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The Journal of Immunology, Vol 142, Issue 7 2321-2324, Copyright © 1989 by American Association of Immunologists

ARTICLES

Endotoxemia elicits increased circulating beta 2-IFN/IL-6 in man

Y Fong, LL Moldawer, M Marano, H Wei, SB Tatter, RH Clarick, U Santhanam, D Sherris, LT May and PB Sehgal
Laboratory of Surgical Metabolism, New York Hospital-Cornell Medical Center 10021.

beta 2-IFN/hepatocyte stimulating factor/IL-6 is a cytokine secreted by monocytes, fibroblasts, and endothelial cells in cell culture that possesses diverse biologic activity including the stimulation of acute phase plasma protein synthesis and immunomodulation. The circulating levels of this cytokine in man in response to bacterial LPS (endotoxin) were studied. A single i.v. bolus of endotoxin (20 U/kg) produced a monophasic rise in circulating immunoreactive IFN-beta 2/IL-6 and IFN- beta 2/IL-6 bioactivity (hepatocyte stimulation and B cell differentiation assays) peaking 2 to 4 h after the endotoxin challenge. Peak IFN-beta 2/IL-6 levels ranged from 4.1 to 27.5 ng/ml. Associated with this was a rise in circulating C-reactive protein levels detected 20 h after the endotoxin bolus. Thus, IFN-beta 2/IL-6 is likely one of the endogenous mediators which is triggered in man during bacterial infection and likely participates in the metabolic and immune responses of the infected host.


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