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The Journal of Immunology, 2007, 178: B178.
Copyright © 2007 by The American Association of Immunologists, Inc.
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B178

Mast cells enable heightened humoral immunity during infection

Christopher P. Shelburne1, Ashley St. John2, James B. McLachlan1, Herman F. Staats1 and Soman N. Abraham1

1 Pathology, 2 Immunology, Duke University Medical Center, Box 3712, Durham, North Carolina, 27710

Abstract

Dendritic cell (DC) accumulation in T-cell zones of secondary lymph organs is a critical event in the maximization of the primary immune response. Here, we demonstrate that mast cell (MC) control of elevated DC trafficking during infection enables the primary adaptive humoral immune response to proceed with heightened intensity. Elevated DC accumulation in draining lymph nodes (DLNs) was found to be the product of continual and incremental recruitment of DCs into the infected tissue site prior to their egress to DLNs. MCs contribute to this pattern of DC trafficking by the release of TNF, which was found to coordinately activate local blood vessel endothelium and DLNs to increase their expression of CD62E and CCL21, respectively. Blockade of either protein interfered with DC accumulation in DLNs, as well as the intensity of the humoral response to bacterial challenge. Thus, MCs enable the humoral immune response to proceed with enhanced intensity, which may be an important consideration in rationale vaccine design.

Supported by grants DK50814 and AI50021 from the National Institutes of Health.





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