The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Perkins, D. L.
Right arrow Articles by Marshak-Rothstein, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Perkins, D. L.
Right arrow Articles by Marshak-Rothstein, A.

The Journal of Immunology, Vol 138, Issue 2 466-469, Copyright © 1987 by American Association of Immunologists

ARTICLES

The lpr gene is associated with resistance to engraftment by lymphoid but not erythroid stem cells from normal mice

DL Perkins, J Michaelson and A Marshak-Rothstein

This study demonstrates cell lineage-specific resistance to engraftment involving lymphocytes but not erythrocytes by the spontaneously autoimmune MRL/lpr mouse strain. In these experiments, MRL/lpr mice were lethally irradiated (1000 R) and reconstituted with normal A-Thy bone marrow stem cells. Periodic analysis from 6 wk to 6 mo posttransplantation demonstrated that the T and B cells of these chimeras were derived from the MRL/lpr host. However, in the same A-Thy- ---MRL/lpr chimeras, erythrocyte repopulation was completely of A-Thy donor origin. In contrast, control MRL/+ (congenic mice that differ from MRL/lpr at the lpr locus and do not develop accelerated autoimmune disease) recipients were successfully repopulated in both the lymphoid and erythroid compartments by the A-Thy donor cells.


This article has been cited by other articles:


Home page
 Cancer Res.Home page
A. Meng, Y. Wang, G. Van Zant, and D. Zhou
Ionizing Radiation and Busulfan Induce Premature Senescence in Murine Bone Marrow Hematopoietic Cells
Cancer Res., September 1, 2003; 63(17): 5414 - 5419.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. R. Rifkin, E. A. Leadbetter, B. C. Beaudette, C. Kiani, M. Monestier, M. J. Shlomchik, and A. Marshak-Rothstein
Immune Complexes Present in the Sera of Autoimmune Mice Activate Rheumatoid Factor B Cells
J. Immunol., August 1, 2000; 165(3): 1626 - 1633.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Zamai, P. Secchiero, S. Pierpaoli, A. Bassini, S. Papa, E. S. Alnemri, L. Guidotti, M. Vitale, and G. Zauli
TNF-related apoptosis-inducing ligand (TRAIL) as a negative regulator of normal human erythropoiesis
Blood, June 15, 2000; 95(12): 3716 - 3724.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. R. M. van den Brink, E. Moore, K. J. Horndasch, J. M. Crawford, J. Hoffman, G. F. Murphy, and S. J. Burakoff
Fas-Deficient lpr Mice Are More Susceptible to Graft-Versus-Host Disease
J. Immunol., January 1, 2000; 164(1): 469 - 480.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. R. Rifkin, P. L. Channavajhala, H. L.B. Kiefer, A. J. Carmack, E. Landesman-Bollag, B. C. Beaudette, B. Jersky, D. J. Salant, S.-T. Ju, A. Marshak-Rothstein, et al.
Acceleration of lpr Lymphoproliferative and Autoimmune Disease by Transgenic Protein Kinase CK2{alpha}
J. Immunol., November 15, 1998; 161(10): 5164 - 5170.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1987 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1987 by The American Association of Immunologists, Inc. All rights reserved.