CUTTING EDGE:

Cutting Edge: Mice Defective in Fas Are Highly Susceptible to Leishmania major Infection Despite Elevated IL-12 Synthesis, Strong Th1 Responses, and Enhanced Nitric Oxide Production

Fang-Ping Huang, Damo Xu, Ehsan-O Esfandiari, William Sands, Xiao-qing Wei, and Foo Y. Liew
J Immunol 1998 160: 4143-4147. [Abstract] [Full Text] [PDF]  

Cutting Edge: Characterization of an Associated 16-kDa Tyrosine Phosphoprotein Required for Ly-49D Signal Transduction

Llewellyn H. Mason, Jami Willette-Brown, Stephen K. Anderson, Pierre Gosselin, Elizabeth W. Shores, Paul E. Love, John R. Ortaldo, and Daniel W. McVicar
J Immunol 1998 160: 4148-4152. [Abstract] [Full Text] [PDF]  

Cutting Edge: IL-4 Induces Functional Cell-Surface Expression of CXCR4 on Human T Cells

Patrick Jourdan, Claire Abbal, Nelly Nora, Toshiyuki Hori, Takashi Uchiyama, Jean-Pierre Vendrell, Jean Bousquet, Naomi Taylor, Jérôme Pène, and Hans Yssel
J Immunol 1998 160: 4153-4157. [Abstract] [Full Text] [PDF]  

TECHNICAL NOTE:

Technical Note: Aberrant Detection of Cell Surface Fas Ligand with Anti-Peptide Antibodies

Dawn Smith, Scott Sieg, and David Kaplan
J Immunol 1998 160: 4159-4160. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Hybrid Membrane IgM with the Transmembrane Region of I-A Facilitates Enhanced Presentation of Distinct Epitopes to T Cells

Ko-Jiunn Liu, Michael Schwen, Philip W. Tucker, and Byung S. Kim
J Immunol 1998 160: 4161-4168. [Abstract] [Full Text] [PDF]  

Polymorphism at the HLA-DQ Locus Determines Susceptibility to Experimental Autoimmune Myasthenia Gravis

Raghavan Raju, Wen-Zhi Zhan, Peter Karachunski, Bianca Conti-Fine, Gary C. Sieck, and Chella David
J Immunol 1998 160: 4169-4174. [Abstract] [Full Text] [PDF]  

Inhibition of Mitogen-Activated Protein Kinase Kinase Blocks T Cell Proliferation But Does Not Induce or Prevent Anergy

Dimuthu R. DeSilva, Elizabeth A. Jones, Margaret F. Favata, Bruce D. Jaffee, Ronald L. Magolda, James M. Trzaskos, and Peggy A. Scherle
J Immunol 1998 160: 4175-4181. [Abstract] [Full Text] [PDF]  

Activation of p21-CDC42/Rac-Activated Kinases by CD28 Signaling: p21-Activated Kinase (PAK) and MEK Kinase 1 (MEKK1) May Mediate the Interplay Between CD3 and CD28 Signals

Shuji Kaga, Scott Ragg, Kem A. Rogers, and Atsuo Ochi
J Immunol 1998 160: 4182-4189. [Abstract] [Full Text] [PDF]  

Expression of ADP-Ribosyltransferase on Normal T Lymphocytes and Effects of Nicotinamide Adenine Dinucleotide on Their Function

Shigefumi Okamoto, Olga Azhipa, Yajing Yu, Elizabeth Russo, and Gunther Dennert
J Immunol 1998 160: 4190-4198. [Abstract] [Full Text] [PDF]  

Mechanisms of CD8ß-Mediated T Cell Response Enhancement: Interaction with MHC Class I/ß₂-Microglobulin and Functional Coupling to TCR/CD3

Christopher J. Wheeler, Jing-Yi Chen, Terry A. Potter, and Jane R. Parnes
J Immunol 1998 160: 4199-4207. [Abstract] [Full Text] [PDF]  

Differential Requirements for LFA-1 Binding to ICAM-1 and LFA-1-Mediated Cell Aggregation

Lilli Petruzzelli, Lisa Maduzia, and Timothy A. Springer
J Immunol 1998 160: 4208-4216. [Abstract] [Full Text] [PDF]  

Newborn Mice Develop Balanced Th1/Th2 Primary Effector Responses In Vivo But Are Biased to Th2 Secondary Responses

Becky Adkins and Rong-Qing Du
J Immunol 1998 160: 4217-4224. [Abstract] [Full Text] [PDF]  

Involvement of CD40 Ligand-CD40 and CTLA4-B7 Pathways in Murine Acute Graft-Versus-Host Disease Induced by Allogeneic T Cells Lacking CD28

Kiyoshi Saito, Jinkyo Sakurai, Junko Ohata, Takao Kohsaka, Hiroshi Hashimoto, Ko Okumura, Ryo Abe, and Miyuki Azuma
J Immunol 1998 160: 4225-4231. [Abstract] [Full Text] [PDF]  

Oligoclonal Development of B Cells Bearing Discrete Ig Chains in Chicken Single Germinal Centers

Hiroshi Arakawa, Kei-ichi Kuma, Masahiro Yasuda, Shuichi Furusawa, Shigeo Ekino, and Hideo Yamagishi
J Immunol 1998 160: 4232-4241. [Abstract] [Full Text] [PDF]  

Costimulation via TCR and IL-1 Receptor Reveals a Novel IL-1-Mediated Autocrine Pathway of Th2 Cell Proliferation

Magdalena Huber, Horst U. Beuscher, Peter Rohwer, Roland Kurrle, Martin Röllinghoff, and Michael Lohoff
J Immunol 1998 160: 4242-4247. [Abstract] [Full Text] [PDF]  

Matrix Metalloproteinases Produced by Rat IL-2-Activated NK Cells

Richard P. Kitson, Pierette M. Appasamy, Ulf Nannmark, Per Albertsson, Megan K. Gabauer, and Ronald H. Goldfarb
J Immunol 1998 160: 4248-4253. [Abstract] [Full Text] [PDF]  

Extensive Junctional Diversity of Ig Heavy Chain Rearrangements Generated in the Progeny of Single Fetal Multipotent Hematopoietic Cells in the Absence of Selection

Françoise Nourrit, Noëlle Doyen, Philippe Kourilsky, François Rougeon, and Ana Cumano
J Immunol 1998 160: 4254-4261. [Abstract] [Full Text] [PDF]  

Ultraviolet Light-Induced Immune Tolerance Is Mediated via the Fas/Fas-Ligand System

Agatha Schwarz, Stephan Grabbe, Karin Grosse-Heitmeyer, Berthold Roters, Helge Riemann, Thomas A. Luger, Giorgio Trinchieri, and Thomas Schwarz
J Immunol 1998 160: 4262-4270. [Abstract] [Full Text] [PDF]  

Presentation of Proteolipid Protein Epitopes and B7-1-Dependent Activation of Encephalitogenic T Cells by IFN--Activated SJL/J Astrocytes

Litjen Tan, Kenneth B. Gordon, John P. Mueller, Louis A. Matis, and Stephen D. Miller
J Immunol 1998 160: 4271-4279. [Abstract] [Full Text] [PDF]  

TNF- Messenger RNA and Protein Expression in the Uteroplacental Unit of Mice with Pregnancy Loss

Marat Gorivodsky, Ilona Zemlyak, Hasida Orenstein, Shoshana Savion, Amos Fein, Arkady Torchinsky, and Vladimir Toder
J Immunol 1998 160: 4280-4288. [Abstract] [Full Text] [PDF]  

Novel Glycosylation of HLA-DR Disrupts Antigen Presentation Without Altering Endosomal Localization

Carolyn B. Guerra, Robert Busch, Robert C. Doebele, Wendy Liu, Tetsuji Sawada, William W. Kwok, Ming-der Y. Chang, and Elizabeth D. Mellins
J Immunol 1998 160: 4289-4297. [Abstract] [Full Text] [PDF]  

Type I IFNs Inhibit Human Dendritic Cell IL-12 Production and Th1 Cell Development

Bradford L. McRae, Roshanak Tolouei Semnani, Mark P. Hayes, and Gijs A. van Seventer
J Immunol 1998 160: 4298-4304. [Abstract] [Full Text] [PDF]  

TAP-Independent MHC Class I Peptide Antigen Presentation to Alloreactive CTL Is Enhanced by Target Cell Incubation at Subphysiologic Temperatures

Yan Shi, Kelly D. Smith, and Charles T. Lutz
J Immunol 1998 160: 4305-4312. [Abstract] [Full Text] [PDF]  

A Noncomitogenic CD2R Monoclonal Antibody Induces Apoptosis of Activated T Cells by a CD95/CD95-L-Dependent Pathway

Sylvie Fournel, Eric Robinet, Nathalie Bonnefoy-Bérard, Olga Assossou, Monique Flacher, Herman Waldmann, Georges Bismuth, and Jean-Pierre Revillard
J Immunol 1998 160: 4313-4321. [Abstract] [Full Text] [PDF]  

IL-15 Enhances the Response of Human T Cells to Nonpetide Microbial Antigens

Verónica E. García, Denis Jullien, Mark Song, Koichi Uyemura, Ke Shuai, Craig T. Morita, and Robert L. Modlin
J Immunol 1998 160: 4322-4329. [Abstract] [Full Text] [PDF]  

Induction of Fas Ligand in Murine Bone Marrow NK Cells by Bacterial Polysaccharides

Øyvind Halaas, Randi Vik, and Terje Espevik
J Immunol 1998 160: 4330-4336. [Abstract] [Full Text] [PDF]  

Analysis of the IFN--Signaling Pathway in Macrophages at Different Stages of Maturation

David M. Lucas, Mary A. Lokuta, Mary Ann McDowell, Joyce E. S. Doan, and Donna M. Paulnock
J Immunol 1998 160: 4337-4342. [Abstract] [Full Text] [PDF]  

The TCR-Binding Region of the HLA Class I ₂ Domain Signals Rapid Fas-Independent Cell Death: A Direct Pathway for T Cell-Mediated Killing of Target Cells?

Rolf D. Pettersen, Gustav Gaudernack, Mette Kløvstad Olafsen, Sverre O. Lie, and Kjetil Hestdal
J Immunol 1998 160: 4343-4352. [Abstract] [Full Text] [PDF]  

Regulation of Transcription of the TATA-less Human Complement Component C4 Gene

Akshay K. Vaishnaw, Tracey J. Mitchell, S. Jane Rose, Mark J. Walport, and Bernard J. Morley
J Immunol 1998 160: 4353-4360. [Abstract] [Full Text] [PDF]  

The Glycosylphosphatidylinositol-Anchored Form and the Transmembrane Form of CD58 Associate with Protein Kinases

Dganit Itzhaky, Nava Raz, and Nurit Hollander
J Immunol 1998 160: 4361-4366. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Evidence for Sulfate Modification of H-2D^d on N-Linked Carbohydrate(s): Possible Involvement in Ly-49A Interaction

Chew Shun Chang and Kevin P. Kane
J Immunol 1998 160: 4367-4374. [Abstract] [Full Text] [PDF]  

Interaction of HLA-E with Peptides and the Peptide Transporter In Vitro: Implications for its Function in Antigen Presentation

Matthias Ulbrecht, Susanne Modrow, Rakesh Srivastava, Per A. Peterson, and Elisabeth H. Weiss
J Immunol 1998 160: 4375-4385. [Abstract] [Full Text] [PDF]  

Promiscuous Binding of Synthetic Copolymer 1 to Purified HLA-DR Molecules

Masha Fridkis-Hareli and Jack L. Strominger
J Immunol 1998 160: 4386-4397. [Abstract] [Full Text] [PDF]  

Dominant Signals Leading to Inhibitor B Protein Degradation Mediate CD40 Ligand Rescue of WEHI 231 Immature B Cells from Receptor-Mediated Apoptosis

Stephanie L. Schauer, Robert E. Bellas, and Gail E. Sonenshein
J Immunol 1998 160: 4398-4405. [Abstract] [Full Text] [PDF]  

Only Selected Light Chains Combine with a Given Heavy Chain to Confer Specificity for a Model Glycopeptide Antigen

Marcin Czerwinski, Dorota Siemaszko, Don L. Siegel, and Steven L. Spitalnik
J Immunol 1998 160: 4406-4417. [Abstract] [Full Text] [PDF]  

The 5' Untranslated Region, Signal Peptide, and the Coding Sequence of the Carboxyl Terminus of IL-15 Participate in Its Multifaceted Translational Control

Richard N. Bamford, Andrew P. DeFilippis, Nazli Azimi, Gloria Kurys, and Thomas A. Waldmann
J Immunol 1998 160: 4418-4426. [Abstract] [Full Text] [PDF]  

Selective Inhibition of IL-5 Receptor -Chain Gene Transcription by IL-5, IL-3, and Granulocyte-Macrophage Colony-Stimulating Factor in Human Blood Eosinophils

Peng Wang, Ping Wu, Boonlert Cheewatrakoolpong, Joyce G. Myers, Robert W. Egan, and M. Motasim Billah
J Immunol 1998 160: 4427-4432. [Abstract] [Full Text] [PDF]  

Transcriptional Repression of the IL-2 Gene in Th Cells by ZEB

Dag H. Yasui, Tom Genetta, Tom Kadesch, Thomas M. Williams, Susan L. Swain, Lisa V. Tsui, and Brigitte T. Huber
J Immunol 1998 160: 4433-4440. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

MHC Class I/Peptide Stability: Implications for Immunodominance, In Vitro Proliferation, and Diversity of Responding CTL

Dirk H. Busch and Eric G. Pamer
J Immunol 1998 160: 4441-4448. [Abstract] [Full Text] [PDF]  

Enhancement of Tumor Outgrowth Through CTL Tolerization After Peptide Vaccination Is Avoided by Peptide Presentation on Dendritic Cells

René E. M. Toes, Ellen I. H. van der Voort, Stephen P. Schoenberger, Jan Wouter Drijfhout, Louis van Bloois, Gert Storm, W. Martin Kast, Rienk Offringa, and Cornelis J. M. Melief
J Immunol 1998 160: 4449-4456. [Abstract] [Full Text] [PDF]  

In Situ Cancer Vaccination: An IL-12 Defective Vector/Replication-Competent Herpes Simplex Virus Combination Induces Local and Systemic Antitumor Activity

Masahiro Toda, Robert L. Martuza, Hidefumi Kojima, and Samuel D. Rabkin
J Immunol 1998 160: 4457-4464. [Abstract] [Full Text] [PDF]  

Repeated Intratracheal Instillations of Nonreplicating Adenovirus 2 Vector Attenuate CTL Responses and IFN- Production

David W. Pascual, Nancy Walters, and Peter Hillemeyer
J Immunol 1998 160: 4465-4472. [Abstract] [Full Text] [PDF]  

IL-10 Regulates Liver Pathology in Acute Murine Schistosomiasis mansoni But Is Not Required for Immune Down-Modulation of Chronic Disease

Thomas A. Wynn, Allen W. Cheever, Megan E. Williams, Sara Hieny, Pat Caspar, Ralf Kühn, Werner Müller, and Alan Sher
J Immunol 1998 160: 4473-4480. [Abstract] [Full Text] [PDF]  

Thrombopoietin (TPO) Knockout Phenotype Induced by Cross-Reactive Antibodies Against TPO Following Injection of Mice with Recombinant Adenovirus Encoding Human TPO

Mohammed-Amine Abina, Micheline Tulliez, Marie-Thérèse Duffour, Najet Debili, Catherine Lacout, Jean-Luc Villeval, Françoise Wendling, William Vainchenker, and Hedi Haddada
J Immunol 1998 160: 4481-4489. [Abstract] [Full Text] [PDF]  

Induction of In Vitro Human Macrophage Anti-Mycobacterium tuberculosis Activity: Requirement for IFN- and Primed Lymphocytes

M. Gloria Bonecini-Almeida, Sadhana Chitale, Iosif Boutsikakis, Jiayuan Geng, Howard Doo, Suhui He, and John L. Ho
J Immunol 1998 160: 4490-4499. [Abstract] [Full Text] [PDF]  

Cellular Mechanisms Involved in Protection Against Influenza Virus Infection in Transgenic Mice Expressing a TCR Receptor Specific for Class II Hemagglutinin Peptide in CD4⁺ and CD8⁺ T Cells

Adrian Bot, Sofia Casares, Simona Bot, Harald von Boehmer, and Constantin Bona
J Immunol 1998 160: 4500-4507. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Analysis of Ligand-Induced and Ligand-Attenuated Epitopes on the Leukocyte Integrin ₄ß₁: VCAM-1, Mucosal Addressin Cell Adhesion Molecule-1, and Fibronectin Induce Distinct Conformational Changes

Peter Newham, Sue E. Craig, Katherine Clark, A. Paul Mould, and Martin J. Humphries
J Immunol 1998 160: 4508-4517. [Abstract] [Full Text] [PDF]  

Down-Regulation of CXCR2 Expression on Human Polymorphonuclear Leukocytes by TNF-

Kohsuke Asagoe, Kokichi Yamamoto, Atsushi Takahashi, Kazuo Suzuki, Akinori Maeda, Masaharu Nohgawa, Nari Harakawa, Kuniko Takano, Naofumi Mukaida, Kouji Matsushima, Minoru Okuma, and Masataka Sasada
J Immunol 1998 160: 4518-4525. [Abstract] [Full Text] [PDF]  

Leukotriene B₄ Activates the NADPH Oxidase in Eosinophils by a Pertussis Toxin-Sensitive Mechanism That Is Largely Independent of Arachidonic Acid Mobilization

Mark A. Lindsay, Rosie S. Perkins, Peter J. Barnes, and Mark A. Giembycz
J Immunol 1998 160: 4526-4534. [Abstract] [Full Text] [PDF]  

Involvement of CD14 and Complement Receptors CR3 and CR4 in Nuclear Factor-B Activation and TNF Production Induced by Lipopolysaccharide and Group B Streptococcal Cell Walls

Andrei E. Medvedev, Trude Flo, Robin R. Ingalls, Douglas T. Golenbock, Giuseppe Teti, Stefanie N. Vogel, and Terje Espevik
J Immunol 1998 160: 4535-4542. [Abstract] [Full Text] [PDF]  

Expression and Function of the Type 3 Complement Receptor in Tissues of the Developing Mouse

Derralynn A. Hughes and Siamon Gordon
J Immunol 1998 160: 4543-4552. [Abstract] [Full Text] [PDF]  

Blockade of Antibody-Induced Glomerulonephritis with Crry-Ig, a Soluble Murine Complement Inhibitor

Richard J. Quigg, Yuko Kozono, Dawn Berthiaume, Alice Lim, David J. Salant, Andrew Weinfeld, Patricia Griffin, Elisabeth Kremmer, and V. Michael Holers
J Immunol 1998 160: 4553-4560. [Abstract] [Full Text] [PDF]  

Regulation of Human Mast Cell ß-Tryptase: Conversion of Inactive Monomer to Active Tetramer at Acid pH

Shunlin Ren, Kentaro Sakai, and Lawrence B. Schwartz
J Immunol 1998 160: 4561-4569. [Abstract] [Full Text] [PDF]  

TNF- Convertase Enzyme from Human Arthritis-Affected Cartilage: Isolation of cDNA by Differential Display, Expression of the Active Enzyme, and Regulation of TNF-

Indravadan R. Patel, Mukundan G. Attur, Rajesh N. Patel, Steven A. Stuchin, Ruben A. Abagyan, Steven B. Abramson, and Ashok R. Amin
J Immunol 1998 160: 4570-4579. [Abstract] [Full Text] [PDF]  

Cationic Lipids Enhance Cytokine and Cell Influx Levels in the Lung Following Administration of Plasmid: Cationic Lipid Complexes

Bruce D. Freimark, H. Paul Blezinger, Valarie J. Florack, Jeffrey L. Nordstrom, Scott D. Long, Deepa S. Deshpande, Sam Nochumson, and Karel L. Petrak
J Immunol 1998 160: 4580-4586. [Abstract] [Full Text] [PDF]  

Dendritic Cells as the Terminal Stage of Monocyte Differentiation

Karolina A. Palucka, Nicolas Taquet, Francoise Sanchez-Chapuis, and Jean Claude Gluckman
J Immunol 1998 160: 4587-4595. [Abstract] [Full Text] [PDF]  

Inducible Expression of the ₁-Acid Glycoprotein by Rat and Human Type II Alveolar Epithelial Cells

Bruno Crestani, Corinne Rolland, Bernard Lardeux, Thierry Fournier, Dominique Bernuau, Christian Poüs, Christiane Vissuzaine, Lin Li, and Michel Aubier
J Immunol 1998 160: 4596-4605. [Abstract] [Full Text] [PDF]  

Monocyte Chemoattractant Protein-1 Synthesis by Murine Lung Fibroblasts Modulates CD4⁺ T Cell Activation

Cory M. Hogaboam, Nicholas W. Lukacs, Stephen W. Chensue, Robert M. Strieter, and Steven L. Kunkel
J Immunol 1998 160: 4606-4614. [Abstract] [Full Text] [PDF]  

Transient Gene Transfer of IL-12 Regulates Chemokine Expression and Disease Severity in Experimental Arthritis

Elizabeth Parks, Robert M. Strieter, Nicholas W. Lukacs, Jack Gauldie, Mary Hitt, Frank L. Graham, and Steven L. Kunkel
J Immunol 1998 160: 4615-4619. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Enhanced Expression of B7.2 (CD86) in Patients with Atopic Dermatitis: A Potential Role in the Modulation of IgE Synthesis

Orathai Jirapongsananuruk, Michaël F. Hofer, Anne E. Trumble, David A. Norris, and Donald Y. M. Leung
J Immunol 1998 160: 4622-4627. [Abstract] [Full Text] [PDF]  

An Immunodominant Epitope from Mycobacterial 65-kDa Heat Shock Protein Protects Against Pristane-Induced Arthritis

Stephen J. Thompson, James N. Francis, L. Khai Siew, Ginette R. Webb, Peter J. Jenner, M. Joseph Colston, and Christopher J. Elson
J Immunol 1998 160: 4628-4634. [Abstract] [Full Text] [PDF]  

Dystrophin Acts as a Transplantation Rejection Antigen in Dystrophin-Deficient Mice: Implication for Gene Therapy

Yoshikazu Ohtsuka, Keiko Udaka, Yuichiro Yamashiro, Hideo Yagita, and Ko Okumura
J Immunol 1998 160: 4635-4640. [Abstract] [Full Text] [PDF]  

In Vitro Stimulation of C1s Proteolytic Activities by C1s-Presenting Autoantibodies from Patients with Systemic Lupus Erythematosus

Shiping He and Ya-Ling Lin
J Immunol 1998 160: 4641-4647. [Abstract] [Full Text] [PDF]  

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