CUTTING EDGE:

Cutting Edge: Targeted Ligation of CTLA-4 In Vivo by Membrane-Bound Anti-CTLA-4 Antibody Prevents Rejection of Allogeneic Cells

Kwang Woo Hwang, William B. Sweatt, Ian E. Brown, Christian Blank, Thomas F. Gajewski, Jeffrey A. Bluestone, and Maria-Luisa Alegre
J Immunol 2002 169: 633-637. [Abstract] [Full Text] [PDF]  

Cutting Edge: CCR7⁺ and CCR7^- Memory T Cells Do Not Differ in Immediate Effector Cell Function

Heike Unsoeld, Stefan Krautwald, David Voehringer, Ulrich Kunzendorf, and Hanspeter Pircher
J Immunol 2002 169: 638-641. [Abstract] [Full Text] [PDF]  

Cutting Edge: IL-17D, a Novel Member of the IL-17 Family, Stimulates Cytokine Production and Inhibits Hemopoiesis

Trevor Starnes, Hal E. Broxmeyer, Michael J. Robertson, and Robert Hromas
J Immunol 2002 169: 642-646. [Abstract] [Full Text] [PDF]  

Cutting Edge: Changes in Histone Acetylation at the IL-4 and IFN- Loci Accompany Th1/Th2 Differentiation

Patrick E. Fields, Sean T. Kim, and Richard A. Flavell
J Immunol 2002 169: 647-650. [Abstract] [Full Text] [PDF]  

Cutting Edge: Th2 Cell Trafficking into the Allergic Lung Is Dependent on Chemoattractant Receptor Signaling

Anuja Mathew, Benjamin D. Medoff, Andrew D. Carafone, and Andrew D. Luster
J Immunol 2002 169: 651-655. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Endothelial Cell Apoptosis Induced by Antibodies Against Dengue Virus Nonstructural Protein 1 Via Production of Nitric Oxide

Chiou-Feng Lin, Huan-Yao Lei, Ai-Li Shiau, Hsiao-Sheng Liu, Trai-Ming Yeh, Shun-Hua Chen, Ching-Chuan Liu, Shu-Chen Chiu, and Yee-Shin Lin
J Immunol 2002 169: 657-664. [Abstract] [Full Text] [PDF]  

Suppressive Effect of Glutamic Acid Decarboxylase 65-Specific Autoimmune B Lymphocytes on Processing of T Cell Determinants Located Within the Antibody Epitope

Juan Carlos Jaume, Sarah Louise Parry, Anne-Marie Madec, Grete Sønderstrup, and Steinunn Baekkeskov
J Immunol 2002 169: 665-672. [Abstract] [Full Text] [PDF]  

A Soluble Isoform of the Rhesus Monkey Nonclassical MHC Class I Molecule Mamu-AG Is Expressed in the Placenta and the Testis

Andy F. Ryan, Richard L. Grendell, Daniel E. Geraghty, and Thaddeus G. Golos
J Immunol 2002 169: 673-683. [Abstract] [Full Text] [PDF]  

Thymic and Extrathymic T Cell Development Pathways Follow Different Rules

Rafik Terra, Nathalie Labrecque, and Claude Perreault
J Immunol 2002 169: 684-692. [Abstract] [Full Text] [PDF]  

CD94/NKG2 Expression Does Not Inhibit Cytotoxic Function of Lymphocytic Choriomeningitis Virus-Specific CD8⁺ T Cells

Joseph D. Miller, Michael Peters, Alp E. Oran, Guy W. Beresford, Laurie Harrington, Jeremy M. Boss, and John D. Altman
J Immunol 2002 169: 693-701. [Abstract] [Full Text] [PDF]  

Phagocytosis of Apoptotic Cells by Macrophages Induces Novel Signaling Events Leading to Cytokine-Independent Survival and Inhibition of Proliferation: Activation of Akt and Inhibition of Extracellular Signal-Regulated Kinases 1 and 2

Suman M. Reddy, K.-H. Kevin Hsiao, Vivian Elizabeth Abernethy, Hanli Fan, Angelika Longacre, Wilfred Lieberthal, Joyce Rauch, Jason S. Koh, and Jerrold S. Levine
J Immunol 2002 169: 702-713. [Abstract] [Full Text] [PDF]  

The Homeostasis But Not the Differentiation of T Cells Is Regulated by p27^Kip1

Randy Shen and Mark H. Kaplan
J Immunol 2002 169: 714-721. [Abstract] [Full Text] [PDF]  

Induction of CD4 T Cell Changes in Murine AIDS Is Dependent on Costimulation and Involves a Dysregulation of Homeostasis

Michael H. Yen, Nancy Lepak, and Susan L. Swain
J Immunol 2002 169: 722-731. [Abstract] [Full Text] [PDF]  

Regulation of Retinoid X Receptor Responsive Element-Dependent Transcription in T Lymphocytes by Ser/Thr Phosphatases: Functional Divergence of Protein Kinase C (PKC) and PKC in Mediating Calcineurin-Induced Transactivation

Mohammad Ishaq, Ming Fan, Kip Wigmore, Arunasri Gaddam, and Ven Natarajan
J Immunol 2002 169: 732-738. [Abstract] [Full Text] [PDF]  

The Majority of Immunogenic Epitopes Generate CD4⁺ T Cells That Are Dependent on MHC Class II-Bound Peptide-Flanking Residues

Paula Y. Arnold, Nicole L. La Gruta, Tim Miller, Kate M. Vignali, P. Scott Adams, David L. Woodland, and Dario A. A. Vignali
J Immunol 2002 169: 739-749. [Abstract] [Full Text] [PDF]  

Modulation of Fas-Dependent Apoptosis: A Dynamic Process Controlling Both the Persistence and Death of CD4 Regulatory T Cells and Effector T Cells

Alice Banz, Christiane Pontoux, and Martine Papiernik
J Immunol 2002 169: 750-757. [Abstract] [Full Text] [PDF]  

The B Cell Antigen Receptor Regulates the Transcriptional Activator -Catenin Via Protein Kinase C-Mediated Inhibition of Glycogen Synthase Kinase-3

Sherri L. Christian, Peter V. Sims, and Michael R. Gold
J Immunol 2002 169: 758-769. [Abstract] [Full Text] [PDF]  

Platelet Factor 4 Inhibits Proliferation and Cytokine Release of Activated Human T Cells

Jens Fleischer, Evelin Grage-Griebenow, Brigitte Kasper, Holger Heine, Martin Ernst, Ernst Brandt, Hans-Dieter Flad, and Frank Petersen
J Immunol 2002 169: 770-777. [Abstract] [Full Text] [PDF]  

Src Homology Region 2 Domain-Containing Phosphatase 1 Positively Regulates B Cell Receptor-Induced Apoptosis by Modulating Association of B Cell Linker Protein with Nck and Activation of c-Jun NH₂-Terminal Kinase

Kazuya Mizuno, Yuko Tagawa, Katsuyuki Mitomo, Noriyuki Watanabe, Tatsuo Katagiri, Mami Ogimoto, and Hidetaka Yakura
J Immunol 2002 169: 778-786. [Abstract] [Full Text] [PDF]  

B Cells Capturing Antigen Conjugated with CpG Oligodeoxynucleotides Induce Th1 Cells by Elaborating IL-12

Hidekazu Shirota, Kunio Sano, Noriyasu Hirasawa, Tadashi Terui, Kazuo Ohuchi, Toshio Hattori, and Gen Tamura
J Immunol 2002 169: 787-794. [Abstract] [Full Text] [PDF]  

Rapid Chromatin Remodeling of Toll-Like Receptor 2 Promoter During Infection of Macrophages with Mycobacterium avium

Tianyi Wang, William P. Lafuse, Kiyoshi Takeda, Shizuo Akira, and Bruce S. Zwilling
J Immunol 2002 169: 795-801. [Abstract] [Full Text] [PDF]  

Inhibition of Antigen-Specific T Cell Proliferation and Cytokine Production by Protein Kinase A Type I

Einar Martin Aandahl, Walter J. Moretto, Patrick A. Haslett, Torkel Vang, Tone Bryn, Kjetil Tasken, and Douglas F. Nixon
J Immunol 2002 169: 802-808. [Abstract] [Full Text] [PDF]  

Tumor-Infiltrating CD4⁺ T Lymphocytes Express APO2 Ligand (APO2L)/TRAIL upon Specific Stimulation with Autologous Lung Carcinoma Cells: Role of IFN- on APO2L/TRAIL Expression and -Mediated Cytotoxicity

Guillaume Dorothée, Isabelle Vergnon, Jeanne Menez, Hamid Echchakir, Dominique Grunenwald, Marek Kubin, Salem Chouaib, and Fathia Mami-Chouaib
J Immunol 2002 169: 809-817. [Abstract] [Full Text] [PDF]  

Effect of Environmental Antigens on the Ig Diversification and the Selection of Productive V-J Joints in the Bursa

Hiroshi Arakawa, Kei-ichi Kuma, Masahiro Yasuda, Shigeo Ekino, Akira Shimizu, and Hideo Yamagishi
J Immunol 2002 169: 818-828. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

A Putative Silencer Element in the IL-5 Gene Recognized by Bcl6

Masafumi Arima, Hirochika Toyama, Hirohito Ichii, Satoko Kojima, Seiji Okada, Masahiko Hatano, Gang Cheng, Masato Kubo, Takeshi Fukuda, and Takeshi Tokuhisa
J Immunol 2002 169: 829-836. [Abstract] [Full Text] [PDF]  

Immunogenically Fit Subunit Vaccine Components Via Epitope Discovery from Natural Peptide Libraries

Leslie J. Matthews, Robert Davis, and George P. Smith
J Immunol 2002 169: 837-846. [Abstract] [Full Text] [PDF]  

IFN- Pretreatment Sensitizes Human Melanoma Cells to TRAIL/Apo2 Ligand-Induced Apoptosis

Mamta Chawla-Sarkar, Douglas W. Leaman, Barbara S. Jacobs, and Ernest C. Borden
J Immunol 2002 169: 847-855. [Abstract] [Full Text] [PDF]  

Bivalent Ligands with Rigid Double-Stranded DNA Spacers Reveal Structural Constraints on Signaling by FcRI

Jodi M. Paar, Nancie T. Harris, David Holowka, and Barbara Baird
J Immunol 2002 169: 856-864. [Abstract] [Full Text] [PDF]  

B Cell Progenitors Are Arrested in Maturation but Have Intact VDJ Recombination in the Absence of Ig- and Ig-

Roberta Pelanda, Uschi Braun, Elias Hobeika, Michel C. Nussenzweig, and Michael Reth
J Immunol 2002 169: 865-872. [Abstract] [Full Text] [PDF]  

Characterization of Chromatin Structure and Enhancer Elements for Murine Recombination Activating Gene-2

Xing-Cheng Wei, Hiroyuki Kishi, Zhe-Xiong Jin, Wen-Pu Zhao, Sachiko Kondo, Tadashi Matsuda, Shigeru Saito, and Atsushi Muraguchi
J Immunol 2002 169: 873-881. [Abstract] [Full Text] [PDF]  

Protein Structure Plays a Critical Role in Peanut Allergen Stability and May Determine Immunodominant IgE-Binding Epitopes

Moon Sen, Randall Kopper, Laurent Pons, Edathara C. Abraham, A. Wesley Burks, and Gary A. Bannon
J Immunol 2002 169: 882-887. [Abstract] [Full Text] [PDF]  

The Primary Antibody Repertoire Represents a Linked Network of Degenerate Antigen Specificities

Venkatasamy Manivel, Fahri Bayiroglu, Zaved Siddiqui, Dinakar M. Salunke, and Kanury V. S. Rao
J Immunol 2002 169: 888-897. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Inhibition of the Spontaneous Apoptosis of Neutrophil Granulocytes by the Intracellular Parasite Leishmania major

Eresso Aga, Dörthe M. Katschinski, Ger van Zandbergen, Helmut Laufs, Birgit Hansen, Kerstin Müller, Werner Solbach, and Tamás Laskay
J Immunol 2002 169: 898-905. [Abstract] [Full Text] [PDF]  

Antigen Presentation by CD1d Contributes to the Amplification of Th2 Responses to Schistosoma mansoni Glycoconjugates in Mice

Christelle Faveeuw, Véronique Angeli, Josette Fontaine, Charles Maliszewski, André Capron, Luc Van Kaer, Muriel Moser, Monique Capron, and François Trottein
J Immunol 2002 169: 906-912. [Abstract] [Full Text] [PDF]  

Production of Granulocyte Colony-Stimulating Factor in the Nonspecific Acute Phase Response Enhances Host Resistance to Bacterial Infection

Mahdad Noursadeghi, Maria C. M. Bickerstaff, Jeff Herbert, David Moyes, Jonathan Cohen, and Mark B. Pepys
J Immunol 2002 169: 913-919. [Abstract] [Full Text] [PDF]  

Human Neutrophil-Expressed CD28 Interacts with Macrophage B7 to Induce Phosphatidylinositol 3-Kinase-Dependent IFN- Secretion and Restriction of Leishmania Growth

K. Venuprasad, Pinaki P. Banerjee, Subhasis Chattopadhyay, Satyan Sharma, Subrata Pal, P. B. Parab, Debashis Mitra, and Bhaskar Saha
J Immunol 2002 169: 920-928. [Abstract] [Full Text] [PDF]  

Cytokine Regulation of Periportal Fibrosis in Humans Infected with Schistosoma mansoni: IFN- Is Associated with Protection Against Fibrosis and TNF- with Aggravation of Disease

Sandrine Henri, Christophe Chevillard, Adil Mergani, Patricia Paris, Jean Gaudart, Christophe Camilla, Hélia Dessein, Felix Montero, Nasr-Eldin M. A. Elwali, Osman K. Saeed, Mubarak Magzoub, and Alain J. Dessein
J Immunol 2002 169: 929-936. [Abstract] [Full Text] [PDF]  

A Role for Inducible Costimulator Protein in the CD28- Independent Mechanism of Resistance to Toxoplasma gondii

Eric N. Villegas, Linda A. Lieberman, Nicola Mason, Sarah L. Blass, Valerie P. Zediak, Robert Peach, Tom Horan, Steve Yoshinaga, and Christopher A. Hunter
J Immunol 2002 169: 937-943. [Abstract] [Full Text] [PDF]  

Identification of T Cell Epitopes on the 33-kDa Fragment of Plasmodium yoelii Merozoite Surface Protein 1 and Their Antibody-Independent Protective Role in Immunity to Blood Stage Malaria

Jiraprapa Wipasa, Chakrit Hirunpetcharat, Yuvadee Mahakunkijcharoen, Huji Xu, Salenna Elliott, and Michael F. Good
J Immunol 2002 169: 944-951. [Abstract] [Full Text] [PDF]  

Segregation of B and T Cell Epitopes of Treponema pallidum Repeat Protein K to Variable and Conserved Regions During Experimental Syphilis Infection

Cecilia A. Morgan, Barbara J. Molini, Sheila A. Lukehart, and Wesley C. Van Voorhis
J Immunol 2002 169: 952-957. [Abstract] [Full Text] [PDF]  

Heat Shock Protein 70 Is a Potential Virulence Factor in Murine Toxoplasma Infection Via Immunomodulation of Host NF-B and Nitric Oxide

Caroline A. Dobbin, Nicholas C. Smith, and Alan M. Johnson
J Immunol 2002 169: 958-965. [Abstract] [Full Text] [PDF]  

In Vitro Correlates of L^d-Restricted Resistance to Toxoplasmic Encephalitis and Their Critical Dependence on Parasite Strain

Jennifer J. Johnson, Craig W. Roberts, Constance Pope, Fiona Roberts, Michael J. Kirisits, Randee Estes, Ernest Mui, Tim Krieger, Charles R. Brown, Jim Forman, and Rima McLeod
J Immunol 2002 169: 966-973. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Differential Effects of Ebselen on Neutrophil Recruitment, Chemokine, and Inflammatory Mediator Expression in a Rat Model of Lipopolysaccharide-Induced Pulmonary Inflammation

El-Bdaoui Haddad, Kerryn McCluskie, Mark A. Birrell, Dominika Dabrowski, Michela Pecoraro, Steve Underwood, Bei Chen, George T. De Sanctis, Steve E. Webber, Martyn L. Foster, and Maria G. Belvisi
J Immunol 2002 169: 974-982. [Abstract] [Full Text] [PDF]  

Vascular Adhesion Protein-1 Mediates Adhesion and Transmigration of Lymphocytes on Human Hepatic Endothelial Cells

Patricia F. Lalor, Sarah Edwards, Gillian McNab, Marko Salmi, Sirpa Jalkanen, and David H. Adams
J Immunol 2002 169: 983-992. [Abstract] [Full Text] [PDF]  

Immobilized Lactoferrin Is a Stimulus for Eosinophil Activation

Larry L. Thomas, Wei Xu, and Tamir T. Ardon
J Immunol 2002 169: 993-999. [Abstract] [Full Text] [PDF]  

Overlapping Roles of P-Selectin and ₄ Integrin to Recruit Leukocytes to the Central Nervous System in Experimental Autoimmune Encephalomyelitis

Steven M. Kerfoot and Paul Kubes
J Immunol 2002 169: 1000-1006. [Abstract] [Full Text] [PDF]  

Intercellular Adhesion Molecule (ICAM)-1, But Not ICAM-2, Activates RhoA and Stimulates c-fos and rhoA Transcription in Endothelial Cells

Paul W. Thompson, Anna M. Randi, and Anne J. Ridley
J Immunol 2002 169: 1007-1013. [Abstract] [Full Text] [PDF]  

Mast Cell Chymase Modifies Cell-Matrix Interactions and Inhibits Mitogen-Induced Proliferation of Human Airway Smooth Muscle Cells

Aili L. Lazaar, Michael I. Plotnick, Umberto Kucich, Irene Crichton, Shidan Lotfi, Susan K. P. Das, Sibyl Kane, Joel Rosenbloom, Reynold A. Panettieri, Jr., Norman M. Schechter, and Ellen Puré
J Immunol 2002 169: 1014-1020. [Abstract] [Full Text] [PDF]  

Eosinophils Express Functional IL-13 in Eosinophilic Inflammatory Diseases

Peter Schmid-Grendelmeier, Frank Altznauer, Barbra Fischer, Christian Bizer, Alex Straumann, Günter Menz, Kurt Blaser, Brunello Wüthrich, and Hans-Uwe Simon
J Immunol 2002 169: 1021-1027. [Abstract] [Full Text] [PDF]  

Inhibition of Allergic Inflammation in the Airways Using Aerosolized Antisense to Syk Kinase

Grant R. Stenton, Marina Ulanova, René E. Déry, Shaheed Merani, Moo-Kyung Kim, Mark Gilchrist, Lakshmi Puttagunta, Sorin Musat-Marcu, Deborah James, Alan D. Schreiber, and A. Dean Befus
J Immunol 2002 169: 1028-1036. [Abstract] [Full Text] [PDF]  

Critical Role for CXCR3 Chemokine Biology in the Pathogenesis of Bronchiolitis Obliterans Syndrome

John A. Belperio, Michael P. Keane, Marie D. Burdick, Joseph P. Lynch, III, Ying Ying Xue, Kewang Li, David J. Ross, and Robert M. Strieter
J Immunol 2002 169: 1037-1049. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Prevention and Induction of Autoimmune Exocrinopathy Is Dependent on Pathogenic Autoantigen Cleavage in Murine Sjögren’s Syndrome

Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi, Kenji Mishima, Rieko Arakaki, Takashi Suda, Ichiro Saito, and Yoshio Hayashi
J Immunol 2002 169: 1050-1057. [Abstract] [Full Text] [PDF]  

Autocrine Production of IFN- by Macrophages Controls Their Recruitment to Kidney and the Development of Glomerulonephritis in MRL/lpr Mice

Carla E. Carvalho-Pinto, María I. García, Mario Mellado, J. Miguel Rodríguez-Frade, Juan Martín-Caballero, Juana Flores, Carlos Martínez-A, and Dimitrios Balomenos
J Immunol 2002 169: 1058-1067. [Abstract] [Full Text] [PDF]  

Characterization of Autoreactive T Cells to the Autoantigens Heterogeneous Nuclear Ribonucleoprotein A2 (RA33) and Filaggrin in Patients with Rheumatoid Arthritis

Ruth Fritsch, Daniela Eselböck, Karl Skriner, Beatrice Jahn-Schmid, Clemens Scheinecker, Barbara Bohle, Makiyeh Tohidast-Akrad, Silvia Hayer, Josef Neumüller, Serafin Pinol-Roma, Josef S. Smolen, and Günter Steiner
J Immunol 2002 169: 1068-1076. [Abstract] [Full Text] [PDF]  

Resistance to Experimental Autoimmune Myasthenia Gravis in IL-6-Deficient Mice Is Associated with Reduced Germinal Center Formation and C3 Production

Caishu Deng, Elzbieta Goluszko, Erdem Tüzün, Huan Yang, and Premkumar Christadoss
J Immunol 2002 169: 1077-1083. [Abstract] [Full Text] [PDF]  

Late Pregnancy Suppresses Relapses in Experimental Autoimmune Encephalomyelitis: Evidence for a Suppressive Pregancy-Related Serum Factor

Annette Langer-Gould, Hideki Garren, Amy Slansky, Pedro J. Ruiz, and Lawrence Steinman
J Immunol 2002 169: 1084-1091. [Abstract] [Full Text] [PDF]  

Persistent Mitochondrial Hyperpolarization, Increased Reactive Oxygen Intermediate Production, and Cytoplasmic Alkalinization Characterize Altered IL-10 Signaling in Patients with Systemic Lupus Erythematosus

Peter Gergely, Jr., Brian Niland, Nick Gonchoroff, Rudolf Pullmann, Jr., Paul E. Phillips, and Andras Perl
J Immunol 2002 169: 1092-1101. [Abstract] [Full Text] [PDF]  

Large Scale Identification of Human Hepatocellular Carcinoma-Associated Antigens by Autoantibodies

Yu Wang, Ke-Jun Han, Xue-Wen Pang, Hilary A. Vaughan, Wei Qu, Xue-Yuan Dong, Ji-Run Peng, Hai-Tao Zhao, Jing-An Rui, Xi-Sheng Leng, Jonathan Cebon, Antony W. Burgess, and Wei-Feng Chen
J Immunol 2002 169: 1102-1109. [Abstract] [Full Text] [PDF]  

TCR-Like Human Antibodies Expressed on Human CTLs Mediate Antibody Affinity-Dependent Cytolytic Activity

Patrick Chames, Ralph A. Willemsen, Gertrudis Rojas, Detlef Dieckmann, Louise Rem, Gerold Schuler, Reinder L. Bolhuis, and Hennie R. Hoogenboom
J Immunol 2002 169: 1110-1118. [Abstract] [Full Text] [PDF]  

"Superhumanized" Antibodies: Reduction of Immunogenic Potential by Complementarity-Determining Region Grafting with Human Germline Sequences: Application to an Anti-CD28

Philip Tan, David A. Mitchell, Timothy N. Buss, Margaret A. Holmes, Claudio Anasetti, and Jefferson Foote
J Immunol 2002 169: 1119-1125. [Abstract] [Full Text] [PDF]  

Histone Peptide-Induced Nasal Tolerance: Suppression of Murine Lupus

Henry Yim Wu, Frank J. Ward, and Norman A. Staines
J Immunol 2002 169: 1126-1134. [Abstract] [Full Text] [PDF]  

ERRATA:

Letter of Retraction

H. Patrick McNeil, Carolyn L. Geczy, and Jason A. Harmer
J Immunol 2002 169: 1135. [Full Text] [PDF]  

Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines

Kol A. Zarember and Paul J. Godowski
J Immunol 2002 169: 1136. [Full Text] [PDF]  

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