| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 144, Issue 9 3318-3325, Copyright © 1990 by American Association of Immunologists
ARTICLES |
JH Russell, P Meleedy-Rey, DE McCulley, WC Sha, CA Nelson and DY Loh
Department of Pharmacology, Washington University School of Medicine, St. Louis, MO 63110.
Double-negative (CD4-/CD8-) T cells expressing the alpha/beta transgenic TCR from the 2C cell line (anti-H-2Ld) were examined in the periphery of animals whose MHC type produces positive, negative, or no selection for differentiation of the TCR on single positive (CD8+) cells. Regardless of the selection haplotype the CD4-/CD8- cells are capable of activation by anticlonotypic mAb indicating that negative selection does not inactivate the "forbidden" TCR. Rather, the lack of response to H-2Ld in the negative haplotype is likely to absence of CD8 required to produce a functional response to H-2Ld. The similarity of surface phenotype and functional activity of these CD4-/CD8- cells maturing in different haplotypes suggests they may arise by an alternative lineage which, unlike the dominant TCR alpha/beta pathway, does not require coexpression of CD4/CD8.
This article has been cited by other articles:
|
|
 |
|
  U. Koelsch, B. Schraven, and L. Simeoni SIT and TRIM Determine T Cell Fate in the Thymus J. Immunol., November 1, 2008; 181(9): 5930 - 5939. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Leng, Q. Ge, T. Nguyen, H. N. Eisen, and J. Chen Stage-dependent reactivity of thymocytes to self-peptide-MHC complexes PNAS, March 20, 2007; 104(12): 5038 - 5043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhang, E. F. Lizzio, E. Gubina, T. Chen, H. Mostowski, and S. Kozlowski Organ-Specific Cytokine Polarization Induced by Adoptive Transfer of Transgenic T Cells J. Immunol., November 15, 2002; 169(10): 5514 - 5521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Priatel, O. Utting, and H.-S. Teh TCR/Self-Antigen Interactions Drive Double-Negative T Cell Peripheral Expansion and Differentiation into Suppressor Cells J. Immunol., December 1, 2001; 167(11): 6188 - 6194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. D. Lacorazza, C. Tucek-Szabo, L. V. Vasovic, K. Remus, and J. Nikolich-Zugich Premature TCR{{alpha}}{{beta}} Expression and Signaling in Early Thymocytes Impair Thymocyte Expansion and Partially Block Their Development J. Immunol., March 1, 2001; 166(5): 3184 - 3193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Utting, J. J. Priatel, S.-J. Teh, and H.-S. Teh p59fyn (Fyn) Promotes the Survival of Anergic CD4-CD8- {{alpha}}{{beta}} TCR+ Cells but Negatively Regulates Their Proliferative Response to Antigen Stimulation J. Immunol., February 1, 2001; 166(3): 1540 - 1546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Terrence, C. P. Pavlovich, E. O. Matechak, and B.J. Fowlkes Premature Expression of T Cell Receptor (TCR){alpha}{beta} Suppresses TCR{gamma}{delta} Gene Rearrangement but Permits Development of {gamma}{delta} Lineage T Cells J. Exp. Med., August 21, 2000; 192(4): 537 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Utting, S.-J. Teh, and H.-S. Teh A Population of In Vivo Anergized T Cells with a Lower Activation Threshold for the Induction of CD25 Exhibit Differential Requirements in Mobilization of Intracellular Calcium and Mitogen-Activated Protein Kinase Activation J. Immunol., March 15, 2000; 164(6): 2881 - 2889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Daniels and S. C. Jameson Critical Role for CD8 in T Cell Receptor Binding and Activation by Peptide/Major Histocompatibility Complex Multimers J. Exp. Med., January 17, 2000; 191(2): 335 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. D. Lacorazza, J. A. Guevara Patino, M. E. Weksler, and D. Radu Failure of Rearranged TCR Transgenes to Prevent Age-Associated Thymic Involution J. Immunol., October 15, 1999; 163(8): 4262 - 4268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zerrahn, A. Volkmann, M. C. Coles, W. Held, F. A. Lemonnier, and D. H. Raulet Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells PNAS, September 28, 1999; 96(20): 11470 - 11475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Caveno, Y. Zhang, B. Motyka, S.-J. Teh, and H.-S. Teh Functional Similarity and Differences Between Selection-Independent CD4-CD8- {alpha}{beta} T Cells and Positively Selected CD8 T Cells Expressing the Same TCR and the Induction of Anergy in CD4-CD8- {alpha}{beta} T Cells in Antigen-Expressing Mice J. Immunol., August 1, 1999; 163(3): 1222 - 1229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Chan, A Limmer, M. Louie, E. Bullock, W. Fung-Leung, T. Mak, and D. Loh Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association Science, September 17, 1993; 261(5128): 1581 - 1584. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
