters, Richard A. Proctor, George R. Dubyak, and Paul J. Bertics
J Immunol 2003 171: 1304-1311. [Abstract] [Full Text] [PDF]  

The Porcine Ig Gene: Unique Chimeric Splicing of the First Constant Region Domain in its Heavy Chain Transcripts

Yaofeng Zhao, Qiang Pan-Hammarström, Imre Kacskovics, and Lennart Hammarström
J Immunol 2003 171: 1312-1318. [Abstract] [Full Text] [PDF]  

The Lyn Tyrosine Kinase Negatively Regulates Neutrophil Integrin Signaling

Shalini Pereira and Clifford Lowell
J Immunol 2003 171: 1319-1327. [Abstract] [Full Text] [PDF]  

B Cell Receptor-Mediated Syk-Independent Activation of Phosphatidylinositol 3-Kinase, Ras, and Mitogen-Activated Protein Kinase Pathways

Takeaki Yokozeki, Kristin Adler, Danielle Lankar, and Christian Bonnerot
J Immunol 2003 171: 1328-1335. [Abstract] [Full Text] [PDF]  

Identification and Characterization of a Novel Regulatory Factor: IgA-Inducing Protein

Amy S. Austin, Karen M. Haas, Sasha M. Naugler, Anna A. Bajer, David Garcia-Tapia, and D. Mark Estes
J Immunol 2003 171: 1336-1342. [Abstract] [Full Text] [PDF]  

Complexes of HLA-G Protein on the Cell Surface Are Important for Leukocyte Ig-Like Receptor-1 Function

Tsufit Gonen-Gross, Hagit Achdout, Roi Gazit, Jacob Hanna, Sa’ar Mizrahi, Gal Markel, Debra Goldman-Wohl, Simcha Yagel, Václav Horejsí, Ofer Levy, Michal Baniyash, and Ofer Mandelboim
J Immunol 2003 171: 1343-1351. [Abstract] [Full Text] [PDF]  

Positive Modulation of IL-12 Signaling by Sphingosine Kinase 2 Associating with the IL-12 Receptor 1 Cytoplasmic Region

Takayuki Yoshimoto, Masae Furuhata, Sadahiro Kamiya, Masayuki Hisada, Hiroko Miyaji, Yasushi Magami, Koh Yamamoto, Hiromi Fujiwara, and Junichiro Mizuguchi
J Immunol 2003 171: 1352-1359. [Abstract] [Full Text] [PDF]  

SLP-76 Coordinates Nck-Dependent Wiskott-Aldrich Syndrome Protein Recruitment with Vav-1/Cdc42-Dependent Wiskott-Aldrich Syndrome Protein Activation at the T Cell-APC Contact Site

Rong Zeng, Judy L. Cannon, Robert T. Abraham, Michael Way, Daniel D. Billadeau, Julie Bubeck-Wardenberg, and Janis K. Burkhardt
J Immunol 2003 171: 1360-1368. [Abstract] [Full Text] [PDF]  

Analysis of HLA-E Peptide-Binding Specificity and Contact Residues in Bound Peptide Required for Recognition by CD94/NKG2

Joseph D. Miller, Dominique A. Weber, Chris Ibegbu, Jan Pohl, John D. Altman, and Peter E. Jensen
J Immunol 2003 171: 1369-1375. [Abstract] [Full Text] [PDF]  

Protein Expression and Peptide Binding Suggest Unique and Interacting Functional Roles for HLA-E, F, and G in Maternal-Placental Immune Recognition

Akiko Ishitani, Noriko Sageshima, Ni Lee, Natalia Dorofeeva, Katsuhiko Hatake, Hans Marquardt, and Daniel E. Geraghty
J Immunol 2003 171: 1376-1384. [Abstract] [Full Text] [PDF]  

Functional Analysis of the TCR Binding Domain of Toxic Shock Syndrome Toxin-1 Predicts Further Diversity in MHC Class II/Superantigen/TCR Ternary Complexes

John K. McCormick, Timothy J. Tripp, Andrea S. Llera, Eric J. Sundberg, Martin M. Dinges, Roy A. Mariuzza, and Patrick M. Schlievert
J Immunol 2003 171: 1385-1392. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Repetitive Elements in Mammalian Telomeres Suppress Bacterial DNA-Induced Immune Activation

Ihsan Gursel, Mayda Gursel, Hiroshi Yamada, Ken J. Ishii, Fumihiko Takeshita, and Dennis M. Klinman
J Immunol 2003 171: 1393-1400. [Abstract] [Full Text] [PDF]  

Inhibition of IFN--Inducible Protein-10 Abrogates Colitis in IL-10^-/- Mice

Udai P. Singh, Shailesh Singh, Dennis D. Taub, and James W. Lillard, Jr.
J Immunol 2003 171: 1401-1406. [Abstract] [Full Text] [PDF]  

Promiscuous CTL Recognition of Viral Epitopes on Multiple Human Leukocyte Antigens: Biological Validation of the Proposed HLA A24 Supertype

Scott R. Burrows, Rebecca A. Elkington, John J. Miles, Katherine J. Green, Susan Walker, Sofia M. Haryana, Denis J. Moss, Heather Dunckley, Jacqueline M. Burrows, and Rajiv Khanna
J Immunol 2003 171: 1407-1412. [Abstract] [Full Text] [PDF]  

Alternate Class I MHC Antigen Processing Is Inhibited by Toll-Like Receptor Signaling Pathogen-Associated Molecular Patterns: Mycobacterium tuberculosis 19-kDa Lipoprotein, CpG DNA, and Lipopolysaccharide

Aaron A. R. Tobian, Nicholas S. Potter, Lakshmi Ramachandra, Rish K. Pai, Marilyn Convery, W. Henry Boom, and Clifford V. Harding
J Immunol 2003 171: 1413-1422. [Abstract] [Full Text] [PDF]  

Clearance of Pneumocystis carinii in Mice Is Dependent on B Cells But Not on P. carinii-Specific Antibody

Frances E. Lund, Kevin Schuer, Melissa Hollifield, Troy D. Randall, and Beth A. Garvy
J Immunol 2003 171: 1423-1430. [Abstract] [Full Text] [PDF]  

Porcine Pulmonary Collectins Show Distinct Interactions with Influenza A Viruses: Role of the N-Linked Oligosaccharides in the Carbohydrate Recognition Domain

Martin van Eijk, Mitchell R. White, Erika C. Crouch, Joseph J. Batenburg, Arie B. Vaandrager, Lambert M. G. van Golde, Henk P. Haagsman, and Kevan L. Hartshorn
J Immunol 2003 171: 1431-1440. [Abstract] [Full Text] [PDF]  

Heat-Killed Brucella abortus Induces TNF and IL-12p40 by Distinct MyD88-Dependent Pathways: TNF, Unlike IL-12p40 Secretion, Is Toll-Like Receptor 2 Dependent

Li-Yun Huang, Julio Aliberti, Cynthia A. Leifer, David M. Segal, Alan Sher, Douglas T. Golenbock, and Basil Golding
J Immunol 2003 171: 1441-1446. [Abstract] [Full Text] [PDF]  

Leptospira interrogans Activation of Human Peripheral Blood Mononuclear Cells: Preferential Expansion of TCR⁺ T Cells vs TCR⁺ T Cells

Gary R. Klimpel, Michael A. Matthias, and Joseph M. Vinetz
J Immunol 2003 171: 1447-1455. [Abstract] [Full Text] [PDF]  

Inhibition of a p38/Stress-Activated Protein Kinase-2-Dependent Phosphatase Restores Function of IL-1 Receptor-Associated Kinase-1 and Reverses Toll-Like Receptor 2- and 4-Dependent Tolerance of Macrophages

Catherine Ropert, Meire Closel, Andréa C. L. Chaves, and Ricardo T. Gazzinelli
J Immunol 2003 171: 1456-1465. [Abstract] [Full Text] [PDF]  

Glycosylinositolphosphate Soluble Variant Surface Glycoprotein Inhibits IFN--Induced Nitric Oxide Production Via Reduction in STAT1 Phosphorylation in African Trypanosomiasis

Susan P. Coller, John M. Mansfield, and Donna M. Paulnock
J Immunol 2003 171: 1466-1472. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Injury Primes the Innate Immune System for Enhanced Toll-Like Receptor Reactivity

Hugh M. Paterson, Thomas J. Murphy, Elizabeth J. Purcell, Odhran Shelley, Sara J. Kriynovich, Egil Lien, John A. Mannick, and James A. Lederer
J Immunol 2003 171: 1473-1483. [Abstract] [Full Text] [PDF]  

NF-B Is Required Within the Innate Immune System to Inhibit Microflora-Induced Colitis and Expression of IL-12 p40

Michal F. Tomczak, Susan E. Erdman, Theofilos Poutahidis, Arlin B. Rogers, Hilda Holcombe, Benjamin Plank, James G. Fox, and Bruce H. Horwitz
J Immunol 2003 171: 1484-1492. [Abstract] [Full Text] [PDF]  

Human Mast Cell -Tryptase Is a Gelatinase

Ignacio Fajardo and Gunnar Pejler
J Immunol 2003 171: 1493-1499. [Abstract] [Full Text] [PDF]  

Pellino3, a Novel Member of the Pellino Protein Family, Promotes Activation of c-Jun and Elk-1 and May Act as a Scaffolding Protein

Liselotte E. Jensen and Alexander S. Whitehead
J Immunol 2003 171: 1500-1506. [Abstract] [Full Text] [PDF]  

Murine Macrophages Produce Secretory Leukocyte Protease Inhibitor During Clearance of Apoptotic Cells: Implications for Resolution of the Inflammatory Response

Chikako Odaka, Toshiaki Mizuochi, Jingxuan Yang, and Aihao Ding
J Immunol 2003 171: 1507-1514. [Abstract] [Full Text] [PDF]  

The Proteasome as a Lipopolysaccharide-Binding Protein in Macrophages: Differential Effects of Proteasome Inhibition on Lipopolysaccharide-Induced Signaling Events

Nilofer Qureshi, Pin-Yu Perera, Jing Shen, Guochi Zhang, Arnd Lenschat, Gary Splitter, David C. Morrison, and Stefanie N. Vogel
J Immunol 2003 171: 1515-1525. [Abstract] [Full Text] [PDF]  

TRAIL Induces Apoptosis and Inflammatory Gene Expression in Human Endothelial Cells

Jie Hui Li, Nancy C. Kirkiles-Smith, Jennifer M. McNiff, and Jordan S. Pober
J Immunol 2003 171: 1526-1533. [Abstract] [Full Text] [PDF]  

Proangiogenic Function of CD40 Ligand-CD40 Interactions

Marlies E. J. Reinders, Masayuki Sho, Stuart W. Robertson, Christopher S. Geehan, and David M. Briscoe
J Immunol 2003 171: 1534-1541. [Abstract] [Full Text] [PDF]  

Role of Regulator of G Protein Signaling 16 in Inflammation- Induced T Lymphocyte Migration and Activation

Eric Lippert, David L. Yowe, Jose-Angel Gonzalo, J. Paul Justice, Jeremy M. Webster, Eric R. Fedyk, Martin Hodge, Cheryl Miller, Jose-Carlos Gutierrez-Ramos, Francisco Borrego, Andrea Keane-Myers, and Kirk M. Druey
J Immunol 2003 171: 1542-1555. [Abstract] [Full Text] [PDF]  

Mucosal T Cells Expressing High Levels of IL-7 Receptor Are Potential Targets for Treatment of Chronic Colitis

Motomi Yamazaki, Tomoharu Yajima, Masanobu Tanabe, Kazuto Fukui, Eriko Okada, Ryuichi Okamoto, Shigeru Oshima, Tetsuya Nakamura, Takanori Kanai, Masahiro Uehira, Tsutomu Takeuchi, Hiromichi Ishikawa, Toshifumi Hibi, and Mamoru Watanabe
J Immunol 2003 171: 1556-1563. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Pivotal Role of Stat4 and Stat6 in the Pathogenesis of the Lupus-Like Disease in the New Zealand Mixed 2328 Mice

Chaim O. Jacob, Song Zang, Lily Li, Voicu Ciobanu, Frank Quismorio, Akiei Mizutani, Minoru Satoh, and Michael Koss
J Immunol 2003 171: 1564-1571. [Abstract] [Full Text] [PDF]  

Systemic Rather Than Local Heme Oxygenase-1 Overexpression Improves Cardiac Allograft Outcomes in a New Transgenic Mouse

Jesus A. Araujo, Lingzhong Meng, Aaron D. Tward, Wayne W. Hancock, Yuan Zhai, Annie Lee, Kazunobu Ishikawa, Suhasini Iyer, Roland Buelow, Ronald W. Busuttil, Diana M. Shih, Aldons J. Lusis, and Jerzy W. Kupiec-Weglinski
J Immunol 2003 171: 1572-1580. [Abstract] [Full Text] [PDF]  

Complement Activation Determines the Therapeutic Activity of Rituximab In Vivo

Nicola Di Gaetano, Elena Cittera, Rachele Nota, Annunciata Vecchi, Valeria Grieco, Eugenio Scanziani, Marina Botto, Martino Introna, and Josée Golay
J Immunol 2003 171: 1581-1587. [Abstract] [Full Text] [PDF]  

HER-2 DNA and Protein Vaccines Containing Potent Th Cell Epitopes Induce Distinct Protective and Therapeutic Antitumor Responses in HER-2 Transgenic Mice

Valéry Renard, Lene Sonderbye, Kirsten Ebbehøj, Peter Birk Rasmussen, Klaus Gregorius, Tine Gottschalk, Søren Mouritsen, Anand Gautam, and Dana R. Leach
J Immunol 2003 171: 1588-1595. [Abstract] [Full Text] [PDF]  

Inhibitory Signal Override Increases Susceptibility to Mercury-Induced Autoimmunity

Yan Zheng and Marc Monestier
J Immunol 2003 171: 1596-1601. [Abstract] [Full Text] [PDF]  

Enhanced Immunogenicity and Protective Efficacy Against Mycobacterium tuberculosis of Bacille Calmette-Guérin Vaccine Using Mucosal Administration and Boosting with a Recombinant Modified Vaccinia Virus Ankara

Nilu P. Goonetilleke, Helen McShane, Carolyn M. Hannan, Richard J. Anderson, Roger H. Brookes, and Adrian V. S. Hill
J Immunol 2003 171: 1602-1609. [Abstract] [Full Text] [PDF]  

CORRECTION:

Short Term Administration of Costimulatory Blockade and Cyclophosphamide Induces Remission of Systemic Lupus Erythematosus Nephritis in NZB/W F₁ Mice by a Mechanism Downstream of Renal Immune Complex Deposition

Lena Schiffer, Jayashree Sinha, Xiaobo Wang, Weiqing Huang, Gero von Gersdorff, Mario Schiffer, Michael P. Madaio, and Anne Davidson
J Immunol 2003 171: 1610. [Full Text] [PDF]  

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