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BRIEF REVIEWS |
An important activity of mucosal surfaces is the production of Ab referred to as secretory IgA (SIgA). SIgA serves as the first line of defense against microorganisms through a mechanism called immune exclusion. In addition, SIgA adheres selectively to M cells in intestinal Peyer’s patches, thus mediating the transepithelial transport of the Ab molecule from the intestinal lumen to underlying gut-associated organized lymphoid tissue. In Peyer’s patches, SIgA binds and is internalized by dendritic cells in the subepithelial dome region. When used as carrier for Ags in oral immunization, SIgA induces mucosal and systemic responses associated with production of anti-inflammatory cytokines and limits activation of dendritic cells. In terms of humoral immunity at mucosal surfaces, SIgA appears thus to combine properties of a neutralizing agent (immune exclusion) and of a mucosal immunopotentiator inducing effector immune responses in a noninflammatory context favorable to preserve local homeostasis of the gastrointestinal tract.
1 Works in the author’s laboratory are supported by Grant 3200-109545 from the Swiss Science Research Foundation.
2 Address correspondence and reprint requests to Dr. Blaise Corthésy, R&D Laboratory of the Division of Immunology and Allergy, State University Hospital (Centré Hospitalìer Universitaire Vandois), Rue du Bugnon, BH 19-650, 1011 Lausanne, Switzerland. E-mail address: blaise.corthesy{at}chuv.ch
3 Abbreviations used in this paper: DC, dendritic cell; SED, subepithelial dome; IFR, interfollicular region; FAE, follicle-associated epithelium; MLN, mesenteric lymph node; pIgA, polymeric IgA; pIgR, polymeric IgR; SC, secretory component.
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