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On the Cover: Tie2-tmTNF-transgenic mice are protected from Con A-induced DNA damage in the liver. Confocal laser imaging of double-immunofluorescent TUNEL (green)- and PECAM-1 (red)-stained liver sections of Con A-treated (20 mg/kg) wild-type mice (B) and tie2-tmTNF-transgenic mice (C). A, DNase I treatment (positive control). Arrows point to TUNEL-positive endothelial cells (yellow). Quantification of TUNEL-positive endothelial cells revealed (±SD): wild-type, untreated, 1.8 ± 1.2 cells/mm2; wild-type, 8 h Con A, 17.1 ± 8.2 cells/mm2; tie2-tmTNF, untreated, 1.0 ± 1.0 cells/mm2; and tie2-tmTNF, 8 h Con A, 8.2 ± 4.1 cells/mm2. (Figure 6 from Willuweit, A., G. Sass, A. Schöneberg, U. Eisel, G. Tiegs, and M. Clauss. Chronic inflammation and protection from acute hepatitis in transgenic mice expressing TNF in endothelial cells. J. Immunol. 167:3944.)
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