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On the Cover: Cooperation of Vav1 with Rac to induce T cell spreading after integrin occupancy does not require Vav1 GEF activity. Jurkat cells contransfected with constitutively active V12Rac and Vav1 mutant lacking GEF activity show that Vav1 can regulate the actin cytoskeleton independently of its GEF activity. del Pozo et al. Guanine exchange-dependent and independent effects of Vav-1 on intergrin-induced T cell spreading. J. Immunol. 170:41.)
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