| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 144, Issue 4 1323-1330, Copyright © 1990 by American Association of Immunologists
ARTICLES |
EJ Leonard, A Skeel, T Yoshimura, K Noer, S Kutvirt and D Van Epps
Immunopathology Section, National Cancer Institute, Frederick, MD 21701.
Neutrophil attractant/activation protein-1 (NAP-1) was previously shown to attract human neutrophils, but not monocytes. The purpose of this study was to determine if NAP-1 interacted with other types of blood leukocytes. In addition to its chemotactic activity for neutrophils, NAP-1 induced chemotactic responses by T lymphocytes and basophils. Chemotactic potency (10(-8) M for an optimal response) was the same for all three cell types. However, NAP-1 caused a chemotactic response in excess of random migration of 7% or 16% of basophils (depending on the medium used) and only 9% of T lymphocytes, in contrast to 30% of neutrophils. This agonist was not chemotactic for partially purified normal human eosinophils. The symmetrical histogram obtained by flow cytometry of neutrophils equilibrated at 0 degree C with fluoresceinated NAP-1 indicates that all neutrophils bound the ligand. A dose-response curve plateau, and inhibition of binding of NAP-1-FITC by unlabeled ligand are evidence for saturable binding to receptors, estimated to be 7000 per cell. Our results suggest that, for induction of an acute inflammatory response, the quantitatively significant action of NAP-1 is on neutrophils.
This article has been cited by other articles:
|
|
 |
|
  E. E. Brown, D. Fallin, I. Ruczinski, A. Hutchinson, B. Staats, F. Vitale, C. Lauria, D. Serraino, G. Rezza, G. Mbisa, et al. Associations of Classic Kaposi Sarcoma with Common Variants in Genes that Modulate Host Immunity. Cancer Epidemiol. Biomarkers Prev., May 1, 2006; 15(5): 926 - 934. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Rice, L. L. Stoll, W.-G. Li, G. M. Denning, J. Weydert, E. Charipar, W. E. Richenbacher, F. J. Miller Jr, and N. L. Weintraub Low-Level Endotoxin Induces Potent Inflammatory Activation of Human Blood Vessels: Inhibition by Statins Arterioscler. Thromb. Vasc. Biol., September 1, 2003; 23(9): 1576 - 1582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Remick, L. B. Green, D. E. Newcomb, S. J. Garg, G. L. Bolgos, and D. R. Call CXC Chemokine Redundancy Ensures Local Neutrophil Recruitment during Acute Inflammation Am. J. Pathol., September 1, 2001; 159(3): 1149 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Cheng, T. Ueda, F. Eda, M. Arima, N. Yoshida, and T. Fukuda A549 Cells Can Express Interleukin-16 and Stimulate Eosinophil Chemotaxis Am. J. Respir. Cell Mol. Biol., August 1, 2001; 25(2): 212 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-F. Lee, R. P. Hellendall, Y. Wang, J. S. Haskill, N. Mukaida, K. Matsushima, and J. P.-Y. Ting IL-8 Reduced Tumorigenicity of Human Ovarian Cancer In Vivo Due to Neutrophil Infiltration J. Immunol., March 1, 2000; 164(5): 2769 - 2775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Barber, A. G. Pantschenko, L. S. Hinckley, and T. J. Yang Inducible and Constitutive In Vitro Neutrophil Chemokine Expression by Mammary Epithelial and Myoepithelial Cells Clin. Vaccine Immunol., November 1, 1999; 6(6): 791 - 798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Leland Booth and J. P. Metcalf Type-Specific Induction of Interleukin-8 by Adenovirus Am. J. Respir. Cell Mol. Biol., October 1, 1999; 21(4): 521 - 527. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Shimoya, A. Moriyama, N. Matsuzaki, I. Ogata, M. Koyama, C. Azuma, F. Saji, and Y. Murata Human placental cells show enhanced production of interleukin (IL)-8 in response to lipopolysaccharide (LPS), IL-1 and tumour necrosis factor (TNF)-{alpha}, but not to IL-6 Mol. Hum. Reprod., September 1, 1999; 5(9): 885 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Milne, H. O. D. Critchley, T. A. Drudy, R. W. Kelly, and D. T. Baird Perivascular Interleukin-8 Messenger Ribonucleic Acid Expression in Human Endometrium Varies across the Menstrual Cycle and in Early Pregnancy Decidua J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2563 - 2567. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. Yamaguchi, T. Mukasa, E. Uchida, T. Kanayasu-Toyoda, and T. Hayakawa The Role of STAT3 in Granulocyte Colony-stimulating Factor-induced Enhancement of Neutrophilic Differentiation of Me2SO-treated HL-60 Cells. GM-CSF INHIBITS THE NUCLEAR TRANSLOCATION OF TYROSINE-PHOSPHORYLATED STAT3 J. Biol. Chem., May 28, 1999; 274(22): 15575 - 15581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Takizawa, T. Ohtoshi, S. Kawasaki, T. Kohyama, M. Desaki, T. Kasama, K. Kobayashi, K. Nakahara, K. Yamamoto, K. Matsushima, et al. Diesel Exhaust Particles Induce NF-{kappa}B Activation in Human Bronchial Epithelial Cells In Vitro: Importance in Cytokine Transcription J. Immunol., April 15, 1999; 162(8): 4705 - 4711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Lippert, M. Artuc, A. Grutzkau, A. Moller, A. Kenderessy-Szabo, D. Schadendorf, J. Norgauer, K. Hartmann, R. Schweitzer-Stenner, T. Zuberbier, et al. Expression and Functional Activity of the IL-8 Receptor Type CXCR1 and CXCR2 on Human Mast Cells J. Immunol., September 1, 1998; 161(5): 2600 - 2608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sakuta, M. Tokuda, M. Tamura, E. Jimi, T. Ikebe, T. Koga, S. Nagaoka, and H. Takada Dual Regulatory Effects of Interferon-{alpha}, -{beta}, and -{gamma} on Interleukin-8 Gene Expression by Human Gingival Fibroblasts in Culture upon Stimulation with Lipopolysaccharide from Prevotella intermedia, Interleukin-1{alpha}, or Tumor Necrosis Factor-{alpha} Journal of Dental Research, August 1, 1998; 77(8): 1597 - 1605. [Abstract] [PDF]
|
|
|
|
|
|
M. R. Barber and T. J. Yang Chemotactic Activities in Nonmastitic and Mastitic Mammary Secretions: Presence of Interleukin-8 in Mastitic but Not Nonmastitic Secretions Clin. Vaccine Immunol., January 1, 1998; 5(1): 82 - 86. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. F. Foxman, J. J. Campbell, and E. C. Butcher Multistep Navigation and the Combinatorial Control of Leukocyte Chemotaxis J. Cell Biol., December 1, 1997; 139(5): 1349 - 1360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.-J. Neumann, I. Ott, N. Marx, T. Luther, S. Kenngott, M. Gawaz, M. Kotzsch, and A. Schomig Effect of Human Recombinant Interleukin-6 and Interleukin-8 on Monocyte Procoagulant Activity Arterioscler. Thromb. Vasc. Biol., December 1, 1997; 17(12): 3399 - 3405. [Abstract] [Full Text]
|
|
|
|
 |
|
 I. Desbaillets, A.-C. Diserens, N. d. Tribolet, M.-F. Hamou, and E. G. V. Meir Upregulation of Interleukin 8 by Oxygen-deprived Cells in Glioblastoma Suggests a Role in Leukocyte Activation, Chemotaxis, and Angiogenesis J. Exp. Med., October 20, 1997; 186(8): 1201 - 1212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kawahito, M. Kawakami, T. Fujiwara, H. Adachi, and T. Ino Interleukin-8 and monocyte chemotactic activating factor responses to cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., July 1, 1995; 110(1): 99 - 102. [Abstract] [Full Text]
|
|
|
|
 |
|
 G Cacalano, J Lee, K Kikly, A. Ryan, S Pitts-Meek, B Hultgren, W. Wood, and M. Moore Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog Science, July 29, 1994; 265(5172): 682 - 684. [Abstract] [PDF]
|
|
|
|
|
|
P. Murphy and H. Tiffany Cloning of complementary DNA encoding a functional human interleukin-8 receptor Science, September 13, 1991; 253(5025): 1280 - 1283. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
