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The Journal of Immunology, Vol 144, Issue 7 2627-2631, Copyright © 1990 by American Association of Immunologists

ARTICLES

Antiidiotypic antibody mimicry of a bluetongue virus neutralizing antigen

FB Grieder and KT Schultz
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706.

Syngeneic antiidiotypic (Anti-Id) mAb were produced to the Bluetongue virus (BTV) serotype 17 neutralizing mAb. Three anti-Id mAb had the characteristics of an internal image of the Id as demonstrated by 1) the internal image anti-Id mAb were capable of mimicking BTV by blocking the neutralizing activity of the idiotypic neutralizing mAb and 2) the anti-Id mAb bound specifically to the surface of BTV susceptible cells in indirect binding experiments as determined by immunocytochemistry and flow cytometric analysis. The potential application of these internal image anti-Id mAb in this arbovirus system is discussed.




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