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The Journal of Immunology, Vol 136, Issue 5 1537-1541, Copyright © 1986 by American Association of Immunologists

ARTICLES

Function and cell distribution of KC-1, a novel natural killer cell- associated antigen

C Clayberger, B Dyer, B McIntyre, TD Koller, B Hardy, P Parham, LL Lanier and AM Krensky

Natural killer (NK) cell have been implicated in immune responses to tumor and viral antigens. We describe here a monoclonal antibody, anti- KC-1, that blocks lysis of NK targets by fresh but not activated NK cells. Anti-KC-1 has no effect on cytotoxic T lymphocyte activity or on antibody-dependent cellular cytotoxicity. This antibody may be useful in the analysis of NK cell activation and the mechanism of lysis.




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