The Journal of Immunology, Vol 138, Issue 1 4-6, Copyright © 1987 by American Association of Immunologists

COMMUNICATIONS

Physiology of IgD. VII. Induction of receptors for IgD on cloned T cells by IgD and interleukin 2

RF Coico, JA Berzofsky, J York-Jolley, S Ozaki, GW Siskind and GJ Thorbecke

The role of IgD in the immune response has remained elusive, although the predominance of IgD on the B cell surface and the paucity of IgD in serum have suggested a receptor function. In support of this hypothesis, it has recently been shown that receptors for IgD on helper T cells can be induced by exposure to IgD in vivo and in vitro. Such IgD receptor-positive T cells (i.e., T delta cells), detectable as RFC using IgD-coated SRBC, augment antibody responses. In this report, we demonstrate that cloned, antigen-specific T cells of helper phenotype show only very low percentages of IgD-RFC, if allowed to rest in vitro after antigen exposure in the absence of IL 2. Exposure to IgD or to IL 2 for 24 hr causes the IgD-specific RFC to increase as much as 25-fold to nearly 80%. Clones that have recently been stimulated with antigen, or T cell hybridomas prepared from such clones, exhibit 40 to 50% IgD- RFC before exposure and twofold higher levels after exposure to IgD. IL 2 also causes a dose-dependent induction of OgD-RFC in normal splenic T cells. Thus, antigen stimulation, IL 2 and IgD can all induce these receptors for IgD which presumably enable helper T cells to interact more effectively with IgD+ B cells.

This article has been cited by other articles:

				N. M. Ponzio G. Jeanette Thorbecke, 1929-2001 Am. J. Pathol., June 1, 2002; 160(6): 1917 - 1920. [Full Text] [PDF]

				A. Billiau Interferons in multiple sclerosis: Warnings from experiences Neurology, June 1, 1995; 45(6_Suppl_6): S50 - S53. [Abstract] [Full Text] [PDF]