The Journal of Immunology, Vol 142, Issue 9 3021-3025, Copyright © 1989 by American Association of Immunologists

ARTICLES

Cytotoxic T lymphocyte recognition of secreted HLA class I molecules

B Kahn-Perles, C Barra, J Jehan, D Fourel, M Barad, JL Maryanski and FA Lemonnier
Centre d'Immunologie de Marseille-Luminy, France.

The cytolytic responses of DBA/2 mice against syngeneic transfected P815 mastocytoma cells expressing either membrane-associated (HLA-Cw3) or -secreted hybrid (HLA-Cw3 x H-2 Q10b) molecules were compared. In spite of the absence of serologically detectable hybrid molecules on their plasma membrane, cells secreting these molecules elicited a CTL response similar to that of cells expressing the membrane associated HLA-Cw3 molecules, in terms of both MHC-restriction and peptide specificity. Together with the observation that syngeneic mice were capable of rejecting the injected secreting cells, these results imply that secreted HLA class I molecules can function as minor histocompatibility Ag and suggest that processing of both the membrane- bound and the -secreted forms of a protein may follow common or overlapping pathways.

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