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Quantitative Estimation of Antibody in the Immunoglobulin Classes of the Mouse

II. Thymic Dependence of the Different Classes

From the Department of Immunology, Middlesex Hospital Medical School, London, W.1, England

Abstract

Thymectomized mice produced a significantly lower level of antibody against human serum albumin (HSA) and the decrease in total antibody activity was due to a decrease in the IgG1 while the other immunoglobulin classes were largely unaffected. The same animals did produce a normal response in all immunoglobulin classes to a high dose of keyhole limpet hemocyanin (KLH). However, a low dose (1 µg) of the same antigen produced a poor response in thymectomized mice, and, as was found with HSA, IgG1 was the main immunoglobulin class affected. It is concluded a) that KLH is a "non-thymic-dependent" antigen only at a relatively high dose and b) that of all the immunoglobulin classes only IgG1 is thymic-dependent.

Footnotes

¹ Present address: Immunology Unit, World Health Organization, 1211 Geneva 27, Switzerland.

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