| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 137, Issue 9 2891-2900, Copyright © 1986 by American Association of Immunologists
ARTICLES |
LJ Miller, R Schwarting and TA Springer
The regulation of Mac-1, LFA-1, and p150,95 expression during leukocyte differentiation was examined. LFA-1 was present on almost all cell types studied. Both Mac-1 and p150,95 were present on the more mature cells of the myelomonocytic series, but only p150,95 was detected on some B cell lines and cloned cytotoxic T lymphocytes. Phorbol myristate acetate (PMA) stimulation of B chronic lymphocytic leukemia cells dramatically increased p150,95 expression. The resultant Mac-1, LFA-1, p150,95 phenotype resembled hairy cell leukemia, a B cell plasmacytoid leukemia. The promonocytic cell line U937 and the promyeloblastic cell line HL-60 expressed only LFA-1. Monocytic differentiation of U937 cells was stimulated by PMA, and induced the concomitant expression of Mac-1 and p150,95, with more p150,95 induced than Mac-1. Granulocyte/macrophage colony-stimulating factor (GM-CSF) stimulation of U937 cells gave similar results. PMA-stimulated monocytic differentiation of the HL-60 cell line also induced expression of both Mac-1 and p150,95. The number of p150,95 molecules on PMA-stimulated U937 and HL-60 cells were 5 X 10(5) and 3 X 10(5), respectively. Retinoic acid stimulated myeloid differentiation of HL-60 cells and induced expression of both Mac-1 and p150,95. These cells acquired a Mac-1, LFA-1, p150,95 profile that resembled that of granulocytes, with more Mac-1 than p150,95 induced. GM-CSF stimulation of HL-60 cells induced a similar Mac-1 and p150,95 phenotype. The contributions of Mac- 1, LFA-1, and p150,95 to aggregation of PMA-differentiated U937 cells were assessed. Monoclonal antibodies to the beta subunit and the LFA-1 alpha subunit, but not those to p150,95 or Mac-1 alpha subunit, inhibited this homotypic adherence.
This article has been cited by other articles:
|
|
 |
|
  S. S. Smith and S. R. Barnum Differential expression of {beta}2-integrins and cytokine production between {gamma}{delta} and {alpha}{beta} T cells in experimental autoimmune encephalomyelitis J. Leukoc. Biol., January 1, 2008; 83(1): 71 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Arndt, C. Melle, K. Mondal, G. Klein, F. von Eggeling, and A.-K. Bosserhoff Interactions of TANGO and leukocyte integrin CD11c/CD18 regulate the migration of human monocytes J. Leukoc. Biol., December 1, 2007; 82(6): 1466 - 1472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Bullard, X. Hu, J. E. Adams, T. R. Schoeb, and S. R. Barnum p150/95 (CD11c/CD18) Expression Is Required for the Development of Experimental Autoimmune Encephalomyelitis Am. J. Pathol., June 1, 2007; 170(6): 2001 - 2008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Healy, R. W. G. Watson, C. O'Keane, J. J. Egan, J. F. McCarthy, J. Hurley, J. Fitzpatrick, and A. E. Wood Neutrophil transendothelial migration potential predicts rejection severity in human cardiac transplantation. Eur. J. Cardiothorac. Surg., May 1, 2006; 29(5): 760 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Yoshimi, S. Yamaji, A. Suzuki, W. Mishima, M. Okamura, T. Obana, C. Matsuda, Y. Miwa, S. Ohno, and Y. Ishigatsubo The {gamma}-Parvin-Integrin-Linked Kinase Complex Is Critically Involved in Leukocyte-Substrate Interaction J. Immunol., March 15, 2006; 176(6): 3611 - 3624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Leroy, F. Berto, I. Bourget, and B. Rossi Down-regulation of Hox A7 is required for cell adhesion and migration on fibronectin during early HL-60 monocytic differentiation J. Leukoc. Biol., April 1, 2004; 75(4): 680 - 688. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Lee, Z. Hmama, A. Mui, and N. E. Reiner Stable Gene Silencing in Human Monocytic Cell Lines Using Lentiviral-delivered Small Interference RNA: SILENCING OF THE p110{alpha} ISOFORM OF PHOSPHOINOSITIDE 3-KINASE REVEALS DIFFERENTIAL REGULATION OF ADHERENCE INDUCED BY 1{alpha},25-DIHYDROXYCHOLECALCIFEROL AND BACTERIAL LIPOPOLYSACCHARIDE J. Biol. Chem., March 5, 2004; 279(10): 9379 - 9388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Park, C. S. Shelley, and M. A. Arnaout The zinc finger transcription factor ZBP-89 is a repressor of the human beta 2-integrin CD11b gene Blood, February 1, 2003; 101(3): 894 - 902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xia, G. Borland, J. Huang, I. F. Mizukami, H. R. Petty, R. F. Todd III, and G. D. Ross Function of the Lectin Domain of Mac-1/Complement Receptor Type 3 (CD11b/CD18) in Regulating Neutrophil Adhesion J. Immunol., December 1, 2002; 169(11): 6417 - 6426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dimberg, F. Bahram, I. Karlberg, L.-G. Larsson, K. Nilsson, and F. Oberg Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p27Kip1 Blood, March 15, 2002; 99(6): 2199 - 2206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Orchekowski, J. Plescia, D. C. Altieri, and M. L. Bajt {alpha}M{beta}2 (CD11b/CD18, Mac-1) integrin activation by a unique monoclonal antibody to {alpha}M I domain that is divalent cation-sensitive J. Leukoc. Biol., November 1, 2000; 68(5): 641 - 649. [Abstract] [Full Text]
|
|
|
|
|
|
S. Tyagi, L. B. Klickstein, and A. Nicholson-Weller C5a-stimulated human neutrophils use a subset of {beta}2 integrins to support the adhesion-dependent phase of superoxide production J. Leukoc. Biol., November 1, 2000; 68(5): 679 - 686. [Abstract] [Full Text]
|
|
|
|
|
|
A. Dimberg, K. Nilsson, and F. Oberg Phosphorylation-deficient Stat1 inhibits retinoic acid-induced differentiation and cell cycle arrest in U-937 monoblasts Blood, October 15, 2000; 96(8): 2870 - 2878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sheng, M. B. Fairbanks, R. L. Heinrikson, G. Canziani, I. M. Chaiken, D. M. Mosser, H. Zhang, and R. W. Colman Cleaved high molecular weight kininogen binds directly to the integrin CD11b/CD18 (Mac-1) and blocks adhesion to fibrinogen and ICAM-1 Blood, June 15, 2000; 95(12): 3788 - 3795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Noti, A. K. Johnson, and J. D. Dillon Structural and Functional Characterization of the Leukocyte Integrin Gene CD11d. ESSENTIAL ROLE OF Sp1 AND Sp3 J. Biol. Chem., March 17, 2000; 275(12): 8959 - 8969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsuguchi, K. Takagi, T. Musikacharoen, and Y. Yoshikai Gene expressions of lipopolysaccharide receptors, toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes Blood, February 15, 2000; 95(4): 1378 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Feuk-Lagerstedt, E. T. Jordan, H. Leffler, C. Dahlgren, and A. Karlsson Identification of CD66a and CD66b as the Major Galectin-3 Receptor Candidates in Human Neutrophils J. Immunol., November 15, 1999; 163(10): 5592 - 5598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Melian, Y.-J. Geng, G. K. Sukhova, P. Libby, and S. A. Porcelli CD1 Expression in Human Atherosclerosis : A Potential Mechanism for T Cell Activation by Foam Cells Am. J. Pathol., September 1, 1999; 155(3): 775 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Griggs, C. M. Schmidt, and C. P. Carron Characteristics of Cation Binding to the I Domains of LFA-1 and MAC-1. THE LFA-1 I DOMAIN CONTAINS A Ca2+-BINDING SITE J. Biol. Chem., August 21, 1998; 273(34): 22113 - 22119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nakamura, T. Oda, K. Hamada, T. Hirano, N. Shimizu, and H. Utiyama Survival by Mac-1-mediated Adherence and Anoikis in Phorbol Ester-treated HL-60 Cells J. Biol. Chem., June 19, 1998; 273(25): 15345 - 15351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Feng, D. Chung, L. Garrard, G. McEnroe, D. Lim, J. Scardina, K. McFadden, A. Guzzetta, A. Lam, J. Abraham, et al. Peptides Derived from the Complementarity-determining Regions of Anti-Mac-1 Antibodies Block Intercellular Adhesion Molecule-1 Interaction with Mac-1 J. Biol. Chem., March 6, 1998; 273(10): 5625 - 5630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. G. Goodman and M. L. Bajt Identifying the Putative Metal Ion-dependent Adhesion Site in the beta 2 (CD18) Subunit Required for alpha Lbeta 2 and alpha Mbeta 2 Ligand Interactions J. Biol. Chem., September 27, 1996; 271(39): 23729 - 23736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.án Aragonés, C. López-Rodríguez, A. Corbí, P. Góm. del Arco, M. López-Cabrera, M. O. de Landázuri, and J. M. Redondo Dithiocarbamates Trigger Differentiation and Induction of CD11c Gene through AP-1 in the Myeloid Lineage J. Biol. Chem., May 3, 1996; 271(18): 10924 - 10931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Seki, N. Koyama, N. L. Kovach, T. Yednock, A. W. Clowes, and J. M. Harlan Regulation of ß1-Integrin Function in Cultured Human Vascular Smooth Muscle Cells Circ. Res., April 1, 1996; 78(4): 596 - 605. [Abstract] [Full Text]
|
|
|
|
|
|
S. L. McGuire and M. L. Bajt Distinct Ligand Binding Sites in the I Domain of Integrin alpha(M)beta(2) That Differentially Affect a Divalent Cation-dependent Conformation J. Biol. Chem., October 27, 1995; 270(43): 25866 - 25871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Bajt, T. Goodman, and S. L. McGuire beta(2)(CD18) Mutations Abolish Ligand Recognition by I Domain Integrins LFA-1 (alpha(L)beta(2), CD11a/CD18) and MAC-1 (alpha(M)beta(2), CD11b/CD18) J. Biol. Chem., January 6, 1995; 270(1): 94 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wilson, A. Ping, J. Krauss, L Mayo-Bond, C. Rogers, D. Anderson, and R. Todd Correction of CD18-deficient lymphocytes by retrovirus-mediated gene transfer Science, June 15, 1990; 248(4961): 1413 - 1416. [Abstract] [PDF]
|
|
|
|
|
|
Q. Zang and T. A. Springer Amino Acid Residues in the PSI Domain and Cysteine-rich Repeats of the Integrin beta 2 Subunit That Restrain Activation of the Integrin alpha xbeta 2 J. Biol. Chem., March 2, 2001; 276(10): 6922 - 6929. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
