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The Journal of Immunology, Vol 145, Issue 1 155-160, Copyright © 1990 by American Association of Immunologists

ARTICLES

Putative gamma-subunit of the IL-2 receptor is detected in low, intermediate, and high affinity IL-2 receptor-bearing cells

OR Colamonici, LM Neckers and A Rosolen
Tumor Cell Biology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Three forms of the IL-2R have been reported: low, intermediate, and high affinity. Each form correlates with the expression of two different chains: p55 (alpha-subunit) and p75 (beta-subunit). We report here a putative new subunit of the IL-2R, termed p95-110 or gamma- subunit. This new subunit has a molecular mass of 95 to 110 kDa and is expressed in low, intermediate, and high affinity IL-2R-bearing cells. We propose that p95-110 is the partner of p75 in the formation of intermediate affinity IL-2R, inasmuch as neither p75 nor p95-110 alone can bind IL-2.


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