CUTTING EDGE:

Cutting Edge: Role of Macrophage Migration Inhibitory Factor in Inhibiting NK Cell Activity and Preserving Immune Privilege

R. S. Apte, D. Sinha, E. Mayhew, G. J. Wistow, and J. Y. Niederkorn
J Immunol 1998 160: 5693-5696. [Abstract] [Full Text] [PDF]  

Cutting Edge: JAK3 Activation and Rescue of T Cells from HIV gp120-Induced Unresponsiveness

Nithianandan Selliah and Terri H. Finkel
J Immunol 1998 160: 5697-5701. [Abstract] [Full Text] [PDF]  

Cutting Edge: Antigen-Dependent Regulation of Telomerase Activity in Murine T Cells

Karen S. Hathcock, Nan-ping Weng, Rebecca Merica, Marc K. Jenkins, and Richard Hodes
J Immunol 1998 160: 5702-5706. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Specific Immune Induction Following DNA-Based Immunization Through In Vivo Transfection and Activation of Macrophages/Antigen-Presenting Cells

Michael A. Chattergoon, Tara M. Robinson, Jean D. Boyer, and David B. Weiner
J Immunol 1998 160: 5707-5718. [Abstract] [Full Text] [PDF]  

Factors Involved in the Differentiation of TGF-ß-Producing Cells from Naive CD4⁺ T Cells: IL-4 and IFN- Have Opposing Effects, While TGF-ß Positively Regulates Its Own Production

Robert A. Seder, Thomas Marth, Myra C. Sieve, Warren Strober, John J. Letterio, Anita B. Roberts, and Brian Kelsall
J Immunol 1998 160: 5719-5728. [Abstract] [Full Text] [PDF]  

Macrophage-Derived Nitric Oxide Regulates T Cell Activation via Reversible Disruption of the Jak3/STAT5 Signaling Pathway

Roland M. Bingisser, Peta A. Tilbrook, Patrick G. Holt, and Ursula R. Kees
J Immunol 1998 160: 5729-5734. [Abstract] [Full Text] [PDF]  

The Trophic Action of IL-7 on Pro-T Cells: Inhibition of Apoptosis of Pro-T1, -T2, and -T3 Cells Correlates with Bcl-2 and Bax Levels and Is Independent of Fas and p53 Pathways

Kyungjae Kim, Chong-kil Lee, Thomas J. Sayers, Kathrin Muegge, and Scott K. Durum
J Immunol 1998 160: 5735-5741. [Abstract] [Full Text] [PDF]  

Targeting the IL-15 Receptor with an Antagonist IL-15 Mutant/Fc2a Protein Blocks Delayed-Type Hypersensitivity

Yon Su Kim, Wlodzimierz Maslinski, Xin Xiao Zheng, A. Christopher Stevens, Xian Chang Li, Gregory H. Tesch, Vicki R. Kelley, and Terry B. Strom
J Immunol 1998 160: 5742-5748. [Abstract] [Full Text] [PDF]  

Immunologic Characterization of CD7-Deficient Mice

David M. Lee, Herman F. Staats, John S. Sundy, Dhavalkumar D. Patel, Gregory D. Sempowski, Richard M. Scearce, Dawn M. Jones, and Barton F. Haynes
J Immunol 1998 160: 5749-5756. [Abstract] [Full Text] [PDF]  

Antigen Activation Rescues Recent Thymic Emigrants from Programmed Cell Death in the BB Rat

Sheela Ramanathan, Ken Norwich, and Philippe Poussier
J Immunol 1998 160: 5757-5764. [Abstract] [Full Text] [PDF]  

Thymus Requirement and Antigen Dependency in the "Infectious" Tolerance Pathway in Transplant Recipients

Kazuhiko Onodera, Hans-Dieter Volk, Thomas Ritter, and Jerzy W. Kupiec-Weglinski
J Immunol 1998 160: 5765-5772. [Abstract] [Full Text] [PDF]  

IL-3 Enhances Both Presentation of Exogenous Particulate Antigen in Association with Class I Major Histocompatibility Antigen and Generation of Primary Tumor-Specific Cytolytic T Lymphocytes

Kun-Yun Yeh, Alexander J. McAdam, Beth A. Pulaski, Nilabh Shastri, John G. Frelinger, and Edith M. Lord
J Immunol 1998 160: 5773-5780. [Abstract] [Full Text] [PDF]  

Cooperation Between CD44 and LFA-1/CD11a Adhesion Receptors in Lymphokine-Activated Killer Cell Cytotoxicity

Goichi Matsumoto, Mai P. Nghiem, Naohito Nozaki, Rudolf Schmits, and Josef M. Penninger
J Immunol 1998 160: 5781-5789. [Abstract] [Full Text] [PDF]  

Differential Involvement of a Fas-CPP32-Like Protease Pathway in Apoptosis of TCR/CD9-Costimulated, Naive T Cells and TCR-Restimulated, Activated T Cells

Cheung-Seog Park, Yumi Yashiro, Xu-Guang Tai, Kazuhito Toyo-oka, Toshiyuki Hamaoka, Hideo Yagita, Ko Okumura, Steven Neben, and Hiromi Fujiwara
J Immunol 1998 160: 5790-5796. [Abstract] [Full Text] [PDF]  

Intracellular Formation and Cell Surface Expression of a Complex of an Intact Lysosomal Protein and MHC Class II Molecules

Balasubramanian Arunachalam, Mary Pan, and Peter Cresswell
J Immunol 1998 160: 5797-5806. [Abstract] [Full Text] [PDF]  

Relationships Among TCR Ligand Potency, Thresholds for Effector Function Elicitation, and the Quality of Early Signaling Events in Human T Cells

Bernhard Hemmer, Irena Stefanova, Marco Vergelli, Ronald N. Germain, and Roland Martin
J Immunol 1998 160: 5807-5814. [Abstract] [Full Text] [PDF]  

Expanding Dendritic Cells In Vivo Enhances the Induction of Oral Tolerance

Joanne L. Viney, Allan M. Mowat, Jamie M. O’Malley, Eilidh Williamson, and Neil A. Fanger
J Immunol 1998 160: 5815-5825. [Abstract] [Full Text] [PDF]  

NK Cell Modulation of Murine Cytomegalovirus Retinitis

John E. Bigger, Charles A. Thomas, III, and Sally S. Atherton
J Immunol 1998 160: 5826-5831. [Abstract] [Full Text] [PDF]  

T Cell Renewal Rates, Telomerase, and Telomere Length Shortening

Rob J. De Boer and André J. Noest
J Immunol 1998 160: 5832-5837. [Abstract] [Full Text] [PDF]  

High Frequency Apoptosis of Recent Thymic Emigrants in the Liver of Lymphopenic Diabetes-Prone BioBreeding Rats

Neal N. Iwakoshi, Irving Goldschneider, Frances Tausche, John P. Mordes, Aldo A. Rossini, and Dale L. Greiner
J Immunol 1998 160: 5838-5850. [Abstract] [Full Text] [PDF]  

The Generation of Human T Cell Repertoires During Fetal Development

Laila D. McVay, Sheila S. Jaswal, Christine Kennedy, Adrian Hayday, and Simon R. Carding
J Immunol 1998 160: 5851-5860. [Abstract] [Full Text] [PDF]  

Exogenous and Endogenous IL-10 Regulate IFN- Production by Peripheral Blood Mononuclear Cells in Response to Viral Stimulation

Faribourz Payvandi, Sheela Amrute, and Patricia Fitzgerald-Bocarsly
J Immunol 1998 160: 5861-5868. [Abstract] [Full Text] [PDF]  

A Pathogenic Role of Th2 Cells and Their Cytokine Products on the Pulmonary Metastasis of Murine B16 Melanoma

Makiko Kobayashi, Hiroyuki Kobayashi, Richard B. Pollard, and Fujio Suzuki
J Immunol 1998 160: 5869-5873. [Abstract] [Full Text] [PDF]  

IL-16 Activates the SAPK Signaling Pathway in CD4⁺ Macrophages

Stefan Krautwald
J Immunol 1998 160: 5874-5879. [Abstract] [Full Text] [PDF]  

Dipeptidyl Peptidase I and Granzyme A Are Coordinately Expressed During CD8⁺ T Cell Development and Differentiation

Christopher L. Mabee, Michael J. McGuire, and Dwain L. Thiele
J Immunol 1998 160: 5880-5885. [Abstract] [Full Text] [PDF]  

Stromal Cell-Independent Maturation of IL-7-Responsive Pro-B Cells

Robert J. Ray, Angela Stoddart, Jacqueline L. Pennycook, H. Ozgur Huner, Caren Furlonger, Gillian E. Wu, and Christopher J. Paige
J Immunol 1998 160: 5886-5897. [Abstract] [Full Text] [PDF]  

CpG Oligodeoxyribonucleotides Rescue Mature Spleen B Cells from Spontaneous Apoptosis and Promote Cell Cycle Entry

Ae-Kyung Yi, Ming Chang, David W. Peckham, Arthur M. Krieg, and Robert F. Ashman
J Immunol 1998 160: 5898-5906. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

The Regulation of Murine H-2D^d Expression by Activation Transcription Factor 1 and cAMP Response Element Binding Protein

Nobuhisa Ishiguro, G. Dalon Brown, Akihiro Ishizu, and Daniel Meruelo
J Immunol 1998 160: 5907-5914. [Abstract] [Full Text] [PDF]  

Expression and Characterization of Recombinant Soluble Peptide: I-A Complexes Associated with Murine Experimental Autoimmune Diseases

Caius G. Radu, Bertram T. Ober, Lucia Colantonio, Ayub Qadri, and E. Sally Ward
J Immunol 1998 160: 5915-5921. [Abstract] [Full Text] [PDF]  

HLA-G Isoforms Produced by Placental Cytotrophoblasts and Found in Amniotic Fluid Are Due to Unusual Glycosylation

Michael McMaster, Yan Zhou, Simon Shorter, Kubra Kapasi, Dan Geraghty, Kee-Hak Lim, and Susan Fisher
J Immunol 1998 160: 5922-5928. [Abstract] [Full Text] [PDF]  

Failure to Activate Cytosolic Phospholipase A₂ Causes TNF Resistance in Human Leukemic Cells

Yu-Ling Wu, Xu-Rong Jiang, Adrian C. Newland, and Stephen M. Kelsey
J Immunol 1998 160: 5929-5935. [Abstract] [Full Text] [PDF]  

Molecular Mechanisms of the Induction of IL-12 and Its Inhibition by IL-10

Miguel Aste-Amezaga, Xiaojing Ma, Alexandrina Sartori, and Giorgio Trinchieri
J Immunol 1998 160: 5936-5944. [Abstract] [Full Text] [PDF]  

Conservation of Structure and Function Between Human and Murine IL-16

Joseph Keane, John Nicoll, Sue Kim, David M. H. Wu, William W. Cruikshank, William Brazer, Barbara Natke, Yujun Zhang, David M. Center, and Hardy Kornfeld
J Immunol 1998 160: 5945-5954. [Abstract] [Full Text] [PDF]  

The Effect of T Cell Depletion on Cytokine Gene Expression in Experimental Allergic Encephalomyelitis

Alice J. Rajan, Jonathan D. S. Klein, and Celia F. Brosnan
J Immunol 1998 160: 5955-5962. [Abstract] [Full Text] [PDF]  

Inefficient Assembly and Intracellular Accumulation of Antibodies with Mutations in V_H CDR2

Tammy M. Martin, Gregory D. Wiens, and Marvin B. Rittenberg
J Immunol 1998 160: 5963-5970. [Abstract] [Full Text] [PDF]  

The ₂ Domain of H-2D^d Restricts the Allelic Specificity of the Murine NK Cell Inhibitory Receptor Ly-49A

Jonas Sundbäck, Mary C. Nakamura, Margareta Waldenström, Eréne C. Niemi, William E. Seaman, James C. Ryan, and Klas Kärre
J Immunol 1998 160: 5971-5978. [Abstract] [Full Text] [PDF]  

Structural and Functional Analysis of J Chain-Deficient IgM

Erik J. Wiersma, Cathy Collins, Shafie Fazel, and Marc J. Shulman
J Immunol 1998 160: 5979-5989. [Abstract] [Full Text] [PDF]  

Structural Requirements for a Specificity Switch and for Maintenance of Affinity Using Mutational Analysis of a Phage-Displayed Anti-Arsonate Antibody of Fab Heavy Chain First Complementarity-Determining Region

Yee Wah Wong, Davinder S. Gill, Behnaz Parhami-Seren, Mary K. Short, Seshi Reddy Sompuram, and Michael N. Margolies
J Immunol 1998 160: 5990-5997. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Role of Mucosal Immunity in Herpes Simplex Virus Infection

Nelly A. Kuklin, Massoud Daheshia, Sangjun Chun, and Barry T. Rouse
J Immunol 1998 160: 5998-6003. [Abstract] [Full Text] [PDF]  

Mechanisms of Macrophage Stimulation Through CD8: Macrophage CD8 and CD8ß Induce Nitric Oxide Production and Associated Killing of the Parasite Leishmania major

Nadir Hirji, Tong-Jun Lin, Elyse Bissonnette, Miodrag Belosevic, and A. Dean Befus
J Immunol 1998 160: 6004-6011. [Abstract] [Full Text] [PDF]  

The Role of T Cells in Allografted Tumor Rejection: IFN- Released from T Cells Is Essential for Induction of Effector Macrophages in the Rejection Site

Yukio Yoneda and Ryotaro Yoshida
J Immunol 1998 160: 6012-6017. [Abstract] [Full Text] [PDF]  

Mucosal Addressin Is Required for the Development of Diabetes in Nonobese Diabetic Mice

Arno Hänninen, Ilkka Jaakkola, and Sirpa Jalkanen
J Immunol 1998 160: 6018-6025. [Abstract] [Full Text] [PDF]  

The Antibody Response to Fungal Melanin in Mice

Joshua D. Nosanchuk, Angel L. Rosas, and Arturo Casadevall
J Immunol 1998 160: 6026-6031. [Abstract] [Full Text] [PDF]  

Influenza A Virus-Induced IFN-/ß and IL-18 Synergistically Enhance IFN- Gene Expression in Human T Cells

Timo Sareneva, Sampsa Matikainen, Masashi Kurimoto, and Ilkka Julkunen
J Immunol 1998 160: 6032-6038. [Abstract] [Full Text] [PDF]  

Clostridium difficile Toxin A Stimulates Macrophage- Inflammatory Protein-2 Production in Rat Intestinal Epithelial Cells

Ignazio Castagliuolo, Andrew C. Keates, Chi Chung Wang, Asiya Pasha, Leyla Valenick, Ciaran P. Kelly, Sigfus T. Nikulasson, J. Thomas LaMont, and Charalabos Pothoulakis
J Immunol 1998 160: 6039-6045. [Abstract] [Full Text] [PDF]  

Th1 Cells Specific for a Secreted Protein of Listeria monocytogenes Are Protective In Vivo

Gernot Geginat, Mio Lalic, Marianne Kretschmar, Werner Goebel, Herbert Hof, Dieter Palm, and Andreas Bubert
J Immunol 1998 160: 6046-6055. [Abstract] [Full Text] [PDF]  

IL-6 Produced by Kupffer Cells Induces STAT Protein Activation in Hepatocytes Early During the Course of Systemic Listerial Infections

Stephen H. Gregory, Edward J. Wing, Kristine L. Danowski, Nico van Rooijen, Kevin F. Dyer, and David J. Tweardy
J Immunol 1998 160: 6056-6061. [Abstract] [Full Text] [PDF]  

Characterization of the Peptide Binding Motif of a Rhesus MHC Class I Molecule (Mamu-A*01) That Binds an Immunodominant CTL Epitope from Simian Immunodeficiency Virus

Todd M. Allen, John Sidney, Marie-France del Guercio, Rhona L. Glickman, Gary L. Lensmeyer, Donald A. Wiebe, R. DeMars, C. David Pauza, R. Paul Johnson, Alessandro Sette, and David I. Watkins
J Immunol 1998 160: 6062-6071. [Abstract] [Full Text] [PDF]  

Blockade of Endogenous TNF- Exacerbates Primary and Secondary Pulmonary Histoplasmosis by Differential Mechanisms

Ruth Allendoerfer and George S. Deepe, Jr.
J Immunol 1998 160: 6072-6082. [Abstract] [Full Text] [PDF]  

Dissection of Pathways Leading to Antigen Receptor-Induced and Fas/CD95-Induced Apoptosis in Human B Cells

Susanne M. A. Lens, Bianca F. A. den Drijver, Andy J. G. Pötgens, Kiki Tesselaar, Marinus H. J. van Oers, and René A. W. van Lier
J Immunol 1998 160: 6083-6092. [Abstract] [Full Text] [PDF]  

T Lymphocytes Are Required for Protection of the Vaginal Mucosae and Sensory Ganglia of Immune Mice Against Reinfection with Herpes Simplex Virus Type 2

Gregg N. Milligan, David I. Bernstein, and Nigel Bourne
J Immunol 1998 160: 6093-6100. [Abstract] [Full Text] [PDF]  

Lack of Both Types 1 and 2 Cytokines, Tissue Inflammatory Responses, and Immune Protection During Pulmonary Infection by Mycobacterium bovis Bacille Calmette-Guérin in IL-12-Deficient Mice

Julia Wakeham, Jun Wang, Jeanne Magram, Kenneth Croitoru, Robin Harkness, Pamela Dunn, Anna Zganiacz, and Zhou Xing
J Immunol 1998 160: 6101-6111. [Abstract] [Full Text] [PDF]  

Altered Intestinal Immune System but Normal Antibacterial Resistance in the Absence of P-Selectin and ICAM-1

Ulrich Steinhoff, Uwe Klemm, Manuela Greiner, Karin Bordasch, and Stefan H. E. Kaufmann
J Immunol 1998 160: 6112-6120. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

IL-4-Dependent Regulation of TGF- and TGF-ß1 Expression in Human Eosinophils

Aram E. Elovic, Hiroe Ohyama, Alan Sauty, Jim McBride, Takanori Tsuji, Masazumi Nagai, Peter F. Weller, and David T. W. Wong
J Immunol 1998 160: 6121-6127. [Abstract] [Full Text] [PDF]  

Complement Activation Occurs on Subendothelial Extracellular Matrix In Vitro and Is Initiated by Retraction or Removal of Overlying Endothelial Cells

Elizabeth J. Hindmarsh and Rory M. Marks
J Immunol 1998 160: 6128-6136. [Abstract] [Full Text] [PDF]  

Immunization with Purified Natural and Recombinant Allergens Induces Mouse IgG1 Antibodies That Recognize Similar Epitopes as Human IgE and Inhibit the Human IgE-Allergen Interaction and Allergen-Induced Basophil Degranulation

Susanne Vrtala, Tanja Ball, Susanne Spitzauer, Budhi Pandjaitan, Cenk Suphioglu, Bruce Knox, Wolfgang R. Sperr, Peter Valent, Dietrich Kraft, and Rudolf Valenta
J Immunol 1998 160: 6137-6144. [Abstract] [Full Text] [PDF]  

Arachidonic Acid Enhances the Tissue Factor Expression of Mononuclear Cells by the Cyclo-Oxygenase-1 Pathway: Beneficial Effect of n-3 Fatty Acids

Yves Cadroy, Dominique Dupouy, and Bernard Boneu
J Immunol 1998 160: 6145-6150. [Abstract] [Full Text] [PDF]  

Complement Receptor 3 of Macrophages Is Associated with Galectin-1-Like Protein

Orly Avni, Zivit Pur, Eitan Yefenof, and Michal Baniyash
J Immunol 1998 160: 6151-6158. [Abstract] [Full Text] [PDF]  

Physiologic Regulation of Postovulatory Neutrophil Migration into Vagina in Mice by a C-X-C Chemokine(s)

Yasuo Sonoda, Naofumi Mukaida, Jian-bin Wang, Motoko Shimada-Hiratsuka, Makoto Naito, Tadashi Kasahara, Akihisa Harada, Masaki Inoue, and Kouji Matsushima
J Immunol 1998 160: 6159-6165. [Abstract] [Full Text] [PDF]  

Novel Role of Transmembrane SCF for Mast Cell Activation and Eotaxin Production in Mast Cell-Fibroblast Interactions

Cory Hogaboam, Steven L. Kunkel, Robert M. Strieter, Dennis D. Taub, Pam Lincoln, Theodore J. Standiford, and Nicholas W. Lukacs
J Immunol 1998 160: 6166-6171. [Abstract] [Full Text] [PDF]  

Low Grade Rhinovirus Infection Induces a Prolonged Release of IL-8 in Pulmonary Epithelium

Sebastian L. Johnston, Alberto Papi, Philip J. Bates, John G. Mastronarde, Martha M. Monick, and Gary W. Hunninghake
J Immunol 1998 160: 6172-6181. [Abstract] [Full Text] [PDF]  

Role of TNFR1 and TNFR2 in TNF-Induced Platelet Consumption in Mice

Fabienne Tacchini-Cottier, Christian Vesin, Mireille Redard, Wim Buurman, and Pierre F. Piguet
J Immunol 1998 160: 6182-6186. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

An Antigen Recognized by Autologous CTLs on a Human Bladder Carcinoma

Maryse Guéguen, Jean-Jacques Patard, Béatrice Gaugler, Francis Brasseur, Jean-Christophe Renauld, Paul J. Van Cangh, Thierry Boon, and Benoît J. Van den Eynde
J Immunol 1998 160: 6188-6194. [Abstract] [Full Text] [PDF]  

Antibody-IL-12 Fusion Proteins Are Effective in SCID Mouse Models of Prostate and Colon Carcinoma Metastases

Stephen D. Gillies, Yan Lan, John S. Wesolowski, Xiuqi Qian, Ralph A. Reisfeld, Sylvia Holden, Michael Super, and Kin-Ming Lo
J Immunol 1998 160: 6195-6203. [Abstract] [Full Text] [PDF]  

Reconstitution of EBV-Specific T Cell Immunity in Solid Organ Transplant Recipients

Tanzina Haque, Peter L. Amlot, Nabeela Helling, J. Alero Thomas, Paul Sweny, Keith Rolles, Andrew K. Burroughs, H. Grant Prentice, and Dorothy H. Crawford
J Immunol 1998 160: 6204-6209. [Abstract] [Full Text] [PDF]  

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