CUTTING EDGE:

Cutting Edge: CpG Oligodeoxynucleotides Trigger Protective and Curative Th1 Responses in Lethal Murine Leishmaniasis

Stefan Zimmermann, Oliver Egeter, Susanne Hausmann, Grayson B. Lipford, Martin Röcken, Hermann Wagner, and Klaus Heeg
J Immunol 1998 160: 3627-3630. [Abstract] [Full Text] [PDF]  

Cutting Edge: Predictable TCR Antigen Recognition Based on Peptide Scans Leads to the Identification of Agonist Ligands with No Sequence Homology

Bernhard Hemmer, Marco Vergelli, Bruno Gran, Nick Ling, Paul Conlon, Clemencia Pinilla, Richard Houghten, Henry F. McFarland, and Roland Martin
J Immunol 1998 160: 3631-3636. [Abstract] [Full Text] [PDF]  

Cutting Edge: Liposomal Formulation of a Self Lymphoma Antigen Induces Potent Protective Antitumor Immunity

Larry W. Kwak, Robin Pennington, Larry Boni, Augusto C. Ochoa, Richard J. Robb, and Mircea C. Popescu
J Immunol 1998 160: 3637-3641. [Abstract] [Full Text] [PDF]  

Cutting Edge: IL-12 and IL-18 Differentially Regulate the Transcriptional Activity of the Human IFN- Promoter in Primary CD4⁺ T Lymphocytes

Karina Barbulescu, Christoph Becker, Jörg F. Schlaak, Edgar Schmitt, Karl-Hermann Meyer zum Büschenfelde, and Markus F. Neurath
J Immunol 1998 160: 3642-3647. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Thymic Lineage Commitment Rather Than Selection Causes Genetic Variations in Size of CD4 and CD8 Compartments

Joost P. M. van Meerwijk, Teresa Bianchi, Samuel Marguerat, and H. Robson MacDonald
J Immunol 1998 160: 3649-3654. [Abstract] [Full Text] [PDF]  

T:T Antigen Presentation by Activated Murine CD8⁺ T Cells Induces Anergy and Apoptosis

Jian-Guo Chai, Istvan Bartok, Diane Scott, Julian Dyson, and Robert Lechler
J Immunol 1998 160: 3655-3665. [Abstract] [Full Text] [PDF]  

Identification of a Developmentally Regulated Phase of Postselection Expansion Driven by Thymic Epithelium

Katherine J. Hare, Robert W. Wilkinson, Eric J. Jenkinson, and Graham Anderson
J Immunol 1998 160: 3666-3672. [Abstract] [Full Text] [PDF]  

CD8⁺ Cells Are Not Necessary for Allograft Rejection or the Induction of Apoptosis in an Experimental Model of Small Intestinal Transplantation

Sheri M. Krams, Michihiro Hayashi, Christine K. Fox, Janeth C. Villanueva, Karen J. Whitmer, Washington Burns, Carlos O. Esquivel, and Olivia M. Martinez
J Immunol 1998 160: 3673-3680. [Abstract] [Full Text] [PDF]  

Mouse CD1-Autoreactive T Cells Have Diverse Patterns of Reactivity to CD1⁺ Targets

Laurent Brossay, Shabnam Tangri, Mark Bix, Susanna Cardell, Richard Locksley, and Mitchell Kronenberg
J Immunol 1998 160: 3681-3688. [Abstract] [Full Text] [PDF]  

Phorbol Esters Induce Differentiation of Human CD34⁺ Hemopoietic Progenitors to Dendritic Cells: Evidence for Protein Kinase C-Mediated Signaling

Thomas A. Davis, Abha A. Saini, Patrick J. Blair, Bruce L. Levine, Nancy Craighead, David M. Harlan, Carl H. June, and Kelvin P. Lee
J Immunol 1998 160: 3689-3697. [Abstract] [Full Text] [PDF]  

Modulation of Naive CD4 T Cell Activation with Altered Peptide Ligands: The Nature of the Peptide and Presentation in the Context of Costimulation Are Critical for a Sustained Response

Paul R. Rogers, Howard M. Grey, and Michael Croft
J Immunol 1998 160: 3698-3704. [Abstract] [Full Text] [PDF]  

MHC Class I Is Required for Peripheral Accumulation of CD8⁺ Thymic Emigrants

Dragana Nesic and Stanislav Vukmanovic
J Immunol 1998 160: 3705-3712. [Abstract] [Full Text] [PDF]  

IFN- Receptor Deletion Prevents Autoantibody Production and Glomerulonephritis in Lupus-Prone (NZB x NZW)F₁ Mice

Cordula Haas, Bernhard Ryffel, and Michel Le Hir
J Immunol 1998 160: 3713-3718. [Abstract] [Full Text] [PDF]  

Cross-Reactivity in Murine Fluoroquinolone Photoallergy: Exclusive Usage of TCR Vß13 by Immune T Cells That Recognize Fluoroquinolone-Photomodified Cells

Yoshiki Tokura, Naohiro Seo, Hiroaki Yagi, Fukumi Furukawa, and Masahiro Takigawa
J Immunol 1998 160: 3719-3728. [Abstract] [Full Text] [PDF]  

Reprogramming of Lipopolysaccharide-Primed Macrophages Is Controlled by a Counterbalanced Production of IL-10 and IL-12

Alexander Shnyra, Ryan Brewington, Arlene Alipio, Claudia Amura, and David C. Morrison
J Immunol 1998 160: 3729-3736. [Abstract] [Full Text] [PDF]  

TCR Usage by Homocysteine-Specific Human CTL

Myo-Myo Chilvers, Paul Wordsworth, Andy Stubbs, and Xiao-Ming Gao
J Immunol 1998 160: 3737-3742. [Abstract] [Full Text] [PDF]  

Bcmd Decreases the Life Span of B-2 But Not B-1 Cells in A/WySnJ Mice

Vicky M. Lentz, Colleen E. Hayes, and Michael P. Cancro
J Immunol 1998 160: 3743-3747. [Abstract] [Full Text] [PDF]  

Generation of the Germline Peripheral B Cell Repertoire: VH81X- B Cells Are Unable to Complete All Developmental Programs

Flavius Martin, Woong-Jai Won, and John F. Kearney
J Immunol 1998 160: 3748-3758. [Abstract] [Full Text] [PDF]  

Differential Capacities of CD4⁺, CD8⁺, and CD4^-CD8^- T Cell Subsets to Express IL-18 Receptor and Produce IFN- in Response to IL-18

Michio Tomura, Seiji Maruo, Jie Mu, Xu-Yu Zhou, Hyun-Jong Ahn, Toshiyuki Hamaoka, Haruki Okamura, Kenji Nakanishi, Steven Clark, Masashi Kurimoto, and Hiromi Fujiwara
J Immunol 1998 160: 3759-3765. [Abstract] [Full Text] [PDF]  

Fas/Fas Ligand Signaling During Gestational T Cell Development

Martin Fleck, Tong Zhou, Toru Tatsuta, Pingar Yang, Zheng Wang, and John D. Mountz
J Immunol 1998 160: 3766-3775. [Abstract] [Full Text] [PDF]  

The Actin-Bundling Protein Fascin Is Involved in the Formation of Dendritic Processes in Maturing Epidermal Langerhans Cells

Ralf Ross, Xiao-Lan Ross, Jens Schwing, Tina Längin, and Angelika B. Reske-Kunz
J Immunol 1998 160: 3776-3782. [Abstract] [Full Text] [PDF]  

A Cytokine Cascade Including Prostaglandin E₂, IL-4, and IL-10 Is Responsible for UV-Induced Systemic Immune Suppression

Vijay Shreedhar, Todd Giese, Victor W. Sung, and Stephen E. Ullrich
J Immunol 1998 160: 3783-3789. [Abstract] [Full Text] [PDF]  

Antiviral Cytotoxic Activity Across a Species Barrier in Mixed Xenogeneic Chimeras: Functional Restriction to Host MHC

Yolonda L. Colson, Ralph A. Tripp, Peter C. Doherty, Sherry M. Wren, Michael Neipp, Ashraf Y. Abou El-Ezz, and Suzanne T. Ildstad
J Immunol 1998 160: 3790-3796. [Abstract] [Full Text] [PDF]  

Potent Apoptotic Signaling and Subsequent Unresponsiveness Induced by a Single CD2 mAb (BTI-322) in Activated Human Peripheral T Cells

Céline Dumont, Olivier Déas, Bertrand Mollereau, Chafika Hebib, Valérie Giovino-Barry, Alain Bernard, François Hirsch, Bernard Charpentier, and Anna Senik
J Immunol 1998 160: 3797-3804. [Abstract] [Full Text] [PDF]  

Transgenic Expression of Fas in T Cells Blocks Lymphoproliferation But Not Autoimmune Disease in MRL-lpr Mice

Hidehiro Fukuyama, Masashi Adachi, Sachiko Suematsu, Keiko Miwa, Takashi Suda, Nobuaki Yoshida, and Shigekazu Nagata
J Immunol 1998 160: 3805-3811. [Abstract] [Full Text] [PDF]  

Critical Roles of Glycosaminoglycan Side Chains of Cartilage Proteoglycan (Aggrecan) in Antigen Recognition and Presentation

Tibor T. Glant, Edit I. Buzás, Alison Finnegan, Gabriela Negroiu, Gabriella Cs-Szabó, and Katalin Mikecz
J Immunol 1998 160: 3812-3819. [Abstract] [Full Text] [PDF]  

Increasing Immunogenicity of Antigens Fused to Ig-Binding Proteins by Cell Surface Targeting

Michel Léonetti, Robert Thai, Joël Cotton, Sandrine Leroy, Pascal Drevet, Frédéric Ducancel, Jean Claude Boulain, and André Ménez
J Immunol 1998 160: 3820-3827. [Abstract] [Full Text] [PDF]  

Differential Requirement for p56^lck in Fetal and Adult Thymopoiesis

Thierry J. Molina, Jean-Yves Perrot, Josef Penninger, Amélia Ramos, Josée Audouin, Pascale Briand, Tak W. Mak, and Jacques Diebold
J Immunol 1998 160: 3828-3834. [Abstract] [Full Text] [PDF]  

Nuclear Factor B Is Required for Peptide Antigen-Induced Differentiation of a CD4⁺CD8⁺ Thymocyte Line

Jorge Ochoa-Garay, Jonathan Kaye, and John E. Coligan
J Immunol 1998 160: 3835-3843. [Abstract] [Full Text] [PDF]  

Thymic Alterations Induced by 2,3,7,8-Tetrachlorodibenzo- p-Dioxin Are Strictly Dependent on Aryl Hydrocarbon Receptor Activation in Hemopoietic Cells

J. Erin Staples, Francis G. Murante, Nancy C. Fiore, Thomas A. Gasiewicz, and Allen E. Silverstone
J Immunol 1998 160: 3844-3854. [Abstract] [Full Text] [PDF]  

CTLA-4 Regulates Tolerance Induction and T Cell Differentiation In Vivo

Theresa L. Walunas and Jeffrey A. Bluestone
J Immunol 1998 160: 3855-3860. [Abstract] [Full Text] [PDF]  

Mouse Cell Surface Antigens: Nomenclature and Immunophenotyping

Lily Lai, Noosheen Alaverdi, Lois Maltais, and Herbert C. Morse, III
J Immunol 1998 160: 3861-3868. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Selective Inhibition of Expression of the Chemokine Receptor CCR2 in Human Monocytes by IFN-

Giselle Penton-Rol, Nadia Polentarutti, Walter Luini, Alessandro Borsatti, Roberta Mancinelli, Antonio Sica, Silvano Sozzani, and Alberto Mantovani
J Immunol 1998 160: 3869-3873. [Abstract] [Full Text] [PDF]  

Characterization of Oct2 from the Channel Catfish: Functional Preference for a Variant Octamer Motif

David A. Ross, Bradley G. Magor, Darlene L. Middleton, Melanie R. Wilson, Norman W. Miller, L. William Clem, and Gregory W. Warr
J Immunol 1998 160: 3874-3882. [Abstract] [Full Text] [PDF]  

Posttranslational Regulation of TCR V Allelic Exclusion During T Cell Differentiation

S. Munir Alam and Nicholas R. J. Gascoigne
J Immunol 1998 160: 3883-3890. [Abstract] [Full Text] [PDF]  

Extracellular HIV-1 Tat Protein Induces the Rapid Ser¹³³ Phosphorylation and Activation of CREB Transcription Factor in Both Jurkat Lymphoblastoid T Cells and Primary Peripheral Blood Mononuclear Cells

Davide Gibellini, Alessandra Bassini, Sabina Pierpaoli, Lucia Bertolaso, Daniela Milani, Silvano Capitani, Michele La Placa, and Giorgio Zauli
J Immunol 1998 160: 3891-3898. [Abstract] [Full Text] [PDF]  

Differentiation-Specific, Octamer-Dependent Costimulation of Transcription

David Liberg, Mikael Sigvardsson, Mats Bemark, and Tomas Leanderson
J Immunol 1998 160: 3899-3907. [Abstract] [Full Text] [PDF]  

IFN- Induction of the Human Monocyte Chemoattractant Protein (hMCP)-1 Gene in Astrocytoma Cells: Functional Interaction Between an IFN--Activated Site and a GC-Rich Element

Z-H Lucy Zhou, Priya Chaturvedi, Yu-long Han, Sumer Aras, Yi-shuan Li, Pappachan E. Kolattukudy, Dongsheng Ping, Jeremy M. Boss, and Richard M. Ransohoff
J Immunol 1998 160: 3908-3916. [Abstract] [Full Text] [PDF]  

Target Recognition of ß₂-Glycoprotein I (ß₂GPI)-Dependent Anticardiolipin Antibodies: Evidence for Involvement of the Fourth Domain of ß₂GPI in Antibody Binding

Jacob George, Boris Gilburd, Maja Hojnik, Yair Levy, Pnina Langevitz, Eiji Matsuura, Takao Koike, and Yehuda Shoenfeld
J Immunol 1998 160: 3917-3923. [Abstract] [Full Text] [PDF]  

Molecular Cloning and Functional Characterization of the Pig Analogue of CD59: Relevance to Xenotransplantation

Stewart J. Hinchliffe, Neil K. Rushmere, S. Melanie Hanna, and B. Paul Morgan
J Immunol 1998 160: 3924-3932. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Dendritic Cells Express Multiple Chemokine Receptors Used as Coreceptors for HIV Entry

Andrea Rubbert, Christophe Combadiere, Mario Ostrowski, James Arthos, Mark Dybul, Elizabeth Machado, Michael A. Cohn, James A. Hoxie, Philip M. Murphy, Anthony S. Fauci, and Drew Weissman
J Immunol 1998 160: 3933-3941. [Abstract] [Full Text] [PDF]  

Lymphocytes Produce IL-1ß in Response to Fc Receptor Cross-Linking: Effects on Parenchymal Cell IL-8 Release

Clay B. Marsh, Melissa P. Lowe, Brad H. Rovin, Jennifer M. Parker, Zhiming Liao, Daren L. Knoell, and Mark D. Wewers
J Immunol 1998 160: 3942-3948. [Abstract] [Full Text] [PDF]  

Induction of a Th1 Immune Response and Simultaneous Lack of Activation of a Th2 Response Are Required for Generation of Immunity to Leishmaniasis

Anders Sjölander, Tracey M. Baldwin, Joan M. Curtis, and Emanuela Handman
J Immunol 1998 160: 3949-3957. [Abstract] [Full Text] [PDF]  

Mice Lacking IL-12 Develop Polarized Th1 Cells During Viral Infection

Virgil E. C. J. Schijns, Bart L. Haagmans, Christel M. H. Wierda, Boudewijn Kruithof, Ingmar A. F. M. Heijnen, Gottfried Alber, and Marian C. Horzinek
J Immunol 1998 160: 3958-3964. [Abstract] [Full Text] [PDF]  

Immunopathology of Herpetic Stromal Keratitis: Discordance in CD4⁺ T Cell Function Between Euthymic Host and Reconstituted SCID Recipients

Johnson Thomas and Barry T. Rouse
J Immunol 1998 160: 3965-3970. [Abstract] [Full Text] [PDF]  

Effect of Antigen-Processing Efficiency on In Vivo T Cell Response Magnitudes

Sujata Vijh, Ingrid M. Pilip, and Eric G. Pamer
J Immunol 1998 160: 3971-3977. [Abstract] [Full Text] [PDF]  

Vascular Adhesion Protein-1 and ICAM-1 Support the Adhesion of Tumor-Infiltrating Lymphocytes to Tumor Endothelium in Human Hepatocellular Carcinoma

Khong F. Yoong, Gillian McNab, Stefan G. Hübscher, and David H. Adams
J Immunol 1998 160: 3978-3988. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Intraepithelial Infiltration by Mast Cells with Both Connective Tissue-Type and Mucosal-Type Characteristics in Gut, Trachea, and Kidneys of IL-9 Transgenic Mice

Catherine Godfraind, Jamila Louahed, Helen Faulkner, Anne Vink, Guy Warnier, Richard Grencis, and Jean-Christophe Renauld
J Immunol 1998 160: 3989-3996. [Abstract] [Full Text] [PDF]  

Preprosomatostatin Messenger RNA Is Expressed by Inflammatory Cells and Induced by Inflammatory Mediators and Cytokines

David E. Elliott, Arthur M. Blum, Jie Li, Ahmed Metwali, and Joel V. Weinstock
J Immunol 1998 160: 3997-4003. [Abstract] [Full Text] [PDF]  

An Antagonistic IL-4 Mutant Prevents Type I Allergy in the Mouse: Inhibition of the IL-4/IL-13 Receptor System Completely Abrogates Humoral Immune Response to Allergen and Development of Allergic Symptoms In Vivo

Susanne M. Grunewald, Antje Werthmann, Bernd Schnarr, C. Eberhard Klein, Eva B. Bröcker, Markus Mohrs, Frank Brombacher, Walter Sebald, and Albert Duschl
J Immunol 1998 160: 4004-4009. [Abstract] [Full Text] [PDF]  

Lidocaine and its Analogues Inhibit IL-5-Mediated Survival and Activation of Human Eosinophils

Shinji Okada, John B. Hagan, Masahiko Kato, Jennifer L. Bankers-Fulbright, Loren W. Hunt, Gerald J. Gleich, and Hirohito Kita
J Immunol 1998 160: 4010-4017. [Abstract] [Full Text] [PDF]  

Impaired Macrophage Function and Enhanced T Cell-Dependent Immune Response in Mice Lacking CCR5, the Mouse Homologue of the Major HIV-1 Coreceptor

Yuhong Zhou, Takao Kurihara, Rolf-Peter Ryseck, Yi Yang, Carol Ryan, James Loy, Glenn Warr, and Rodrigo Bravo
J Immunol 1998 160: 4018-4025. [Abstract] [Full Text] [PDF]  

Induction and Enhancement of FcRI-Dependent Mast Cell Degranulation Following Coculture with Activated T Cells: Dependency on ICAM-1- and Leukocyte Function-Associated Antigen (LFA)-1-Mediated Heterotypic Aggregation

Noriaki Inamura, Yoseph A. Mekori, Siba P. Bhattacharyya, Peter J. Bianchine, and Dean D. Metcalfe
J Immunol 1998 160: 4026-4033. [Abstract] [Full Text] [PDF]  

Posttranslational Modifications Affect the Activity of the Human Monocyte Chemotactic Proteins MCP-1 and MCP-2: Identification of MCP-2(6–76) as a Natural Chemokine Inhibitor

Paul Proost, Sofie Struyf, Mikaël Couvreur, Jean-Pierre Lenaerts, René Conings, Patricia Menten, Peter Verhaert, Anja Wuyts, and Jo Van Damme
J Immunol 1998 160: 4034-4041. [Abstract] [Full Text] [PDF]  

Hydrogen Peroxide Induces Up-Regulation of Fas in Human Endothelial Cells

Toshimitsu Suhara, Keisuke Fukuo, Tomosada Sugimoto, Shigeto Morimoto, Takeshi Nakahashi, Shigeki Hata, Masumi Shimizu, and Toshio Ogihara
J Immunol 1998 160: 4042-4047. [Abstract] [Full Text] [PDF]  

Involvement of the IL-2 Receptor -Chain (_c) in the Control by IL-4 of Human Monocyte and Macrophage Proinflammatory Mediator Production

Claudine S. Bonder, Harold L. Dickensheets, John J. Finlay-Jones, Raymond P. Donnelly, and Prue H. Hart
J Immunol 1998 160: 4048-4056. [Abstract] [Full Text] [PDF]  

Human Polymorphonuclear Leukocytes Adhere to Complement Factor H Through an Interaction That Involves _Mß₂ (CD11b/CD18)

Richard G. DiScipio, Pamela J. Daffern, Ingrid U. Schraufstätter, and Pragda Sriramarao
J Immunol 1998 160: 4057-4066. [Abstract] [Full Text] [PDF]  

Regulation of E-Cadherin-Mediated Adhesion in Langerhans Cell-Like Dendritic Cells by Inflammatory Mediators That Mobilize Langerhans Cells In Vivo

Thilo Jakob and Mark C. Udey
J Immunol 1998 160: 4067-4073. [Abstract] [Full Text] [PDF]  

IFN- Limits Macrophage Expansion in MRL-Fas^lpr Autoimmune Interstitial Nephritis: A Negative Regulatory Pathway

Andreas Schwarting, Kathryn Moore, Takashi Wada, Gregory Tesch, Hyung-Jin Yoon, and Vicki Rubin Kelley
J Immunol 1998 160: 4074-4081. [Abstract] [Full Text] [PDF]  

Disparate Roles for TNF- and Fas Ligand in Concanavalin A-Induced Hepatitis

Riadh Ksontini, Dorothy B. Colagiovanni, Michael D. Josephs, Carl K. Edwards, III, Cynthia L. Tannahill, Carmen C. Solorzano, James Norman, Woody Denham, Michael Clare-Salzler, Sally L. D. MacKay, and Lyle L. Moldawer
J Immunol 1998 160: 4082-4089. [Abstract] [Full Text] [PDF]  

Dendritic Cells Are Required for the Development of Chronic Eosinophilic Airway Inflammation in Response to Inhaled Antigen in Sensitized Mice

Bart N. Lambrecht, Benoît Salomon, David Klatzmann, and Romain A. Pauwels
J Immunol 1998 160: 4090-4097. [Abstract] [Full Text] [PDF]  

A p55 TNF Receptor Immunoadhesin Prevents T Cell-Mediated Intestinal Injury by Inhibiting Matrix Metalloproteinase Production

Sylvia L. F. Pender, John M. E. Fell, Steven M. Chamow, Avi Ashkenazi, and Thomas T. MacDonald
J Immunol 1998 160: 4098-4103. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Flt-3 Ligand Increases Microchimerism But Can Prevent the Therapeutic Effect of Donor Bone Marrow in Transiently Immunosuppressed Cardiac Allograft Recipients

Mary A. Antonysamy, Raymond J. Steptoe, Ajai Khanna, William A. Rudert, Vladimir M. Subbotin, and Angus W. Thomson
J Immunol 1998 160: 4106-4113. [Abstract] [Full Text] [PDF]  

Complement-Fixing Elicited Antibodies Are a Major Component in the Pathogenesis of Xenograft Rejection

Tsukasa Miyatake, Koichiro Sato, Ko Takigami, Nozomi Koyamada, Wayne W. Hancock, Herve Bazin, Dominique Latinne, Fritz H. Bach, and Miguel P. Soares
J Immunol 1998 160: 4114-4123. [Abstract] [Full Text] [PDF]  

ERRATUM:

Requirement for In Vivo Production of IL-4, But Not IL-10, in the Induction of Proliferative Suppression by Filarial Parasites

Andrew S. MacDonald, Rick M. Maizels, Rachel A. Lawrence, Ian Dransfield, and Judith E. Allen
J Immunol 1998 160: 4124-4132. [Abstract] [Full Text] [PDF]  

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