CUTTING EDGE:

Cutting Edge: TRANK, a Novel Cytokine That Activates NF-B and c-Jun N-Terminal Kinase

Valsala Haridas, Jian Ni, Anthony Meager, Jeffery Su, Guo-Liang Yu, Yifan Zhai, Hla Kyaw, Keith T. Akama, Jingru Hu, Linda J. Van Eldik, and Bharat B. Aggarwal
J Immunol 1998 161: 1-6. [Abstract] [Full Text] [PDF]  

Cutting Edge: Ly-49D and Ly-49H Associate with Mouse DAP12 and Form Activating Receptors

Kathleen M. Smith, Jun Wu, Alexander B. H. Bakker, Joseph H. Phillips, and Lewis L. Lanier
J Immunol 1998 161: 7-10. [Abstract] [Full Text] [PDF]  

Cutting Edge: The Expression In Vivo of a Second Isoform of pT: Implications for the Mechanism of pT Action

Domingo F. Barber, Lorena Passoni, Li Wen, Liping Geng, and Adrian C. Hayday
J Immunol 1998 161: 11-16. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Differences in the Immune Response During the Acute Phase of E-55+ Murine Leukemia Virus Infection in Progressor BALB and Long Term Nonprogressor C57BL Mice

Vily Panoutsakopoulou, C. Scott Little, Thomas G. Sieck, Elizabeth P. Blankenhorn, and Kenneth J. Blank
J Immunol 1998 161: 17-26. [Abstract] [Full Text] [PDF]  

The Role of Estrogen Receptors and Androgen Receptors in Sex Steroid Regulation of B Lymphopoiesis

Glennda Smithson, John F. Couse, Dennis B. Lubahn, Kenneth S. Korach, and Paul W. Kincade
J Immunol 1998 161: 27-34. [Abstract] [Full Text] [PDF]  

Proteasome Activation Occurs at an Early, Premitochondrial Step of Thymocyte Apoptosis

Tamara Hirsch, Bruno Dallaporta, Naoufal Zamzami, Santos A. Susin, Luigi Ravagnan, Isabel Marzo, Catherine Brenner, and Guido Kroemer
J Immunol 1998 161: 35-40. [Abstract] [Full Text] [PDF]  

Repertoire Analysis of CD8⁺ T Cell Responses to Minor Histocompatibility Antigens Involved in Graft-Versus-Host Disease

Thea M. Friedman, Michael Gilbert, Constance Briggs, and Robert Korngold
J Immunol 1998 161: 41-48. [Abstract] [Full Text] [PDF]  

Requirements for B7-CD28 Costimulation in Mucosal IgA Responses: Paradoxes Observed in CTLA4-H1 Transgenic Mice

Eva Gärdby, Peter Lane, and Nils Y. Lycke
J Immunol 1998 161: 49-59. [Abstract] [Full Text] [PDF]  

A Viral Peptide with Limited Homology to a Self Peptide Can Induce Clinical Signs of Experimental Autoimmune Encephalomyelitis

Anand M. Gautam, Roland Liblau, Gareth Chelvanayagam, Lawrence Steinman, and Tanya Boston
J Immunol 1998 161: 60-64. [Abstract] [Full Text] [PDF]  

Pentoxifylline Inhibits Adhesion and Activation of Human T Lymphocytes

Roberto González-Amaro, Diana Portales-Pérez, Lourdes Baranda, Juan M. Redondo, Sara Martínez-Martínez, María Yáñez-Mó, Rosario García-Vicuña, Carlos Cabañas, and Francisco Sánchez-Madrid
J Immunol 1998 161: 65-72. [Abstract] [Full Text] [PDF]  

De Novo-Developed T Cells Have Compromised Response to Existing Alloantigens: Using L^d-Specific Transgenic 2C T Cells as Tracers in a Mouse Heart Transplantation Model

Hongyu Luo, Huifang Chen, Shijie Qi, Dennis Loh, Pierre Daloze, André Veillette, Dasheng Xu, and Jiangping Wu
J Immunol 1998 161: 73-82. [Abstract] [Full Text] [PDF]  

Allelic Differences in the Relationship Between Proteasome Activity and MHC Class I Peptide Loading

Adam M. Benham, Monique Grommé, and Jacques Neefjes
J Immunol 1998 161: 83-89. [Abstract] [Full Text] [PDF]  

H2-M3 Presents a Nonformylated Viral Epitope to CTLs Generated In Vitro

Derek E. Byers and Kirsten Fischer Lindahl
J Immunol 1998 161: 90-96. [Abstract] [Full Text] [PDF]  

In Vivo Persistence of CD8 Polarized T Cell Subsets Producing Type 1 or Type 2 Cytokines

Adelheid Cerwenka, Laura L. Carter, Joyce B. Reome, Susan L. Swain, and Richard W. Dutton
J Immunol 1998 161: 97-105. [Abstract] [Full Text] [PDF]  

TCR Agonist and Antagonist Exert In Vivo Cross-Regulation When Presented on Igs

Kevin L. Legge, Booki Min, Aimee E. Cestra, Christopher D. Pack, and Habib Zaghouani
J Immunol 1998 161: 106-111. [Abstract] [Full Text] [PDF]  

Proteasomes Can Either Generate or Destroy MHC Class I Epitopes: Evidence for Nonproteasomal Epitope Generation in the Cytosol

Chance John Luckey, Gina M. King, Jarrod A. Marto, Sunita Venketeswaran, Bernhard F. Maier, Victoria L. Crotzer, Teresa A. Colella, Jeffrey Shabanowitz, Donald F. Hunt, and Victor H. Engelhard
J Immunol 1998 161: 112-121. [Abstract] [Full Text] [PDF]  

Endogenous IL-12 Is Required for Induction and Expression of Experimental Autoimmune Uveitis

Teresa K. Tarrant, Phyllis B. Silver, Chi-Chao Chan, Barbara Wiggert, and Rachel R. Caspi
J Immunol 1998 161: 122-127. [Abstract] [Full Text] [PDF]  

In Vivo Expression of a TCR Antagonist: T Cells Escape Central Tolerance But Are Antagonized in the Periphery

Calvin B. Williams, Karine Vidal, David Donermeyer, Daniel A. Peterson, J. Michael White, and Paul M. Allen
J Immunol 1998 161: 128-137. [Abstract] [Full Text] [PDF]  

Characterization of Human Fibroleukin, a Fibrinogen-Like Protein Secreted by T Lymphocytes

Susanna Marazzi, Stephanie Blum, Reto Hartmann, Doris Gundersen, Magali Schreyer, Scott Argraves, Vladimir von Fliedner, Robert Pytela, and Curzio Rüegg
J Immunol 1998 161: 138-147. [Abstract] [Full Text] [PDF]  

Strong Alloantigenicity of the -Helices Residues of the MHC Class I Molecule

Ghada Noun, Murielle Reboul, Jean-Pierre Abastado, Philippe Kourilsky, François Sigaux, and Marika Pla
J Immunol 1998 161: 148-153. [Abstract] [Full Text] [PDF]  

Induction of Oral Tolerance in TGF-ß1 Null Mice

K. Siobhan Barone, Dana D. Tolarova, Ilona Ormsby, Thomas Doetschman, and J. Gabriel Michael
J Immunol 1998 161: 154-160. [Abstract] [Full Text] [PDF]  

A Role for Heat Shock Protein 27 in CTL-Mediated Cell Death

Paul J. Beresford, Madhuri Jaju, Rachel S. Friedman, Margaret J. Yoon, and Judy Lieberman
J Immunol 1998 161: 161-167. [Abstract] [Full Text] [PDF]  

A Comparison of Signaling Requirements for Apoptosis of Human B Lymphocytes Induced by the B Cell Receptor and CD95/Fas

Jonathan D. Graves, Kevin E. Draves, Andrew Craxton, Edwin G. Krebs, and Edward A. Clark
J Immunol 1998 161: 168-174. [Abstract] [Full Text] [PDF]  

CD4⁺ T Cells Mature in the Absence of MHC Class I and Class II Expression in Ly-6A.2 Transgenic Mice

S. Christine Henderson, Alla Berezovskaya, Andrea English, Deborah Palliser, Kenneth L. Rock, and Anil Bamezai
J Immunol 1998 161: 175-182. [Abstract] [Full Text] [PDF]  

The Cytoplasmic Domain of CD8ß Regulates Lck Kinase Activation and CD8 T Cell Development

Hanna Yoko Irie, Mimi S. Mong, Andrea Itano, M. E. Casey Crooks, Dan R. Littman, Steven J. Burakoff, and Ellen Robey
J Immunol 1998 161: 183-191. [Abstract] [Full Text] [PDF]  

Tissue-Specific Up-Regulation of B7-1 Expression and Function During the Course of Murine Relapsing Experimental Autoimmune Encephalomyelitis

Nitin J. Karandikar, Carol L. Vanderlugt, Todd Eagar, Litjen Tan, Jeffrey A. Bluestone, and Stephen D. Miller
J Immunol 1998 161: 192-199. [Abstract] [Full Text] [PDF]  

A Partially Modified Retro-Inverso Pseudopeptide Modulates the Cytokine Profile of CTL Specific for an Influenza Virus Epitope

Marina Ostankovitch, Gilles Guichard, Francine Connan, Sylviane Muller, Aude Chaboissier, Johan Hoebeke, Jeannine Choppin, Jean-Paul Briand, and Jean-Gérard Guillet
J Immunol 1998 161: 200-208. [Abstract] [Full Text] [PDF]  

V7 (CD101) Ligation Inhibits TCR/CD3-Induced IL-2 Production by Blocking Ca²⁺ Flux and Nuclear Factor of Activated T Cell Nuclear Translocation

Luis R. B. Soares, Larisa Tsavaler, Alberto Rivas, and Edgar G. Engleman
J Immunol 1998 161: 209-217. [Abstract] [Full Text] [PDF]  

Differential Regulation of the Janus Kinase-STAT Pathway and Biologic Function of IL-13 in Primary Human NK and T Cells: A Comparative Study with IL-4

Cheng-Rong Yu, Robert A. Kirken, M. Grazia Malabarba, Howard A. Young, and John R. Ortaldo
J Immunol 1998 161: 218-227. [Abstract] [Full Text] [PDF]  

Development of Human Peripheral TCRBJ Gene Repertoire

Toshihiro Nanki, Hitoshi Kohsaka, and Nobuyuki Miyasaka
J Immunol 1998 161: 228-233. [Abstract] [Full Text] [PDF]  

The Prototypic Th2 Autoimmunity Induced by Mercury Is Dependent on IFN- and Not Th1/Th2 Imbalance

Dwight H. Kono, Dimitri Balomenos, Deborah L. Pearson, Miyo S. Park, Bernhard Hildebrandt, Per Hultman, and K. Michael Pollard
J Immunol 1998 161: 234-240. [Abstract] [Full Text] [PDF]  

Fas/Fas Ligand Interactions Are Involved in Ultraviolet-B-Induced Human Lymphocyte Apoptosis

Roberto Caricchio, Elizabeth A. Reap, and Philip L. Cohen
J Immunol 1998 161: 241-251. [Abstract] [Full Text] [PDF]  

Role of µ Heavy Chain in B Cell Development. I. Blocked B Cell Maturation But Complete Allelic Exclusion in the Absence of Ig/ß

Frank E. Cronin, Ming Jiang, Abul K. Abbas, and Stephan A. Grupp
J Immunol 1998 161: 252-259. [Abstract] [Full Text] [PDF]  

Two Distinct Pathways Exist for Down-Regulation of the TCR

Jens Peter H. Lauritsen, Mette D. Christensen, Jes Dietrich, Jesper Kastrup, Niels Ødum, and Carsten Geisler
J Immunol 1998 161: 260-267. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Both PU.1 and Nuclear Factor-B Mediate Lipopolysaccharide-Induced HIV-1 Long Terminal Repeat Transcription in Macrophages

Tracey A. Lodie, Marshall Reiner, Salvatore Coniglio, Gregory Viglianti, and Matthew J. Fenton
J Immunol 1998 161: 268-276. [Abstract] [Full Text] [PDF]  

An NFAT-Dependent Enhancer Is Necessary for Anti-IgM-Mediated Induction of Murine CD5 Expression in Primary Splenic B Cells

Robert Berland and Henry H. Wortis
J Immunol 1998 161: 277-285. [Abstract] [Full Text] [PDF]  

Crucial Role of TCR Chain Junctional Region in Prenyl Pyrophosphate Antigen Recognition by T Cells

Jack F. Bukowski, Craig T. Morita, Hamid Band, and Michael B. Brenner
J Immunol 1998 161: 286-293. [Abstract] [Full Text] [PDF]  

A 3' Enhancer Drives Active and Untemplated Somatic Hypermutation of a ₁ Transgene

Qingzhong Kong, Lisa Zhao, Sathish Subbaiah, and Nancy Maizels
J Immunol 1998 161: 294-301. [Abstract] [Full Text] [PDF]  

STAT6 Is Required for IL-4-Induced Germline Ig Gene Transcription and Switch Recombination

Leslie A. Linehan, Wendy D. Warren, Patricia A. Thompson, Michael J. Grusby, and Michael T. Berton
J Immunol 1998 161: 302-310. [Abstract] [Full Text] [PDF]  

Expression and Characterization of Recombinant Subunits of Human Complement Component C8: Further Analysis of the Function of C8 and C8

Steven F. Schreck, Mnason E. Plumb, Peter L. Platteborze, Kenneth M. Kaufman, Gregory A. Michelotti, Carole S. Letson, and James M. Sodetz
J Immunol 1998 161: 311-318. [Abstract] [Full Text] [PDF]  

The N-Terminal Domains Target TNF Receptor-Associated Factor-2 to the Nucleus and Display Transcriptional Regulatory Activity

Wang Min, John R. Bradley, Jennifer J. Galbraith, Sally J. Jones, Elizabeth C. Ledgerwood, and Jordan S. Pober
J Immunol 1998 161: 319-324. [Abstract] [Full Text] [PDF]  

Regulation of IL-6 Signaling by p53: STAT3- and STAT5-Masking in p53-Val¹³⁵-Containing Human Hepatoma Hep3B Cell Lines

Ravi J. Rayanade, MacKevin I. Ndubuisi, Joseph D. Etlinger, and Pravin B. Sehgal
J Immunol 1998 161: 325-334. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Differences Between B Cell and Macrophage Transformation by the Bovine Parasite, Theileria annulata: A Clonal Approach

Heinz Sager, Giuseppe Bertoni, and Thomas W. Jungi
J Immunol 1998 161: 335-341. [Abstract] [Full Text] [PDF]  

Reduced Tumorigenicity and Augmented Leukocyte Infiltration After Monocyte Chemotactic Protein-3 (MCP-3) Gene Transfer: Perivascular Accumulation of Dendritic Cells in Peritumoral Tissue and Neutrophil Recruitment Within the Tumor

Francesca Fioretti, Didier Fradelizi, Antonella Stoppacciaro, Simona Ramponi, Luigi Ruco, Adrian Minty, Silvano Sozzani, Cecilia Garlanda, Annunciata Vecchi, and Alberto Mantovani
J Immunol 1998 161: 342-346. [Abstract] [Full Text] [PDF]  

A Longitudinal Study of Type-Specific Antibody Responses to Plasmodium falciparum Merozoite Surface Protein-1 in an Area of Unstable Malaria in Sudan

David R. Cavanagh, Ibrahim M. Elhassan, Cally Roper, V. Jane Robinson, Haider Giha, Anthony A. Holder, Lars Hviid, Thor G. Theander, David E. Arnot, and Jana S. McBride
J Immunol 1998 161: 347-359. [Abstract] [Full Text] [PDF]  

Susceptibility to Pneumocystis carinii in Mice Is Dependent on Simultaneous Deletion of IFN- and Type 1 and 2 TNF Receptor Genes

Daniel G. Rudmann, Angela M. Preston, Mark W. Moore, and James M. Beck
J Immunol 1998 161: 360-366. [Abstract] [Full Text] [PDF]  

Stability of Virus-Specific CD4⁺ T Cell Frequencies from Acute Infection into Long Term Memory

Steven M. Varga and Raymond M. Welsh
J Immunol 1998 161: 367-374. [Abstract] [Full Text] [PDF]  

Antigen-Specific Cytolysis by Neutrophils and NK Cells Expressing Chimeric Immune Receptors Bearing or Signaling Domains

Margo R. Roberts, Keegan S. Cooke, Annie-Chen Tran, Kent A. Smith, Wei Yu Lin, Martin Wang, Thomas J. Dull, Deborah Farson, Krisztina M. Zsebo, and Mitchell H. Finer
J Immunol 1998 161: 375-384. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Galectin-3 Down-Regulates IL-5 Gene Expression on Different Cell Types

Isabel Cortegano, Victoria del Pozo, Blanca Cárdaba, Belén de Andrés, Soledad Gallardo, Ana del Amo, Ignacio Arrieta, Aurora Jurado, Pilar Palomino, Fu-Tong Liu, and Carlos Lahoz
J Immunol 1998 161: 385-389. [Abstract] [Full Text] [PDF]  

Cooperation of Both TNF Receptors in Inducing Apoptosis: Involvement of the TNF Receptor-Associated Factor Binding Domain of the TNF Receptor 75

Wim Declercq, Geertrui Denecker, Walter Fiers, and Peter Vandenabeele
J Immunol 1998 161: 390-399. [Abstract] [Full Text] [PDF]  

Differential Expression and Function of L-Selectin on CD56^bright and CD56^dim Natural Killer Cell Subsets

Margaret Frey, Nalini B. Packianathan, Todd A. Fehniger, Mary E. Ross, Wan-Chao Wang, Carleton C. Stewart, Michael A. Caligiuri, and Sharon S. Evans
J Immunol 1998 161: 400-408. [Abstract] [Full Text] [PDF]  

Enhancing Effect of IL-17 on IL-1-Induced IL-6 and Leukemia Inhibitory Factor Production by Rheumatoid Arthritis Synoviocytes and Its Regulation by Th2 Cytokines

Martine Chabaud, François Fossiez, Jean-Luc Taupin, and Pierre Miossec
J Immunol 1998 161: 409-414. [Abstract] [Full Text] [PDF]  

Human Eosinophils Produce Biologically Active IL-12: Implications for Control of T Cell Responses

Markus Grewe, Wolfgang Czech, Akimichi Morita, Thomas Werfel, Michaela Klammer, Alexander Kapp, Thomas Ruzicka, Erwin Schöpf, and Jean Krutmann
J Immunol 1998 161: 415-420. [Abstract] [Full Text] [PDF]  

A Synthetic CD4-CDR3 Peptide Analog Enhances Skin Allograft Survival Across a MHC Class II Barrier

Ute Koch, Swati Choksi, Lisa Marcucci, and Robert Korngold
J Immunol 1998 161: 421-429. [Abstract] [Full Text] [PDF]  

Angiotensin II Participates in Mononuclear Cell Recruitment in Experimental Immune Complex Nephritis Through Nuclear Factor-B Activation and Monocyte Chemoattractant Protein-1 Synthesis

Marta Ruiz-Ortega, Carmen Bustos, Miguel A. Hernández-Presa, Oscar Lorenzo, Juan J. Plaza, and Jesús Egido
J Immunol 1998 161: 430-439. [Abstract] [Full Text] [PDF]  

Hemorrhagic Shock Primes for Increased Expression of Cytokine-Induced Neutrophil Chemoattractant in the Lung: Role in Pulmonary Inflammation Following Lipopolysaccharide

Jie Fan, John C. Marshall, Maria Jimenez, Pang N. Shek, John Zagorski, and Ori D. Rotstein
J Immunol 1998 161: 440-447. [Abstract] [Full Text] [PDF]  

T Cell Epitopes in Japanese Cedar (Cryptomeria japonica) Pollen Allergens: Choice of Major T Cell Epitopes in Cry j 1 and Cry j 2 Toward Design of the Peptide-Based Immunotherapeutics for the Management of Japanese Cedar Pollinosis

Toshio Sone, Keiko Morikubo, Michinori Miyahara, Naoki Komiyama, Kimiko Shimizu, Hajime Tsunoo, and Kohsuke Kino
J Immunol 1998 161: 448-457. [Abstract] [Full Text] [PDF]  

Ubiquitination and Dimerization of Complement Receptor Type 2 on Sheep B Cells

Wayne R. Hein, Lisbeth Dudler, Wendy L. Marston, Thor Landsverk, Alan J. Young, and David Avila
J Immunol 1998 161: 458-466. [Abstract] [Full Text] [PDF]  

SB 203580 Inhibits p38 Mitogen-Activated Protein Kinase, Nitric Oxide Production, and Inducible Nitric Oxide Synthase in Bovine Cartilage-Derived Chondrocytes

Alison M. Badger, Michael N. Cook, Michael W. Lark, Tonie M. Newman-Tarr, Barbara A. Swift, Allen H. Nelson, Frank C. Barone, and Sanjay Kumar
J Immunol 1998 161: 467-473. [Abstract] [Full Text] [PDF]  

Systemic Administration of Endotoxin Induces Bronchopulmonary Hyperreactivity Dissociated from TNF- Formation and Neutrophil Sequestration into the Murine Lungs

Jean Lefort, Monique Singer, Dominique Leduc, Patricia Renesto, Marie Anne Nahori, Michel Huerre, Christophe Créminon, Michel Chignard, and B. Boris Vargaftig
J Immunol 1998 161: 474-480. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Demonstration of Human T Lymphotropic Virus Type I (HTLV-I) Tax-Specific CD8⁺ Lymphocytes Directly in Peripheral Blood of HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis Patients by Intracellular Cytokine Detection

Ryuji Kubota, Taketo Kawanishi, Hidetoshi Matsubara, Angela Manns, and Steven Jacobson
J Immunol 1998 161: 482-488. [Abstract] [Full Text] [PDF]  

Lymphocyte Activation Gene-3 (LAG-3) Expression and IFN- Production Are Variably Coregulated in Different Human T Lymphocyte Subpopulations

Enrico Scala, Maurizio Carbonari, Paola Del Porto, Marina Cibati, Tiziana Tedesco, Anna Maria Mazzone, Roberto Paganelli, and Massimo Fiorilli
J Immunol 1998 161: 489-493. [Abstract] [Full Text] [PDF]  

IFN- Receptor Signaling Is Essential for the Initiation, Acceleration, and Destruction of Autoimmune Kidney Disease in MRL-Fas^lpr Mice

Andreas Schwarting, Takashi Wada, Koji Kinoshita, Gregory Tesch, and Vicki Rubin Kelley
J Immunol 1998 161: 494-503. [Abstract] [Full Text] [PDF]  

Experimental Autoimmune Encephalomyelitis Induced with a Combination of Myelin Basic Protein and Myelin Oligodendrocyte Glycoprotein Is Ameliorated by Administration of a Single Myelin Basic Protein Peptide

Elizabeth A. Leadbetter, Cheryl R. Bourque, Brigitte Devaux, Carl D. Olson, Geoffrey H. Sunshine, Shirish Hirani, Barbara P. Wallner, Dawn E. Smilek, and Mary Pat Happ
J Immunol 1998 161: 504-512. [Abstract] [Full Text] [PDF]  

In Vitro Effects of IL-12 on HIV-1-Specific CTL Lines from HIV-1-Infected Children

Elizabeth J. McFarland, Paul A. Harding, Samantha MaWhinney, Robert T. Schooley, and Daniel R. Kuritzkes
J Immunol 1998 161: 513-519. [Abstract] [Full Text] [PDF]  

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