IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2003 170: 3449-3450. [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: A Toll-Like Receptor 2 Polymorphism That Is Associated with Lepromatous Leprosy Is Unable to Mediate Mycobacterial Signaling

Pierre-Yves Bochud, Thomas R. Hawn, and Alan Aderem
J Immunol 2003 170: 3451-3454. [Abstract] [Full Text] [PDF]  

Cutting Edge: CD40-Induced Expression of Recombination Activating Gene (RAG) 1 and RAG2: A Mechanism for the Generation of Autoaggressive T Cells in the Periphery

Gisela M. Vaitaitis, Michelle Poulin, Richard J. Sanderson, Kathryn Haskins, and David H. Wagner, Jr.
J Immunol 2003 170: 3455-3459. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

IL-9 Enhances the Growth of Human Mast Cell Progenitors Under Stimulation with Stem Cell Factor

Shigeyuki Matsuzawa, Kazuo Sakashita, Tatsuya Kinoshita, Susumu Ito, Tetsuji Yamashita, and Kenichi Koike
J Immunol 2003 170: 3461-3467. [Abstract] [Full Text] [PDF]  

CpG-A Oligonucleotides Induce a Monocyte-Derived Dendritic Cell-Like Phenotype That Preferentially Activates CD8 T Cells

Anne Krug, Simon Rothenfusser, S. Selinger, C. Bock, M. Kerkmann, J. Battiany, A. Sarris, Thomas Giese, D. Speiser, Stefan Endres, and Gunther Hartmann
J Immunol 2003 170: 3468-3477. [Abstract] [Full Text] [PDF]  

Expression of a Constitutively Active Stat6 In Vivo Alters Lymphocyte Homeostasis with Distinct Effects in T and B Cells

Heather A. Bruns, Ulrike Schindler, and Mark H. Kaplan
J Immunol 2003 170: 3478-3487. [Abstract] [Full Text] [PDF]  

Gangliosides from Human Melanoma Tumors Impair Dendritic Cell Differentiation from Monocytes and Induce Their Apoptosis

Josette Péguet-Navarro, Myriam Sportouch, Iuliana Popa, Odile Berthier, Daniel Schmitt, and Jacques Portoukalian
J Immunol 2003 170: 3488-3494. [Abstract] [Full Text] [PDF]  

IL-4 Potentiates Activated T Cell Apoptosis Via an IL-2-Dependent Mechanism

Jian Zhang, Tamás Bárdos, Qing Shao, Jurg Tschopp, Katalin Mikecz, Tibor T. Glant, and Alison Finnegan
J Immunol 2003 170: 3495-3503. [Abstract] [Full Text] [PDF]  

Presentation by Recycling MHC Class II Molecules of an Influenza Hemagglutinin-Derived Epitope That Is Revealed in the Early Endosome by Acidification

Gomathinayagam Sinnathamby and Laurence C. Eisenlohr
J Immunol 2003 170: 3504-3513. [Abstract] [Full Text] [PDF]  

Two Developmentally Distinct Populations of Dendritic Cells Inhabit the Adult Mouse Thymus: Demonstration by Differential Importation of Hematogenous Precursors Under Steady State Conditions

Elina Donskoy and Irving Goldschneider
J Immunol 2003 170: 3514-3521. [Abstract] [Full Text] [PDF]  

Prevention of Autoantibody-Mediated Graves’-Like Hyperthyroidism in Mice with IL-4, a Th2 Cytokine

Yuji Nagayama, Hiroyuki Mizuguchi, Takao Hayakawa, Masami Niwa, Sandra M. McLachlan, and Basil Rapoport
J Immunol 2003 170: 3522-3527. [Abstract] [Full Text] [PDF]  

The MHC Class I-Like IgG Receptor Controls Perinatal IgG Transport, IgG Homeostasis, and Fate of IgG-Fc-Coupled Drugs

Derry C. Roopenian, Gregory J. Christianson, Thomas J. Sproule, Aaron C. Brown, Shreeram Akilesh, Nadja Jung, Stefka Petkova, Lia Avanessian, Eun Young Choi, Daniel J. Shaffer, Peter A. Eden, and Clark L. Anderson
J Immunol 2003 170: 3528-3533. [Abstract] [Full Text] [PDF]  

The B Cell Coreceptor CD22 Associates with AP50, a Clathrin-Coated Pit Adapter Protein, Via Tyrosine-Dependent Interaction

BinuJoy John, Brantley R. Herrin, Chander Raman, Yan-ni Wang, Kevin R. Bobbitt, Brian A. Brody, and Louis B. Justement
J Immunol 2003 170: 3534-3543. [Abstract] [Full Text] [PDF]  

The Mechanism of CD47-Dependent Killing of T Cells: Heterotrimeric G_i-Dependent Inhibition of Protein Kinase A

Partha Pratim Manna and William A. Frazier
J Immunol 2003 170: 3544-3553. [Abstract] [Full Text] [PDF]  

Murine Flt3 Ligand Expands Distinct Dendritic Cells with Both Tolerogenic and Immunogenic Properties

George Miller, Venu G. Pillarisetty, Alaap B. Shah, Svenja Lahrs, and Ronald P. DeMatteo
J Immunol 2003 170: 3554-3564. [Abstract] [Full Text] [PDF]  

Toll-Like Receptor 3 Mediates a More Potent Antiviral Response Than Toll-Like Receptor 4

Sean E. Doyle, Ryan O’Connell, Sagar A. Vaidya, Edward K. Chow, Kathleen Yee, and Genhong Cheng
J Immunol 2003 170: 3565-3571. [Abstract] [Full Text] [PDF]  

Activated, But Not Resting, T Cells Can Be Recognized and Killed by Syngeneic NK Cells

Brian A. Rabinovich, Jennifer Li, John Shannon, Rose Hurren, Jan Chalupny, David Cosman, and Richard G. Miller
J Immunol 2003 170: 3572-3576. [Abstract] [Full Text] [PDF]  

Ligation of Retinoic Acid Receptor Regulates Negative Selection of Thymocytes by Inhibiting Both DNA Binding of nur77 and Synthesis of Bim

Éva Szegezdi, Ildikó Kiss, Ágnes Simon, Bernadett Blaskó, Uwe Reichert, Serge Michel, Mátyás Sándor, László Fésüs, and Zsuzsa Szondy
J Immunol 2003 170: 3577-3584. [Abstract] [Full Text] [PDF]  

IL-10 Mediates Sigma₁ Receptor-Dependent Suppression of Antitumor Immunity

Li X. Zhu, Sherven Sharma, Brian Gardner, Brian Escuadro, Kimberly Atianzar, Donald P. Tashkin, and Steven M. Dubinett
J Immunol 2003 170: 3585-3591. [Abstract] [Full Text] [PDF]  

Infections That Induce Autoimmune Diabetes in BBDR Rats Modulate CD4⁺CD25⁺ T Cell Populations

Danny Zipris, Jan-Luuk Hillebrands, Raymond M. Welsh, Jan Rozing, Jenny X. Xie, John P. Mordes, Dale L. Greiner, and Aldo A. Rossini
J Immunol 2003 170: 3592-3602. [Abstract] [Full Text] [PDF]  

Role of MHC Class I in Immune Surveillance of Mitochondrial DNA Integrity

Yiping Gu, Chunjie Wang, Chaim M. Roifman, and Amos Cohen
J Immunol 2003 170: 3603-3607. [Abstract] [Full Text] [PDF]  

Requirement of Species-Specific Interactions for the Activation of Human T Cells by Pamidronate

Yu Kato, Yoshimasa Tanaka, Hidenori Tanaka, Seiji Yamashita, and Nagahiro Minato
J Immunol 2003 170: 3608-3613. [Abstract] [Full Text] [PDF]  

The Molecular Basis for the Lack of Immunostimulatory Activity of Vertebrate DNA

Katryn J. Stacey, Greg R. Young, Francis Clark, David P. Sester, Tara L. Roberts, Shalin Naik, Matthew J. Sweet, and David A. Hume
J Immunol 2003 170: 3614-3620. [Abstract] [Full Text] [PDF]  

More Is Not Necessarily Better: Prozone-Like Effects in Passive Immunization with IgG

Carlos P. Taborda, Johanna Rivera, Oscar Zaragoza, and Arturo Casadevall
J Immunol 2003 170: 3621-3630. [Abstract] [Full Text] [PDF]  

Galectin-9 Induces Apoptosis Through the Calcium-Calpain-Caspase-1 Pathway

Yumiko Kashio, Kazuhiro Nakamura, Mohammad J. Abedin, Masako Seki, Nozomu Nishi, Naoko Yoshida, Takanori Nakamura, and Mitsuomi Hirashima
J Immunol 2003 170: 3631-3636. [Abstract] [Full Text] [PDF]  

B7-H1 (Programmed Death-1 Ligand) on Dendritic Cells Is Involved in the Induction and Maintenance of T Cell Anergy

Nicole Selenko-Gebauer, Otto Majdic, Andreas Szekeres, Gerald Höfler, Elisabeth Guthann, Ulf Korthäuer, Gerhard Zlabinger, Peter Steinberger, Winfried F. Pickl, Hannes Stockinger, Walter Knapp, and Johannes Stöckl
J Immunol 2003 170: 3637-3644. [Abstract] [Full Text] [PDF]  

TGF1 Inhibits Ca²⁺-Calcineurin-Mediated Activation in Thymocytes

Ramireddy Bommireddy, Ilona Ormsby, Moying Yin, Gregory P. Boivin, George F. Babcock, and Thomas Doetschman
J Immunol 2003 170: 3645-3652. [Abstract] [Full Text] [PDF]  

SS-A/Ro52, an Autoantigen Involved in CD28-Mediated IL-2 Production

Tomonori Ishii, Kei Ohnuma, Akikazu Murakami, Naruhiko Takasawa, Tadanori Yamochi, Satoshi Iwata, Masahiko Uchiyama, Nam H. Dang, Hirotoshi Tanaka, and Chikao Morimoto
J Immunol 2003 170: 3653-3661. [Abstract] [Full Text] [PDF]  

Sphingosine-1-Phosphate Receptor Agonism Impairs the Efficiency of the Local Immune Response by Altering Trafficking of Naive and Antigen-Activated CD4⁺ T Cells

Jenny H. Xie, Naomi Nomura, Sam L. Koprak, Elizabeth J. Quackenbush, Michael J. Forrest, and Hugh Rosen
J Immunol 2003 170: 3662-3670. [Abstract] [Full Text] [PDF]  

B Cell Complement Receptor 2 Transfer Reaction

Margaret A. Lindorfer, Hasmig B. Jinivizian, Patricia L. Foley, Adam D. Kennedy, Michael D. Solga, and Ronald P. Taylor
J Immunol 2003 170: 3671-3678. [Abstract] [Full Text] [PDF]  

The Possible Role of TGF--Induced Suppressors of Cytokine Signaling Expression in Osteoclast/Macrophage Lineage Commitment In Vitro

Simon W. Fox, S. Jaharul Haque, Alison C. Lovibond, and Timothy J. Chambers
J Immunol 2003 170: 3679-3687. [Abstract] [Full Text] [PDF]  

Lipopolysaccharide Promotes the Survival of Osteoclasts Via Toll-Like Receptor 4, but Cytokine Production of Osteoclasts in Response to Lipopolysaccharide Is Different from That of Macrophages

Kanami Itoh, Nobuyuki Udagawa, Kanichiro Kobayashi, Koji Suda, Xiaotong Li, Masamichi Takami, Nobuo Okahashi, Tatsuji Nishihara, and Naoyuki Takahashi
J Immunol 2003 170: 3688-3695. [Abstract] [Full Text] [PDF]  

Conservation of Nonpeptide Antigen Recognition by Rhesus Monkey V2V2 T Cells

Hong Wang, Hoi K. Lee, Jack F. Bukowski, Hongmin Li, Roy A. Mariuzza, Zheng W. Chen, Ki-Hoan Nam, and Craig T. Morita
J Immunol 2003 170: 3696-3706. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

ATM Is Not Required in Somatic Hypermutation of V_H, but Is Involved in the Introduction of Mutations in the Switch µ Region

Qiang Pan-Hammarström, Shujing Dai, Yaofeng Zhao, Iris F. van Dijk-Härd, Richard A. Gatti, Anne-Lise Børresen-Dale, and Lennart Hammarström
J Immunol 2003 170: 3707-3716. [Abstract] [Full Text] [PDF] Data Supplement  

Transactivation of gp130 in Myeloma Cells

Jena D. French, Denise K. Walters, and Diane F. Jelinek
J Immunol 2003 170: 3717-3723. [Abstract] [Full Text] [PDF]  

c-Rel Is Required for Chromatin Remodeling Across the IL-2 Gene Promoter

Sudha Rao, Steve Gerondakis, Donna Woltring, and M. Frances Shannon
J Immunol 2003 170: 3724-3731. [Abstract] [Full Text] [PDF]  

Regulation of the Human FcRI -Chain Distal Promoter

Masanari Hasegawa, Chiharu Nishiyama, Makoto Nishiyama, Yushiro Akizawa, Kyoko Takahashi, Tomonobu Ito, Susumu Furukawa, Chisei Ra, Ko Okumura, and Hideoki Ogawa
J Immunol 2003 170: 3732-3738. [Abstract] [Full Text] [PDF]  

A New Model of Sheep Ig Diversification: Shifting the Emphasis Toward Combinatorial Mechanisms and Away from Hypermutation

Craig N. Jenne, Laurie J. Kennedy, Peter McCullagh, and John D. Reynolds
J Immunol 2003 170: 3739-3750. [Abstract] [Full Text] [PDF]  

DM Loss in k Haplotype Mice Reveals Isotype-Specific Chaperone Requirements

Chad H. Koonce, Gordana Wutz, Elizabeth J. Robertson, Anne B. Vogt, Harald Kropshofer, and Elizabeth K. Bikoff
J Immunol 2003 170: 3751-3761. [Abstract] [Full Text] [PDF]  

Actin Tyrosine Dephosphorylation by the Src Homology 1-Containing Protein Tyrosine Phosphatase Is Essential for Actin Depolymerization After Membrane IgM Cross-Linking

Takeshi Baba, Noemi Fusaki, Nobuko Shinya, Akihiro Iwamatsu, and Nobumichi Hozumi
J Immunol 2003 170: 3762-3768. [Abstract] [Full Text] [PDF]  

Investigation of Early Events in FcRI-Mediated Signaling Using a Detailed Mathematical Model

James R. Faeder, William S. Hlavacek, Ilona Reischl, Michael L. Blinov, Henry Metzger, Antonio Redondo, Carla Wofsy, and Byron Goldstein
J Immunol 2003 170: 3769-3781. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Depletion of Neutrophils in IL-10^-/- Mice Delays Clearance of Gastric Helicobacter Infection and Decreases the Th1 Immune Response to Helicobacter

Hanan F. Ismail, Pamela Fick, Juan Zhang, Richard G. Lynch, and Daniel J. Berg
J Immunol 2003 170: 3782-3789. [Abstract] [Full Text] [PDF]  

The Hypervariable Region of Anaplasma marginale Major Surface Protein 2 (MSP2) Contains Multiple Immunodominant CD4⁺ T Lymphocyte Epitopes That Elicit Variant-Specific Proliferative and IFN- Responses in MSP2 Vaccinates

Wendy C. Brown, Kelly A. Brayton, Cathryn M. Styer, and Guy H. Palmer
J Immunol 2003 170: 3790-3798. [Abstract] [Full Text] [PDF]  

A Common Mucosal Chemokine (Mucosae-Associated Epithelial Chemokine/CCL28) Selectively Attracts IgA Plasmablasts

Nicole H. Lazarus, Eric J. Kunkel, Brent Johnston, Eric Wilson, Kenneth R. Youngman, and Eugene C. Butcher
J Immunol 2003 170: 3799-3805. [Abstract] [Full Text] [PDF]  

Tumor-Derived TGF- Reduces the Efficacy of Dendritic Cell/Tumor Fusion Vaccine

John Y. Kao, Yusong Gong, Chuan-Min Chen, Qiong-Duan Zheng, and Jian-Jun Chen
J Immunol 2003 170: 3806-3811. [Abstract] [Full Text] [PDF]  

A Role for Triggering Receptor Expressed on Myeloid Cells-1 in Host Defense During the Early-Induced and Adaptive Phases of the Immune Response

Joshua R. Bleharski, Viviane Kiessler, Cecilia Buonsanti, Peter A. Sieling, Steffen Stenger, Marco Colonna, and Robert L. Modlin
J Immunol 2003 170: 3812-3818. [Abstract] [Full Text] [PDF]  

The Resolution of Relapsing Fever Borreliosis Requires IgM and Is Concurrent with Expansion of B1b Lymphocytes

Kishore R. Alugupalli, Rachel M. Gerstein, Jianzhu Chen, Eva Szomolanyi-Tsuda, Robert T. Woodland, and John M. Leong
J Immunol 2003 170: 3819-3827. [Abstract] [Full Text] [PDF]  

Differential -Herpesvirus Distribution in Distinct Anatomical Locations and Cell Subsets During Persistent Infection in Mice

Emilio Flaño, In-Jeong Kim, John Moore, David L. Woodland, and Marcia A. Blackman
J Immunol 2003 170: 3828-3834. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

IL-4 Exacerbates Anaphylaxis

Richard T. Strait, Suzanne C. Morris, Kristi Smiley, Joseph F. Urban, Jr., and Fred D. Finkelman
J Immunol 2003 170: 3835-3842. [Abstract] [Full Text] [PDF]  

Unique Regulation of CCL18 Production by Maturing Dendritic Cells

Marisa Vulcano, Sofie Struyf, Patrizia Scapini, Marco Cassatella, Sergio Bernasconi, Raffaella Bonecchi, Angelica Calleri, Giuseppe Penna, Luciano Adorini, Walter Luini, Alberto Mantovani, Jo Van Damme, and Silvano Sozzani
J Immunol 2003 170: 3843-3849. [Abstract] [Full Text] [PDF]  

The Extracellular Matrix and Cytokines Regulate Microglial Integrin Expression and Activation

Richard Milner and Iain L. Campbell
J Immunol 2003 170: 3850-3858. [Abstract] [Full Text] [PDF]  

STAT4 Signal Pathways Regulate Inflammation and Airway Physiology Changes in Allergic Airway Inflammation Locally Via Alteration of Chemokines

Kavita Raman, Mark H. Kaplan, Cory M. Hogaboam, Aaron Berlin, and Nicholas W. Lukacs
J Immunol 2003 170: 3859-3865. [Abstract] [Full Text] [PDF]  

Modulation of Cutaneous Inflammation by Angiotensin-Converting Enzyme

Thomas E. Scholzen, Sonja Ständer, Helge Riemann, Thomas Brzoska, and Thomas A. Luger
J Immunol 2003 170: 3866-3873. [Abstract] [Full Text] [PDF]  

Sodium Phenylacetate Inhibits Adoptive Transfer of Experimental Allergic Encephalomyelitis in SJL/J Mice at Multiple Steps

Subhajit Dasgupta, You Zhou, Malabendu Jana, Naren L. Banik, and Kalipada Pahan
J Immunol 2003 170: 3874-3882. [Abstract] [Full Text] [PDF]  

Complement Factor C5a Mediates Renal Ischemia-Reperfusion Injury Independent from Neutrophils

Bart de Vries, Jörg Köhl, Wouter K. G. Leclercq, Tim G. A. M. Wolfs, Annemarie A. J. H. M. van Bijnen, Peter Heeringa, and Wim A. Buurman
J Immunol 2003 170: 3883-3889. [Abstract] [Full Text] [PDF]  

IFN- Induces High Mobility Group Box 1 Protein Release Partly Through a TNF-Dependent Mechanism

Beatriz Rendon-Mitchell, Mahendar Ochani, Jianhua Li, Jialian Han, Hong Wang, Huan Yang, Seenu Susarla, Christopher Czura, Robert A. Mitchell, Guoqian Chen, Andrew E. Sama, Kevin J. Tracey, and Haichao Wang
J Immunol 2003 170: 3890-3897. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Intranasal Immunotherapy Is More Effective Than Intradermal Immunotherapy for the Induction of Airway Allergen Tolerance in Th2-Sensitized Mice

Kenji Takabayashi, Lev Libet, Dugald Chisholm, Jose Zubeldia, and Anthony A. Horner
J Immunol 2003 170: 3898-3905. [Abstract] [Full Text] [PDF]  

Viremia Control Despite Escape from a Rapid and Potent Autologous Neutralizing Antibody Response After Therapy Cessation in an HIV-1-Infected Individual

David C. Montefiori, Marcus Altfeld, Paul K. Lee, Miroslawa Bilska, Jintao Zhou, Mary N. Johnston, Feng Gao, Bruce D. Walker, and Eric S. Rosenberg
J Immunol 2003 170: 3906-3914. [Abstract] [Full Text] [PDF]  

IL-12 Deficiency in MRL-Fas^lpr Mice Delays Nephritis and Intrarenal IFN- Expression, and Diminishes Systemic Pathology

Eriya Kikawada, Deborah M. Lenda, and Vicki R. Kelley
J Immunol 2003 170: 3915-3925. [Abstract] [Full Text] [PDF]  

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