| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 144, Issue 4 1432-1437, Copyright © 1990 by American Association of Immunologists
ARTICLES |
TW Huizinga, KM Dolman, NJ van der Linden, M Kleijer, JH Nuijens, AE von dem Borne and D Roos
Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
In this report, we present data on the activation of different neutrophil effector functions by two distinct Fc-gamma receptors, FcRII and FcRIII. We and others have shown previously that IgG-dependent activation of phagocytosis and superoxide generation is mediated via FcRII. IgG-dependent exocytosis of granule proteins was assessed with Staphylococcus aureus Oxford opsonized with human IgG or with IgG- coated latex. Both anti-FcRII mAb and anti-FcRIII-F(ab')2 mAb inhibited this release, whereas the combination of these mAb inhibited this process more strongly than either mAb alone. This indicates that both FcRII and FcRIII are involved in IgG-dependent release of granule proteins. Cross-linking of the receptors by anti-FcR mAb and F(ab')2 fragments of goat-anti-mouse-Ig showed again that both FcRII and FcRIII mediate lysozyme release, whereas cross-linking of a control antigen (CD67) did not. By measuring the release of elastase and lactoferrin, we found that cross-linking of either FcRII or FcRIII induced release of both azurophilic and specific granules. Under these conditions, we did not measure any activation of the respiratory burst. When FcRIII was removed by treatment of neutrophils with glycosylphosphatidylinositol-specific phospholipase C, the lysozyme release induced by cross-linking of FcRIII was lower than the release from control neutrophils, whereas the release induced by cross-linking of FcRII was similar. Therefore, we conclude that IgG-dependent activation of neutrophils follows two distinct pathways: one via transmembrane FcRII, activating both the NADPH oxidase and the release of granule proteins (as was demonstrated previously by us and by others), and the other via phosphatidylinositol-linked FcRIII, activating exocytosis of granule proteins.
This article has been cited by other articles:
|
|
 |
|
  L. C. Willcocks, P. A. Lyons, M. R. Clatworthy, J. I. Robinson, W. Yang, S. A. Newland, V. Plagnol, N. N. McGovern, A. M. Condliffe, E. R. Chilvers, et al. Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake J. Exp. Med., July 7, 2008; 205(7): 1573 - 1582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Werwitzke, D Trick, P Sondermann, K Kamino, B Schlegelberger, K Kniesch, A Tiede, U Jacob, R E Schmidt, and T Witte Treatment of lupus-prone NZB/NZW F1 mice with recombinant soluble Fc{gamma} receptor II (CD32) Ann Rheum Dis, February 1, 2008; 67(2): 154 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Jakus, T. Nemeth, J. S. Verbeek, and A. Mocsai Critical but Overlapping Role of Fc{gamma}RIII and Fc{gamma}RIV in Activation of Murine Neutrophils by Immobilized Immune Complexes J. Immunol., January 1, 2008; 180(1): 618 - 629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. G. Fernandes, G. Lachance, G. Pare, E. Rollet-Labelle, and P. H. Naccache Signaling through CD16b in human neutrophils involves the Tec family of tyrosine kinases J. Leukoc. Biol., August 1, 2005; 78(2): 524 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Naucler, S. Grinstein, R. Sundler, and H. Tapper Signaling to localized degranulation in neutrophils adherent to immune complexes J. Leukoc. Biol., April 1, 2002; 71(4): 701 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C M Marzocchi-Machado, C M O S Alves, A E C S Azzolini, A M N Polizello, I F Carvalho, and Y M Lucisano-Valim Fcgamma and complement receptors: expression, role and co-operation in mediating the oxidative burst and degranulation of neutrophils of Brazilian systemic lupus erythematosus patients Lupus, April 1, 2002; 11(4): 240 - 248. [Abstract] [PDF]
|
|
|
|
 |
|
 P. L. E. M. Van Lent, K. Nabbe, A. B. Blom, A. E. M. Holthuysen, A. Sloetjes, L. B. A. Van De Putte, S. Verbeek, and W. B. Van Den Berg Role of Activatory Fc{gamma}RI and Fc{gamma}RIII and Inhibitory Fc{gamma}RII in Inflammation and Cartilage Destruction during Experimental Antigen-Induced Arthritis Am. J. Pathol., December 1, 2001; 159(6): 2309 - 2320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Durand, J.-O. Pers, Y. Renaudineau, A. Saraux, P. Youinou, and C. Jamin Differential effects of anti-Fc{gamma}RIIIb autoantibodies on polymorphonuclear neutrophil apoptosis and function J. Leukoc. Biol., February 1, 2001; 69(2): 233 - 240. [Abstract] [Full Text]
|
|
|
|
|
|
G. Frumento, L. Ottonello, M. Bertolotto, S. Franchello, G. Melioli, and F. Dallegri Spontaneous apoptosis in neutrophils is associated with downregulation of HLA Class I and is prevented by ligation of Class I J. Leukoc. Biol., December 1, 2000; 68(6): 873 - 880. [Abstract] [Full Text]
|
|
|
|
|
|
P. Y. Coxon, M. J. Rane, D. W. Powell, J. B. Klein, and K. R. McLeish Differential Mitogen-Activated Protein Kinase Stimulation by Fc{gamma} Receptor IIa and Fc{gamma} Receptor IIIb Determines the Activation Phenotype of Human Neutrophils J. Immunol., June 15, 2000; 164(12): 6530 - 6537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Hazan-Halevy, R. Seger, and R. Levy The Requirement of Both Extracellular Regulated Kinase and p38 Mitogen-activated Protein Kinase for Stimulation of Cytosolic Phospholipase A2 Activity by Either Fcgamma RIIA or Fcgamma RIIIB in Human Neutrophils. A POSSIBLE ROLE FOR Pyk2 BUT NOT FOR THE Grb2-Sos-Shc COMPLEX J. Biol. Chem., April 21, 2000; 275(17): 12416 - 12423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nagarajan, K. Venkiteswaran, M. Anderson, U. Sayed, C. Zhu, and P. Selvaraj Cell-specific, activation-dependent regulation of neutrophil CD32A ligand-binding function Blood, February 1, 2000; 95(3): 1069 - 1077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Kindzelskii, Z.-y. Yang, G. J. Nabel, R. F. Todd III, and H. R. Petty Ebola Virus Secretory Glycoprotein (sGP) Diminishes Fc{gamma}RIIIB-to-CR3 Proximity on Neutrophils J. Immunol., January 15, 2000; 164(2): 953 - 958. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Meddows-Taylor, D. J. Martin, and C. T. Tiemessen Impaired Interleukin-8-Induced Degranulation of Polymorphonuclear Neutrophils from Human Immunodeficiency Virus Type 1-Infected Individuals Clin. Vaccine Immunol., May 1, 1999; 6(3): 345 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bux, K. Kissel, C. Hofmann, and S. Santoso The Use of Allele-Specific Recombinant Fcgamma Receptor IIIb Antigens for the Detection of Granulocyte Antibodies Blood, January 1, 1999; 93(1): 357 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Svenson, M. B. Hansen, C. Ross, M. Diamant, K. Rieneck, H. Nielsen, and K. Bendtzen Antibody to Granulocyte-Macrophage Colony-Stimulating Factor Is a Dominant Anti-Cytokine Activity in Human IgG Preparations Blood, March 15, 1998; 91(6): 2054 - 2061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bux, E.-L. Stein, P. Bierling, P. Fromont, M. Clay, D. Stroncek, and S. Santoso Characterization of a New Alloantigen (SH) on the Human Neutrophil Fcgamma receptor IIIb Blood, February 1, 1997; 89(3): 1027 - 1034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nagarajan, S. Chesla, L. Cobern, P. Anderson, C. Zhu, and P. Selvaraj Ligand Binding and Phagocytosis by CD16 (Fc [IMAGE] Receptor III) Isoforms J. Biol. Chem., October 27, 1995; 270(43): 25762 - 25770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. M. Vossebeld, J. Kessler, A. E. G. Kr. von dem Borne, D. Roos, and A. J. Verhoeven Heterotypic Fc[IMAGE]R Clusters Evoke a Synergistic Ca[IMAGE] Response in Human Neutrophils J. Biol. Chem., May 5, 1995; 270(18): 10671 - 10679. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
