CUTTING EDGE:

Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8^- Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8⁺ Dendritic Cells

Joanne L. Pooley, William R. Heath, and Ken Shortman
J Immunol 2001 166: 5327-5330. [Abstract] [Full Text] [PDF]  

Cutting Edge: Distinct Motifs Within CD28 Regulate T Cell Proliferation and Induction of Bcl-X_L

John S. Burr, Nigel D. L. Savage, Grace E. Messah, Stephanie L. Kimzey, Andrey S. Shaw, Robert H. Arch, and Jonathan M. Green
J Immunol 2001 166: 5331-5335. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

The Role of NF-B in TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis of Melanoma Cells

Agustin V. Franco, Xu Dong Zhang, Elisabeth Van Berkel, Jayne E. Sanders, Xi Yi Zhang, Wayne D. Thomas, Tam Nguyen, and Peter Hersey
J Immunol 2001 166: 5337-5345. [Abstract] [Full Text] [PDF]  

Papillomavirus-Like Particles Induce Acute Activation of Dendritic Cells

Petra Lenz, Patricia M. Day, Yuk-Ying S. Pang, Stephan A. Frye, Peter N. Jensen, Douglas R. Lowy, and John T. Schiller
J Immunol 2001 166: 5346-5355. [Abstract] [Full Text] [PDF]  

Three-Cell Interactions in T Cell-Mediated Suppression? A Mathematical Analysis of Its Quantitative Implications

Kalet León, Rolando Peréz, Agustin Lage, and Jorge Carneiro
J Immunol 2001 166: 5356-5365. [Abstract] [Full Text] [PDF]  

Defined Flanking Spacers and Enhanced Proteolysis Is Essential for Eradication of Established Tumors by an Epitope String DNA Vaccine

Markwin P. Velders, Sanne Weijzen, Gretchen L. Eiben, Amira G. Elmishad, Peter-M. Kloetzel, Terry Higgins, Richard B. Ciccarelli, Mererid Evans, Stephen Man, Larry Smith, and W. Martin Kast
J Immunol 2001 166: 5366-5373. [Abstract] [Full Text] [PDF]  

Engineering of Macrophages to Produce IFN- in Response to Hypoxia

Luca Carta, Sandra Pastorino, Giovanni Melillo, Maria C. Bosco, Stefano Massazza, and Luigi Varesio
J Immunol 2001 166: 5374-5380. [Abstract] [Full Text] [PDF]  

HIV-1 gp120 Stimulates the Production of -Chemokines in Human Peripheral Blood Monocytes Through a CD4-Independent Mechanism

Laura Fantuzzi, Irene Canini, Filippo Belardelli, and Sandra Gessani
J Immunol 2001 166: 5381-5387. [Abstract] [Full Text] [PDF]  

Ceramide Inhibits Lipopolysaccharide-Mediated Nitric Oxide Synthase and Cyclooxygenase-2 Induction in Macrophages: Effects on Protein Kinases and Transcription Factors

Ya-Wen Hsu, Kwan-Hwa Chi, Wan-Chen Huang, and Wan-Wan Lin
J Immunol 2001 166: 5388-5397. [Abstract] [Full Text] [PDF]  

Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1⁺ Myeloid Cells

Dmitry I. Gabrilovich, Markwin P. Velders, Eduardo M. Sotomayor, and W. Martin Kast
J Immunol 2001 166: 5398-5406. [Abstract] [Full Text] [PDF]  

The Involvement of TNF--Related Apoptosis-Inducing Ligand in the Enhanced Cytotoxicity of IFN--Stimulated Human Dendritic Cells to Tumor Cells

Shuxun Liu, Yizhi Yu, Minghui Zhang, Wenya Wang, and Xuetao Cao
J Immunol 2001 166: 5407-5415. [Abstract] [Full Text] [PDF]  

Modulation of CD8⁺ T Cell Response to Antigen by the Levels of Self MHC Class I

Fabio R. Santori, Ivica Arsov, and Stanislav Vukmanovic
J Immunol 2001 166: 5416-5421. [Abstract] [Full Text] [PDF]  

META-Controlled env-Initiated Transcripts Encoding Superantigens of Murine Mtv29 and Mtv7 and Their Possible Role in B Cell Lymphomagenesis

Namita Sen, William J. Simmons, Rajan M. Thomas, Gregory Erianne, Da-Jun Zhang, Nelson S. Jaeggli, Ching Huang, Xiaozhong Xiong, Vincent K. Tsiagbe, Nicholas M. Ponzio, and G. Jeanette Thorbecke
J Immunol 2001 166: 5422-5429. [Abstract] [Full Text] [PDF]  

Antigen-Specific Primary Activation of CD8⁺ T Cells Within the Liver

Patrick Bertolino, David G. Bowen, Geoffrey W. McCaughan, and Barbara Fazekas de St. Groth
J Immunol 2001 166: 5430-5438. [Abstract] [Full Text] [PDF]  

The Mechanism of a Defective IFN- Response to Bacterial Toxins in an Atopic Dermatitis Model, NC/Nga Mice, and the Therapeutic Effect of IFN-, IL-12, or IL-18 on Dermatitis

Yoshiko Habu, Shuhji Seki, Eiji Takayama, Takashi Ohkawa, Yuji Koike, Katsunori Ami, Takashi Majima, and Hoshio Hiraide
J Immunol 2001 166: 5439-5447. [Abstract] [Full Text] [PDF]  

Differential Production of IL-12, IFN-, and IFN- by Mouse Dendritic Cell Subsets

Hubertus Hochrein, Ken Shortman, David Vremec, Bernadette Scott, Paul Hertzog, and Meredith O’Keeffe
J Immunol 2001 166: 5448-5455. [Abstract] [Full Text] [PDF]  

Distinct Autoreactive T Cell Responses to Native and Fragmented DNA Topoisomerase I: Influence of APC Type and IL-2

Timothy B. Oriss, Paul Q. Hu, and Timothy M. Wright
J Immunol 2001 166: 5456-5463. [Abstract] [Full Text] [PDF]  

Fine Tuning of TCR Signaling by CD5

Hala S. Azzam, Jan B. DeJarnette, Kun Huang, Rebecca Emmons, Cheung-Seog Park, Connie L. Sommers, Dalal El-Khoury, Elizabeth W. Shores, and Paul E. Love
J Immunol 2001 166: 5464-5472. [Abstract] [Full Text] [PDF]  

Prime-Boost Immunization with DNA Vaccine: Mucosal Route of Administration Changes the Rules

Seong Kug Eo, Malgorzata Gierynska, Amal Abou Kamar, and Barry T. Rouse
J Immunol 2001 166: 5473-5479. [Abstract] [Full Text] [PDF]  

CD150 Association with Either the SH2-Containing Inositol Phosphatase or the SH2-Containing Protein Tyrosine Phosphatase Is Regulated by the Adaptor Protein SH2D1A

Larysa M. Shlapatska, Svitlana V. Mikhalap, Anna G. Berdova, Oleksander M. Zelensky, Theodore J. Yun, Kim E. Nichols, Edward A. Clark, and Svetlana P. Sidorenko
J Immunol 2001 166: 5480-5487. [Abstract] [Full Text] [PDF]  

Quantitation of Lysozyme Peptides Bound to Class II MHC Molecules Indicates Very Large Differences in Levels of Presentation

Carlos Velazquez, Richard DiPaolo, and Emil R. Unanue
J Immunol 2001 166: 5488-5494. [Abstract] [Full Text] [PDF]  

Prolonged Exposure of T Cells to TNF Down-Regulates TCR and Expression of the TCR/CD3 Complex at the Cell Surface

Pia Isomäki, Manvinder Panesar, Alex Annenkov, Joanna M. Clark, Brian M. J. Foxwell, Yuti Chernajovsky, and Andrew P. Cope
J Immunol 2001 166: 5495-5507. [Abstract] [Full Text] [PDF]  

Essential Requirement of Antigen Presentation by Monocyte Lineage Cells for the Activation of Primary Human T Cells by Aminobisphosphonate Antigen

Fumi Miyagawa, Yoshimasa Tanaka, Seiji Yamashita, and Nagahiro Minato
J Immunol 2001 166: 5508-5514. [Abstract] [Full Text] [PDF]  

IL-12 Enhances CD8 T Cell Homeostatic Expansion

William C. Kieper, Martin Prlic, Clint S. Schmidt, Matthew F. Mescher, and Stephen C. Jameson
J Immunol 2001 166: 5515-5521. [Abstract] [Full Text] [PDF]  

Lymphocyte Lineages at Mucosal Effector Sites: Rat Salivary Glands

Nancy L. O’Sullivan, Cheryl A. Skandera, and Paul C. Montgomery
J Immunol 2001 166: 5522-5529. [Abstract] [Full Text] [PDF]  

IFN- and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells

Megan K. Levings, Romina Sangregorio, Francesca Galbiati, Stefania Squadrone, Rene de Waal Malefyt, and Maria-Grazia Roncarolo
J Immunol 2001 166: 5530-5539. [Abstract] [Full Text] [PDF]  

Differential Roles of Lck and Itk in T Cell Response to Antigen Recognition Revealed by Calcium Imaging and Electron Microscopy

Emmanuel Donnadieu, Valérie Lang, Georges Bismuth, Wilfried Ellmeier, Oreste Acuto, Frédérique Michel, and Alain Trautmann
J Immunol 2001 166: 5540-5549. [Abstract] [Full Text] [PDF] Supplemental data  

The Vasodilator-Stimulated Phosphoprotein Is Regulated by Cyclic GMP-Dependent Protein Kinase During Neutrophil Spreading

Donald W. Lawrence and Katherine B. Pryzwansky
J Immunol 2001 166: 5550-5556. [Abstract] [Full Text] [PDF]  

Tumor Progression Despite Efficient Tumor Antigen Cross-Presentation and Effective "Arming" of Tumor Antigen-Specific CTL

Delia J. Nelson, Sutapa Mukherjee, Christine Bundell, Scott Fisher, Deborah van Hagen, and Bruce Robinson
J Immunol 2001 166: 5557-5566. [Abstract] [Full Text] [PDF]  

CD24 Induces Apoptosis in Human B Cells Via the Glycolipid-Enriched Membrane Domains/Rafts-Mediated Signaling System

Toyo Suzuki, Nobutaka Kiyokawa, Tomoko Taguchi, Takaomi Sekino, Yohko U. Katagiri, and Junichiro Fujimoto
J Immunol 2001 166: 5567-5577. [Abstract] [Full Text] [PDF]  

Stimulatory Effects of B7-Related Protein-1 on Cellular and Humoral Immune Responses in Mice

Jane Guo, Marina Stolina, James V. Bready, Songmei Yin, Tom Horan, Steven K. Yoshinaga, and Giorgio Senaldi
J Immunol 2001 166: 5578-5584. [Abstract] [Full Text] [PDF]  

Fc Receptor Cross-Linking Causes Translocation of Phosphatidylinositol-Dependent Protein Kinase 1 and Protein Kinase B to MHC Class II Peptide-Loading-Like Compartments

Mark L. Lang, Li Shen, Hong Gao, William F. Cusack, Gillian A. Lang, and William F. Wade
J Immunol 2001 166: 5585-5593. [Abstract] [Full Text] [PDF]  

Neonatal Exposure to Antigen Induces a Defective CD40 Ligand Expression that Undermines Both IL-12 Production by APC and IL-2 Receptor Up-Regulation on Splenic T Cells and Perpetuates IFN--Dependent T Cell Anergy

Booki Min, Kevin L. Legge, J. Jeremiah Bell, Randal K. Gregg, Lequn Li, Jacque C. Caprio, and Habib Zaghouani
J Immunol 2001 166: 5594-5603. [Abstract] [Full Text] [PDF]  

Antigen Recognition and Immunomodulation by T Cells in Bovine Tuberculosis

Shelley G. Rhodes, R. Glyn Hewinson, and H. Martin Vordermeier
J Immunol 2001 166: 5604-5610. [Abstract] [Full Text] [PDF]  

Sanglifehrin A, a Novel Cyclophilin-Binding Immunosuppressant, Inhibits IL-2-Dependent T Cell Proliferation at the G₁ Phase of the Cell Cycle

Ling-Hua Zhang and Jun O. Liu
J Immunol 2001 166: 5611-5618. [Abstract] [Full Text] [PDF]  

IL-12 Antagonism Enhances Apoptotic Death of T Cells Within Hepatic Allografts from Flt3 Ligand-Treated Donors and Promotes Graft Acceptance

Wei Li, Lina Lu, Zhiliang Wang, Lianfu Wang, John J. Fung, Angus W. Thomson, and Shiguang Qian
J Immunol 2001 166: 5619-5628. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Epitope Mapping of Antibodies to the C-Terminal Region of the Integrin ₂ Subunit Reveals Regions that Become Exposed Upon Receptor Activation

Chafen Lu, Mazen Ferzly, Junichi Takagi, and Timothy A. Springer
J Immunol 2001 166: 5629-5637. [Abstract] [Full Text] [PDF]  

Mice Triallelic for the Ig Heavy Chain Locus: Implications for V_HDJ_H Recombination

Vasco Barreto, Tommaso Meo, and Ana Cumano
J Immunol 2001 166: 5638-5645. [Abstract] [Full Text] [PDF]  

Isoforms of Jun Kinase Are Differentially Expressed and Activated in Human Monocyte/Macrophage (THP-1) Cells

Stephen C. Dreskin, Gregory W. Thomas, Sara N. Dale, and Lynn E. Heasley
J Immunol 2001 166: 5646-5653. [Abstract] [Full Text] [PDF]  

ZAP-70 and SLP-76 Regulate Protein Kinase C- and NF-B Activation in Response to Engagement of CD3 and CD28

Thomas M. Herndon, Xiaochuan C. Shan, George C. Tsokos, and Ronald L. Wange
J Immunol 2001 166: 5654-5664. [Abstract] [Full Text] [PDF]  

Protein Kinase C- Participates in the Activation of Cyclic AMP-Responsive Element-Binding Protein and Its Subsequent Binding to the -180 Site of the IL-2 Promoter in Normal Human T Lymphocytes

Elena E. Solomou, Yuang-Taung Juang, and George C. Tsokos
J Immunol 2001 166: 5665-5674. [Abstract] [Full Text] [PDF]  

Cloning, Expression, and Function of BLAME, a Novel Member of the CD2 Family

Gillian A. Kingsbury, Lee Ann Feeney, Yuhua Nong, Susan A Calandra, Curran J. Murphy, Justin M. Corcoran, Yanjun Wang, Mercy R. Prabhu Das, Samantha J. Busfield, Christopher C. Fraser, and Jean Luc Villeval
J Immunol 2001 166: 5675-5680. [Abstract] [Full Text] [PDF]  

Uncoordinated HLA-D Gene Expression in a RFXANK-Defective Patient with MHC Class II Deficiency

Ana-Maria Lennon-Duménil, Mohamed-Ridha Barbouche, Jocelyn Vedrenne, Thomas Prod’Homme, Mohamed Béjaoui, Salma Ghariani, Dominique Charron, Marc Fellous, Koussay Dellagi, and Catherine Alcaïde-Loridan
J Immunol 2001 166: 5681-5687. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Endotoxin-Induced Maturation of MyD88-Deficient Dendritic Cells

Tsuneyasu Kaisho, Osamu Takeuchi, Taro Kawai, Katsuaki Hoshino, and Shizuo Akira
J Immunol 2001 166: 5688-5694. [Abstract] [Full Text] [PDF]  

Human Cytomegalovirus pp65- and Immediate Early 1 Antigen-Specific HLA Class I-Restricted Cytotoxic T Cell Responses Induced by Cross-Presentation of Viral Antigens

Zsuzsanna Tabi, Magdalena Moutaftsi, and Leszek K. Borysiewicz
J Immunol 2001 166: 5695-5703. [Abstract] [Full Text] [PDF]  

Neonatal T Cells in an Adult Lung Environment Are Competent to Resolve Pneumocystis carinii Pneumonia

Mahboob H. Qureshi and Beth A. Garvy
J Immunol 2001 166: 5704-5711. [Abstract] [Full Text] [PDF]  

A Heritable Defect in IL-12 Signaling in B10.Q/J Mice. I. In Vitro Analysis

Robert Ortmann, Ronald Smeltz, George Yap, Alan Sher, and Ethan M. Shevach
J Immunol 2001 166: 5712-5719. [Abstract] [Full Text] [PDF]  

A Heritable Defect in IL-12 Signaling in B10.Q/J Mice. II. Effect on Acute Resistance to Toxoplasma gondii and Rescue by IL-18 Treatment

George S. Yap, Robert Ortmann, Ethan Shevach, and Alan Sher
J Immunol 2001 166: 5720-5725. [Abstract] [Full Text] [PDF]  

A Role for CD44 in the Production of IFN- and Immunopathology During Infection with Toxoplasma gondii

Sarah L. Blass, Ellen Puré, and Christopher A. Hunter
J Immunol 2001 166: 5726-5732. [Abstract] [Full Text] [PDF]  

Improving Vaccine Potency Through Intercellular Spreading and Enhanced MHC Class I Presentation of Antigen

Chien-Fu Hung, Wen-Fang Cheng, Chee-Yin Chai, Keng-Fu Hsu, Liangmei He, Morris Ling, and T.-C. Wu
J Immunol 2001 166: 5733-5740. [Abstract] [Full Text] [PDF]  

Salmonella Pathogenicity Island 2-Encoded Type III Secretion System Mediates Exclusion of NADPH Oxidase Assembly from the Phagosomal Membrane

Annabelle Gallois, Joanna R. Klein, Lee-Ann H. Allen, Bradley D. Jones, and William M. Nauseef
J Immunol 2001 166: 5741-5748. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Expression of Stromal-Derived Factor-1 Is Decreased by IL-1 and TNF and in Dermal Wound Healing

Eric R. Fedyk, Dan Jones, Hilary O. D. Critchley, Richard P. Phipps, Timothy M. Blieden, and Timothy A. Springer
J Immunol 2001 166: 5749-5754. [Abstract] [Full Text] [PDF]  

Combinatorial Model of Chemokine Involvement in Glomerular Monocyte Recruitment: Role of CXC Chemokine Receptor 2 in Infiltration During Nephrotoxic Nephritis

Alma Zernecke, Kim S. C. Weber, Lars P. Erwig, David C. Kluth, Bernd Schröppel, Andrew J. Rees, and Christian Weber
J Immunol 2001 166: 5755-5762. [Abstract] [Full Text] [PDF]  

Eosinophils Are a Major Source of Nitric Oxide-Derived Oxidants in Severe Asthma: Characterization of Pathways Available to Eosinophils for Generating Reactive Nitrogen Species

Jennifer C. MacPherson, Suzy A. A. Comhair, Serpil C. Erzurum, Dennis F. Klein, Mary F. Lipscomb, Mani S. Kavuru, Michael K. Samoszuk, and Stanley L. Hazen
J Immunol 2001 166: 5763-5772. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Rapid Depletion of Peripheral Antigen-Specific T Cells in TCR-Transgenic Mice After Oral Administration of Myelin Basic Protein

Abbie L. Meyer, Jacqueline Benson, Fei Song, Najma Javed, Ingrid E. Gienapp, Joan Goverman, Thea A. Brabb, Leroy Hood, and Caroline C. Whitacre
J Immunol 2001 166: 5773-5781. [Abstract] [Full Text] [PDF]  

Carcinogen-Induced Inflammation and Immunosuppression Are Enhanced in Xeroderma Pigmentosum Group A Model Mice Associated with Hyperproduction of Prostaglandin E₂

Hiroko Miyauchi-Hashimoto, Kazue Kuwamoto, Yoshihiro Urade, Kiyoji Tanaka, and Takeshi Horio
J Immunol 2001 166: 5782-5791. [Abstract] [Full Text] [PDF]  

A Murine IL-4 Receptor Antagonist That Inhibits IL-4- and IL-13-Induced Responses Prevents Antigen-Induced Airway Eosinophilia and Airway Hyperresponsiveness

A. Tomkinson, C. Duez, G. Cieslewicz, J. C. Pratt, A. Joetham, M.-C. Shanafelt, R. Gundel, and E. W. Gelfand
J Immunol 2001 166: 5792-5800. [Abstract] [Full Text] [PDF]  

Possible Involvement of EBV-Mediated -Fodrin Cleavage for Organ-Specific Autoantigen in Sjogren’s Syndrome

Hiroko Inoue, Kazuo Tsubota, Masafumi Ono, Yasuhiro Kizu, Fumio Mizuno, Kenzo Takada, Koichi Yamada, Kumiko Yanagi, Yoshio Hayashi, and Ichiro Saito
J Immunol 2001 166: 5801-5809. [Abstract] [Full Text] [PDF]  

SIN-1, a Nitric Oxide Donor, Ameliorates Experimental Allergic Encephalomyelitis in Lewis Rats in the Incipient Phase: The Importance of the Time Window

Ling-Yun Xu, Jian-She Yang, Hans Link, and Bao-Guo Xiao
J Immunol 2001 166: 5810-5816. [Abstract] [Full Text] [PDF]  

Kinetics of TCR Use in Response to Repeated Epitope-Specific Immunization

Vladia Monsurrò, Mai-Britt Nielsen, Ainhoa Perez-Diez, Mark E. Dudley, Ena Wang, Steven A. Rosenberg, and Francesco M. Marincola
J Immunol 2001 166: 5817-5825. [Abstract] [Full Text] [PDF]  

Cognate T Cell Help Is Sufficient to Trigger Anti-Nuclear Autoantibodies in Naive Mice

Catherine L. Keech, A. Darise Farris, Dimitra Beroukas, Tom P. Gordon, and James McCluskey
J Immunol 2001 166: 5826-5834. [Abstract] [Full Text] [PDF]  

Anti-CD3 F(ab')₂ Prevents Graft-Versus-Host Disease by Selectively Depleting Donor T Cells Activated by Recipient Alloantigens

Xue-Zhong Yu, Sasha J. Bidwell, Paul J. Martin, and Claudio Anasetti
J Immunol 2001 166: 5835-5839. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction

J Immunol 2001 166: 5840. [Full Text] [PDF]  

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