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The Journal of Immunology, Vol 144, Issue 10 3784-3788, Copyright © 1990 by American Association of Immunologists

ARTICLES

IL-1 beta modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat

CA Wilson, C Jacobs, P Baker, DG Baskin, S Dower, A Lernmark, B Toivola, S Vertrees and D Wilson
Department of Medicine, University of Washington, Seattle 98195.

Long term effects of in vivo treatment with human rIL-1 beta on diabetogenesis and thyroid disease were determined in the Biobreeding rat. Administration of high dose (10 micrograms/kg) IL-1 beta accelerated the onset of insulin-dependent diabetes mellitus compared to saline-injected controls. High dose treatment resulted in goiter development, pronounced LT, reduced serum T4 levels, and overall growth reduction. In contrast, low dose IL-1 beta (0.5 microgram/kg) administration significantly reduced the frequency of insulin-dependent diabetes mellitus (48%) compared to placebo (86%) and high dose IL-1 beta (93%) treatment groups. Rats protected by low dose IL-1 beta had unaffected growth rates and minimal to no pancreatic and thyroid pathology. Our results demonstrate that exogenous administration of IL- 1 beta modulates Biobreeding rat idiopathic autoimmune diabetes and thyroid disease in a dose-dependent manner.


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[Abstract] [Full Text] [PDF]


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