| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 144, Issue 8 3028-3033, Copyright © 1990 by American Association of Immunologists
ARTICLES |
CR Maliszewski, TA Sato, T Vanden Bos, S Waugh, SK Dower, J Slack, MP Beckmann and KH Grabstein
Department of Immunology, Immunex Corporation, Seattle, WA 98101.
IL-1 and IL-4 are important mediators of B cell growth and differentiation. The cell-surface receptors for these cytokines have recently been cloned and recombinant soluble receptors have been produced that bind their respective ligand. The ability of soluble forms of the murine IL-1R (sIL-1R) and IL-4R (sIL-4R) to inhibit B cell functions in vitro was examined. Proliferation of B cells treated with anti-Ig plus IL-1 or IL-4 was inhibited by the appropriate soluble receptor. sIL-4R also inhibited IL-4-dependent B cell differentiation as measured by: induction of IgG1 and IgE secretion by LPS blasts, down- regulation of IgG3 secretion by LPS blasts, increased Ia expression, and increased Fc epsilon R (CD23) expression. The inhibitory effects of the soluble receptors were found to be highly specific in that sIL-4R had no effect on IL-1-induced B cell activity and sIL-1R had no effect on IL-4 activity, further demonstrating the existence of two independent pathways of B cell activation directed by IL-1 and IL-4.
This article has been cited by other articles:
|
|
 |
|
  A.-L. Andrews, J. W. Holloway, S. T. Holgate, and D. E. Davies IL-4 Receptor {alpha} Is an Important Modulator of IL-4 and IL-13 Receptor Binding: Implications for the Development of Therapeutic Targets. J. Immunol., June 15, 2006; 176(12): 7456 - 7461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. R. Henderson Jr., E. Y. Chi, and C. R. Maliszewski Soluble IL-4 Receptor Inhibits Airway Inflammation Following Allergen Challenge in a Mouse Model of Asthma J. Immunol., January 15, 2000; 164(2): 1086 - 1095. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. BORISH, H. S. NELSON, M. J. LANZ, L. CLAUSSEN, J. B. WHITMORE, J. M. AGOSTI, and L. GARRISON Interleukin-4 Receptor in Moderate Atopic Asthma . A Phase I/II Randomized, Placebo-controlled Trial Am. J. Respir. Crit. Care Med., December 1, 1999; 160(6): 1816 - 1823. [Abstract] [Full Text]
|
|
|
|
|
|
H. Kobayashi, M. Kobayashi, T. Utsunomiya, D. N. Herndon, R. B. Pollard, and F. Suzuki Therapeutic Protective Effects of IL-12 Combined with Soluble IL-4 Receptor Against Established Infections of Herpes Simplex Virus Type 1 in Thermally Injured Mice J. Immunol., June 15, 1999; 162(12): 7148 - 7154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. McKenna and P. J. Morrissey Flt3 Ligand Plus IL-7 Supports the Expansion of Murine Thymic B Cell Progenitors That Can Mature Intrathymically J. Immunol., May 15, 1998; 160(10): 4801 - 4809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Peters, P. Schirmacher, J. Goldschmitt, M. Odenthal, C. Peschel, E. Fattori, G. Ciliberto, H.-P. Dienes, K.-H. M. z. Buschenfelde, and S. Rose-John Extramedullary Expansion of Hematopoietic Progenitor Cells in Interleukin (IL)-6-sIL-6R Double Transgenic Mice J. Exp. Med., February 17, 1997; 185(4): 755 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Davis, T. Aldrich, N. Ip, N Stahl, S Scherer, T Farruggella, P. DiStefano, R Curtis, N Panayotatos, H Gascan, et al. Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses Science, March 19, 1993; 259(5102): 1736 - 1739. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
