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The Journal of Immunology, Vol 145, Issue 10 3216-3222, Copyright © 1990 by American Association of Immunologists

ARTICLES

Development of B cell lineages during a primary anti-hapten immune response

W Tao and AL Bothwell
Section of Immunobiology, Yale University, School of Medicine, New Haven, CT 06510.

Cell lineage relationships were examined in large numbers of hybridomas derived from a single mouse at 7 days and from a single mouse at 12 days after a primary immunization. The properties of these developing lineages provide unique insight into their biologic selection and differentiation. The unique VDJ junctions, the characteristics of the somatic mutations, and the nonproductive H chain gene rearrangements observed at day 12 all indicate that the hybridomas were derived from a limited number of progenitor B cells. Clonally related hybridomas were also observed at day 7. The activation of these lineages occurred very early, because somatic variants were strongly selected for within a few days after the primary immunization.


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