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The Journal of Immunology, Vol 144, Issue 6 2167-2172, Copyright © 1990 by American Association of Immunologists

ARTICLES

Prevention of experimental autoimmune thyroiditis through the anti- idiotypic network

C Roubaty, C Bedin and J Charreire
INSERM U, 283, Hopital Cochin, Paris, France.

The central goal in the therapy of autoimmune diseases is to develop potent tools able to exert specific control of the immune response to self Ag. Anti-Id may provide such specific immunodulators because the relevance of the idiotypic network in autoimmunity is well documented. We now describe the protective immunity against experimental autoimmune thyroiditis induced exclusively by a thyroglobulin (Tg)-specific cytotoxic T cell clone and show that this down-regulation occurs through the generation of anti-Id antibodies (Ab) (Ab2Beta) which recognize the paratope of a anti-Tg mAb (Ab1) specific to the pathogenic epitope of the Tg molecule. We further analyze the various steps of the Ab responses (Ab1, Ab2, and Ab3) in terms of poly-, mono-, and autospecificities for the pathogenic epitope of the Tg molecule and for the idiotope of the related Ab.


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F. Batteux, L. Tourneur, H. Trebeden, J. Charreire, and G. Chiocchia
Gene Therapy of Experimental Autoimmune Thyroiditis by In Vivo Administration of Plasmid DNA Coding for Fas Ligand
J. Immunol., January 1, 1999; 162(1): 603 - 608.
[Abstract] [Full Text] [PDF]


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