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The Journal of Immunology, Vol 144, Issue 3 960-963, Copyright © 1990 by American Association of Immunologists

ARTICLES

Murine IL-4 antagonizes the protective effects of IFN on virus-mediated lysis of murine L929 fibroblast cells

M Lohoff, E Marsig and M Rollinghoff
Institut fur klinische Mikrobiologie der Universitat, Erlangen- Nurnberg, FRG.

IFN-alpha, -beta, and -gamma protect murine fibroblasts from lysis by vesicular stomatitis virus. In this report we show that culture supernatants derived from a Th cell clone of the TH2-type completely block the protective effects of the IFN. The active component in inhibiting IFN is identified to be IL-4. rIL-4 has similar effects as the T cell supernatant.




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