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The Journal of Immunology, Vol 144, Issue 8 2925-2930, Copyright © 1990 by American Association of Immunologists

ARTICLES

Expression and ontogeny of CD2 on murine B cells

J Sen, N Rosenberg and SJ Burakoff
Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.

Expression of CD2 on developing and mature murine B cells was examined by using an antipeptide antiserum (L50). Most Ig-bearing splenic B cells were found to express CD2. Anti-CD5 and anti-B220 mAb divided the peritoneal B cells into two populations expressing high and low levels of these proteins; both populations were found to express uniform levels of CD2. Abelson murine leukemia virus-transformed pre-B cell lines derived from fetal liver and adult bone marrow were analyzed to delineate the ontogeny of CD2 in the B cell lineage. The results show that onset of CD2 expression correlates with the presence of cytoplasmic mu-chain. Therefore, the earliest CD2+ pre-B cell in the developing B cell population appears to be the classical pre-B cell.


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