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The Journal of Immunology, Vol 144, Issue 12 4507-4512, Copyright © 1990 by American Association of Immunologists

ARTICLES

Double-negative (CD4- CD8-) T cells with an alpha/beta T cell receptor. Non-MHC-restricted cytolytic activity and lymphokine production

EG Brooks, DP Wirt, RM Goldblum, S Vaidya, MT Asuncion, JC Patterson, CF Ware and GR Klimpel
Department of Pediatrics, University of Texas Medical Branch, Galveston 77550.

T cell lines with a novel phenotype (CD3+ TCR-alpha/beta+ CD4- CD8-) were developed from the peripheral blood of a patient with a combined immunodeficiency and tissue injury resembling graft-vs-host disease. One of these IL-2-dependent T cell lines demonstrated non-MHC- restricted cytolytic function against tumor targets, syngeneic and allogeneic fibroblasts, and PHA blasts from allogeneic donors. The other cell line only became cytotoxic in the presence of lectin or anti- CD3 antibody. The two cell lines also differed in their expression of the T-200 gene products CD45RO (gp180) and CD45RA (gp220). Both cell lines produced tumor necrosis factor-alpha and -beta and IFN-gamma activity when activated with mitogens or PMA and IL-1. The in vitro functions of these T-cell lines suggest a potential role for alpha/beta double-negative T lymphocytes in tissue injury resembling graft-vs-host disease.


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E. G. Brooks, A. H. Filipovich, J. W. Padgett, R. Mamlock, and R. M. Goldblum
T-Cell Receptor Analysis in Omenn's Syndrome: Evidence for Defects in Gene Rearrangement and Assembly
Blood, January 1, 1999; 93(1): 242 - 250.
[Abstract] [Full Text] [PDF]


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