The Journal of Immunology, Vol 145, Issue 4 1222-1226, Copyright © 1990 by American Association of Immunologists

ARTICLES

Antigenic challenge of immunized mice induces endogeneous production of IL-3 that increases histamine synthesis in hematopoietic organs

B Lebel, E Schneider, C Piquet-Pellorce, F Machavoine, V Kindler, G Luffau and M Dy
INSERM U 25 Hopital Necker, Paris, France.

Antigenic challenge of Nippostrongylus brasiliensis-infected mice induces a striking increase in histidine decarboxylase (HDC) activity in both spleen and bone marrow cells. This enhancement takes place within 1 h after injection, with a maximum at 4 h and a return to pretreatment values 20 h later. It is associated with the appearance of IL-3 in the sera of these mice. In addition, the intracellular histamine content in both hematopoietic organs is concomitantly increased. A similar injection of worm Ag into normal mice has no significant effect. Comparable enhancement of HDC activity and intracellular histamine content with almost identical kinetics is promoted by i.v. injection of rIL-3 into normal mice. Moreover, HDC levels in infected mice are increased to the same extent in response to either specific antigen or rIL-3 injection. Taken together these results support the conclusion that antigenic challenge of immunized mice induces endogeneous IL-3 which, in turn, promotes a rapid increase in histamine synthesis in hematopoietic organs.

This article has been cited by other articles:

				E. Schneider, F. Machavoine, J.-M. Pleau, A.-F. Bertron, R. L. Thurmond, H. Ohtsu, T. Watanabe, A. H. Schinkel, and M. Dy Organic cation transporter 3 modulates murine basophil functions by controlling intracellular histamine levels J. Exp. Med., August 1, 2005; 202(3): 387 - 393. [Abstract] [Full Text] [PDF]

				M. Arock, E. Schneider, M. Boissan, V. Tricottet, and M. Dy Differentiation of human basophils: an overview of recent advances and pending questions J. Leukoc. Biol., April 1, 2002; 71(4): 557 - 564. [Abstract] [Full Text] [PDF]