CUTTING EDGE:

Cutting Edge: A Single, Essential Hydrogen Bond Controls the Stability of Peptide-MHC Class II Complexes

Benjamin J. McFarland, Craig Beeson, and Andrea J. Sant
J Immunol 1999 163: 3567-3571. [Abstract] [Full Text] [PDF]  

Cutting Edge: Mouse IgG1 Antibodies Comprise Two Functionally Distinct Types That Are Differentially Regulated by IL-4 and IL-12

Eliana L. Faquim-Mauro, Robert L. Coffman, Ises A. Abrahamsohn, and Mahasti S. Macedo
J Immunol 1999 163: 3572-3576. [Abstract] [Full Text] [PDF]  

Cutting Edge: Thymic Selection and Autoreactivity Are Regulated by Multiple Coreceptors Involved in T Cell Activation

Dawne M. Page
J Immunol 1999 163: 3577-3581. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Unexpected Reactivities of T Cells Selected by a Single MHC-Peptide Ligand

Nagendra Singh and Luc Van Kaer
J Immunol 1999 163: 3583-3591. [Abstract] [Full Text] [PDF]  

B Cells Are Required for Lupus Nephritis in the Polygenic, Fas-Intact MRL Model of Systemic Autoimmunity

Owen T. M. Chan, Michael P. Madaio, and Mark J. Shlomchik
J Immunol 1999 163: 3592-3596. [Abstract] [Full Text] [PDF]  

Dendritic Cells Generated Either from CD34⁺ Progenitor Cells or from Monocytes Differ in Their Ability to Activate Antigen-Specific CD8⁺ T Cells

Guido Ferlazzo, Amy Wesa, Wei-Zen Wei, and Anne Galy
J Immunol 1999 163: 3597-3604. [Abstract] [Full Text] [PDF]  

Fibroblast-Secreted Macrophage Colony-Stimulating Factor Is Responsible for Generation of Biphenotypic B/Macrophage Cells from a Subset of Mouse B Lymphocytes

Melinda A. Borrello and Richard P. Phipps
J Immunol 1999 163: 3605-3611. [Abstract] [Full Text] [PDF]  

Expression of Stromal Cell-Derived Factor-1/Pre-B Cell Growth-Stimulating Factor Receptor, CXC Chemokine Receptor 4, on CD34⁺ Human Bone Marrow Cells Is a Phenotypic Alteration for Committed Lymphoid Progenitors

Takefumi Ishii, Masamichi Nishihara, Feng Ma, Yasuhiro Ebihara, Kohichiro Tsuji, Shigetaka Asano, Tatsutoshi Nakahata, and Taira Maekawa
J Immunol 1999 163: 3612-3620. [Abstract] [Full Text] [PDF]  

ß₁ Integrin- and Proteoglycan-Mediated Stimulation of T Lymphoma Cell Adhesion and Mitogen-Activated Protein Kinase Signaling by Thrombospondin-1 and Thrombospondin-1 Peptides

Katherine E. Wilson, Zhuqing Li, Murat Kara, Kevin L. Gardner, and David D. Roberts
J Immunol 1999 163: 3621-3628. [Abstract] [Full Text] [PDF]  

Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Stimulate the Induction of Th2 Responses by Up-Regulating B7.2 Expression

Mario Delgado, Javier Leceta, Rosa P. Gomariz, and Doina Ganea
J Immunol 1999 163: 3629-3635. [Abstract] [Full Text] [PDF]  

MHC Class II Engagement in Brain Endothelial Cells Induces Protein Kinase A-Dependent IL-6 Secretion and Phosphorylation of cAMP Response Element-Binding Protein

Sandrine Etienne, Sandrine Bourdoulous, A. Donny Strosberg, and Pierre-Olivier Couraud
J Immunol 1999 163: 3636-3641. [Abstract] [Full Text] [PDF]  

Oligodeoxynucleotides Containing Palindrome Sequences with Internal 5'-CpG-3' Act Directly on Human NK and Activated T Cells to Induce IFN- Production In Vitro

Sumiko Iho, Toshiko Yamamoto, Takayuki Takahashi, and Saburo Yamamoto
J Immunol 1999 163: 3642-3652. [Abstract] [Full Text] [PDF]  

TNF- Inhibits HIV-1 Replication in Peripheral Blood Monocytes and Alveolar Macrophages by Inducing the Production of RANTES and Decreasing C-C Chemokine Receptor 5 (CCR5) Expression

Brian R. Lane, David M. Markovitz, Nina L. Woodford, Rosemary Rochford, Robert M. Strieter, and Michael J. Coffey
J Immunol 1999 163: 3653-3661. [Abstract] [Full Text] [PDF]  

Expression of the Transcription Factor Lung Krüppel-Like Factor Is Regulated by Cytokines and Correlates with Survival of Memory T Cells In Vitro and In Vivo

Sonya L. Schober, Chay T. Kuo, Kimberly S. Schluns, Leo Lefrancois, Jeffrey M. Leiden, and Stephen C. Jameson
J Immunol 1999 163: 3662-3667. [Abstract] [Full Text] [PDF]  

Modulating Dendritic Cells to Optimize Mucosal Immunization Protocols

Eilidh Williamson, Gina M. Westrich, and Joanne L. Viney
J Immunol 1999 163: 3668-3675. [Abstract] [Full Text] [PDF]  

T Cell Memory Against Colon Carcinoma Is Long-Lived in the Absence of Antigen

Rong Xiang, Holger N. Lode, Stephen D. Gillies, and Ralph A. Reisfeld
J Immunol 1999 163: 3676-3683. [Abstract] [Full Text] [PDF]  

Induction of CD4⁺ T Cell Alloantigen-Specific Hyporesponsiveness by IL-10 and TGF-ß

Jay C. Zeller, Angela Panoskaltsis-Mortari, William J. Murphy, Francis W. Ruscetti, Satwant Narula, Maria G. Roncarolo, and Bruce R. Blazar
J Immunol 1999 163: 3684-3691. [Abstract] [Full Text] [PDF]  

Kinetic Analysis of Oral Tolerance: Memory Lymphocytes Are Refractory to Oral Tolerance

Yeonseok Chung, Sun-Young Chang, and Chang-Yuil Kang
J Immunol 1999 163: 3692-3698. [Abstract] [Full Text] [PDF]  

NK and CTL Recognition of a Single Chain H-2D^d Molecule: Distinct Sites of H-2D^d Interact with NK and TCR

Doo Hyun Chung, Jeffrey Dorfman, Daniel Plaksin, Kannan Natarajan, Igor M. Belyakov, Rosemarie Hunziker, Jay A. Berzofsky, Wayne M. Yokoyama, Michael G. Mage, and David H. Margulies
J Immunol 1999 163: 3699-3708. [Abstract] [Full Text] [PDF]  

Contact Hypersensitivity Responses Following Ribavirin Treatment In Vivo Are Influenced by Type 1 Cytokine Polarization, Regulation of IL-10 Expression, and Costimulatory Signaling

Robert C. Tam, Charmaine Lim, Josie Bard, and Bharati Pai
J Immunol 1999 163: 3709-3717. [Abstract] [Full Text] [PDF]  

Tumor Gangliosides Inhibit the Tumor-Specific Immune Response

Robert McKallip, Ruixiang Li, and Stephan Ladisch
J Immunol 1999 163: 3718-3726. [Abstract] [Full Text] [PDF]  

Tyrosine Phosphorylation of Crk-Associated Substrate Lymphocyte-Type Is a Critical Element in TCR- and ß₁ Integrin-Induced T Lymphocyte Migration

Yoshiyuki Ohashi, Satoshi Iwata, Kenjiro Kamiguchi, and Chikao Morimoto
J Immunol 1999 163: 3727-3734. [Abstract] [Full Text] [PDF]  

The Induction of Virus-Specific CTL as a Function of Increasing Epitope Expression: Responses Rise Steadily Until Excessively High Levels of Epitope Are Attained

E. John Wherry, Kristin A. Puorro, Angel Porgador, and Laurence C. Eisenlohr
J Immunol 1999 163: 3735-3745. [Abstract] [Full Text] [PDF]  

(1,3)-Fucosyltransferase VII and (2,3)-Sialyltransferase IV Are Up-Regulated in Activated CD4 T Cells and Maintained After Their Differentiation into Th1 and Migration into Inflammatory Sites

J. Magarian Blander, Irene Visintin, Charles A. Janeway, Jr., and Ruslan Medzhitov
J Immunol 1999 163: 3746-3752. [Abstract] [Full Text] [PDF]  

Expression of B7 Molecules in Recipient, Not Donor, Mice Determines the Survival of Cardiac Allografts

Didier A. Mandelbrot, Yutaka Furukawa, Alexander J. McAdam, Stephen I. Alexander, Peter Libby, Richard N. Mitchell, and Arlene H. Sharpe
J Immunol 1999 163: 3753-3757. [Abstract] [Full Text] [PDF]  

Estradiol Coupling to Human Monocyte Nitric Oxide Release Is Dependent on Intracellular Calcium Transients: Evidence for an Estrogen Surface Receptor

George B. Stefano, Vincent Prevot, Jean-Claude Beauvillain, Caterina Fimiani, Ingeborg Welters, Patrick Cadet, Christophe Breton, Joel Pestel, Michel Salzet, and Thomas V. Bilfinger
J Immunol 1999 163: 3758-3763. [Abstract] [Full Text] [PDF]  

Cross-Reactivity of Myelin Basic Protein-Specific T Cells with Multiple Microbial Peptides: Experimental Autoimmune Encephalomyelitis Induction in TCR Transgenic Mice

Jane L. Grogan, Achim Kramer, Axel Nogai, Liying Dong, Manuela Ohde, Jens Schneider-Mergener, and Thomas Kamradt
J Immunol 1999 163: 3764-3770. [Abstract] [Full Text] [PDF]  

Th1/Th2-Regulated Expression of Arginase Isoforms in Murine Macrophages and Dendritic Cells

Markus Munder, Klaus Eichmann, José M. Morán, Francisco Centeno, Germán Soler, and Manuel Modolell
J Immunol 1999 163: 3771-3777. [Abstract] [Full Text] [PDF]  

IL-5 Mediates Eosinophilic Rejection of MHC Class II-Disparate Skin Allografts in Mice

Alain Le Moine, Murielle Surquin, François Xavier Demoor, Jean Christophe Noël, Marie-Anne Nahori, Marina Pretolani, Véronique Flamand, Michel Y. Braun, Michel Goldman, and Daniel Abramowicz
J Immunol 1999 163: 3778-3784. [Abstract] [Full Text] [PDF]  

Thymic Transplantation Across an MHC Class I Barrier in Swine

Gary W. Haller, Nestor Esnaola, Kazuhiko Yamada, Anette Wu, Akira Shimizu, Andrew Hansen, Vincent R. Ferrara, Kenneth S. Allison, Robert B. Colvin, Megan Sykes, and David H. Sachs
J Immunol 1999 163: 3785-3792. [Abstract] [Full Text] [PDF]  

Regulation of T Cell Homeostasis by Heparan Sulfate-Bound IL-2

Lucile E. Wrenshall and Jeffrey L. Platt
J Immunol 1999 163: 3793-3800. [Abstract] [Full Text] [PDF]  

Restricted Receptor Segregation into Membrane Microdomains Occurs on Human T Cells During Apoptosis Induced by Galectin-1

Karen E. Pace, Christina Lee, Phoebe L. Stewart, and Linda G. Baum
J Immunol 1999 163: 3801-3811. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Phosphorylated Peptides Can Be Transported by TAP Molecules, Presented by Class I MHC Molecules, and Recognized by Phosphopeptide-Specific CTL

Mads Hald Andersen, Jordi Espuny Bonfill, Anne Neisig, Gemma Arsequell, Ib Søndergaard, Jacques Neefjes, Jesper Zeuthen, Tim Elliott, and John S. Haurum
J Immunol 1999 163: 3812-3818. [Abstract] [Full Text] [PDF]  

ADP-Ribosylation of Rho by C3 Ribosyltransferase Inhibits IL-2 Production and Sustained Calcium Influx in Activated T Cells

Vachras Angkachatchai and Terri H. Finkel
J Immunol 1999 163: 3819-3825. [Abstract] [Full Text] [PDF]  

Two Ancient Allelic Lineages at the Single Classical Class I Locus in the Xenopus MHC

Martin F. Flajnik, Yuko Ohta, Andrew S. Greenberg, Luisa Salter-Cid, Ana Carrizosa, Louis Du Pasquier, and Masanori Kasahara
J Immunol 1999 163: 3826-3833. [Abstract] [Full Text] [PDF]  

IFN- Activates Stat6 and Leads to the Formation of Stat2:Stat6 Complexes in B Cells

Sanjay Gupta, Man Jiang, and Alessandra B. Pernis
J Immunol 1999 163: 3834-3841. [Abstract] [Full Text] [PDF]  

Mapping the Major Interaction Between Binding Protein and Ig Light Chains to Sites Within the Variable Domain

David P. Davis, Ritu Khurana, Stephen Meredith, Fred J. Stevens, and Yair Argon
J Immunol 1999 163: 3842-3850. [Abstract] [Full Text] [PDF]  

The Signal Transduction Pathway of CD23 (FcRIIb) Targets IB Kinase

Rosa M. Ten, Melissa J. McKinstry, Sergey A. Trushin, Susana Asin, and Carlos V. Paya
J Immunol 1999 163: 3851-3857. [Abstract] [Full Text] [PDF]  

Characterization of an Avian (Gallus gallus domesticus) TCR Gene Locus

Takayuki Kubota, Jin-yi Wang, Thomas W. F. Göbel, Richard D. Hockett, Max D. Cooper, and Chen-lo H. Chen
J Immunol 1999 163: 3858-3866. [Abstract] [Full Text] [PDF]  

Identification and Functional Characterization of the -Chain Dimerization Motif for TCR Surface Expression

Luca Bolliger and Britt Johansson
J Immunol 1999 163: 3867-3876. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Elucidation and Role of Critical Residues of Immunodominant Peptide Associated with T Cell-Mediated Parasitic Disease

Hector J. Hernandez and Miguel J. Stadecker
J Immunol 1999 163: 3877-3882. [Abstract] [Full Text] [PDF]  

TNF Receptor p55 Is Required for Elimination of Inflammatory Cells Following Control of Intracellular Pathogens

Suzanne T. Kanaly, Michelle Nashleanas, Brian Hondowicz, and Phillip Scott
J Immunol 1999 163: 3883-3889. [Abstract] [Full Text] [PDF]  

Dendritic Cell (DC)-Based Anti-Infective Strategies: DCs Engineered to Secrete IL-12 Are a Potent Vaccine in a Murine Model of an Intracellular Infection

Seema S. Ahuja, Robert L. Reddick, Naoko Sato, Elleanor Montalbo, Vannessa Kostecki, Weiguo Zhao, Matthew J. Dolan, Peter C. Melby, and Sunil K. Ahuja
J Immunol 1999 163: 3890-3897. [Abstract] [Full Text] [PDF]  

Mycobacterium tuberculosis Inhibits IFN- Transcriptional Responses Without Inhibiting Activation of STAT1

Li-Min Ting, Anne C. Kim, Ashok Cattamanchi, and Joel D. Ernst
J Immunol 1999 163: 3898-3906. [Abstract] [Full Text] [PDF]  

Ig Heavy Chain Complex-Linked Genes Influence the Immune Response in a Murine Cryptococcal Infection

Julie A. Lovchik, Julie A. Wilder, Gary B. Huffnagle, Roy Riblet, C. Richard Lyons, and Mary F. Lipscomb
J Immunol 1999 163: 3907-3913. [Abstract] [Full Text] [PDF]  

Monocyte-Driven Activation-Induced Apoptotic Cell Death of Human T-Lymphotropic Virus Type I-Infected T Cells

Shin-ichi Wakamatsu, Masahiko Makino, Chuuwa Tei, and Masanori Baba
J Immunol 1999 163: 3914-3919. [Abstract] [Full Text] [PDF]  

Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis

Terry K. Means, Shuyan Wang, Egil Lien, Atsutoshi Yoshimura, Douglas T. Golenbock, and Matthew J. Fenton
J Immunol 1999 163: 3920-3927. [Abstract] [Full Text] [PDF]  

The Inhibitory Action of Mycobacterium ulcerans Soluble Factor on Monocyte/T Cell Cytokine Production and NF-B Function

Ali A. Pahlevan, David J. M. Wright, Caroline Andrews, Kathleen M. George, Pamela L. C. Small, and Brian M. Foxwell
J Immunol 1999 163: 3928-3935. [Abstract] [Full Text] [PDF]  

Pulmonary Epithelial Cells are a Source of IL-8 in the Response to Mycobacterium tuberculosis: Essential Role of IL-1 from Infected Monocytes in a NF-B-Dependent Network

Melissa I. Wickremasinghe, Lynette H. Thomas, and Jon S. Friedland
J Immunol 1999 163: 3936-3947. [Abstract] [Full Text] [PDF]  

Apoptosis of a Human Melanoma Cell Line Specifically Induced by Membrane-Bound Single-Chain Antibodies

Concepción de Inés, Björn Cochlovius, Stefanie Schmidt, Sergey Kipriyanov, Hans-Jürgen Rode, and Melvyn Little
J Immunol 1999 163: 3948-3956. [Abstract] [Full Text] [PDF]  

Regulation of Complement Activation by C-Reactive Protein: Targeting the Complement Inhibitory Activity of Factor H by an Interaction with Short Consensus Repeat Domains 7 and 8–11

Hanna Jarva, T. Sakari Jokiranta, Jens Hellwage, Peter F. Zipfel, and Seppo Meri
J Immunol 1999 163: 3957-3962. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Inflammatory Cytokines IL-1, IL-1ß, IL-6, and TNF- Impart Neuroprotection to an Excitotoxin Through Distinct Pathways

Noel G. Carlson, Whitney A. Wieggel, Jian Chen, Annalisa Bacchi, Scott W. Rogers, and Lorise C. Gahring
J Immunol 1999 163: 3963-3968. [Abstract] [Full Text] [PDF]  

Intracellular IL-1 Receptor Antagonist Is Elevated in Human Dermal Fibroblasts That Overexpress Intracellular Precursor IL-1

Gloria C. Higgins, Yong Wu, and Arnold E. Postlethwaite
J Immunol 1999 163: 3969-3975. [Abstract] [Full Text] [PDF]  

C-C Chemokines in Allergen-Induced Late-Phase Cutaneous Responses in Atopic Subjects: Association of Eotaxin with Early 6-Hour Eosinophils, and of Eotaxin-2 and Monocyte Chemoattractant Protein-4 with the Later 24-Hour Tissue Eosinophilia, and Relationship to Basophils and Other C-C Chemokines (Monocyte Chemoattractant Protein-3 and RANTES)

Sun Ying, Douglas S. Robinson, Qiu Meng, Luis T. Barata, Alan R. McEuen, Mark G. Buckley, Andrew F. Walls, Philip W. Askenase, and A. Barry Kay
J Immunol 1999 163: 3976-3984. [Abstract] [Full Text] [PDF]  

Chemokine Amplification in Mesangial Cells

Yi Luo, Clare Lloyd, Jose-Carlos Gutierrez-Ramos, and Martin E. Dorf
J Immunol 1999 163: 3985-3992. [Abstract] [Full Text] [PDF]  

TNF- and IL-1 Sequentially Induce Endothelial ICAM-1 and VCAM-1 Expression in MRL/lpr Lupus-Prone Mice

Julie F. McHale, Olivier A. Harari, Diane Marshall, and Dorian O. Haskard
J Immunol 1999 163: 3993-4000. [Abstract] [Full Text] [PDF]  

Involvement of Phosphatidylinositol 3-Kinase in Stromal Cell-Derived Factor-1-Induced Lymphocyte Polarization and Chemotaxis

Miguel Vicente-Manzanares, Mercedes Rey, David R. Jones, David Sancho, Mario Mellado, Jose Miguel Rodriguez-Frade, Miguel Angel del Pozo, María Yáñez-Mó, Ana Martín de Ana, Carlos Martínez-A., Isabel Mérida, and Francisco Sánchez-Madrid
J Immunol 1999 163: 4001-4012. [Abstract] [Full Text] [PDF]  

ß₂-Microglobulin-Deficient Background Ameliorates Lethal Phenotype of the TGF-ß1 Null Mouse

Shigetoshi Kobayashi, Kunihiro Yoshida, Jerrold M. Ward, John J. Letterio, Glenn Longenecker, Linda Yaswen, Barbara Mittleman, Edna Mozes, Anita B. Roberts, Stefan Karlsson, and Ashok B. Kulkarni
J Immunol 1999 163: 4013-4019. [Abstract] [Full Text] [PDF]  

Inhibition of Bacterial Cell Wall-Induced Leukocyte Recruitment and Hepatic Granuloma Formation by TGF-ß Gene Transfer

Xiao-yu Song, Li Zeng, Carey M. Pilo, John Zagorski, and Sharon M. Wahl
J Immunol 1999 163: 4020-4026. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Human Transaldolase and Cross-Reactive Viral Epitopes Identified by Autoantibodies of Multiple Sclerosis Patients

Maria Esposito, Vijay Venkatesh, Laszlo Otvos, Zhiping Weng, Sandor Vajda, Katalin Banki, and Andras Perl
J Immunol 1999 163: 4027-4032. [Abstract] [Full Text] [PDF]  

Protection from Radiation-Induced Colitis Requires MHC Class II Antigen Expression by Cells of Hemopoietic Origin

Samuel Marguerat, H. Robson MacDonald, Jean-Pierre Kraehenbuhl, and Joost P. M. van Meerwijk
J Immunol 1999 163: 4033-4040. [Abstract] [Full Text] [PDF]  

IL-2 Receptor-Targeted Cytolytic IL-2/Fc Fusion Protein Treatment Blocks Diabetogenic Autoimmunity in Nonobese Diabetic Mice

Xin Xiao Zheng, Alan W. Steele, Wayne W. Hancock, Kensaku Kawamoto, Xian Chang Li, Peter W. Nickerson, Yongsheng Li, Yan Tian, and Terry B. Strom
J Immunol 1999 163: 4041-4048. [Abstract] [Full Text] [PDF]  

Hyperexpression of CD40 Ligand (CD154) in Inflammatory Bowel Disease and Its Contribution to Pathogenic Cytokine Production

Zhanju Liu, Stefaan Colpaert, Geert R. D’Haens, Ahmad Kasran, Mark de Boer, Paul Rutgeerts, Karel Geboes, and Jan L. Ceuppens
J Immunol 1999 163: 4049-4057. [Abstract] [Full Text] [PDF]  

An HLA-A2 Polyepitope Vaccine for Melanoma Immunotherapy

Luis Mateo, Joy Gardner, Qiyuan Chen, Christopher Schmidt, Michelle Down, Suzanne L. Elliott, Stephanie J. Pye, Hüseyin Firat, Francois A. Lemonnier, Jonathon Cebon, and Andreas Suhrbier
J Immunol 1999 163: 4058-4063. [Abstract] [Full Text] [PDF]  

Involvement of IL-15 in the Pathogenesis of Human T Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis: Implications for Therapy with a Monoclonal Antibody Directed to the IL-2/15Rß Receptor

Nazli Azimi, Steven Jacobson, Thomas Leist, and Thomas A. Waldmann
J Immunol 1999 163: 4064-4072. [Abstract] [Full Text] [PDF]  

Depressed IL-12-Mediated Signal Transduction in T Cells from Patients with Sézary Syndrome Is Associated with the Absence of IL-12 Receptor ß2 mRNA and Highly Reduced Levels of STAT4

Louise C. Showe, Floyd E. Fox, Donna Williams, Karen Au, Zhutian Niu, and Alain H. Rook
J Immunol 1999 163: 4073-4079. [Abstract] [Full Text] [PDF]  

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