| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 144, Issue 2 532-540, Copyright © 1990 by American Association of Immunologists
ARTICLES |
TF Tedder, AC Penta, HB Levine and AS Freedman
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA 02115.
The LAM1 molecule is a member of the new family of cellular adhesion/homing molecules that contain a lectin-like domain at their amino-terminal end followed by an epidermal growth factor-like domain and short consensus repeat units like those found in C3/C4 binding proteins. Two mAb that react with the leukocyte adhesion molecule 1 (LAM1) were produced and used to examine the cell-surface expression of LAM1. The anti-LAM1 antibodies were reactive with the majority of blood lymphocytes, NK cells, neutrophils, and monocytes. LAM1 was also expressed by subpopulations of phenotypically immature and mature thymocytes. Blood lymphocytes rapidly modulated LAM1 from the cell surface during PMA exposure for 60 min. Coordinate with the loss of LAM1 from the cell surface, PMA-treated lymphocytes lost the ability to bind to lymph node high endothelial venules, indicating that expression of LAM1 may play a role in lymphocyte homing. Mitogen stimulation of blood T and B lymphocytes also resulted in decreased LAM1 expression, but at a slower rate. LAM1 was only weakly expressed by a minority of spleen lymphocytes. However, culturing spleen lymphocytes in media alone resulted in increased expression of LAM1 by a subpopulation of the cells (40 to 60%). Concomitant mitogen stimulation of spleen lymphocytes resulted initially in down-regulation of LAM1 expression followed by increased expression of LAM1 and then subsequent loss of LAM1 from the cell surface. The pattern of anti-LAM1 antibody reactivity was identical to that reported for the TQ1 and Leu-8 antibodies, and all of these antibodies reacted with cells transfected with the LAM1 cDNA. Thus, LAM1 is broadly expressed by leukocytes, and binding of LAM1 may participate in the process of leukocyte extravasation into lymphoid organs or sites of acute inflammation with subsequent loss of LAM1 from the cell surface.
This article has been cited by other articles:
|
|
 |
|
  G. M. Venturi, R. M. Conway, D. A. Steeber, and T. F. Tedder CD25+CD4+ Regulatory T Cell Migration Requires L-Selectin Expression: L-Selectin Transcriptional Regulation Balances Constitutive Receptor Turnover J. Immunol., January 1, 2007; 178(1): 291 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. M. Shpacovitch, G. Varga, A. Strey, M. Gunzer, F. Mooren, J. Buddenkotte, N. Vergnolle, C. P. Sommerhoff, S. Grabbe, V. Gerke, et al. Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices J. Leukoc. Biol., August 1, 2004; 76(2): 388 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Li, Y.-J. Kim, C. Mantel, and H. E. Broxmeyer P-Selectin Enhances Generation of CD14+CD16+ Dendritic-Like Cells and Inhibits Macrophage Maturation from Human Peripheral Blood Monocytes J. Immunol., July 15, 2003; 171(2): 669 - 677. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Suwa, J. C. Hogg, K. B. Quinlan, and S. F. van Eeden The effect of interleukin-6 on L-selectin levels on polymorphonuclear leukocytes Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H879 - H884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li, L. Tu, P. G Murphy, T. Kadono, D. A Steeber, and T. F. Tedder CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin J. Leukoc. Biol., April 1, 2001; 69(4): 565 - 574. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. Drillenburg and S. T. Pals Cell adhesion receptors in lymphoma dissemination Blood, March 15, 2000; 95(6): 1900 - 1910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bartholdy, O. Marker, and A. R. Thomsen Migration of activated CD8+ T lymphocytes to sites of viral infection does not require endothelial selectins Blood, February 15, 2000; 95(4): 1362 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Tu, P. G. Murphy, X. Li, and T. F. Tedder L-Selectin Ligands Expressed by Human Leukocytes Are HECA-452 Antibody-Defined Carbohydrate Epitopes Preferentially Displayed by P-Selectin Glycoprotein Ligand-1 J. Immunol., November 1, 1999; 163(9): 5070 - 5078. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Brocke, C. Piercy, L. Steinman, I. L. Weissman, and T. Veromaa Antibodies to CD44 and integrin alpha 4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment PNAS, June 8, 1999; 96(12): 6896 - 6901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nakagawa, G. P. Bondy, D. Waisman, D. Minshall, J. C. Hogg, and S. F. van Eeden The Effect of Glucocorticoids on the Expression of L-Selectin on Polymorphonuclear Leukocyte Blood, April 15, 1999; 93(8): 2730 - 2737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Evans, D. M. Schleider, L. A. Bowman, M. L. Francis, G. S. Kansas, and J. D. Black Dynamic Association of L-Selectin with the Lymphocyte Cytoskeletal Matrix J. Immunol., March 15, 1999; 162(6): 3615 - 3624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. van Eeden, J. Granton, J. M. Hards, B. Moore, and J. C. Hogg Expression of the cell adhesion molecules on leukocytes that demarginate during acute maximal exercise J Appl Physiol, March 1, 1999; 86(3): 970 - 976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ardavin, P. Martin, I. Ferrero, I. Azcoitia, F. Anjuere, H. Diggelmann, F. Luthi, S. Luther, and H. Acha-Orbea B Cell Response After MMTV Infection: Extrafollicular Plasmablasts Represent the Main Infected Population and Can Transmit Viral Infection J. Immunol., March 1, 1999; 162(5): 2538 - 2545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Tu, M. D. Delahunty, H. Ding, F. W. Luscinskas, and T. F. Tedder The Cutaneous Lymphocyte Antigen Is an Essential Component of the L-selectin Ligand Induced on Human Vascular Endothelial Cells J. Exp. Med., January 18, 1999; 189(2): 241 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. M. Dong, L. Jackson, and J. W. Murphy Mechanisms for Induction of L-Selectin Loss from T Lymphocytes by a Cryptococcal Polysaccharide, Glucuronoxylomannan Infect. Immun., January 1, 1999; 67(1): 220 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Robinson, L. Tu, D. A. Steeber, O. Preis, J. L. Platt, and T. F. Tedder The Role of Adhesion Molecules in Human Leukocyte Attachment to Porcine Vascular Endothelium: Implications for Xenotransplantation J. Immunol., December 15, 1998; 161(12): 6931 - 6938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Extermann, M. Bacchi, N. Monai, M. Fopp, M. Fey, A. Tichelli, M. Schapira, and O. Spertini Relationship Between Cleaved L-Selectin Levels and the Outcome of Acute Myeloid Leukemia Blood, November 1, 1998; 92(9): 3115 - 3122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li, D. A. Steeber, M. L.K. Tang, M. A. Farrar, R. M. Perlmutter, and T. F. Tedder Regulation of L-Selectin-mediated Rolling through Receptor Dimerization J. Exp. Med., October 5, 1998; 188(7): 1385 - 1390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Kunkel, C. L. Ramos, D. A. Steeber, W. Muller, N. Wagner, T. F. Tedder, and K. Ley The Roles of L-Selectin, {beta}7 Integrins, and P-Selectin in Leukocyte Rolling and Adhesion in High Endothelial Venules of Peyer's Patches J. Immunol., September 1, 1998; 161(5): 2449 - 2456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Frey, N. B. Packianathan, T. A. Fehniger, M. E. Ross, W.-C. Wang, C. C. Stewart, M. A. Caligiuri, and S. S. Evans Differential Expression and Function of L-Selectin on CD56bright and CD56dim Natural Killer Cell Subsets J. Immunol., July 1, 1998; 161(1): 400 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Ramos, M. J. Smith, K. R. Snapp, G. S. Kansas, G. W. Stickney, K. Ley, and M. B. Lawrence Functional Characterization of L-Selectin Ligands on Human Neutrophils and Leukemia Cell Lines: Evidence for Mucinlike Ligand Activity Distinct From P-Selectin Glycoprotein Ligand-1 Blood, February 1, 1998; 91(3): 1067 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Haribabu, D. A. Steeber, H. Ali, R. M. Richardson, R. Snyderman, and T. F. Tedder Chemoattractant Receptor-induced Phosphorylation of L-selectin J. Biol. Chem., May 23, 1997; 272(21): 13961 - 13965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zakrzewicz, M. Grafe, D. Terbeek, M. Bongrazio, W. Auch-Schwelk, B. Walzog, K. Graf, E. Fleck, K. Ley, and P. Gaehtgens L-Selectin-Dependent Leukocyte Adhesion to Microvascular But Not to Macrovascular Endothelial Cells of the Human Coronary System Blood, May 1, 1997; 89(9): 3228 - 3235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Kunkel and K. Ley Distinct Phenotype of E-Selectin–Deficient Mice: E-Selectin Is Required for Slow Leukocyte Rolling In Vivo Circ. Res., December 1, 1996; 79(6): 1196 - 1204. [Abstract] [Full Text]
|
|
|
|
 |
|
 J Ng-Sikorski, L Linden, D Eierman, L Franzen, L Molony, and T Andersson Engagement of L-selectin impairs the actin polymerizing capacity of beta 2-integrins on neutrophils J. Cell Sci., January 9, 1996; 109(9): 2361 - 2369. [Abstract] [PDF]
|
|
|
|
 |
|
 N. A. Ahmed, J. Yee, B. Giannias, B. Kapadia, and N. V. Christou Expression of Human Neutrophil L-Selectin During the Systemic Inflammatory Response Syndrome Is Partly Mediated by Tumor Necrosis Factor {alpha} Arch Surg, January 1, 1996; 131(1): 31 - 36. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Huber, S. Kunkel, R. Todd 3rd, and S. Weiss Regulation of transendothelial neutrophil migration by endogenous interleukin-8 Science, October 4, 1991; 254(5028): 99 - 102. [Abstract] [PDF]
|
|
|
|
|
|
A. Freedman, J. Munro, G. Rice, M. Bevilacqua, C Morimoto, B. McIntyre, K Rhynhart, J. Pober, and L. Nadler Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110 Science, August 31, 1990; 249(4972): 1030 - 1033. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
